Keck School Faculty

Allison Knoll
Allison Knoll
Assistant Professor Of Research Pediatrics
Pediatrics
4640 West Sunset Boulevard Off Campus Los Angeles
My research focuses on understanding the genetic and environmental basis of individual differences in typical social behavior and in risk for neurodevelopmental disorders (NDDs). We model genetic diversity using large families of recombinant inbred mouse strains in which genetic variation is extensive, fixed, and well-characterized. Current studies focus on 1) identifying genes that underlie strain differences in sociability and cognition using quantitative trait locus mapping and advanced gene validation strategies, 2) examining the interaction between genetic background and common genetic risk variants for autism spectrum disorder (ASD) to identify the biological mechanisms underlying disorder risk/resilience, and 3) identifying the role of strain genetics in moderating risk/resilience to adverse outcomes associated with early-life stress. The goal of these studies is to understand the biology of heritable variation in sociability and cognition and to advance precision medicine approaches for the treatment of NDDs and early-adversity.

MUPET-Mouse Ultrasonic Profile ExTraction: A Signal Processing Tool for Rapid and Unsupervised Analysis of Ultrasonic VocalizationsNeuron. 2017 May 03; 94(3):465-485. e5. . View in PubMed

Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning J Neurosci. 2016 06 08; 36(23):6258-68. . View in PubMed

Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice Physiol Behav. 2015 Nov 01; 151:469-77. . View in PubMed

Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats Biol Psychiatry. 2011 Sep 01; 70(5):425-33. . View in PubMed

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