Keck School Faculty

Ambrose Yaw-Shong Jong, PhD
Ambrose Yaw-Shong Jong, PhD
Associate Professor of Pediatrics
Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles

Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells J Extracell Vesicles. 2019; 8(1):1588538. . View in PubMed

Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms Cancer Res. 2019 03 15; 79(6):1151-1164. . View in PubMed

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines J Extracell Vesicles. 2018; 7(1):1535750. . View in PubMed

Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells J Extracell Vesicles. 2017; 6(1):1294368. . View in PubMed

Biological roles and potential applications of immune cell-derived extracellular vesicles J Extracell Vesicles. 2017; 6(1):1400370. . View in PubMed

Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine Sci Rep. 2017 01 11; 7:40467. . View in PubMed

The 14-3-3 Gene Function of Cryptococcus neoformans Is Required for its Growth and Virulence J Microbiol Biotechnol. 2016 May 28; 26(5):918-27. . View in PubMed

Front Microbiol. 2016; 7:148. . View in PubMed

Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque PLoS One. 2016; 11(6):e0156170. . View in PubMed

Alpha7 nicotinic acetylcholine receptor is required for blood-brain barrier injury-related CNS disorders caused by Cryptococcus neoformans and HIV-1 associated comorbidity factors BMC Infect Dis. 2015 Aug 19; 15:352. . View in PubMed

Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy J Natl Cancer Inst. 2015 Jul; 107(7). . View in PubMed

How Cryptococcus interacts with the blood-brain barrier Future Microbiol. 2015; 10(10):1669-82. . View in PubMed

Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans mBio. 2013 May 07; 4(3):e00220-13. . View in PubMed

Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors PLoS One. 2013; 8(4):e62164. . View in PubMed

Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection J Biol Chem. 2012 May 04; 287(19):15298-306. . View in PubMed

The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity Cell Host Microbe. 2012 Mar 15; 11(3):277-89. . View in PubMed

Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells J Biomed Sci. 2012 Feb 08; 19:19. . View in PubMed

Retinoid-regulated FGF8f secretion by osteoblasts bypasses retinoid stimuli to mediate granulocytic differentiation of myeloid leukemia cells Mol Cancer Ther. 2012 Feb; 11(2):267-76. . View in PubMed

Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection PLoS One. 2012; 7(11):e48570. . View in PubMed

Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system PLoS One. 2012; 7(9):e45083. . View in PubMed

coli K1 induced activation and nuclear translocation of NF-?B in human brain endothelial cells. PLoS One. 2012; 7(4):e35862. . View in PubMed

Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3) J Biol Chem. 2011 Oct 07; 286(40):34761-9. . View in PubMed

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities Biochem J. 2011 Sep 15; 438(3):457-66. . View in PubMed

Recruitment of a7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells Future Microbiol. 2011 Aug; 6(8):953-66. . View in PubMed

Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence PLoS One. 2011 Apr 29; 6(4):e19162. . View in PubMed

[Effect of HIV-1gp41 ectodomain on Cryptococcus neoformans-induced cytoskeletal changes in human brain microvascular endothelial cells] Nan Fang Yi Ke Da Xue Xue Bao. 2011 Mar; 31(3):478-81. . View in PubMed

Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor PLoS One. 2011; 6(9):e25016. . View in PubMed

Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation FASEB J. 2010 Mar; 24(3):833-43. . View in PubMed

Evolving role of laminin receptors in microbial pathogenesis and therapeutics of CNS infection Future Microbiol. 2009 Oct; 4(8):959-62. . View in PubMed

Lactobacillus rhamnosus GG Suppresses Meningitic Ecoli K1 Penetration across Human Intestinal Epithelial Cells In Vitro and Protects Neonatal Rats against Experimental Hematogenous Meningitis. Int J Microbiol. 2009; 2009:647862. . View in PubMed

Identification of IbeR as a stationary-phase regulator in meningitic Escherichia coli K1 that carries a loss-of-function mutation in rpoS J Biomed Biotechnol. 2009; 2009:520283. . View in PubMed

Involvement of Escherichia coli K1 ibeT in bacterial adhesion that is associated with the entry into human brain microvascular endothelial cells Med Microbiol Immunol. 2008 Dec; 197(4):337-44. . View in PubMed

Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation Cell Microbiol. 2008 Sep; 10(9):1854-65. . View in PubMed

Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells Cell Microbiol. 2008 Jun; 10(6):1313-26. . View in PubMed

Cdc6 knockdown inhibits human neuroblastoma cell proliferation Mol Cell Biochem. 2008 Apr; 311(1-2):189-97. . View in PubMed

Infectomic analysis of gene expression profiles of human brain microvascular endothelial cells infected with Cryptococcus neoformans J Biomed Biotechnol. 2008; 2008:375620. . View in PubMed

Focal point theory models for dissecting dynamic duality problems of microbial infections J Biomed Biotechnol. 2008; 2008:856314. . View in PubMed

