{"id":500,"date":"2024-09-23T10:22:51","date_gmt":"2024-09-23T17:22:51","guid":{"rendered":"https:\/\/keck.usc.edu\/cpbh\/?page_id=500"},"modified":"2026-04-30T19:52:31","modified_gmt":"2026-05-01T02:52:31","slug":"research-highlights","status":"publish","type":"page","link":"https:\/\/keck.usc.edu\/cpbh\/research\/research-highlights\/","title":{"rendered":"Research Highlights"},"content":{"rendered":"\n\n\n\n\n    \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--hero-primary has-image horizontal-navigation\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--hero-primary\"\n    \n      >\n\n    \n      <div class=\"image-container\">\n\n                  \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/iStock-1411439130-768x432.jpg\"\n          data-srcset=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/iStock-1411439130-1920x1080.jpg 1920w,https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/iStock-1411439130-1280x720.jpg 1280w,https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/iStock-1411439130-768x432.jpg 768w\"          data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n        alt=\"Test tube with pipette dripping down.\"\n        \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n      \n      \n      \n    <\/div>\n  \n  <div class=\"inner-wrapper has-horizontal-nav\">\n\n          <div class=\"title-wrapper\">\n\n                  <div class=\"eyebrow-container\">\n                              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <a href=\"https:\/\/keck.usc.edu\/cpbh\/\"  aria-label=\"Read more about USC Center for Personalized Brain Health\">USC Center for Personalized Brain Health<\/a>\n\n\n\n<\/div>\n                              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <a href=\"https:\/\/keck.usc.edu\/cpbh\/research\/\"  aria-label=\"Read more about Research\">Research<\/a>\n\n\n\n<\/div>\n                      <\/div>\n        \n                      \n<div class=\"f--field f--page-title has-stripe\">\n\n    \n      <h1>Research Highlights<\/h1>\n\n\n<\/div>\n        \n              <\/div>\n    \n              \n<div class=\"f--field f--link eyebrow-link\">\n\n    \n    \n  \n<a\n  class=\"link \"\n  href=\"https:\/\/giveto.usc.edu\/?fundid=GF1908144&#038;appealcode=WK24WG335&#038;radioamount0=25&#038;radioamount1=100&#038;radioamount2=500&#038;radioamount3=1000&#038;radioamount4=2500&#038;buttongen=1&#038;blankradio=true&#038;hidetop=1\"\n  target=\"_blank\"  aria-label=\"Read&#x20;more&#x20;about&#x20;Give&#x20;Now\">\n        Give Now\n    <\/a>\n\n\n<\/div>\n    \n    \n      \n              <div 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begins with basic and clinical research. Ongoing, dedicated research in the lab drives critical insights and understanding about the mechanisms of Alzheimer\u2019s Disease and the role of modifiable and non-modifiable risk factors in disease progression and intervention.<\/p>\n<p style=\"font-weight: 400;\">We invite you to explore examples of our work below. \u00a0Please visit <strong><a href=\"https:\/\/www.yassinelab.org\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/yassinelab.com&amp;source=gmail&amp;ust=1725635642720000&amp;usg=AOvVaw1cTTo8daJ9IRJKPuop3GZO\">yassinelab.org<\/a><\/strong> for additional information about our research or or <a href=\"https:\/\/mailchi.mp\/2099ac361c6d\/cpbh\"><strong>sign up<\/strong><\/a> for our newsletter to stay current with our work.<\/p>\n<p>&nbsp;<\/p>\n<hr style=\"color: #ffcc00;\" \/>\n<h2><a href=\"https:\/\/www.nature.com\/articles\/s44386-025-00035-0\"><em><strong>Development of potent, selective cPLA2\u00a0inhibitors for targeting neuroinflammation in Alzheimer\u2019s disease and other neurodegenerative disorders<\/strong><\/em><\/a><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-940\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2026\/03\/Screenshot-2026-02-10-at-10.50.24-AM-300x168.png\" alt=\"Immunofluorescence images of iPSC-derived neurons stained for synapsin (green), CaMKII\u03b1 (red), MAP2 (grey), and DAPI (blue) comparing control, A\u03b2420, and A\u03b2420+460; includes quantification bar charts (panels C\u2013E).