Keck School Faculty

Andrew P. McMahon, PhD
Andrew P. McMahon, PhD
W.M. Keck Provost Professor of Stem Cell Biology and Regenerative Medicine and Biological Sciences;Chair of Stem Cell Biology and Regenerative Medicine;Director, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC
Stem Cell Biology & Regenerative Medicine
BCC 312 1425 San Pablo Street Health Sciences Campus Los Angeles
Professor Andrew (Andy) McMahon is the Chair of the Department of Stem Cell Biology and Regenerative Medicine and Director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the Keck School of Medicine of the University of Southern California (USC). McMahon joined USC from Harvard University in 2012 as the W.M. Keck Provost Professor of Stem Cell Biology and Regenerative Medicine, and Biological Sciences, and founding chair of the Department of Stem Cell Biology and Regenerative Medicine.

McMahon is a leader in the field of developmental biology. McMahon’s research has provided fundamental insights into the cell interactions driving assembly of multiple organ systems, including the central nervous system, skeleton and kidney. McMahon’s research has identified diverse mechanisms regulating organ development, tissue repair and cancer. Current research focuses on development, injury and repair of the mammalian kidney, to model and treat kidney disease.

McMahon received his bachelor's degree from Oxford University and his PhD from University College London. McMahon completed his postdoctoral research at the California Institute of Technology, then moved to London to start his independent research laboratory in 1984. In 1988, McMahon took up a position as assistant member at the Roche Institute for Molecular Biology, becoming full member and chair of the department in 1992. In 1993, McMahon became a professor of Molecular and Cellular Biology in the Faculty of Arts and Sciences at Harvard University. In a 19-year career at Harvard, McMahon was the Frank B. Baird Jr., Professor of Science, chair of the Department of Cell and Developmental Biology, a founding faculty of the Department of Stem Cells and Regenerative Biology, and principal investigator of the Harvard Stem Cell Institute.

McMahon is an elected fellow of the American Association for the Advancement of Science, the American Academy of Arts and Sciences, the European Molecular Biology Organization and the Royal Society.

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells Stem Cell Reports. 2018 Aug 14; 11(2):470-484. . View in PubMed

Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression Development. 2018 Aug 09. . View in PubMed

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells Stem Cell Reports. 2018 Jul 13. . View in PubMed

Disparate levels of beta-catenin activity determine nephron progenitor cell fate Dev Biol. 2018 Apr 26. . View in PubMed

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis J Am Soc Nephrol. 2018 Mar; 29(3):785-805. . View in PubMed

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning J Am Soc Nephrol. 2018 Mar; 29(3):825-840. . View in PubMed

Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney J Am Soc Nephrol. 2018 Mar; 29(3):806-824. . View in PubMed

Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney J Am Soc Nephrol. 2018 03; 29(3):806-824. . View in PubMed

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis J Am Soc Nephrol. 2018 03; 29(3):785-805. . View in PubMed

Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression Development. 2018 08 20; 145(17). . View in PubMed

Disparate levels of beta-catenin activity determine nephron progenitor cell fate Dev Biol. 2018 08 01; 440(1):13-21. . View in PubMed

Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants EBioMedicine. 2018 Jan; 27:275-283. . View in PubMed

(Re)Building a Kidney J Am Soc Nephrol. 2017 May; 28(5):1370-1378. . View in PubMed

Hedgehog Signaling: From Basic Biology to Cancer Therapy Cell Chem Biol. 2017 Mar 16; 24(3):252-280. . View in PubMed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development Development. 2017 09 01; 144(17):3177-3188. . View in PubMed

An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections PLoS One. 2017; 12(11):e0188413. . View in PubMed

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry BreakingDev Cell. 2017 03 13; 40(5):439-452. e4. . View in PubMed

Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation PLoS Genet. 2016 Dec; 12(12):e1006533. . View in PubMed

Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators Development. 2016 Feb 15; 143(4):595-608. . View in PubMed

An Emerging Regulatory Landscape for Skeletal Development Trends Genet. 2016 12; 32(12):774-787. . View in PubMed