PSF is an IbeA-binding protein contributing to meningitic Escherichia coli K1 invasion of human brain microvascular endothelial cells Med Microbiol Immunol. 2007 Sep; 196(3):135-43. . View in PubMed

Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection Eukaryot Cell. 2007 Aug; 6(8):1486-96. . View in PubMed

The evolving role of infectomics in drug discovery Expert Opin Drug Discov. 2007 Jul; 2(7):961-75. . View in PubMed

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to HBMEC Biochem Biophys Res Commun. 2007 May 18; 356(4):899-905. . View in PubMed

CPS1, a homolog of the Streptococcus pneumoniae type 3 polysaccharide synthase gene, is important for the pathobiology of Cryptococcus neoformans Infect Immun. 2006 Jul; 74(7):3930-8. . View in PubMed

Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis FEBS Lett. 2006 Jun 26; 580(15):3687-93. . View in PubMed

Spatial distribution of nerve sprouting after myocardial infarction in mice Heart Rhythm. 2006 Jun; 3(6):728-36. . View in PubMed

The histopathology of Candida albicans invasion in neonatal rat tissues and in the human blood-brain barrier in culture revealed by light, scanning, transmission and immunoelectron microscopy Histol Histopathol. 2006 10; 21(10):1029-41. . View in PubMed

Downregulation of human Cdc6 protein using a lentivirus RNA interference expression vector Methods Mol Biol. 2006; 342:287-93. . View in PubMed

Blood-brain barrier drug discovery for central nervous system infections Curr Drug Targets Infect Disord. 2005 Mar; 5(1):65-72. . View in PubMed

Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells J Med Microbiol. 2003 Nov; 52(Pt 11):961-70. . View in PubMed

Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells J Med Microbiol. 2003 Aug; 52(Pt 8):615-22. . View in PubMed

Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma Am J Pathol. 2003 Jun; 162(6):1961-74. . View in PubMed

Use of inverse PCR to clone cDNA ends Methods Mol Biol. 2003; 221:51-8. . View in PubMed

Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha J Biol Chem. 2002 Nov 08; 277(45):43369-76. . View in PubMed

Enhanced Escherichia coli invasion of human brain microvascular endothelial cells is associated with alternations in cytoskeleton induced by nicotine Cell Microbiol. 2002 Aug; 4(8):503-14. . View in PubMed

Infectomics: genomics and proteomics of microbial infections Funct Integr Genomics. 2002 Apr; 1(6):331-44. . View in PubMed

Inverse PCRGenomic DNA cloning. Methods Mol Biol. 2002; 192:301-7. . View in PubMed

Gene cloning and expression profiling by rapid amplification of gene inserts with universal vector primers Methods Mol Biol. 2002; 192:309-14. . View in PubMed

A novel genetic island of meningitic Escherichia coli K1 containing the ibeA invasion gene (GimA): functional annotation and carbon-source-regulated invasion of human brain microvascular endothelial cells Funct Integr Genomics. 2001 Sep; 1(5):312-22. . View in PubMed

Traversal of Candida albicans across human blood-brain barrier in vitro Infect Immun. 2001 Jul; 69(7):4536-44. . View in PubMed

Cellular mechanisms of microbial proteins contributing to invasion of the blood-brain barrier Cell Microbiol. 2001 May; 3(5):277-87. . View in PubMed

Further characterization of Escherichia coli brain microvascular endothelial cell invasion gene ibeA by deletion, complementation, and protein expression J Infect Dis. 2001 Apr 01; 183(7):1071-8. . View in PubMed

MAT1-modulated CAK activity regulates cell cycle G(1) exit Mol Cell Biol. 2001 Jan; 21(1):260-70. . View in PubMed

Loss control of Mcm5 interaction with chromatin in cdc6-1 mutated in CDC-NTP motif DNA Cell Biol. 2000 Jul; 19(7):447-57. . View in PubMed

Identification and characterization of Saccharomyces cerevisiae Cdc6 DNA-binding properties Mol Biol Cell. 2000 May; 11(5):1673-85. . View in PubMed

The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association J Biol Chem. 1999 Mar 19; 274(12):8291-8. . View in PubMed

RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells J Biol Chem. 1999 Feb 26; 274(9):5564-72. . View in PubMed

Saccharomyces cerevisiae Cdc6 stimulates Abf1 DNA binding activity J Biol Chem. 1998 Jan 16; 273(3):1298-302. . View in PubMed

A simple and sensitive ribonucleotide reductase assay J Biomed Sci. 1998; 5(1):62-8. . View in PubMed

Expression and preparation of fusion proteins from recombinant lambda gt11 phages Methods Mol Biol. 1997; 69:241-5. . View in PubMed

Rapid amplification of gene ends (RAGE) from gene libraries by anchored PCR Methods Mol Biol. 1997; 67:295-300. . View in PubMed

Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases Mol Biol Cell. 1996 Nov; 7(11):1723-35. . View in PubMed

