Keck School Faculty

Andrew P. McMahon

Andrew P. McMahon

W.M. Keck Provost and University Professor of Stem Cell Biology and Regenerative Medicine and Biological Sciences
Chair of Stem Cell Biology and Regenerative Medicine
Director, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC
Stem Cell Biology & Regenerative Medicine
BCC 312 1425 San Pablo Street Health Sciences Campus Los Angeles

Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium Kidney Int. 2022 05; 101(5):845-853. . View in PubMed

A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discoveryCell Stem Cell. 2022 07 07; 29(7):1083-1101. e7. . View in PubMed

Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing Proc Natl Acad Sci U S A. 2022 06 21; 119(25):e2203179119. . View in PubMed

Repairing the blood-brain barrier Science. 2022 02 18; 375(6582):715-716. . View in PubMed

Multi-omic approaches to acute kidney injury and repair Curr Opin Biomed Eng. 2021 Dec; 20. . View in PubMed

Correction: A ß-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells Elife. 2021 Apr 29; 10. . View in PubMed

Multi-omics integration in the age of million single-cell data Nat Rev Nephrol. 2021 11; 17(11):710-724. . View in PubMed

Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury Proc Natl Acad Sci U S A. 2021 07 06; 118(27). . View in PubMed

Spatial transcriptional mapping of the human nephrogenic programDev Cell. 2021 08 23; 56(16):2381-2398. e6. . View in PubMed

Proteomics of protein trafficking by in vivo tissue-specific labeling Nat Commun. 2021 04 22; 12(1):2382. . View in PubMed

A ß-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells Elife. 2021 02 15; 10. . View in PubMed

Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors Nat Commun. 2021 06 15; 12(1):3641. . View in PubMed

Author Correction: Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality Nat Metab. 2020 09; 2(9):989. . View in PubMed

Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality Nat Metab. 2020 08; 2(8):732-743. . View in PubMed

Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney Dev Dyn. 2020 06; 249(6):765-774. . View in PubMed

Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury J Am Soc Nephrol. 2020 04; 31(4):701-715. . View in PubMed

Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system Dev Biol. 2020 02 15; 458(2):164-176. . View in PubMed

A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene Am J Physiol Renal Physiol. 2020 09 01; 319(3):F423-F435. . View in PubMed

Cellular Recruitment by Podocyte-Derived Pro-migratory Factors in Assembly of the Human Renal Filter iScience. 2019 Oct 25; 20:402-414. . View in PubMed

Single-Cell RNA Sequencing of the Adult Mouse Kidney: From Molecular Cataloging of Cell Types to Disease-Associated Predictions Am J Kidney Dis. 2019 01; 73(1):140-142. . View in PubMed

A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation Nat Commun. 2019 03 11; 10(1):1157. . View in PubMed

Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback Nat Commun. 2019 01 16; 10(1):239. . View in PubMed

Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease Dev Biol. 2019 10 15; 454(2):156-169. . View in PubMed

In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived PodocytesDev Cell. 2019 07 01; 50(1):102-116. e6. . View in PubMed

Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse KidneyDev Cell. 2019 11 04; 51(3):399-413. e7. . View in PubMed

Determination of Total Biotin by Liquid Chromatography Coupled with Immunoaffinity Column Cleanup Extraction: Multilaboratory Testing, Final Action 201602. J AOAC Int. 2018 May 01; 101(3):831-842. . View in PubMed

Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions PLoS Genet. 2018 04; 14(4):e1007346. . View in PubMed

Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney J Am Soc Nephrol. 2018 03; 29(3):806-824. . View in PubMed

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis J Am Soc Nephrol. 2018 03; 29(3):785-805. . View in PubMed

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning J Am Soc Nephrol. 2018 03; 29(3):825-840. . View in PubMed

Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies PLoS Genet. 2018 01; 14(1):e1007181. . View in PubMed

Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human NephrogenesisDev Cell. 2018 06 04; 45(5):651-660. e4. . View in PubMed

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells Stem Cell Reports. 2018 08 14; 11(2):470-484. . View in PubMed

Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants EBioMedicine. 2018 Jan; 27:275-283. . View in PubMed

Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression Development. 2018 08 20; 145(17). . View in PubMed

Disparate levels of beta-catenin activity determine nephron progenitor cell fate Dev Biol. 2018 08 01; 440(1):13-21. . View in PubMed

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment Elife. 2018 12 05; 7. . View in PubMed

Transcriptional trajectories of human kidney injury progression JCI Insight. 2018 11 15; 3(22). . View in PubMed