Development of the Mammalian Kidney Curr Top Dev Biol. 2016; 117:31-64. . View in PubMed

An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1 Elife. 2016 05 05; 5. . View in PubMed

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy Development. 2016 08 15; 143(16):3012-23. . View in PubMed

A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors Development. 2015 Oct 01; 142(19):3286-93. . View in PubMed

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte Cell Rep. 2015 Jul 14; 12(2):229-43. . View in PubMed

Collecting duct-derived cells display mesenchymal stem cell properties and retain selective in vitro and in vivo epithelial capacity J Am Soc Nephrol. 2015 Jan; 26(1):81-94. . View in PubMed

A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning Dev Cell. 2014 Nov 24; 31(4):448-60. . View in PubMed

Genome-wide RNA Tomography in the zebrafish embryo Cell. 2014 Oct 23; 159(3):662-75. . View in PubMed

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation PLoS Genet. 2014 Oct; 10(10):e1004604. . View in PubMed

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs Nature. 2014 Jul 03; 511(7507):46-51. . View in PubMed

Defining the acute kidney injury and repair transcriptome Semin Nephrol. 2014 Jul; 34(4):404-17. . View in PubMed

Global quantification of tissue dynamics in the developing mouse kidney Dev Cell. 2014 Apr 28; 29(2):188-202. . View in PubMed

Defining kidney biology to understand renal disease Clin J Am Soc Nephrol. 2014 Apr; 9(4):809-11. . View in PubMed

Cell-specific translational profiling in acute kidney injury J Clin Invest. 2014 Mar; 124(3):1242-54. . View in PubMed

A novel site comes into sight Elife. 2013 Dec 03; 2:e01680. . View in PubMed

Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells Stem Cells. 2013 Dec; 31(12):2667-79. . View in PubMed

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis J Clin Invest. 2013 Sep; 123(9):4023-35. . View in PubMed

Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning Development. 2013 Aug; 140(16):3423-34. . View in PubMed

Filopodia: the cellular quills of hedgehog signaling? Dev Cell. 2013 May 28; 25(4):328-30.. View in PubMed

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity Chem Biol. 2012 Aug 24; 19(8):972-82. . View in PubMed

An embryonic stem cell-based system for rapid analysis of transcriptional enhancers Genesis. 2012 May; 50(5):443-50. . View in PubMed

Germ cells are not required to establish the female pathway in mouse fetal gonads PLoS One. 2012; 7(10):e47238. . View in PubMed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract Front Neurosci. 2012; 6:130. . View in PubMed

Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation Dev Cell. 2011 Jun 14; 20(6):788-801. . View in PubMed

Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney Kidney Int. 2011 Feb; 79(3):317-30. . View in PubMed

A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment Biomed Microdevices. 2010 Dec; 12(6):1027-41. . View in PubMed

Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9736-41. . View in PubMed

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract Development. 2010 May; 137(10):1721-9. . View in PubMed

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis Am J Pathol. 2010 Jan; 176(1):85-97. . View in PubMed

An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry Curr Biol. 2009 Dec 01; 19(22):1912-7. . View in PubMed

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment Dev Biol. 2009 Aug 15; 332(2):273-86. . View in PubMed

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis Cell Stem Cell. 2009 Jun 05; 4(6):559-67. . View in PubMed

Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb Dev Cell. 2009 Apr; 16(4):600-6. . View in PubMed

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney Development. 2009 Jan; 136(1):161-71. . View in PubMed

Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature Science. 2008 Nov 21; 322(5905):1247-50. . View in PubMed

Atlas of gene expression in the developing kidney at microanatomic resolution Dev Cell. 2008 Nov; 15(5):781-91. . View in PubMed

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb Genes Dev. 2008 Oct 01; 22(19):2651-63. . View in PubMed

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma Cancer Cell. 2008 Aug 12; 14(2):123-34. . View in PubMed

An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo J Am Chem Soc. 2008 Jul 30; 130(30):9925-30. . View in PubMed

Developmental biologyGrasping limb patterning. Science. 2008 Jul 18; 321(5887):350-2. . View in PubMed

