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Russell E. Jacobs, PhD

Professor of Research Physiology & Neuroscience

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Phone +1 323 865 1668
Email jacobsr@usc.edu
CTSI Profile

Publications

  • Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2024 Apr 05. . View in PubMed
  • KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injuryCell Stem Cell. 2024 Apr 04; 31(4):519-536. e8. . View in PubMed
  • MRI Detection of Lymph Node Metastasis through Molecular Targeting of C-C Chemokine Receptor Type 2 and Monocyte Hitchhiking ACS Nano. 2024 Jan 23; 18(3):2091-2104. . View in PubMed
  • Synthesis and Preclinical Evaluation of 22-[18F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics ACS Chem Neurosci. 2023 Dec 20; 14(24):4409-4418. . View in PubMed
  • Reconfiguration of brain-wide neural activity after early life adversity bioRxiv. 2023 Sep 10. . View in PubMed
  • The C9ORF72 repeat expansion alters neurodevelopment Cell Rep. 2023 08 29; 42(8):112983. . View in PubMed
  • Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial prefrontal cortical domains Front Cell Dev Biol. 2023; 11:1278831. . View in PubMed
  • Diffusion MRI Connections in the Octopus Brain Exp Neurobiol. 2022 Feb 28; 31(1):17-28. . View in PubMed
  • Radiosynthesis of 20-[18F]fluoroarachidonic acid for PET-MR imaging: Biological evaluation in ApoE4-TR mice Prostaglandins Leukot Essent Fatty Acids. 2022 11; 186:102510. . View in PubMed
  • Longitudinal manganese-enhanced magnetic resonance imaging of neural projections and activity NMR Biomed. 2022 06; 35(6):e4675. . View in PubMed
  • Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2113310119. . View in PubMed
  • Studying Axonal Transport in the Brain by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Methods Mol Biol. 2022; 2431:111-142. . View in PubMed
  • Author Correction: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-ß Nat Aging. 2021 Jul; 1(7):624. . View in PubMed
  • APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-ß Nat Aging. 2021 06; 1(6):506-520. . View in PubMed
  • Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model Sci Rep. 2021 07 23; 11(1):15077. . View in PubMed
  • Mbnl1 and Mbnl2 regulate brain structural integrity in mice Commun Biol. 2021 11 30; 4(1):1342. . View in PubMed
  • Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in CraniosynostosisCell. 2021 01 07; 184(1):243-256. e18. . View in PubMed
  • Collagenase-Cleavable Peptide Amphiphile Micelles as a Novel Theranostic Strategy in Atherosclerosis Adv Ther (Weinh). 2020 Mar; 3(3). . View in PubMed
  • Evolution of brain-wide activity in the awake behaving mouse after acute fear by longitudinal manganese-enhanced MRI Neuroimage. 2020 11 15; 222:116975. . View in PubMed
  • Imaging the evolution acute fear: Longitudinal whole brain imaging in living mice of neural activity with MEMRI Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson Med Sci Meet Exhib. 2019 May; 27. . View in PubMed
  • Vascular dysfunction-The disregarded partner of Alzheimer’s disease Alzheimers Dement. 2019 01; 15(1):158-167. . View in PubMed
  • Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-ß Plaques on Axonal Transport Dynamics in the Living Brain Front Cell Neurosci. 2019; 13:501. . View in PubMed
  • When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity Brain Struct Funct. 2018 Jul; 223(6):2841-2858. . View in PubMed
  • Neural activation imaged by MEMRI in mouse models of PTSD: Early Life Stress and Role of the Serotonergic System in Prolonged Response to Fear Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson Med Sci Meet Exhib. 2018 Jun; 2018. . View in PubMed
  • Alterations of functional circuitry in aging brain and the impact of mutated APP expression Neurobiol Aging. 2018 10; 70:276-290. . View in PubMed
  • Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 03; 24(3):326-337. . View in PubMed
  • 7? Tesla. Otol Neurotol. 2017 01; 38(1):133-138.. View in PubMed
  • Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI Magn Reson Med. 2016 May; 75(5):1967-77. . View in PubMed
  • A simple rapid process for semi-automated brain extraction from magnetic resonance images of the whole mouse head J Neurosci Methods. 2016 Jan 15; 257:185-93. . View in PubMed
  • Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects PLoS Biol. 2016 09; 14(9):e2000197. . View in PubMed
  • ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies BMC Med Imaging. 2015 Jun 16; 15:19. . View in PubMed
  • 7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. . View in PubMed
  • Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed
  • Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats PLoS One. 2015; 10(12):e0145205. . View in PubMed
  • Low Dose Focused Ultrasound Induces Enhanced Tumor Accumulation of Natural Killer Cells PLoS One. 2015; 10(11):e0142767. . View in PubMed
  • Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):E2492-500. . View in PubMed
  • Multimodality PET/MRI agents targeted to activated macrophages J Biol Inorg Chem. 2014 Feb; 19(2):247-58. . View in PubMed
  • In vivo monitoring of natural killer cell trafficking during tumor immunotherapy Magn Reson Insights. 2014; 7:15-21. . View in PubMed
  • Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy CRLX101 Clin Cancer Res. 2013 May 01; 19(9):2518-27. . View in PubMed