Sox9 positive periosteal cells in fracture repair of the adult mammalian long bone Bone. 2017 Oct; 103:12-19. . View in PubMed

(Re)Building a Kidney J Am Soc Nephrol. 2017 May; 28(5):1370-1378. . View in PubMed

Hedgehog Signaling: From Basic Biology to Cancer Therapy Cell Chem Biol. 2017 Mar 16; 24(3):252-280. . View in PubMed

An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections PLoS One. 2017; 12(11):e0188413. . View in PubMed

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney DevelopmentDev Cell. 2017 05 22; 41(4):349-365. e3. . View in PubMed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development Development. 2017 09 01; 144(17):3177-3188. . View in PubMed

Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion JCI Insight. 2017 09 21; 2(18). . View in PubMed

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry BreakingDev Cell. 2017 03 13; 40(5):439-452. e4. . View in PubMed

Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation PLoS Genet. 2016 Dec; 12(12):e1006533. . View in PubMed

Sonoelastography of the Achilles Tendon: Prevalence and Prognostic Value Among Asymptomatic Elite Australian Rules Football Players Clin J Sport Med. 2016 Jul; 26(4):299-306. . View in PubMed

Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators Development. 2016 Feb 15; 143(4):595-608. . View in PubMed

An Emerging Regulatory Landscape for Skeletal Development Trends Genet. 2016 12; 32(12):774-787. . View in PubMed

Stem cells for all ages, yet hostage to aging Stem Cell Investig. 2016; 3:11. . View in PubMed

Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity Exp Cell Res. 2016 Jan 01; 340(1):43-52. . View in PubMed

An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1 Elife. 2016 05 05; 5. . View in PubMed

Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification Dev Cell. 2016 05 09; 37(3):238-53. . View in PubMed

Development of the Mammalian Kidney Curr Top Dev Biol. 2016; 117:31-64. . View in PubMed

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy Development. 2016 08 15; 143(16):3012-23. . View in PubMed

Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State Dev Cell. 2015 Nov 09; 35(3):358-65. . View in PubMed

A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors Development. 2015 Oct 01; 142(19):3286-93. . View in PubMed

Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney Cell Rep. 2015 Aug 25; 12(8):1325-38. . View in PubMed

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte Cell Rep. 2015 Jul 14; 12(2):229-43. . View in PubMed

Collecting duct-derived cells display mesenchymal stem cell properties and retain selective in vitro and in vivo epithelial capacity J Am Soc Nephrol. 2015 Jan; 26(1):81-94. . View in PubMed

Stk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity Bone. 2014 Dec; 69:98-108. . View in PubMed

Induction and patterning of the metanephric nephron Semin Cell Dev Biol. 2014 Dec; 36:31-8. . View in PubMed

A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning Dev Cell. 2014 Nov 24; 31(4):448-60. . View in PubMed

Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis Oncogene. 2014 Nov 13; 33(46):5370-8. . View in PubMed

Genome-wide RNA Tomography in the zebrafish embryo Cell. 2014 Oct 23; 159(3):662-75. . View in PubMed

Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis Stem Cell Reports. 2014 Oct 14; 3(4):650-62. . View in PubMed

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation PLoS Genet. 2014 Oct; 10(10):e1004604. . View in PubMed

Translational profiles of medullary myofibroblasts during kidney fibrosis J Am Soc Nephrol. 2014 Sep; 25(9):1979-90. . View in PubMed

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs Nature. 2014 Jul 03; 511(7507):46-51. . View in PubMed

Defining the acute kidney injury and repair transcriptome Semin Nephrol. 2014 Jul; 34(4):404-17. . View in PubMed

Global quantification of tissue dynamics in the developing mouse kidney Dev Cell. 2014 Apr 28; 29(2):188-202. . View in PubMed

Defining kidney biology to understand renal disease Clin J Am Soc Nephrol. 2014 Apr; 9(4):809-11. . View in PubMed

Cell-specific translational profiling in acute kidney injury J Clin Invest. 2014 Mar; 124(3):1242-54. . View in PubMed

A novel site comes into sight Elife. 2013 Dec 03; 2:e01680. . View in PubMed

Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells Stem Cells. 2013 Dec; 31(12):2667-79. . View in PubMed

Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19450-5. . View in PubMed

Retinoid signaling in progenitors controls specification and regeneration of the urothelium Dev Cell. 2013 Sep 16; 26(5):469-482. . View in PubMed

Wnt4/ß-catenin signaling in medullary kidney myofibroblasts J Am Soc Nephrol. 2013 Sep; 24(9):1399-412. . View in PubMed

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis J Clin Invest. 2013 Sep; 123(9):4023-35. . View in PubMed

