Keck School Faculty

Amir H. Kashani

Amir H. Kashani

Associate Professor of Ophthalmology (Clinical Scholar)
HC4 4900 1450 San Pablo Street Off Campus Los Angeles

The Ophthalmologist: Rising Stars Power List, 2017

Ocular Surgery News: Nominated to 150 leading innovators in medical and surgical retina, 2016

: Ron G. Michel's Fellowhship, 2012

Society of Heed Scholars: Heed Ophthalmic Foundation Fellow, 2012

Association for Research in Vision and Ophthalmology: Member, 2009

: Henry and Lilian Nesburn Award, 2009

: Heed Resident Research Symposium (Rank #4), 2009

USC Department of Ophthalmology: Resident Research Award, 2008

: ARVO Research Travel Grant, 2007

ARVO: Retinal Research Foundation Grant, 2006

Johns Hopkins School of Medicine: Medical Student Research Fellowship, 2000

: Medical Scientist Training Program Fellowship (MSTP), 1999-2006

3D Retinal Vessel Density Mapping with OCTA- Angiography IEEE J Biomed Health Inform. 2020 Sep 10; PP. . View in PubMed

Classification of advanced and early stages of diabetic retinopathy from non-diabetic subjects by an ordinary least squares modeling method applied to OCTA images Biomed Opt Express. 2020 Aug 01; 11(8):4666-4678. . View in PubMed

3D Shape Modeling and Analysis of Retinal Microvasculature in OCT-Angiography Images IEEE Trans Med Imaging. 2020 May; 39(5):1335-1346. . View in PubMed

Hypoalbuminemia and Bandemia Predict Failure of Infliximab Rescue Therapy in Acute Severe Ulcerative Colitis Dig Dis Sci. 2020 Mar 13. . View in PubMed

Efficacy and safety of cap-assisted endoscopic mucosal resection of ileocecal valve polyps Endosc Int Open. 2020 Mar; 8(3):E241-E246. . View in PubMed

Surgical Method for Implantation of a Biosynthetic Retinal Pigment Epithelium Monolayer for Geographic Atrophy: Experience from a Phase 1/2a Study Ophthalmol Retina. 2020 03; 4(3):264-273. . View in PubMed

Automated Deformation-Based Analysis of 3D Optical Coherence Tomography in Diabetic Retinopathy IEEE Trans Med Imaging. 2020 01; 39(1):236-245. . View in PubMed

Lower retinal capillary density in minimal cognitive impairment among older Latinx adults Alzheimers Dement (Amst). 2020; 12(1):e12071. . View in PubMed

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography J Vis Exp. 2020 03 26; (157). . View in PubMed

Impaired layer specific retinal vascular reactivity among diabetic subjects PLoS One. 2020; 15(9):e0233871. . View in PubMed

Pseudoflow with OCT Angiography in Eyes with Hard Exudates and Macular Drusen Transl Vis Sci Technol. 2019 May; 8(3):50. . View in PubMed

Systemic Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study Am J Ophthalmol. 2019 11; 207:240-247. . View in PubMed

Effect of Scan Size on Glaucoma Diagnostic Performance Using OCT Angiography En Face Images of the Radial Peripapillary Capillaries J Glaucoma. 2019 05; 28(5):465-472. . View in PubMed

Ocular Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study Invest Ophthalmol Vis Sci. 2019 08 01; 60(10):3368-3373. . View in PubMed

Impaired Retinal Vascular Reactivity in Diabetic Retinopathy as Assessed by Optical Coherence Tomography Angiography Invest Ophthalmol Vis Sci. 2019 06 03; 60(7):2468-2473. . View in PubMed

Subretinal Implantation of a Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium Monolayer in a Porcine Model Adv Exp Med Biol. 2019; 1185:569-574. . View in PubMed

Diagnostic Performance of Macular Versus Peripapillary Vessel Parameters by Optical Coherence Tomography Angiography for Glaucoma Transl Vis Sci Technol. 2018 Nov; 7(6):21. . View in PubMed

Double balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography in Roux-en-Y gastric bypass anatomy: expert vsnovice experience. Endosc Int Open. 2018 Jul; 6(7):E885-E891. . View in PubMed

Suspended Scattering Particles in Motion: A Novel Feature of OCT Angiography in Exudative Maculopathies Ophthalmol Retina. 2018 Jul; 2(7):694-702. . View in PubMed

Am J Ophthalmol Case Rep. 2018 Jun; 10:77-80. . View in PubMed

The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients' self-reported well-being: A randomized double-blind controlled trial J Cell Biochem. 2018 11; 119(11):9552-9559. . View in PubMed

