Keck School Faculty

Andre J Ouellette, PhD
Andre J Ouellette, PhD
Professor of Pathology
NRT 7505 Health Sciences Campus Los Angeles

Correction for Cobo et al, "Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency". Infect Immun. 2018 Oct; 86(10). . View in PubMed

Entamoeba histolytica Alters ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency Infect Immun. 2018 Apr 23. . View in PubMed

Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. . View in PubMed

A novel role for lipid droplets in the organismal antibacterial response Elife. 2012 Nov 13; 1:e00003. . View in PubMed

ImmunologyHD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. . View in PubMed

Biosynthesis and antimicrobial evaluation of backbone-cyclized a-defensins Biochemistry. 2011 Dec 06; 50(48):10508-19. . View in PubMed

Paneth cell a-defensins in enteric innate immunity Cell Mol Life Sci. 2011 Jul; 68(13):2215-29. . View in PubMed

Paneth cells and innate mucosal immunity Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53. . View in PubMed

Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue Biochemistry. 2008 Nov 25; 47(47):12626-34. . View in PubMed

Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers J Pept Sci. 2008 Apr; 14(4):503-9. . View in PubMed

Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. . View in PubMed

A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion J Immunol. 2007 Jul 15; 179(2):1245-53. . View in PubMed

Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity J Biol Chem. 2006 Sep 29; 281(39):28932-42. . View in PubMed

Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4 J Biol Chem. 2006 Sep 22; 281(38):28068-78. . View in PubMed

Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. . View in PubMed

Mammalian defensins in the antimicrobial immune response Nat Immunol. 2005 Jun; 6(6):551-7. . View in PubMed

The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides Mol Microbiol. 2005 May; 56(3):789-99. . View in PubMed

Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria Infect Immun. 2005 Apr; 73(4):2312-20. . View in PubMed

Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin Biochemistry. 2004 Dec 21; 43(50):15759-66. . View in PubMed

Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities J Virol. 2004 Nov; 78(21):11622-31. . View in PubMed

Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4 J Biol Chem. 2004 Oct 15; 279(42):44188-96. . View in PubMed

Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. . View in PubMed

Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response J Biol Chem. 2004 May 07; 279(19):19902-7. . View in PubMed

Defensin-mediated innate immunity in the small intestine Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. . View in PubMed

Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions J Biol Chem. 2004 Mar 19; 279(12):11976-83. . View in PubMed

Paneth cell alpha-defensins from rhesus macaque small intestine Infect Immun. 2004 Mar; 72(3):1470-8. . View in PubMed

Quantitative interactions between cryptdin-4 amino terminal variants and membranes Peptides. 2003 Nov; 24(11):1795-805. . View in PubMed

Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranesProsegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. . View in PubMed

Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7 J Biol Chem. 2003 Mar 07; 278(10):7910-9. . View in PubMed

Activation of Paneth cell alpha-defensins in mouse small intestine J Biol Chem. 2002 Feb 15; 277(7):5219-28. . View in PubMed

Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel J Biol Chem. 2002 Feb 01; 277(5):3793-800. . View in PubMed

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