Mutations in Hedgehog pathway genes in fetal rhabdomyomas J Pathol. 2013 Sep; 231(1):44-52. . View in PubMed

Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning Development. 2013 Aug; 140(16):3423-34. . View in PubMed

Filopodia: the cellular quills of hedgehog signaling? Dev Cell. 2013 May 28; 25(4):328-30.. View in PubMed

Progenitor programming in mammalian nephrogenesis Nephrology (Carlton). 2013 Mar; 18(3):177-9. . View in PubMed

Modeling recent human evolution in mice by expression of a selected EDAR variant Cell. 2013 Feb 14; 152(4):691-702. . View in PubMed

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells Nat Commun. 2013; 4:1367. . View in PubMed

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning Genes Dev. 2012 Dec 15; 26(24):2802-16. . View in PubMed

Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis J Am Soc Nephrol. 2012 Oct; 23(10):1682-90. . View in PubMed

Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks Dev Cell. 2012 Sep 11; 23(3):637-51. . View in PubMed

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity Chem Biol. 2012 Aug 24; 19(8):972-82. . View in PubMed

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12592-7. . View in PubMed

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation ACS Chem Biol. 2012 Jun 15; 7(6):1040-8. . View in PubMed

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney Development. 2012 May; 139(10):1863-73. . View in PubMed

An embryonic stem cell-based system for rapid analysis of transcriptional enhancers Genesis. 2012 May; 50(5):443-50. . View in PubMed

Mammalian kidney development: principles, progress, and projections Cold Spring Harb Perspect Biol. 2012 May 01; 4(5). . View in PubMed

The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1038-47. . View in PubMed

Hedgehog-Gli pathway activation during kidney fibrosis Am J Pathol. 2012 Apr; 180(4):1441-53. . View in PubMed

Signaling by SHH rescues facial defects following blockade in the brain Dev Dyn. 2012 Feb; 241(2):247-56. . View in PubMed

Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice Biol Reprod. 2012 Feb; 86(2):37. . View in PubMed

Germ cells are not required to establish the female pathway in mouse fetal gonads PLoS One. 2012; 7(10):e47238. . View in PubMed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract Front Neurosci. 2012; 6:130. . View in PubMed

Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells Development. 2011 Oct; 138(19):4245-54. . View in PubMed

The GUDMAP database--an online resource for genitourinary research Development. 2011 Jul; 138(13):2845-53. . View in PubMed

Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation Dev Cell. 2011 Jun 14; 20(6):788-801. . View in PubMed

Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function Dev Cell. 2011 Jun 14; 20(6):775-87. . View in PubMed

Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney Kidney Int. 2011 Feb; 79(3):317-30. . View in PubMed

A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment Biomed Microdevices. 2010 Dec; 12(6):1027-41. . View in PubMed

Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9736-41. . View in PubMed

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract Development. 2010 May; 137(10):1721-9. . View in PubMed

Macrophage Wnt7b is critical for kidney repair and regeneration Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4194-9. . View in PubMed

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal Genes Dev. 2010 Feb 01; 24(3):312-26. . View in PubMed

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis Am J Pathol. 2010 Jan; 176(1):85-97. . View in PubMed

Using mechanistic Bayesian networks to identify downstream targets of the sonic hedgehog pathway BMC Bioinformatics. 2009 Dec 18; 10:433. . View in PubMed

An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry Curr Biol. 2009 Dec 01; 19(22):1912-7. . View in PubMed

High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population Dev Biol. 2009 Sep 15; 333(2):312-23. . View in PubMed

Hedgehog signalling: Kif7 is not that fishy after all Curr Biol. 2009 Sep 15; 19(17):R729-31. . View in PubMed

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment Dev Biol. 2009 Aug 15; 332(2):273-86. . View in PubMed

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis Cell Stem Cell. 2009 Jun 05; 4(6):559-67. . View in PubMed

Modeling the spatio-temporal network that drives patterning in the vertebrate central nervous system Biochim Biophys Acta. 2009 Apr; 1789(4):299-305. . View in PubMed

Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb Dev Cell. 2009 Apr; 16(4):600-6. . View in PubMed

Motor neurons with axial muscle projections specified by Wnt4/5 signaling Neuron. 2009 Mar 12; 61(5):708-20. . View in PubMed

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2623-8. . View in PubMed

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney Development. 2009 Jan; 136(1):161-71. . View in PubMed

Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney Dev Biol. 2008 Dec 01; 324(1):88-98. . View in PubMed

Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature Science. 2008 Nov 21; 322(5905):1247-50. . View in PubMed

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):16976-81. . View in PubMed