\" width=\"1773\" height=\"990\" srcset=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2026\/03\/Screenshot-2026-02-10-at-10.50.24-AM-300x168.png 300w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2026\/03\/Screenshot-2026-02-10-at-10.50.24-AM-320x180.png 320w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2026\/03\/Screenshot-2026-02-10-at-10.50.24-AM.png 650w\" sizes=\"auto, (max-width: 1773px) 100vw, 1773px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Chronic neuroinflammation plays a key role in the progression of Alzheimer\u2019s disease (AD), and the cytosolic calcium-dependent phospholipase A<sub>2<\/sub>\u00a0(cPLA<sub>2<\/sub>) enzyme is a critical mediator of inflammatory lipid signaling pathways. We investigated the therapeutic potential of novel cPLA<sub>2<\/sub> inhibitors in modulating neuroinflammation in AD. In vivo studies revealed favorable brain-to-plasma ratios, highlighting the ability of BRI-50460 to penetrate the central nervous system, modulating neuroinflammatory pathways, and restoring lipid homeostasis. Our results support that small molecule inhibitors of cPLA<sub>2<\/sub>\u00a0can modulate the downstream inflammatory signaling, offering a promising therapeutic strategy for neurodegenerative diseases.<br \/>\n<\/span><\/p>\n<hr style=\"color: #ffcc00;\" \/>\n<h2><em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36958720\/\"><b>Associations of APOE <\/b><\/a><\/em><b><\/b><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36958720\/\"><b><span style=\"font-weight: 400;\">\u03b54<\/span><\/b><\/a><em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36958720\/\"><b> status and DHA supplementation on plasma and CSF lipid profiles and entorhinal cortex thickness<\/b><\/a><\/em><\/h2>\n<p><span style=\"font-weight: 400;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-502\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.12.25-PM-300x282.png\" alt=\"two graphs showing data.\" width=\"503\" height=\"473\" srcset=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.12.25-PM-300x282.png 300w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.12.25-PM-1024x963.png 1024w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.12.25-PM-768x722.png 768w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.12.25-PM-1536x1444.png 1536w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.12.25-PM.png 1766w\" sizes=\"auto, (max-width: 503px) 100vw, 503px\" \/>The aim of this study was to\u00a0 identify the effect of <em>APOE <\/em>\u03b54 and DHA lipid species on the entorhinal cortex (EC). EC refers to a part of the brain that is affected early in Alzheimer\u2019s disease (AD) and is rich in DHA. In the study, plasma and cerebrospinal fluid (CSF) were analyzed for lipid content. Findings demonstrated that there is an exchange of DHA at the CSF-blood barrier and into the brain within all lipid species, with <em>APOE<\/em> having the strongest effect on DHA-containing triglycerides.\u00a0<\/span><\/p>\n<h2><em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36479795\/\"><b>Nutritional metabolism and cerebral bioenergetics in Alzheimer&#8217;s disease and related dementias<\/b><\/a><\/em><\/h2>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-503\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.13.55-PM-300x198.png\" alt=\"infographic of brain cells.\" width=\"549\" height=\"362\" srcset=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.13.55-PM-300x198.png 300w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.13.55-PM-1024x675.png 1024w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.13.55-PM-768x506.png 768w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.13.55-PM-1536x1013.png 1536w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.13.55-PM-2048x1350.png 2048w\" sizes=\"auto, (max-width: 549px) 100vw, 549px\" \/>If the brain is unable to meet its energy demands, the risk for synaptic loss, neurodegeneration and cognitive decline may increase. This study suggests that nutritional and metabolic interventions may help treat and prevent AD. The study specifically investigates the mechanisms of cerebral bioenergetic breakdown and the consequences of disturbed bioenergetics. Novel therapeutic nutrition approaches integrating studies of the gut microbiome, neuroimaging and other biomarkers are provided.\u00a0<\/span><\/p>\n<h2><em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38170690\/\"><b>Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition?