Keck School Faculty

Adam de Smith, PhD
Adam de Smith, PhD
Assistant Professor Of Clinical Preventive Medicine
Center for Genetic Epidemiology
1450 Biggy Street Health Sciences Campus Los Angeles
Adam de Smith is an Assistant Professor in the USC Center for Genetic Epidemiology in the Department of Preventive Medicine, and is a member of the USC Norris Comprehensive Cancer Center. He is a genetic epidemiologist with a research focus on identifying the causes of acute lymphoblastic leukemia (ALL), the most common childhood cancer. Dr. de Smith leads studies investigating the role of common and rare genetic variants in ALL etiology, with a particular interest in elucidating the increased ALL risk in Latinos. He also leads a study of leukemia in children with Down syndrome, the International Study of Down Syndrome Acute Leukemia (IS-DSAL), investigating genetic and epigenetic variation associated with risk of DS-ALL. In addition, Dr. de Smith utilizes whole genome sequencing of tumors to examine potential causative agents, i.e. DNA mutational signatures as molecular footprints of environmental exposures.

Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome Leukemia. 2019 Jul 11. . View in PubMed

Germline genetic landscape of pediatric central nervous system (CNS) tumors Neuro Oncol. 2019 Jun 19. . View in PubMed

Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children Genes Chromosomes Cancer. 2019 May 18. . View in PubMed

Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in etiology Haematologica. 2019 03 28. . View in PubMed

Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk Cancer Epidemiol Biomarkers Prev. 2018 Oct; 27(10):1151-1158. . View in PubMed

Genetic determinants of childhood and adult height associated with osteosarcoma risk Cancer. 2018 Sep 15; 124(18):3742-3752. . View in PubMed

GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q2421. Nat Commun. 2018 01 18; 9(1):286. . View in PubMed

To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes Front Genet. 2018; 9:298. . View in PubMed

A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology Haematologica. 2018 Jan; 103(1):e29-e31. . View in PubMed

BMI1 enhancer polymorphism underlies chromosome 10p1231 association with childhood acute lymphoblastic leukemia. Int J Cancer. 2018 12 01; 143(11):2647-2658. . View in PubMed

Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers Environ Health. 2018 05 02; 17(1):43. . View in PubMed

Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma J Neurooncol. 2017 Nov; 135(2):237-244. . View in PubMed

In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia Blood. 2017 03 23; 129(12):1680-1684. . View in PubMed

Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia Cancer Res. 2017 04 01; 77(7):1674-1683. . View in PubMed

Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia Oncotarget. 2016 Nov 08; 7(45):72733-72745. . View in PubMed

Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia Arch Med Res. 2016 11; 47(8):677-683. . View in PubMed

Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates Epigenetics. 2016 09; 11(9):664-673. . View in PubMed

Cortical Lewy bodies and Aß burden are associated with prevalence and timing of dementia in Lewy body diseases Neuropathol Appl Neurobiol. 2016 08; 42(5):436-50. . View in PubMed

Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1043-9. . View in PubMed

Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers Carcinogenesis. 2016 06; 37(6):576-582. . View in PubMed

A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros Leukemia. 2016 05; 30(5):1194-7. . View in PubMed

A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution Cancer Res. 2015 Nov 15; 75(22):4884-94. . View in PubMed

PDGFRa demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium Nat Commun. 2015 May 18; 6:6930. . View in PubMed

Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602. . View in PubMed

Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA PLoS One. 2015; 10(11):e0143343. . View in PubMed

Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes Epigenetics. 2015; 10(12):1166-76. . View in PubMed

PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia Int J Cancer. 2014 Sep 01; 135(5):1101-9. . View in PubMed

Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia Am J Hematol. 2014 Jul; 89(7):721-5. . View in PubMed

Imprinted expression of UBE3A in non-neuronal cells from a Prader-Willi syndrome patient with an atypical deletion Hum Mol Genet. 2014 May 01; 23(9):2364-73. . View in PubMed

The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia Blood. 2014 Apr 17; 123(16):2497-503. . View in PubMed

Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children Leukemia. 2013 Dec; 27(12):2416-9. . View in PubMed

GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL Blood. 2013 Nov 07; 122(19):3385-7. . View in PubMed

Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype Blood. 2013 Jun 06; 121(23):4808-9. . View in PubMed

Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity PLoS One. 2013; 8(3):e58048. . View in PubMed

A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network Nucleic Acids Res. 2012 Dec; 40(22):11339-51. . View in PubMed

Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity Hum Mol Genet. 2012 Aug 15; 21(16):3727-38. . View in PubMed

Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry Clin Chem. 2011 Aug; 57(8):1188-95. . View in PubMed

Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly Nat Biotechnol. 2011 Jul 24; 29(8):723-30. . View in PubMed

Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants Ann Hum Genet. 2011 May; 75(3):383-97. . View in PubMed

Chromosome 19p133 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems. Am J Med Genet A. 2011 May; 155A(5):1192-5. . View in PubMed

Implications of copy number variation in people with chromosomal abnormalities: potential for greater variation in copy number state may contribute to variability of phenotype Hugo J. 2010 Dec; 4(1-4):1-9. . View in PubMed

cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs Nat Methods. 2010 Jul; 7(7):541-6. . View in PubMed

A new highly penetrant form of obesity due to deletions on chromosome 16p112. Nature. 2010 Feb 04; 463(7281):671-5. . View in PubMed

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism Hum Mol Genet. 2009 Sep 01; 18(17):3257-65. . View in PubMed

Small deletion variants have stable breakpoints commonly associated with alu elements PLoS One. 2008 Aug 29; 3(8):e3104. . View in PubMed

Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease Cytogenet Genome Res. 2008; 123(1-4):17-26. . View in PubMed

Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases Hum Mol Genet. 2007 Dec 01; 16(23):2783-94. . View in PubMed

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity Nat Genet. 2007 Jun; 39(6):721-3. . View in PubMed

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