Keck School Faculty

Ambrose Yaw-Shong Jong, PhD
Ambrose Yaw-Shong Jong, PhD
Associate Professor of Pediatrics
Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles

Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms Cancer Res. 2019 Mar 15; 79(6):1151-1164. . View in PubMed

Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells J Extracell Vesicles. 2019; 8(1):1588538. . View in PubMed

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines J Extracell Vesicles. 2018; 7(1):1535750. . View in PubMed

Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine Sci Rep. 2017 Jan 11; 7:40467. . View in PubMed

Biological roles and potential applications of immune cell-derived extracellular vesicles J Extracell Vesicles. 2017; 6(1):1400370. . View in PubMed

Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells J Extracell Vesicles. 2017; 6(1):1294368. . View in PubMed

Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine Sci Rep. 2017 01 11; 7:40467. . View in PubMed

The 14-3-3 Gene Function of Cryptococcus neoformans Is Required for its Growth and Virulence J Microbiol Biotechnol. 2016 May 28; 26(5):918-27. . View in PubMed

Front Microbiol. 2016; 7:148. . View in PubMed

Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque PLoS One. 2016; 11(6):e0156170. . View in PubMed

Alpha7 nicotinic acetylcholine receptor is required for blood-brain barrier injury-related CNS disorders caused by Cryptococcus neoformans and HIV-1 associated comorbidity factors BMC Infect Dis. 2015 Aug 19; 15:352. . View in PubMed

Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy J Natl Cancer Inst. 2015 Jul; 107(7). . View in PubMed

How Cryptococcus interacts with the blood-brain barrier Future Microbiol. 2015; 10(10):1669-82. . View in PubMed

Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans MBio. 2013 May 07; 4(3):e00220-13. . View in PubMed

Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors PLoS One. 2013; 8(4):e62164. . View in PubMed

Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection J Biol Chem. 2012 May 04; 287(19):15298-306. . View in PubMed

The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity Cell Host Microbe. 2012 Mar 15; 11(3):277-89. . View in PubMed

Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells J Biomed Sci. 2012 Feb 08; 19:19. . View in PubMed

Retinoid-regulated FGF8f secretion by osteoblasts bypasses retinoid stimuli to mediate granulocytic differentiation of myeloid leukemia cells Mol Cancer Ther. 2012 Feb; 11(2):267-76. . View in PubMed

coli K1 induced activation and nuclear translocation of NF-?B in human brain endothelial cells. PLoS One. 2012; 7(4):e35862. . View in PubMed

Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system PLoS One. 2012; 7(9):e45083. . View in PubMed

Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection PLoS One. 2012; 7(11):e48570. . View in PubMed

Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3) J Biol Chem. 2011 Oct 07; 286(40):34761-9. . View in PubMed

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities Biochem J. 2011 Sep 15; 438(3):457-66. . View in PubMed

Recruitment of a7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells Future Microbiol. 2011 Aug; 6(8):953-66. . View in PubMed

Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence PLoS One. 2011 Apr 29; 6(4):e19162. . View in PubMed

[Effect of HIV-1gp41 ectodomain on Cryptococcus neoformans-induced cytoskeletal changes in human brain microvascular endothelial cells] Nan Fang Yi Ke Da Xue Xue Bao. 2011 Mar; 31(3):478-81. . View in PubMed

Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor PLoS One. 2011; 6(9):e25016. . View in PubMed

Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation FASEB J. 2010 Mar; 24(3):833-43. . View in PubMed

Evolving role of laminin receptors in microbial pathogenesis and therapeutics of CNS infection Future Microbiol. 2009 Oct; 4(8):959-62. . View in PubMed

Lactobacillus rhamnosus GG Suppresses Meningitic Ecoli K1 Penetration across Human Intestinal Epithelial Cells In Vitro and Protects Neonatal Rats against Experimental Hematogenous Meningitis. Int J Microbiol. 2009; 2009:647862. . View in PubMed

Identification of IbeR as a stationary-phase regulator in meningitic Escherichia coli K1 that carries a loss-of-function mutation in rpoS J Biomed Biotechnol. 2009; 2009:520283. . View in PubMed

Involvement of Escherichia coli K1 ibeT in bacterial adhesion that is associated with the entry into human brain microvascular endothelial cells Med Microbiol Immunol. 2008 Dec; 197(4):337-44. . View in PubMed

Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation Cell Microbiol. 2008 Sep; 10(9):1854-65. . View in PubMed

Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells Cell Microbiol. 2008 Jun; 10(6):1313-26. . View in PubMed

Cdc6 knockdown inhibits human neuroblastoma cell proliferation Mol Cell Biochem. 2008 Apr; 311(1-2):189-97. . View in PubMed

Infectomic analysis of gene expression profiles of human brain microvascular endothelial cells infected with Cryptococcus neoformans J Biomed Biotechnol. 2008; 2008:375620. . View in PubMed