<\/b><\/a><b>\u00a0<\/b><\/em><\/h2>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-504\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.10-PM-300x200.png\" alt=\"Infographic of food's influence on brain health.\" width=\"565\" height=\"376\" srcset=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.10-PM-300x200.png 300w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.10-PM-1024x681.png 1024w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.10-PM-768x511.png 768w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.10-PM-1536x1022.png 1536w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.10-PM-2048x1363.png 2048w\" sizes=\"auto, (max-width: 565px) 100vw, 565px\" \/>The purpose of this review was to determine whether the gut microbiome can help elucidate the inconsistent findings regarding omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation. The study concluded that a high-saturated-fat Western diet, obesity and lack of exercise can strain the gut microbiome. By contrast, a plant-based diet yielded beneficial effects even when deficient in n-3 PUFAs. It was concluded that the composition of the gut microbiome can help define the effects of n-3 PUFA supplementation on the brain and increase personalized nutritional interventions.\u00a0<\/span><\/p>\n<h2><em><a href=\"https:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2023.0814\"><b>State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer\u2019s Disease<\/b><\/a><b>\u00a0<\/b><\/em><\/h2>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-505\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.52-PM-300x294.png\" alt=\"Infographic about insulin's effect on the brain.\" width=\"504\" height=\"494\" srcset=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.52-PM-300x294.png 300w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.52-PM-1024x1004.png 1024w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.52-PM-768x753.png 768w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.52-PM-1536x1506.png 1536w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.15.52-PM.png 1562w\" sizes=\"auto, (max-width: 504px) 100vw, 504px\" \/><\/span><\/p>\n<p><span style=\"font-weight: 400;\">This study highlights a current public health issue: type 2 diabetes mellitus (T2DM). T2DM is common and increasing in prevalence worldwide, leading to serious consequences. Recent data support the presence of brain insulin resistance (BIR) in the aging brain and found that BIR may contribute to AD and cognitive impairment. The review highlights BIR as a plausible therapeutic target for the prevention of cognitive decline and dementia.\u00a0<\/span><\/p>\n<h2><em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5812012\/\"><b>Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E \u03b54 Carriers<\/b><\/a><\/em><\/h2>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-506\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.16.40-PM-300x196.png\" alt=\"Infographic about human body and APOE.\" width=\"513\" height=\"335\" srcset=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.16.40-PM-300x196.png 300w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.16.40-PM-1024x667.png 1024w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.16.40-PM-768x501.png 768w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.16.40-PM-1536x1001.png 1536w, https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/08\/Screenshot-2024-08-28-at-2.16.40-PM-2048x1335.png 2048w\" sizes=\"auto, (max-width: 513px) 100vw, 513px\" \/>While observational studies have associated \u03c9-3 intake, including DHA, with a reduced risk for incident AD, randomized clinical trials have yielded mixed and inconsistent results. This literature review incorporated various study results in order to understand these mixed results. It was concluded that high-dose DHA supplementation in <em>APOE <\/em>\u03b54 carriers before the onset of AD can be a promising approach to decrease the incidence of AD. Considering the safety profile, availability and affordability of DHA supplements, researchers suggest that refining an \u03c9-3 intervention in <em>APOE <\/em>\u03b54 carriers is warranted.