Andrew Abba Stolz, MD

Professor of Medicine

Associate Chair for Faculty Affairs for the Department of Medicine

Chair, Faculty Appointments and Promotion Tenure Committee (FAPTC Panel B)

Image of Andrew Abba Stolz, MD
Is this your profile? Click to edit

Overview

Dr. Stolz’s major areas of research interest are mechanisms of protein mediated intracellular transport of bile acids in the liver, molecular characterization of Aldo-Keto Reductase supergene family members in rat, mouse and human, dysregulation of hormone catabolism in human breast and prostate cancers, and drug-induced liver injury, among others.

Dr. Stolz earned his medical degree at Albert Einstein College of Medicine. He then performed his residency at Mt. Sinai Hospital, immediately followed by a Gastroenterology Fellowship at UCLA. Dr. Stolz has been a part of the Division of Gastrointestinal and Liver Diseases since 1990, earning tenure shortly after.

Awards

  • 17th International Symposium of the Journal of Steroid Biochemistry & Molecular Biology: Fabre Laboratories Best Poster, 2006
  • American Liver Foundation: Postdoctoral Fellowship, 1983-1985

Publications

  • Steroid responsiveness in alcohol-associated hepatitis is linked to glucocorticoid metabolism, mitochondrial repair, and heat shock proteins Hepatol Commun. 2024 Mar 01; 8(3). . View in PubMed
  • Identification of integrated proteomics and transcriptomics signature of alcohol-associated liver disease using machine learning PLOS Digit Health. 2024 Feb; 3(2):e0000447. . View in PubMed
  • Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate Gastroenterology. 2023 03; 164(3):454-466. . View in PubMed
  • Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN] Am J Med. 2023 02; 136(2):200-206. . View in PubMed
  • A phase II, multicenter, open-label, randomized trial of pegfilgrastim for patients with alcohol-associated hepatitis EClinicalMedicine. 2022 Dec; 54:101689. . View in PubMed
  • Naltrexone for alcohol use disorder: Hepatic safety in patients with and without liver disease Hepatol Commun. 2022 Dec; 6(12):3433-3442. . View in PubMed
  • Differentiating between liver diseases by applying multiclass machine learning approaches to transcriptomics of liver tissue or blood-based samples JHEP Rep. 2022 Oct; 4(10):100560. . View in PubMed
  • Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis Am J Pathol. 2022 12; 192(12):1658-1669. . View in PubMed
  • Hepatic Protein and Phosphoprotein Signatures of Alcohol-Associated Cirrhosis and Hepatitis Am J Pathol. 2022 07; 192(7):1066-1082. . View in PubMed
  • Garcinia cambogia, Either Alone or in Combination With Green Tea, Causes Moderate to Severe Liver Injury Clin Gastroenterol Hepatol. 2022 06; 20(6):e1416-e1425. . View in PubMed
  • Newly identified genetic variants associated with idiosyncratic drug-induced liver injury Curr Opin Gastroenterol. 2022 05 01; 38(3):230-238. . View in PubMed
  • Inhibition of Estrogen-Related Receptor a Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis Am J Pathol. 2021 07; 191(7):1240-1254. . View in PubMed
  • HLA-B*35:01 and Green Tea-Induced Liver Injury Hepatology. 2021 06; 73(6):2484-2493. . View in PubMed
  • Human Leukocyte Antigen B*14:01 and B*35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury Hepatology. 2021 01; 73(1):268-281. . View in PubMed
  • Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease Alcohol Clin Exp Res. 2020 05; 44(5):1061-1074. . View in PubMed
  • United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts Toxicol Rep. 2020; 7:386-402. . View in PubMed
  • Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis Hepatol Int. 2019 Sep; 13(5):641-648. . View in PubMed
  • Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug-Induced Liver Injury Hepatol Commun. 2019 Aug; 3(8):1032-1035. . View in PubMed
  • The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled Hepatol Commun. 2019 Jun; 3(6):792-794. . View in PubMed
  • Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury Dig Dis Sci. 2019 09; 64(9):2645-2652. . View in PubMed
  • A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver InjuryGastroenterology. 2019 05; 156(6):1707-1716. e2. . View in PubMed
  • Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors Aliment Pharmacol Ther. 2019 05; 49(9):1195-1204. . View in PubMed
  • Sclerosing Cholangitis-Like Changes on Magnetic Resonance Cholangiography in Patients With Drug Induced Liver Injury Clin Gastroenterol Hepatol. 2019 03; 17(4):789-790. . View in PubMed
  • Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group PLoS One. 2019; 14(2):e0212394. . View in PubMed
  • Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group PLoS One. 2018; 13(10):e0206389. . View in PubMed