Focal point theory models for dissecting dynamic duality problems of microbial infections J Biomed Biotechnol. 2008; 2008:856314. . View in PubMed

PSF is an IbeA-binding protein contributing to meningitic Escherichia coli K1 invasion of human brain microvascular endothelial cells Med Microbiol Immunol. 2007 Sep; 196(3):135-43. . View in PubMed

Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection Eukaryot Cell. 2007 Aug; 6(8):1486-96. . View in PubMed

The evolving role of infectomics in drug discovery Expert Opin Drug Discov. 2007 Jul; 2(7):961-75. . View in PubMed

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to HBMEC Biochem Biophys Res Commun. 2007 May 18; 356(4):899-905. . View in PubMed

CPS1, a homolog of the Streptococcus pneumoniae type 3 polysaccharide synthase gene, is important for the pathobiology of Cryptococcus neoformans Infect Immun. 2006 Jul; 74(7):3930-8. . View in PubMed

Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis FEBS Lett. 2006 Jun 26; 580(15):3687-93. . View in PubMed

Spatial distribution of nerve sprouting after myocardial infarction in mice Heart Rhythm. 2006 Jun; 3(6):728-36. . View in PubMed

The histopathology of Candida albicans invasion in neonatal rat tissues and in the human blood-brain barrier in culture revealed by light, scanning, transmission and immunoelectron microscopy Histol Histopathol. 2006 10; 21(10):1029-41. . View in PubMed

Downregulation of human Cdc6 protein using a lentivirus RNA interference expression vector Methods Mol Biol. 2006; 342:287-93. . View in PubMed

Blood-brain barrier drug discovery for central nervous system infections Curr Drug Targets Infect Disord. 2005 Mar; 5(1):65-72. . View in PubMed

Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells J Med Microbiol. 2003 Nov; 52(Pt 11):961-70. . View in PubMed

Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells J Med Microbiol. 2003 Aug; 52(Pt 8):615-22. . View in PubMed

Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma Am J Pathol. 2003 Jun; 162(6):1961-74. . View in PubMed

Use of inverse PCR to clone cDNA ends Methods Mol Biol. 2003; 221:51-8. . View in PubMed

Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha J Biol Chem. 2002 Nov 08; 277(45):43369-76. . View in PubMed

Enhanced Escherichia coli invasion of human brain microvascular endothelial cells is associated with alternations in cytoskeleton induced by nicotine Cell Microbiol. 2002 Aug; 4(8):503-14. . View in PubMed

Infectomics: genomics and proteomics of microbial infections Funct Integr Genomics. 2002 Apr; 1(6):331-44. . View in PubMed

Gene cloning and expression profiling by rapid amplification of gene inserts with universal vector primers Methods Mol Biol. 2002; 192:309-14. . View in PubMed

Inverse PCRGenomic DNA cloning. Methods Mol Biol. 2002; 192:301-7. . View in PubMed

A novel genetic island of meningitic Escherichia coli K1 containing the ibeA invasion gene (GimA): functional annotation and carbon-source-regulated invasion of human brain microvascular endothelial cells Funct Integr Genomics. 2001 Sep; 1(5):312-22. . View in PubMed

Traversal of Candida albicans across human blood-brain barrier in vitro Infect Immun. 2001 Jul; 69(7):4536-44. . View in PubMed

Cellular mechanisms of microbial proteins contributing to invasion of the blood-brain barrier Cell Microbiol. 2001 May; 3(5):277-87. . View in PubMed

Further characterization of Escherichia coli brain microvascular endothelial cell invasion gene ibeA by deletion, complementation, and protein expression J Infect Dis. 2001 Apr 01; 183(7):1071-8. . View in PubMed

MAT1-modulated CAK activity regulates cell cycle G(1) exit Mol Cell Biol. 2001 Jan; 21(1):260-70. . View in PubMed

Loss control of Mcm5 interaction with chromatin in cdc6-1 mutated in CDC-NTP motif DNA Cell Biol. 2000 Jul; 19(7):447-57. . View in PubMed

Identification and characterization of Saccharomyces cerevisiae Cdc6 DNA-binding properties Mol Biol Cell. 2000 May; 11(5):1673-85. . View in PubMed

The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association J Biol Chem. 1999 Mar 19; 274(12):8291-8. . View in PubMed

RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells J Biol Chem. 1999 Feb 26; 274(9):5564-72. . View in PubMed

Saccharomyces cerevisiae Cdc6 stimulates Abf1 DNA binding activity J Biol Chem. 1998 Jan 16; 273(3):1298-302. . View in PubMed

A simple and sensitive ribonucleotide reductase assay J Biomed Sci. 1998; 5(1):62-8. . View in PubMed

Rapid amplification of gene ends (RAGE) from gene libraries by anchored PCR Methods Mol Biol. 1997; 67:295-300. . View in PubMed

Expression and preparation of fusion proteins from recombinant lambda gt11 phages Methods Mol Biol. 1997; 69:241-5. . View in PubMed

Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases Mol Biol Cell. 1996 Nov; 7(11):1723-35. . View in PubMed

Intracellular location of the Saccharomyces cerevisiae CDC6 gene product DNA Cell Biol. 1996 Oct; 15(10):883-95. . View in PubMed

Pulsed field gel electrophoresis labeling method to study the pattern of Saccharomyces cerevisiae chromosomal DNA synthesis during the G1/S phase of the cell cycle Anal Biochem. 1995 May 01; 227(1):32-9. . View in PubMed

Temporal and spatial distributions of yeast nucleoside diphosphate kinase activities and its association with the Cdc8p Cell Mol Biol Res. 1995; 41(5):333-46. . View in PubMed

Efficient induction and preparation of fusion proteins from recombinant phage lambda gt11 clones Trends Genet. 1994 Jun; 10(6):183. . View in PubMed

Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth DNA Cell Biol. 1994 May; 13(5):461-71. . View in PubMed

Characteristics, substrate analysis, and intracellular location of Saccharomyces cerevisiae UMP kinase Arch Biochem Biophys. 1993 Jul; 304(1):197-204. . View in PubMed

Mutation analysis of Saccharomyces cerevisiae CDC6 promoter: defining its UAS domain and cell cycle regulating element DNA Cell Biol. 1993 May; 12(4):363-70. . View in PubMed

Amplification of gene ends from gene libraries by polymerase chain reaction with single-sided specificity Methods Mol Biol. 1993; 15:357-63. . View in PubMed

Functional and structural conservation of Schizosaccharomyces pombe dTMP kinase gene Biochim Biophys Acta. 1992 Sep 24; 1132(2):222-4. . View in PubMed

Saccharomyces cerevisiae nucleoside-diphosphate kinase: purification, characterization, and substrate specificity Arch Biochem Biophys. 1991 Dec; 291(2):241-6. . View in PubMed

Molecular characterization of Saccharomyces cerevisiae URA6 geneDNA sequence, mutagenesis analysis, and cell cycle regulation relevant to its suppression mechanism to cdc8 mutation. J Biol Chem. 1991 Sep 25; 266(27):18287-93. . View in PubMed

Human deoxycytidine kinaseSequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. J Biol Chem. 1991 Mar 15; 266(8):5353. . View in PubMed

CDC6 mRNA fluctuates periodically in the yeast cell cycle J Biol Chem. 1990 Nov 15; 265(32):19904-9. . View in PubMed

The CDC4 gene product is associated with the yeast nuclear skeleton Biochem Biophys Res Commun. 1990 Nov 15; 172(3):1324-30. . View in PubMed

Purification and characterization of Saccharomyces cerevisiae uridine monophosphate kinase J Biol Chem. 1990 Nov 05; 265(31):19122-7. . View in PubMed

A protocol for using T7 DNA polymerase in oligonucleotide site-directed mutagenesis Biotechniques. 1990 May; 8(5):503. . View in PubMed

Mini-prep in ten minutes Biotechniques. 1990 Feb; 8(2):172-3. . View in PubMed

The Saccharomyces cerevisiae SOC8-1 gene and its relationship to a nucleotide kinase J Biol Chem. 1989 Sep 15; 264(26):15593-9. . View in PubMed

Human deoxycytidine kinaseSequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. J Biol Chem. 1989 Sep 05; 264(25):14762-8. . View in PubMed

Isolation of multiple types of plasminogen activator inhibitors from vascular smooth muscle cells Thromb Haemost. 1989 Jun 30; 61(3):517-21. . View in PubMed

Molecular cloning of Saccharomyces cerevisiae CDC6 geneIsolation, identification, and sequence analysis. J Biol Chem. 1989 May 25; 264(15):9022-9. . View in PubMed

Saccharomyces cerevisiae SSB1 protein and its relationship to nucleolar RNA-binding proteins Mol Cell Biol. 1987 Aug; 7(8):2947-55. . View in PubMed

Isolation of the gene encoding yeast single-stranded nucleic acid binding protein 1 Proc Natl Acad Sci U S A. 1986 Feb; 83(4):877-81. . View in PubMed

Yeast DNA replication Basic Life Sci. 1986; 40:463-78. . View in PubMed

Multiple species of single-stranded nucleic acid-binding proteins in Saccharomyces cerevisiae J Biol Chem. 1985 Dec 25; 260(30):16367-74. . View in PubMed

DNA synthesis in yeast cell-free extracts dependent on recombinant DNA plasmids purified from Escherichia coli Nucleic Acids Res. 1985 Apr 25; 13(8):2943-58. . View in PubMed

Characterization of Saccharomyces cerevisiae thymidylate kinase, the CDC8 gene productGeneral properties, kinetic analysis, and subcellular localization. J Biol Chem. 1984 Dec 10; 259(23):14394-8. . View in PubMed

The CDC8 gene of yeast encodes thymidylate kinase J Biol Chem. 1984 Sep 10; 259(17):11052-9. . View in PubMed

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