<\/span><\/p>\n<p>&nbsp;<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n\n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text two-column-lists white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <h3>Additional Publications<\/h3>\n<style>\n.pub-item {\n  display: flex;\n  gap: 20px;\n  margin-bottom: 40px;\n  align-items: flex-start;\n}\n.pub-img { flex: 1; }\n.pub-img img { width: 100%; height: auto; }\n.pub-text { flex: 2; }\n.pub-text h4 { margin: 0 0 10px; }\n@media (max-width: 768px) {\n  .pub-item { flex-direction: column; }\n}\n<\/style>\n<p><!-- 2024 --><\/p>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/04\/pub20240103-mj_img-2-1-300x200.png\" alt=\"DHA capsules supplement\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38170690\/\" target=\"_blank\">Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition?<\/a><\/h4>\n<p><strong>January 3, 2024<\/strong><\/p>\n<p>Review of variability in omega-3 supplementation trials and the role of the gut microbiome.<\/p>\n<p><em>Bilal E Kerman<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj_cpbh_23-1-300x200.png\" alt=\"PET MRI brain imaging machine\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38048230\/\" target=\"_blank\">Synthesis and Preclinical Evaluation of 22-[18F]Fluorodocosahexaenoic Acid<\/a><\/h4>\n<p><strong>December 4, 2023<\/strong><\/p>\n<p>PET probe development for monitoring DHA uptake in the brain.<\/p>\n<p><em>Marlon Vincent V Duro<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/04\/pub20231024-mj_img-1-300x200.png\" alt=\"Omega-3 DHA capsules\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37874103\/\" target=\"_blank\">Baseline Findings of PreventE4 Clinical Trial<\/a><\/h4>\n<p><strong>October 24, 2023<\/strong><\/p>\n<p>High-dose DHA trial in APOE \u03b54 carriers and dementia prevention.<\/p>\n<p><em>H N Yassine<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/04\/pub20230823-mj_img-300x200.png\" alt=\"Blood glucose monitoring device\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37611907\/\" target=\"_blank\">Brain Insulin Resistance and Cognitive Decline<\/a><\/h4>\n<p><strong>August 23, 2023<\/strong><\/p>\n<p>Role of brain insulin resistance in Alzheimer&#8217;s disease.<\/p>\n<p><em>Elizabeth M Rhea<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj-cpbh-38-300x200.png\" alt=\"Laboratory test tubes and samples\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37221560\/\" target=\"_blank\">CSF APOE Glycosylation and Amyloid-beta<\/a><\/h4>\n<p><strong>May 23, 2023<\/strong><\/p>\n<p>Association between APOE glycosylation and Alzheimer&#8217;s disease biomarkers.<\/p>\n<p><em>Cristiana J Meuret<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/04\/pub20230323-mj_img-300x200.png\" alt=\"Human brain illustration\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36958720\/\" target=\"_blank\">APOE \u03b54 Status and DHA Supplementation<\/a><\/h4>\n<p><strong>March 23, 2023<\/strong><\/p>\n<p>Impact of APOE genotype on DHA metabolism and brain structure.<\/p>\n<p><em>Mikaila Ann Bantugan<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<p><!-- 2022 --><\/p>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/04\/pub20221208-mj_img-300x200.png\" alt=\"Healthy food and nutrition concept\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36479795\/\" target=\"_blank\">Nutritional Metabolism and Cerebral Bioenergetics<\/a><\/h4>\n<p><strong>December 8, 2022<\/strong><\/p>\n<p>Metabolic interventions for Alzheimer\u2019s disease prevention.<\/p>\n<p><em>Hussein N Yassine<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj_cpbh_36-300x200.png\" alt=\"Fatty acids molecular concept\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36436355\/\" target=\"_blank\">APOE \u03b54 and Fatty Acid Metabolism<\/a><\/h4>\n<p><strong>November 27, 2022<\/strong><\/p>\n<p>Influence of APOE genotype on fatty acid oxidation pathways.<\/p>\n<p><em>Claire J C Huguenard<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj_cpbh_2-300x200.png\" alt=\"Chromosome and genetic data visualization\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36389057\/\" target=\"_blank\">APOE Alleles and Plasma Metabolites<\/a><\/h4>\n<p><strong>November 17, 2022<\/strong><\/p>\n<p>Study of genetic variants and metabolite associations.<\/p>\n<p><em>Alireza Nazarian<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj_cpbh_3-300x200.png\" alt=\"Brain inflammation imaging scan\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36341886\/\" target=\"_blank\">Fluoroarachidonic Acid Imaging Study<\/a><\/h4>\n<p><strong>November 7, 2022<\/strong><\/p>\n<p>Imaging brain inflammation using PET-MR techniques.