Structural and Functional Associations of Macular Microcirculation in the Ganglion Cell-Inner Plexiform Layer in Glaucoma Using Optical Coherence Tomography Angiography J Glaucoma. 2018 03; 27(3):281-290. . View in PubMed

A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration Sci Transl Med. 2018 04 04; 10(435). . View in PubMed

Eur Heart J. 2018 11 07; 39(42):3810-3820. . View in PubMed

Normative Retinal Thicknesses in Common Animal Models of Eye Disease Using Spectral Domain Optical Coherence Tomography Adv Exp Med Biol. 2018; 1074:157-166. . View in PubMed

Diagnostic and Therapeutic Challenges Retina. 2017 09; 37(9):1805-1808. . View in PubMed

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications Prog Retin Eye Res. 2017 09; 60:66-100. . View in PubMed

Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography PLoS One. 2017; 12(4):e0176404. . View in PubMed

Surgically Induced Focal Retinal Detachment Does Not Cause Detectable SD-OCT Retinal Changes in Normal Human Retina Invest Ophthalmol Vis Sci. 2017 10 01; 58(12):5270-5279. . View in PubMed


Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography Am J Ophthalmol. 2016 Nov; 171:101-112. . View in PubMed

The tipping point: Tamoxifen toxicity, central serous chorioretinopathy, and the role of estrogen and its receptors Am J Ophthalmol Case Rep. 2016 Oct; 3:8-13. . View in PubMed

Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-1565. . View in PubMed

Stem Cell Therapy in Nonneovascular Age-Related Macular Degeneration Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFm1-9. . View in PubMed

Impaired Retinal Perfusion Resulting From Vitreoretinal Traction: A Mechanism of Retinal Vascular Insufficiency Ophthalmic Surg Lasers Imaging Retina. 2016 Mar; 47(3):1-11. . View in PubMed

Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography Invest Ophthalmol Vis Sci. 2016 07 01; 57(9):OCT362-70. . View in PubMed

Spatial Variations in Vitreous Oxygen Consumption PLoS One. 2016; 11(3):e0149961. . View in PubMed


Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects Ophthalmic Surg Lasers Imaging Retina. 2015 Sep; 46(8):796-805. . View in PubMed

Stem cell based therapies for age-related macular degeneration: The promises and the challenges Prog Retin Eye Res. 2015 Sep; 48:1-39. . View in PubMed

Snapshot retinal imaging Mueller matrix polarimeter Proc SPIE Int Soc Opt Eng. 2015 Aug; 9613. . View in PubMed

Whole vitreous humor dissection for vitreodynamic analysis J Vis Exp. 2015 May 24; (99):e52759. . View in PubMed

Spleen size in cirrhosis of different etiologies J Ultrasound Med. 2015 Feb; 34(2):233-8. . View in PubMed

Longitudinal optical density analysis of subretinal fluid after surgical repair of rhegmatogenous retinal detachment Retina. 2015 Jan; 35(1):149-56. . View in PubMed

MULTIMODAL IMAGING OF GEOGRAPHIC AREAS OF RETINAL DARKENING Retin Cases Brief Rep. 2015; 9(4):347-51. . View in PubMed

Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy Ophthalmology. 2014 Nov; 121(11):2220-7. . View in PubMed

OCT angiography in healthy human subjects Ophthalmic Surg Lasers Imaging Retina. 2014 Nov-Dec; 45(6):510-5. . View in PubMed

Noninvasive assessment of retinal vascular oxygen content among normal and diabetic human subjects: a study using hyperspectral computed tomographic imaging spectroscopy Retina. 2014 Sep; 34(9):1854-60. . View in PubMed

Can endoscopic ultrasound distinguish between mediastinal benign lymph nodes and those involved by sarcoidosis, lymphoma, or metastasis? Dig Dis Sci. 2014 Sep; 59(9):2191-8.. View in PubMed

Subretinal peripapillary neovascularization associated with persistent fetal vasculature Retin Cases Brief Rep. 2014; 8(1):83-6. . View in PubMed

Profile of ocriplasmin and its potential in the treatment of vitreomacular adhesion Clin Ophthalmol. 2014; 8:847-56. . View in PubMed

Staphylococcus lugdunensis endophthalmitis after intravitreal injection: a case series Retin Cases Brief Rep. 2014; 8(1):41-4. . View in PubMed

High prevalence of peripheral retinal vascular anomalies in family members of patients with familial exudative vitreoretinopathy Ophthalmology. 2014 Jan; 121(1):262-268. . View in PubMed

Vitreomacular traction as a consequence of posterior hyaloidal contraction after transpupillary thermotherapy Am J Ophthalmol. 2013 May; 155(5):937-45. . View in PubMed