Atlas of gene expression in the developing kidney at microanatomic resolution Dev Cell. 2008 Nov; 15(5):781-91. . View in PubMed

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb Genes Dev. 2008 Oct 01; 22(19):2651-63. . View in PubMed

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma Cancer Cell. 2008 Aug 12; 14(2):123-34. . View in PubMed

Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development Cell Stem Cell. 2008 Aug 07; 3(2):169-81. . View in PubMed

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye Dev Biol. 2008 Aug 01; 320(1):242-55. . View in PubMed

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network Development. 2008 Aug; 135(15):2489-503. . View in PubMed

An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo J Am Chem Soc. 2008 Jul 30; 130(30):9925-30. . View in PubMed

In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation J Biol Chem. 2008 Jul 25; 283(30):21002-10. . View in PubMed

Developmental biologyGrasping limb patterning. Science. 2008 Jul 18; 321(5887):350-2. . View in PubMed

Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo Dev Biol. 2008 Jul 15; 319(2):396-405. . View in PubMed

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease Genes Dev. 2008 Jun 15; 22(12):1662-76. . View in PubMed

Disp1 regulates growth of mammalian long bones through the control of Ihh distribution Dev Biol. 2008 May 15; 317(2):480-5. . View in PubMed

Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation Gene Expr Patterns. 2008 May; 8(5):297-306. . View in PubMed

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme Development. 2008 May; 135(9):1625-34. . View in PubMed

GUDMAP: the genitourinary developmental molecular anatomy project J Am Soc Nephrol. 2008 Apr; 19(4):667-71. . View in PubMed

Intrinsic epithelial cells repair the kidney after injury Cell Stem Cell. 2008 Mar 06; 2(3):284-91. . View in PubMed

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning Development. 2008 Mar; 135(6):1097-106. . View in PubMed

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1949-54. . View in PubMed

Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state Dev Biol. 2008 Feb 01; 314(1):112-26. . View in PubMed

Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis Dev Biol. 2007 Dec 01; 312(1):312-20. . View in PubMed

The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros PLoS Genet. 2007 Oct; 3(10):1922-38. . View in PubMed

Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen Development. 2007 Oct; 134(20):3603-13. . View in PubMed

Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2 Nat Genet. 2007 Oct; 39(10):1225-34. . View in PubMed

Regulation of skeletogenic differentiation in cranial dermal bone Development. 2007 Sep; 134(17):3133-44. . View in PubMed

Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development Development. 2007 Jul; 134(13):2533-9. . View in PubMed

A high-resolution anatomical ontology of the developing murine genitourinary tract Gene Expr Patterns. 2007 Jun; 7(6):680-99. . View in PubMed

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development Genes Dev. 2007 May 15; 21(10):1244-57. . View in PubMed

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning Development. 2007 May; 134(10):1977-89. . View in PubMed

Shifting paradigms in Hedgehog signaling Curr Opin Cell Biol. 2007 Apr; 19(2):159-65. . View in PubMed

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron Development. 2007 Feb; 134(4):801-11. . View in PubMed

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling Dev Cell. 2007 Jan; 12(1):99-112. . View in PubMed

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation Dev Cell. 2007 Jan; 12(1):113-27. . View in PubMed

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway Cancer Res. 2006 Oct 15; 66(20):10171-8. . View in PubMed

Independent regulation of skeletal growth by Ihh and IGF signaling Dev Biol. 2006 Oct 01; 298(1):327-33. . View in PubMed

Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test Birth Defects Res A Clin Mol Teratol. 2006 Aug; 76(8):574-9. . View in PubMed

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors Development. 2006 Aug; 133(16):3231-44. . View in PubMed

Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein J Am Chem Soc. 2006 Jul 12; 128(27):8939-46. . View in PubMed

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice Dev Cell. 2006 May; 10(5):647-56. . View in PubMed

Reproducible and inducible knockdown of gene expression in mice Genesis. 2006 May; 44(5):252-61. . View in PubMed

BMP signaling stimulates cellular differentiation at multiple steps during cartilage development Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18023-7. . View in PubMed

Retraction: Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse Development. 2005 Dec; 132(24):5615. . View in PubMed

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway Nat Genet. 2005 Dec; 37(12):1323-32. . View in PubMed

An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo Nucleic Acids Res. 2005 Oct 12; 33(18):e155. . View in PubMed

Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1 Infect Immun. 2005 Oct; 73(10):6981-9. . View in PubMed

Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder Nat Genet. 2005 Oct; 37(10):1082-9. . View in PubMed

Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse Dev Biol. 2005 Oct 01; 286(1):149-57. . View in PubMed

WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature Nature. 2005 Sep 15; 437(7057):417-21. . View in PubMed

Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation Dev Biol. 2005 Sep 15; 285(2):490-5. . View in PubMed

Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system Dev Cell. 2005 Aug; 9(2):283-92. . View in PubMed

Neural crest origins of the neck and shoulder Nature. 2005 Jul 21; 436(7049):347-55. . View in PubMed

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP J Clin Invest. 2005 Jul; 115(7):1734-42. . View in PubMed

Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development Development. 2005 Jun; 132(12):2809-23. . View in PubMed

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation Dev Cell. 2005 May; 8(5):751-64. . View in PubMed

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction Dev Cell. 2005 Feb; 8(2):229-39. . View in PubMed

Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand Development. 2005 Jan; 132(1):133-42. . View in PubMed

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1 Development. 2005 Jan; 132(1):143-54. . View in PubMed

Mouse brain organization revealed through direct genome-scale TF expression analysis Science. 2004 Dec 24; 306(5705):2255-7. . View in PubMed

Temporal requirement for hedgehog signaling in ventral telencephalic patterning Development. 2004 Oct; 131(20):5031-40. . View in PubMed

Recent genetic studies of mouse kidney development Curr Opin Genet Dev. 2004 Oct; 14(5):550-7. . View in PubMed

Hedgehog signaling is essential for endothelial tube formation during vasculogenesis Development. 2004 Sep; 131(17):4371-80. . View in PubMed

Hedgehog signaling: iguana debuts as a nuclear gatekeeper Curr Biol. 2004 Aug 24; 14(16):R668-70. . View in PubMed

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities Cell. 2004 Aug 20; 118(4):517-28. . View in PubMed

Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse Development. 2004 Aug; 131(16):4021-33. . View in PubMed

The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells Science. 2004 Jul 16; 305(5682):396-9. . View in PubMed

Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum Dev Biol. 2004 Jun 15; 270(2):393-410. . View in PubMed

Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate J Clin Invest. 2004 Jun; 113(12):1692-700. . View in PubMed

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia Genes Dev. 2004 Apr 15; 18(8):937-51. . View in PubMed

Derivation of embryonic stem-cell lines from human blastocysts N Engl J Med. 2004 Mar 25; 350(13):1353-6. . View in PubMed

SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult Dev Neurosci. 2004 Mar-Aug; 26(2-4):148-65. . View in PubMed

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton Development. 2004 Mar; 131(6):1309-18. . View in PubMed

Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice Science. 2003 Oct 03; 302(5642):113-7. . View in PubMed

Maternal inheritance of Cre activity in a Sox2Cre deleter strain Genesis. 2003 Oct; 37(2):51-3. . View in PubMed

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Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling Genes Dev. 2000 Mar 15; 14(6):650-4. . View in PubMed

The organizer factors Chordin and Noggin are required for mouse forebrain development Nature. 2000 Feb 10; 403(6770):658-61. . View in PubMed

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Professor Andrew (Andy) McMahon is the Chair of the Department of Stem Cell Biology and Regenerative Medicine and Director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the Keck School of Medicine of the University of Southern California (USC). McMahon joined USC from Harvard University in 2012 as the W.M. Keck Provost Professor of Stem Cell Biology and Regenerative Medicine, and Biological Sciences, and founding chair of the Department of Stem Cell Biology and Regenerative Medicine.

McMahon is a leader in the field of developmental biology. McMahon’s research has provided fundamental insights into the cell interactions driving assembly of multiple organ systems, including the central nervous system, skeleton and kidney. McMahon’s research has identified diverse mechanisms regulating organ development, tissue repair and cancer. Current research focuses on development, injury and repair of the mammalian kidney, to model and treat kidney disease.

McMahon received his bachelor's degree from Oxford University and his PhD from University College London. McMahon completed his postdoctoral research at the California Institute of Technology, then moved to London to start his independent research laboratory in 1984. In 1988, McMahon took up a position as assistant member at the Roche Institute for Molecular Biology, becoming full member and chair of the department in 1992. In 1993, McMahon became a professor of Molecular and Cellular Biology in the Faculty of Arts and Sciences at Harvard University. In a 19-year career at Harvard, McMahon was the Frank B. Baird Jr., Professor of Science, chair of the Department of Cell and Developmental Biology, a founding faculty of the Department of Stem Cells and Regenerative Biology, and principal investigator of the Harvard Stem Cell Institute.

McMahon is an elected fellow of the National Academy of Sciences, the American Association for the Advancement of Science, the American Academy of Arts and Sciences, the European Molecular Biology Organization and the Royal Society.
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