  • Idiosyncratic Drug Induced Liver Injury in African-Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians Am J Gastroenterol. 2017 Sep; 112(9):1382-1388. . View in PubMed
  • Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy Hepatol Commun. 2017 12; 1(10):1070-1084. . View in PubMed
  • Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B*35:02 as a risk factor J Hepatol. 2017 07; 67(1):137-144. . View in PubMed
  • Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study Gastroenterology. 2017 04; 152(5):1078-1089. . View in PubMed
  • Liver injury from nonsteroidal anti-inflammatory drugs in the United States Liver Int. 2016 Apr; 36(4):603-9. . View in PubMed
  • Erratum to: Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series Dig Dis Sci. 2016 12; 61(12):3638. . View in PubMed
  • Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series Dig Dis Sci. 2016 09; 61(9):2741-8. . View in PubMed
  • Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury Am J Gastroenterol. 2015 Oct; 110(10):1450-9. . View in PubMed
  • Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid HepatotoxicityClin Gastroenterol Hepatol. 2015 Sep; 13(9):1676-82. e1. . View in PubMed
  • Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective StudyGastroenterology. 2015 Jun; 148(7):1340-52. e7. . View in PubMed
  • Reliability of causality assessment for drug, herbal and dietary supplement hepatotoxicity in the Drug-Induced Liver Injury Network (DILIN) Liver Int. 2015 May; 35(5):1623-32. . View in PubMed
  • Clinical and histologic features of azithromycin-induced liver injuryClin Gastroenterol Hepatol. 2015 Feb; 13(2):369-376. e3. . View in PubMed
  • Liver injury from herbals and dietary supplements in the US. Drug-Induced Liver Injury Network. Hepatology. 2014 Oct; 60(4):1399-408. . View in PubMed
  • Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onsetGastroenterology. 2014 Jul; 147(1):96-108. e4. . View in PubMed
  • Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations Hepatology. 2014 Feb; 59(2):661-70. . View in PubMed
  • Profiles of serum cytokines in acute drug-induced liver injury and their prognostic significance PLoS One. 2013; 8(12):e81974. . View in PubMed
  • Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs Pharmacogenet Genomics. 2012 Nov; 22(11):784-95. . View in PubMed
  • AKR1C1 and SRD5A1 messenger RNA expression at term in the human myometrium and chorioamniotic membranes Am J Perinatol. 2008 Oct; 25(9):577-82. . View in PubMed
  • 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism J Clin Endocrinol Metab. 2008 Apr; 93(4):1298-303. . View in PubMed
  • Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling Cancer Res. 2007 Feb 01; 67(3):1361-9. . View in PubMed
  • Induction of AKR1C2 by phase II inducers: identification of a distal consensus antioxidant response element regulated by NRF2 Mol Pharmacol. 2006 May; 69(5):1662-72. . View in PubMed
  • Localization and altered expression of AKR1C family members in human ovarian tissues Mol Cell Probes. 2005 Aug; 19(4):261-6. . View in PubMed
  • Frequent loss of estrogen and progesterone receptors in human prostatic tumors determined by quantitative real-time PCR Mol Cell Endocrinol. 2005 Jan 14; 229(1-2):103-10. . View in PubMed
  • Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling Cancer Res. 2004 Oct 15; 64(20):7610-7. . View in PubMed
  • Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. . View in PubMed
  • Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism Prostate. 2003 Mar 01; 54(4):275-89. . View in PubMed
  • A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13 J Lipid Res. 2003 Mar; 44(3):503-11. . View in PubMed
  • Vitamin C transport in human lens epithelial cells: evidence for the presence of SVCT2 Exp Eye Res. 2001 Aug; 73(2):159-65. . View in PubMed
  • Rat and human bile acid binders are members of the monomeric reductase gene family Adv Exp Med Biol. 1995; 372:269-80. . View in PubMed
  • Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding J Biol Chem. 1994 Mar 18; 269(11):8416-22. . View in PubMed
  • Identification and purification of a human liver cytosolic tocopherol binding protein Protein Expr Purif. 1993 Oct; 4(5):382-9. . View in PubMed
  • cDNA cloning and expression of the human hepatic bile acid-binding proteinA member of the monomeric reductase gene family. J Biol Chem. 1993 May 15; 268(14):10448-57. . View in PubMed
  • Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol J Lipid Res. 1992 Mar; 33(3):343-50. . View in PubMed
  • Molecular structure of rat hepatic 3 alpha-hydroxysteroid dehydrogenaseA member of the oxidoreductase gene family. J Biol Chem. 1991 Aug 15; 266(23):15253-7. . View in PubMed