The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA: basic and clinical advances J Ophthalmic Inflamm Infect. 2013 Feb 04; 3(1):28. . View in PubMed

Quantitative analysis of retinal structures using spectral domain optical coherence tomography in normal rabbits Curr Eye Res. 2013 Feb; 38(2):299-304. . View in PubMed

Acute variations in retinal vascular oxygen content in a rabbit model of retinal venous occlusion PLoS One. 2012; 7(11):e50179. . View in PubMed

Bilateral Klebsiella pneumoniae (K1 serotype) endogenous endophthalmitis as the presenting sign of disseminated infection Ophthalmic Surg Lasers Imaging. 2011 Feb 10; 42 Online:e12-4. . View in PubMed

Hyperspectral computed tomographic imaging spectroscopy of vascular oxygen gradients in the rabbit retina in vivo PLoS One. 2011; 6(9):e24482. . View in PubMed

Retinal thickness analysis by race, gender, and age using Stratus OCTAm J Ophthalmol. 2010 Mar; 149(3):496-502. e1. . View in PubMed

Quantitative subanalysis of cystoid spaces and outer nuclear layer using optical coherence tomography in age-related macular degeneration Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3366-73. . View in PubMed

Predicting response to HBV vaccination in people with positive anti-HBc but negative HBsAg and anti-HBs Hum Vaccin. 2008 Sep-Oct; 4(5):379-83. . View in PubMed

Fluid retention in cirrhosis: pathophysiology and management QJM. 2008 Feb; 101(2):71-85. . View in PubMed

Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections J Neurosci. 2006 Aug 09; 26(32):8398-408. . View in PubMed

Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2105-10. . View in PubMed

The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity J Neurocytol. 2003 Jun-Sep; 32(5-8):489-503. . View in PubMed

Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription Neuron. 2002 Jun 13; 34(6):999-1010. . View in PubMed

Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency Am J Med Genet. 2002 Feb 15; 108(1):57-63. . View in PubMed

Meningeal-cutaneous relationships in anencephaly: evidence for a primary mesenchymal abnormality Hum Pathol. 2001 May; 32(5):553-8. . View in PubMed

Hypertonic enhancement of transmitter release from frog motor nerve terminals: Ca2+ independence and role of integrins J Physiol. 2001 Jan 15; 530(Pt 2):243-52. . View in PubMed

High dose intramuscular methylprednisolone in experimental Staphylococcus aureus endophthalmitis J Ocul Pharmacol Ther. 1999 Feb; 15(1):91-6. . View in PubMed

Safety of repeated intravitreous injections of antibiotics and dexamethasone Retina. 1999; 19(5):437-41. . View in PubMed

Amir H. Kashani, MD, PhD, attended Johns Hopkins School of Medicine where he obtained both his MD and PhD in Neuroscience in 2006. He completed an internship at the Johns Hopkins Hospital in 2007 and ophthalmology residency at the USC Roski Eye Institute from 2007-2010. He then completed a fellowship in vitreoretinal surgery at the top-rated Associated Retinal Consultants in Royal Oak, Michigan. During his training, we was awarded both the Heed and Michel’s Fellowships (National Honors given on a competitive basis among all vitreoretinal trainees in the country) during his training. In his clinical practice, he treats patients with medical and surgical retinal diseases including diabetic retinopathy, retinal vein occlusions, age-related macular degeneration and retinal detachments among other common retinal diseases. He also specializes in complex retinal detachment surgeries.

In the laboratory, Dr. Kashani is developing novel diagnostic and therapeutic methods to diagnose and treat retinal diseases. His investigates the use of advanced imaging spectroscopy and optical coherence tomography methods to improve the early detection of chronic diseases like diabetic retinopathy, retinal venous occlusion and neurodegenerative diseases such as Alzheimer’s disease. Dr. Kashani is the principal investigator for a clinical trial to test a novel stem cell therapy for severe vision loss from advanced dry age-related macular degeneration. The preliminary results of this study were published in Science Translation Medicine in April 2018. In recognition of his cutting edge research Dr. Kashani has been recognized internationally by his peers. In 2016 he was named as one of the top 150 innovators in the field of medical and surgical retina by Ocular Surgery News. In 2017 he was named as one of the top 50
ising stars world-wide in the field of ophthalmology by The Ophthalmologist. Dr. Kashani has co-authored more than 40 peer reviewed articles in the scientific literature, several subject reviews, and recently co-authored an ophthalmology book entitled Optical Coherence Tomography and OCT Angiography: Clinical Reference and Case Studies. Dr. Kashani clinical work has been recognized by multiple organizations and publications including Pasadena’s Top Doctors, America’s Top Ophthalmologist, Best Doctors in America, Marquis Who’s Who in the World.
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