CME Modules

1. Epidemiology and Pathology of Dementia and MCI: Community Based Studies

Helena Chui, MD
Chair, Department of Neurology
Raymond and Betty McCarron Chair of Neurology
Professor of Neurology and Gerontology
Keck School of Medicine of the University of Southern California
Los Angeles, California
Declares No Financial Relationship with a Commercial Interest

Objectives

  1. Know the age-specific life-time risk of Alzheimer disease and other dementing disorders
  2. Recognize the overlapping pathologic changes associated with AD, CVD, DLB, and FTD
  3. Recognize genetic and environment risk factors, and the importance of targeting vascular risk factors to reduce the incidence of dementia

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2. Clinical Assessment: Cognitive & Behavioral Networks

Liliana Ramirez-Gomez, MD
Assistant Professor of Clinical Neurology
Keck School of Medicine of the University of Southern California
Los Angeles, California
Declares No Financial Relationship with a Commercial Interest

Objectives

  1. Outline cognitive screening tools for the evaluation of patients with cognitive complaints
  2. Distinguish memory impairment due to compromise of the medial temporal-diencephalic memory system from frontal executive system
  3. Discuss the differential diagnosis of dementia syndromes based on history, neurobehavioral and neurological exam
  4. Identify the cognitive and behavioral symptoms associated with AD, DLB, FTD and VCI

3. Imaging Dementia: Evidence for Neural Network Degeneration and Vascular Pathology on MRI and FDG PET

Collins Liu, MD
Assistant Professor of Clinical Neurology
Keck School of Medicine of the University of Southern California
Los Angeles, California
Declares No Financial Relationship with a Commercial Interest

Objectives

  1. Describe the role of MRI and FDG PET in diagnosing dementia
  2. Recognize typical patterns of cortical atrophy and hypometabolism in dementia

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4. Cerebrospinal Fluid (CSF) and Amyloid Positron Emission Tomography (PET) Markers of Alzheimer’s Disease: Current Status & Future Directions

John Ringman, MD
Professor of Clinical Neurology
Keck School of Medicine of the University of Southern California
Los Angeles, California
Grant/research support from Avid Pharmaceuticals

Objectives

  1. Outline the utility of currently available molecular biomarkers in the differential diagnosis of dementia
  2. Define appropriate contexts to order lumbar punctures and PET scans for dementia
  3. Discuss future directions of CSF and PET biomarkers in diagnosis and treatment of dementia

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5. Symptomatic Treatment

Freddi Segal-Gidan PA-C, PhD
Assistant Professor of Clinical Neurology and
Family Medicine
Keck School of Medicine of the University of Southern California
Los Angeles, California
Declares No Financial Relationship with a Commercial Interest

Objectives

  1. Outline limitations of current medications used for treatment of cognitive symptoms
  2. Identify non-pharmacologic approaches to treatment of behavioral symptoms of dementia
  3. Discuss use and limitations of medications for management of behavioral symptoms of dementia

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6. Models of Care in the Era of the Affordable Care Act

Laura Mosqueda, MD
Chair, Department of Family Medicine
Professor of Clinical Family Medicine
Keck School of Medicine of the University of Southern California
Los Angeles, California
Declares No Financial Relationship with a Commercial Interest

Objectives

  1. Understand the importance of team-based care
  2. Know 2 new models of care for the people with dementia

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7. KEYNOTE ADDRESS: Genetics of Alzheimer Disease

Kenneth Kosik, MD
Harriman Professor of Neuroscience Research
Co-Director of the Neuroscience Research Institute
University of California, Santa Barbara
Santa Barbara, California
Declares No Financial Relationship with a Commercial Interest

Objectives

  1. Know the genetic risks of Alzheimer’s disease
  2. Understand the conduct of Alzheimer’s disease research in families that harbor mutations

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8. Does Dyslipidemia of Obesity Contribute to Alzheimer ’s disease?

Hussein Yassine, MD
Assistant Professor of Medicine
Keck School of Medicine of the University of Southern California
Los Angeles, California
Declares No Financial Relationship with a Commercial Interest

Objectives

  1. Discuss basics of brain lipid metabolism
  2. Understand the link between peripheral and brain lipid metabolism
  3. Discuss the relation between lipid metabolism and beta amyloid

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9. Neural Mechanisms Associated with Memory Dysfunction and Treatment in Individuals at Risk for AD

Judy Pa, PhD
Assistant Professor of Neurology
Stevens Brain Institute for Neuroimaging and Informatics
Keck School of Medicine of the University of Southern California
Los Angeles, California
Declares No Financial Relationship with a Commercial Interest

Objectives

  1. Identify neural and cognitive risk factors for Alzheimer’s disease
  2. Discuss promising secondary prevention approaches for individuals at risk for developing Alzheimer’s disease

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10. Clinical Trials Update: Pre-symptomatic & Symptomatic Treatments

Lon Schneider, MD, MS
Professor of Psychiatry, Neurology and Gerontology
Keck School of Medicine of the University of Southern California
Los Angeles, California
Declares No Financial Relationship with a Commercial Interest
Grant/research support from Eli Lilly, Forum, Roche/Genentech,
Lundbeck, Merck, Novartis, Tau Rx; Consultant for Cerespir,
Forum, Medavante, Merck, Novartis, Orion, Roche, Servier,
Stemedica, Takeda, Tau Rx, Toyama, TransTech Pharma and
Zinfandel

Objectives

  1. Learn about drugs in development for Alzheimer’s disease
  2. Know the FDA criteria for drug approval for AD
  3. Know the rationale for several drugs in development for AD or MCI due to AD

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11. Clinical Trials Update

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12. Panel Discussion & Session Closing Remarks

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