Keck School Faculty

Ambrose Yaw-Shong Jong, PhD
Ambrose Yaw-Shong Jong, PhD
Associate Professor of Pediatrics
Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles

Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine Sci Rep. 2017 Jan 11; 7:40467. . View in PubMed

Biological roles and potential applications of immune cell-derived extracellular vesicles J Extracell Vesicles. 2017; 6(1):1400370. . View in PubMed

Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells J Extracell Vesicles. 2017; 6(1):1294368. . View in PubMed

Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine Sci Rep. 2017 01 11; 7:40467. . View in PubMed

The 14-3-3 Gene Function of Cryptococcus neoformans Is Required for its Growth and Virulence J Microbiol Biotechnol. 2016 May 28; 26(5):918-27. . View in PubMed

Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque PLoS One. 2016; 11(6):e0156170. . View in PubMed

Front Microbiol. 2016; 7:148. . View in PubMed

Alpha7 nicotinic acetylcholine receptor is required for blood-brain barrier injury-related CNS disorders caused by Cryptococcus neoformans and HIV-1 associated comorbidity factors BMC Infect Dis. 2015 Aug 19; 15:352. . View in PubMed

Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy J Natl Cancer Inst. 2015 Jul; 107(7). . View in PubMed

How Cryptococcus interacts with the blood-brain barrier Future Microbiol. 2015; 10(10):1669-82. . View in PubMed

Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans MBio. 2013 May 07; 4(3):e00220-13. . View in PubMed

Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors PLoS One. 2013; 8(4):e62164. . View in PubMed

Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection J Biol Chem. 2012 May 04; 287(19):15298-306. . View in PubMed

The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity Cell Host Microbe. 2012 Mar 15; 11(3):277-89. . View in PubMed

Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells J Biomed Sci. 2012 Feb 08; 19:19. . View in PubMed

Retinoid-regulated FGF8f secretion by osteoblasts bypasses retinoid stimuli to mediate granulocytic differentiation of myeloid leukemia cells Mol Cancer Ther. 2012 Feb; 11(2):267-76. . View in PubMed

Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system PLoS One. 2012; 7(9):e45083. . View in PubMed

coli K1 induced activation and nuclear translocation of NF-?B in human brain endothelial cells. PLoS One. 2012; 7(4):e35862. . View in PubMed

Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection PLoS One. 2012; 7(11):e48570. . View in PubMed

Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3) J Biol Chem. 2011 Oct 07; 286(40):34761-9. . View in PubMed

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities Biochem J. 2011 Sep 15; 438(3):457-66. . View in PubMed

Recruitment of a7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells Future Microbiol. 2011 Aug; 6(8):953-66. . View in PubMed

Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence PLoS One. 2011 Apr 29; 6(4):e19162. . View in PubMed

[Effect of HIV-1gp41 ectodomain on Cryptococcus neoformans-induced cytoskeletal changes in human brain microvascular endothelial cells] Nan Fang Yi Ke Da Xue Xue Bao. 2011 Mar; 31(3):478-81. . View in PubMed

Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor PLoS One. 2011; 6(9):e25016. . View in PubMed

Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation FASEB J. 2010 Mar; 24(3):833-43. . View in PubMed

Evolving role of laminin receptors in microbial pathogenesis and therapeutics of CNS infection Future Microbiol. 2009 Oct; 4(8):959-62. . View in PubMed

Lactobacillus rhamnosus GG Suppresses Meningitic Ecoli K1 Penetration across Human Intestinal Epithelial Cells In Vitro and Protects Neonatal Rats against Experimental Hematogenous Meningitis. Int J Microbiol. 2009; 2009:647862. . View in PubMed

Identification of IbeR as a stationary-phase regulator in meningitic Escherichia coli K1 that carries a loss-of-function mutation in rpoS J Biomed Biotechnol. 2009; 2009:520283. . View in PubMed

Involvement of Escherichia coli K1 ibeT in bacterial adhesion that is associated with the entry into human brain microvascular endothelial cells Med Microbiol Immunol. 2008 Dec; 197(4):337-44. . View in PubMed

Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation Cell Microbiol. 2008 Sep; 10(9):1854-65. . View in PubMed

Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells Cell Microbiol. 2008 Jun; 10(6):1313-26. . View in PubMed

Cdc6 knockdown inhibits human neuroblastoma cell proliferation Mol Cell Biochem. 2008 Apr; 311(1-2):189-97. . View in PubMed

Infectomic analysis of gene expression profiles of human brain microvascular endothelial cells infected with Cryptococcus neoformans J Biomed Biotechnol. 2008; 2008:375620. . View in PubMed

PSF is an IbeA-binding protein contributing to meningitic Escherichia coli K1 invasion of human brain microvascular endothelial cells Med Microbiol Immunol. 2007 Sep; 196(3):135-43. . View in PubMed

Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection Eukaryot Cell. 2007 Aug; 6(8):1486-96. . View in PubMed

The evolving role of infectomics in drug discovery Expert Opin Drug Discov. 2007 Jul; 2(7):961-75. . View in PubMed

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to HBMEC Biochem Biophys Res Commun. 2007 May 18; 356(4):899-905. . View in PubMed

Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis FEBS Lett. 2006 Jun 26; 580(15):3687-93. . View in PubMed

Spatial distribution of nerve sprouting after myocardial infarction in mice Heart Rhythm. 2006 Jun; 3(6):728-36. . View in PubMed

Downregulation of human Cdc6 protein using a lentivirus RNA interference expression vector Methods Mol Biol. 2006; 342:287-93. . View in PubMed

Blood-brain barrier drug discovery for central nervous system infections Curr Drug Targets Infect Disord. 2005 Mar; 5(1):65-72. . View in PubMed

Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells J Med Microbiol. 2003 Nov; 52(Pt 11):961-70. . View in PubMed

Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells J Med Microbiol. 2003 Aug; 52(Pt 8):615-22. . View in PubMed

Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma Am J Pathol. 2003 Jun; 162(6):1961-74. . View in PubMed

Use of inverse PCR to clone cDNA ends Methods Mol Biol. 2003; 221:51-8. . View in PubMed

Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha J Biol Chem. 2002 Nov 08; 277(45):43369-76. . View in PubMed

Enhanced Escherichia coli invasion of human brain microvascular endothelial cells is associated with alternations in cytoskeleton induced by nicotine Cell Microbiol. 2002 Aug; 4(8):503-14. . View in PubMed

Infectomics: genomics and proteomics of microbial infections Funct Integr Genomics. 2002 Apr; 1(6):331-44. . View in PubMed

Gene cloning and expression profiling by rapid amplification of gene inserts with universal vector primers Methods Mol Biol. 2002; 192:309-14. . View in PubMed

Inverse PCRGenomic DNA cloning. Methods Mol Biol. 2002; 192:301-7. . View in PubMed

Traversal of Candida albicans across human blood-brain barrier in vitro Infect Immun. 2001 Jul; 69(7):4536-44. . View in PubMed

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