<\/p>\n<p><em>Juno Van Valkenburgh<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj_cpbh-37-300x200.png\" alt=\"Omega-3 capsules and supplements\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36253954\/\" target=\"_blank\">Omega-3 Index in Alzheimer\u2019s Disease<\/a><\/h4>\n<p><strong>October 18, 2022<\/strong><\/p>\n<p>Potential use of omega-3 index as a dementia biomarker.<\/p>\n<p><em>Hussein N Yassine<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj_cpbh_12-300x200.png\" alt=\"3D lipid molecules illustration\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36217192\/\" target=\"_blank\">Eicosanoid Lipidome Activation<\/a><\/h4>\n<p><strong>October 10, 2022<\/strong><\/p>\n<p>Chronic inflammation pathways in Alzheimer&#8217;s disease.<\/p>\n<p><em>Brandon Ebright<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj_cpbh_11-300x200.png\" alt=\"Brain cell and neuron illustration\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36200578\/\" target=\"_blank\">Brain Inflammation Mechanisms with APOE \u03b54<\/a><\/h4>\n<p><strong>October 6, 2022<\/strong><\/p>\n<p>Single-cell lipidomics approach to neuroinflammation.<\/p>\n<p><em>Isaac Asante<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj_cpbh_28-300x200.png\" alt=\"Healthy cooking and vegetables\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35821792\/\" target=\"_blank\">Nutrition and Dementia Prevention<\/a><\/h4>\n<p><strong>July 13, 2022<\/strong><\/p>\n<p>Recommendations on diet and cognitive health.<\/p>\n<p><em>Hussein N Yassine<\/em><\/p>\n<\/p><\/div>\n<\/div>\n<div class=\"pub-item\">\n<div class=\"pub-img\">\n    <img decoding=\"async\" src=\"https:\/\/keck.usc.edu\/cpbh\/wp-content\/uploads\/sites\/154\/2024\/05\/mj-cpbh-39-300x200.png\" alt=\"Financial vulnerability and aging concept\">\n  <\/div>\n<div class=\"pub-text\">\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35811006\/\" target=\"_blank\">Financial Exploitation and Cognitive Decline<\/a><\/h4>\n<p><strong>July 10, 2022<\/strong><\/p>\n<p>Early behavioral indicators of Alzheimer&#8217;s disease risk.<\/p>\n<p><em>Laura Fenton<\/em><\/p>\n<\/p><\/div>\n<\/div>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n\n\n\n        \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--full-width-cta white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--full-width-cta\"\n    \n     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The Center for Personalized Brain Health welcomes your involvement in changing the landscape of dementia care.<\/span><\/p>\n\n\n\n<\/div>\n              <\/div>\n    \n          <div class=\"links-container\">\n        \n              \n<div class=\"f--field f--link\">\n\n    \n    \n  \n<a\n  class=\"link \"\n  href=\"https:\/\/keck.usc.edu\/cpbh\/give-now\/\"\n    aria-label=\"Read&#x20;more&#x20;about&#x20;Give&#x20;Now\">\n        Give Now\n    <\/a>\n\n\n<\/div>\n        \n              \n<div class=\"f--field f--link\">\n\n    \n    \n  \n<a\n  class=\"link \"\n  href=\"https:\/\/keck.usc.edu\/cpbh\/study-enrollment-hub\/usc-gene-screen\/\"\n    aria-label=\"Read&#x20;more&#x20;about&#x20;Join&#x20;the&#x20;USC&#x20;GeneScreen&#x20;Registry\">\n        Join the USC GeneScreen Registry\n    <\/a>\n\n\n<\/div>\n        \n              \n<div class=\"f--field f--link\">\n\n    \n    \n  \n<a\n  class=\"link \"\n  href=\"https:\/\/keck.usc.edu\/cpbh\/study-enrollment-hub\/usc-alzheimers-disease-research-center\/\"\n    aria-label=\"Read&#x20;more&#x20;about&#x20;Explore&#x20;USC&#x20;ADRC&#x20;Clinical&#x20;Studies\">\n        Explore USC ADRC Clinical Studies\n    <\/a>\n\n\n<\/div>\n        \n              \n<div class=\"f--field f--link\">\n\n    \n    \n  \n<a\n  class=\"link \"\n  href=\"https:\/\/mailchi.mp\/2099ac361c6d\/cpbh\"\n    aria-label=\"Read&#x20;more&#x20;about&#x20;STAY&#x20;UPDATED&#x20;WITH&#x20;CPBH\">\n        STAY UPDATED WITH CPBH\n    <\/a>\n\n\n<\/div>\n              <\/div>\n      <\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":307,"featured_media":541,"parent":495,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":true,"footnotes":""},"class_list":["post-500","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - 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