Intracellular location of the Saccharomyces cerevisiae CDC6 gene product DNA Cell Biol. 1996 Oct; 15(10):883-95. . View in PubMed

Pulsed field gel electrophoresis labeling method to study the pattern of Saccharomyces cerevisiae chromosomal DNA synthesis during the G1/S phase of the cell cycle Anal Biochem. 1995 May 01; 227(1):32-9. . View in PubMed

Temporal and spatial distributions of yeast nucleoside diphosphate kinase activities and its association with the Cdc8p Cell Mol Biol Res. 1995; 41(5):333-46. . View in PubMed

Efficient induction and preparation of fusion proteins from recombinant phage lambda gt11 clones Trends Genet. 1994 Jun; 10(6):183. . View in PubMed

Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth DNA Cell Biol. 1994 May; 13(5):461-71. . View in PubMed

Characteristics, substrate analysis, and intracellular location of Saccharomyces cerevisiae UMP kinase Arch Biochem Biophys. 1993 Jul; 304(1):197-204. . View in PubMed

Mutation analysis of Saccharomyces cerevisiae CDC6 promoter: defining its UAS domain and cell cycle regulating element DNA Cell Biol. 1993 May; 12(4):363-70. . View in PubMed

Amplification of gene ends from gene libraries by polymerase chain reaction with single-sided specificity Methods Mol Biol. 1993; 15:357-63. . View in PubMed

Functional and structural conservation of Schizosaccharomyces pombe dTMP kinase gene Biochim Biophys Acta. 1992 Sep 24; 1132(2):222-4. . View in PubMed

Saccharomyces cerevisiae nucleoside-diphosphate kinase: purification, characterization, and substrate specificity Arch Biochem Biophys. 1991 Dec; 291(2):241-6. . View in PubMed

Molecular characterization of Saccharomyces cerevisiae URA6 geneDNA sequence, mutagenesis analysis, and cell cycle regulation relevant to its suppression mechanism to cdc8 mutation. J Biol Chem. 1991 Sep 25; 266(27):18287-93. . View in PubMed

Human deoxycytidine kinaseSequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. J Biol Chem. 1991 Mar 15; 266(8):5353. . View in PubMed

CDC6 mRNA fluctuates periodically in the yeast cell cycle J Biol Chem. 1990 Nov 15; 265(32):19904-9. . View in PubMed

The CDC4 gene product is associated with the yeast nuclear skeleton Biochem Biophys Res Commun. 1990 Nov 15; 172(3):1324-30. . View in PubMed

Purification and characterization of Saccharomyces cerevisiae uridine monophosphate kinase J Biol Chem. 1990 Nov 05; 265(31):19122-7. . View in PubMed

A protocol for using T7 DNA polymerase in oligonucleotide site-directed mutagenesis Biotechniques. 1990 May; 8(5):503. . View in PubMed

Mini-prep in ten minutes Biotechniques. 1990 Feb; 8(2):172-3. . View in PubMed

The Saccharomyces cerevisiae SOC8-1 gene and its relationship to a nucleotide kinase J Biol Chem. 1989 Sep 15; 264(26):15593-9. . View in PubMed

Human deoxycytidine kinaseSequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. J Biol Chem. 1989 Sep 05; 264(25):14762-8. . View in PubMed

Isolation of multiple types of plasminogen activator inhibitors from vascular smooth muscle cells Thromb Haemost. 1989 Jun 30; 61(3):517-21. . View in PubMed

Molecular cloning of Saccharomyces cerevisiae CDC6 geneIsolation, identification, and sequence analysis. J Biol Chem. 1989 May 25; 264(15):9022-9. . View in PubMed

Saccharomyces cerevisiae SSB1 protein and its relationship to nucleolar RNA-binding proteins Mol Cell Biol. 1987 Aug; 7(8):2947-55. . View in PubMed

Isolation of the gene encoding yeast single-stranded nucleic acid binding protein 1 Proc Natl Acad Sci U S A. 1986 Feb; 83(4):877-81. . View in PubMed

Yeast DNA replication Basic Life Sci. 1986; 40:463-78. . View in PubMed

Multiple species of single-stranded nucleic acid-binding proteins in Saccharomyces cerevisiae J Biol Chem. 1985 Dec 25; 260(30):16367-74. . View in PubMed

DNA synthesis in yeast cell-free extracts dependent on recombinant DNA plasmids purified from Escherichia coli Nucleic Acids Res. 1985 Apr 25; 13(8):2943-58. . View in PubMed

Characterization of Saccharomyces cerevisiae thymidylate kinase, the CDC8 gene productGeneral properties, kinetic analysis, and subcellular localization. J Biol Chem. 1984 Dec 10; 259(23):14394-8. . View in PubMed

The CDC8 gene of yeast encodes thymidylate kinase J Biol Chem. 1984 Sep 10; 259(17):11052-9. . View in PubMed

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