  • Altered reward circuitry in the norepinephrine transporter knockout mouse PLoS One. 2013; 8(3):e57597. . View in PubMed
  • Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis J Neurosci Res. 2012 Jul; 90(7):1310-23. . View in PubMed
  • Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner J Nucl Med. 2012 Jul; 53(7):1102-9. . View in PubMed
  • Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI Neuroimage. 2012 Apr 15; 60(3):1856-66. . View in PubMed
  • Quantitative pharmacologic MRI in mice NMR Biomed. 2012 Apr; 25(4):498-505. . View in PubMed
  • Receptor-targeted iron oxide nanoparticles for molecular MR imaging of inflamed atherosclerotic plaques Biomaterials. 2011 Oct; 32(29):7209-16. . View in PubMed
  • Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice Neuroimage. 2011 Mar 15; 55(2):622-8. . View in PubMed
  • MRI in developmental biology and the construction of developmental atlases Cold Spring Harb Protoc. 2011 Mar 01; 2011(3):top100. . View in PubMed
  • Altered neurocircuitry in the dopamine transporter knockout mouse brain PLoS One. 2010 Jul 09; 5(7):e11506. . View in PubMed
  • Increased anatomical detail by in vitro MR microscopy with a modified Golgi impregnation method Magn Reson Med. 2010 May; 63(5):1391-7. . View in PubMed
  • A robust coregistration method for in vivo studies using a first generation simultaneous PET/MR scanner Med Phys. 2010 May; 37(5):1995-2003. . View in PubMed
  • Purkinje cell loss in experimental autoimmune encephalomyelitis Neuroimage. 2009 Dec; 48(4):637-51. . View in PubMed
  • Reward circuitry is perturbed in the absence of the serotonin transporter Neuroimage. 2009 Jul 15; 46(4):1091-104. . View in PubMed
  • Imaging immune response in vivo: cytolytic action of genetically altered T cells directed to glioblastoma multiforme Clin Cancer Res. 2008 Jun 15; 14(12):3832-9. . View in PubMed
  • Simultaneous in vivo positron emission tomography and magnetic resonance imaging Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3705-10. . View in PubMed
  • Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I J Clin Invest. 2007 Nov; 117(11):3258-70. . View in PubMed
  • Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome Neuroimage. 2007 Aug 01; 37(1):230-42. . View in PubMed
  • Digital three-dimensional atlas of quail development using high-resolution MRI ScientificWorldJournal. 2007 May 11; 7:592-604. . View in PubMed
  • Formation of the dorsal marginal zone in Xenopus laevis analyzed by time-lapse microscopic magnetic resonance imaging Dev Biol. 2007 May 01; 305(1):161-71. . View in PubMed
  • Two-dimensional and three-dimensional time-lapse microscopic magnetic resonance imaging of Xenopus gastrulation movements using intrinsic tissue-specific contrast Dev Dyn. 2007 Feb; 236(2):494-501. . View in PubMed
  • T(2)-weighted microMRI and evoked potential of the visual system measurements during the development of hypomyelinated transgenic mice Neurochem Res. 2007 Feb; 32(2):159-65. . View in PubMed
  • Multimodal, multidimensional models of mouse brain Epilepsia. 2007; 48 Suppl 4:75-81. . View in PubMed
  • Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI) Neuroimage. 2007; 37 Suppl 1:S37-46. . View in PubMed
  • Magnetic resonance imaging of functional anatomy: use for small animal epilepsy models Epilepsia. 2007; 48 Suppl 4:11-7. . View in PubMed
  • Myelin deficiencies visualized in vivo: visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type mice J Neurosci Res. 2006 Dec; 84(8):1716-26. . View in PubMed
  • Time-lapse tracing of mitotic cell divisions in the early Xenopus embryo using microscopic MRI Dev Dyn. 2006 Nov; 235(11):3059-62. . View in PubMed
  • Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis Neuroimage. 2006 Sep; 32(3):1016-23. . View in PubMed
  • Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant Neuroimage. 2006 Feb 15; 29(4):1058-65. . View in PubMed
  • Standard atlas space for C57BL/6J neonatal mouse brain Anat Embryol (Berl). 2005 Nov; 210(4):245-63. . View in PubMed
  • Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene J Neurosci. 2005 Jul 27; 25(30):7004-13. . View in PubMed
  • Magnetic resonance microscopy: recent advances and applications Curr Opin Biotechnol. 2005 Feb; 16(1):93-9. . View in PubMed
  • A multimodal, multidimensional atlas of the C57BL/6J mouse brain J Anat. 2004 Feb; 204(2):93-102. . View in PubMed
  • Superiority of 3D wavelet-packet denoising in MR microscopy Magn Reson Imaging. 2003 Oct; 21(8):913-21. . View in PubMed
  • MRI: volumetric imaging for vital imaging and atlas construction Nat Rev Mol Cell Biol. 2003 Sep; Suppl:SS10-6. . View in PubMed
  • In vivo trans-synaptic tract tracing from the murine striatum and amygdala utilizing manganese enhanced MRI (MEMRI) Magn Reson Med. 2003 Jul; 50(1):33-9. . View in PubMed
  • Micro-MRI at 117 T of a murine brain tumor model using delayed contrast enhancement. Mol Imaging. 2003 Jul; 2(3):150-8. . View in PubMed
  • Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson’s disease Neuron. 2003 Mar 27; 37(6):899-909. . View in PubMed
  • Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1381-6. . View in PubMed
  • Towards effective and rewarding data sharing Neuroinformatics. 2003; 1(3):289-95. . View in PubMed

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