Keck School Faculty

Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate Gastroenterology. 2023 03; 164(3):454-466. . View in PubMed

Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN] Am J Med. 2023 02; 136(2):200-206. . View in PubMed

A phase II, multicenter, open-label, randomized trial of pegfilgrastim for patients with alcohol-associated hepatitis EClinicalMedicine. 2022 Dec; 54:101689. . View in PubMed

Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis Am J Pathol. 2022 Dec; 192(12):1658-1669. . View in PubMed

Naltrexone for alcohol use disorder: Hepatic safety in patients with and without liver disease Hepatol Commun. 2022 Dec; 6(12):3433-3442. . View in PubMed

Differentiating between liver diseases by applying multiclass machine learning approaches to transcriptomics of liver tissue or blood-based samples JHEP Rep. 2022 Oct; 4(10):100560. . View in PubMed

Hepatic Protein and Phosphoprotein Signatures of Alcohol-Associated Cirrhosis and Hepatitis Am J Pathol. 2022 07; 192(7):1066-1082. . View in PubMed

Garcinia cambogia, Either Alone or in Combination With Green Tea, Causes Moderate to Severe Liver Injury Clin Gastroenterol Hepatol. 2022 06; 20(6):e1416-e1425. . View in PubMed

Newly identified genetic variants associated with idiosyncratic drug-induced liver injury Curr Opin Gastroenterol. 2022 05 01; 38(3):230-238. . View in PubMed

Inhibition of Estrogen-Related Receptor a Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis Am J Pathol. 2021 07; 191(7):1240-1254. . View in PubMed

HLA-B*35:01 and Green Tea-Induced Liver Injury Hepatology. 2021 06; 73(6):2484-2493. . View in PubMed

Human Leukocyte Antigen B*14:01 and B*35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury Hepatology. 2021 01; 73(1):268-281. . View in PubMed

Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease Alcohol Clin Exp Res. 2020 05; 44(5):1061-1074. . View in PubMed

United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts Toxicol Rep. 2020; 7:386-402. . View in PubMed

Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis Hepatol Int. 2019 Sep; 13(5):641-648. . View in PubMed

Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug-Induced Liver Injury Hepatol Commun. 2019 Aug; 3(8):1032-1035. . View in PubMed

The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled Hepatol Commun. 2019 Jun; 3(6):792-794. . View in PubMed

Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury Dig Dis Sci. 2019 09; 64(9):2645-2652. . View in PubMed

Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors Aliment Pharmacol Ther. 2019 05; 49(9):1195-1204. . View in PubMed

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver InjuryGastroenterology. 2019 05; 156(6):1707-1716. e2. . View in PubMed

Sclerosing Cholangitis-Like Changes on Magnetic Resonance Cholangiography in Patients With Drug Induced Liver Injury Clin Gastroenterol Hepatol. 2019 03; 17(4):789-790. . View in PubMed

Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group PLoS One. 2019; 14(2):e0212394. . View in PubMed

Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group PLoS One. 2018; 13(10):e0206389. . View in PubMed

Idiosyncratic Drug Induced Liver Injury in African-Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians Am J Gastroenterol. 2017 Sep; 112(9):1382-1388. . View in PubMed

Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy Hepatol Commun. 2017 12; 1(10):1070-1084. . View in PubMed

Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B*35:02 as a risk factor J Hepatol. 2017 07; 67(1):137-144. . View in PubMed

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study Gastroenterology. 2017 04; 152(5):1078-1089. . View in PubMed

Liver injury from nonsteroidal anti-inflammatory drugs in the United States Liver Int. 2016 Apr; 36(4):603-9. . View in PubMed

Erratum to: Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series Dig Dis Sci. 2016 12; 61(12):3638. . View in PubMed

Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series Dig Dis Sci. 2016 09; 61(9):2741-8. . View in PubMed

Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury Am J Gastroenterol. 2015 Oct; 110(10):1450-9. . View in PubMed

Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid HepatotoxicityClin Gastroenterol Hepatol. 2015 Sep; 13(9):1676-82. e1. . View in PubMed

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective StudyGastroenterology. 2015 Jun; 148(7):1340-52. e7. . View in PubMed

Reliability of causality assessment for drug, herbal and dietary supplement hepatotoxicity in the Drug-Induced Liver Injury Network (DILIN) Liver Int. 2015 May; 35(5):1623-32. . View in PubMed

Clinical and histologic features of azithromycin-induced liver injuryClin Gastroenterol Hepatol. 2015 Feb; 13(2):369-376. e3. . View in PubMed

Liver injury from herbals and dietary supplements in the US. Drug-Induced Liver Injury Network. Hepatology. 2014 Oct; 60(4):1399-408. . View in PubMed

Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onsetGastroenterology. 2014 Jul; 147(1):96-108. e4. . View in PubMed

Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations Hepatology. 2014 Feb; 59(2):661-70. . View in PubMed

Profiles of serum cytokines in acute drug-induced liver injury and their prognostic significance PLoS One. 2013; 8(12):e81974. . View in PubMed

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs Pharmacogenet Genomics. 2012 Nov; 22(11):784-95. . View in PubMed

AKR1C1 and SRD5A1 messenger RNA expression at term in the human myometrium and chorioamniotic membranes Am J Perinatol. 2008 Oct; 25(9):577-82. . View in PubMed

3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism J Clin Endocrinol Metab. 2008 Apr; 93(4):1298-303. . View in PubMed

Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling Cancer Res. 2007 Feb 01; 67(3):1361-9. . View in PubMed

Induction of AKR1C2 by phase II inducers: identification of a distal consensus antioxidant response element regulated by NRF2 Mol Pharmacol. 2006 May; 69(5):1662-72. . View in PubMed

Localization and altered expression of AKR1C family members in human ovarian tissues Mol Cell Probes. 2005 Aug; 19(4):261-6. . View in PubMed

Frequent loss of estrogen and progesterone receptors in human prostatic tumors determined by quantitative real-time PCR Mol Cell Endocrinol. 2005 Jan 14; 229(1-2):103-10. . View in PubMed

Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling Cancer Res. 2004 Oct 15; 64(20):7610-7. . View in PubMed

Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. . View in PubMed

Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism Prostate. 2003 Mar 01; 54(4):275-89. . View in PubMed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13 J Lipid Res. 2003 Mar; 44(3):503-11. . View in PubMed

Vitamin C transport in human lens epithelial cells: evidence for the presence of SVCT2 Exp Eye Res. 2001 Aug; 73(2):159-65. . View in PubMed

Rat and human bile acid binders are members of the monomeric reductase gene family Adv Exp Med Biol. 1995; 372:269-80. . View in PubMed

Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding J Biol Chem. 1994 Mar 18; 269(11):8416-22. . View in PubMed

Identification and purification of a human liver cytosolic tocopherol binding protein Protein Expr Purif. 1993 Oct; 4(5):382-9. . View in PubMed

cDNA cloning and expression of the human hepatic bile acid-binding proteinA member of the monomeric reductase gene family. J Biol Chem. 1993 May 15; 268(14):10448-57. . View in PubMed

Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol J Lipid Res. 1992 Mar; 33(3):343-50. . View in PubMed

Molecular structure of rat hepatic 3 alpha-hydroxysteroid dehydrogenaseA member of the oxidoreductase gene family. J Biol Chem. 1991 Aug 15; 266(23):15253-7. . View in PubMed