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease Genes Dev. 2008 Jun 15; 22(12):1662-76. . View in PubMed

Disp1 regulates growth of mammalian long bones through the control of Ihh distribution Dev Biol. 2008 May 15; 317(2):480-5. . View in PubMed

GUDMAP: the genitourinary developmental molecular anatomy project J Am Soc Nephrol. 2008 Apr; 19(4):667-71. . View in PubMed

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1949-54. . View in PubMed

Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state Dev Biol. 2008 Feb 01; 314(1):112-26. . View in PubMed

A high-resolution anatomical ontology of the developing murine genitourinary tract Gene Expr Patterns. 2007 Jun; 7(6):680-99. . View in PubMed

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning Development. 2007 May; 134(10):1977-89. . View in PubMed

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling Dev Cell. 2007 Jan; 12(1):99-112. . View in PubMed

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway Cancer Res. 2006 Oct 15; 66(20):10171-8. . View in PubMed

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors Development. 2006 Aug; 133(16):3231-44. . View in PubMed

Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein J Am Chem Soc. 2006 Jul 12; 128(27):8939-46. . View in PubMed

BMP signaling stimulates cellular differentiation at multiple steps during cartilage development Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18023-7. . View in PubMed

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway Nat Genet. 2005 Dec; 37(12):1323-32. . View in PubMed

An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo Nucleic Acids Res. 2005 Oct 12; 33(18):e155. . View in PubMed

Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1 Infect Immun. 2005 Oct; 73(10):6981-9. . View in PubMed

Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder Nat Genet. 2005 Oct; 37(10):1082-9. . View in PubMed

Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation Dev Biol. 2005 Sep 15; 285(2):490-5. . View in PubMed

Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development Development. 2005 Jun; 132(12):2809-23. . View in PubMed

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation Dev Cell. 2005 May; 8(5):751-64. . View in PubMed

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1 Development. 2005 Jan; 132(1):143-54. . View in PubMed

Hedgehog signaling is essential for endothelial tube formation during vasculogenesis Development. 2004 Sep; 131(17):4371-80. . View in PubMed

Hedgehog signaling: iguana debuts as a nuclear gatekeeper Curr Biol. 2004 Aug 24; 14(16):R668-70. . View in PubMed

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities Cell. 2004 Aug 20; 118(4):517-28. . View in PubMed

Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse Development. 2004 Aug; 131(16):4021-33. . View in PubMed

Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate J Clin Invest. 2004 Jun; 113(12):1692-700. . View in PubMed

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia Genes Dev. 2004 Apr 15; 18(8):937-51. . View in PubMed

Derivation of embryonic stem-cell lines from human blastocysts N Engl J Med. 2004 Mar 25; 350(13):1353-6. . View in PubMed

Combined activities of hedgehog signaling inhibitors regulate pancreas development Development. 2003 Oct; 130(20):4871-9. . View in PubMed

Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance J Clin Invest. 2003 Aug; 112(4):554-65. . View in PubMed

FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals EMBO J. 2003 Apr 15; 22(8):1811-23. . View in PubMed

Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung Genes Dev. 2003 Feb 01; 17(3):342-7. . View in PubMed

Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge Genes Dev. 2003 Feb 01; 17(3):394-409. . View in PubMed

Branching morphogenesis of the lung: new molecular insights into an old problem Trends Cell Biol. 2003 Feb; 13(2):86-91. . View in PubMed

Developmental roles and clinical significance of hedgehog signaling Curr Top Dev Biol. 2003; 53:1-114. . View in PubMed

Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain Mech Dev. 2002 Dec; 119 Suppl 1:S97-S101. . View in PubMed

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord Genes Dev. 2002 Nov 15; 16(22):2849-64. . View in PubMed

Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling Development. 2002 Nov; 129(21):4963-74. . View in PubMed

Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain Gene Expr Patterns. 2002 Nov; 2(1-2):93-7. . View in PubMed

A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo Development. 2002 Oct; 129(20):4807-19. . View in PubMed

Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells Nat Neurosci. 2002 Sep; 5(9):831-2. . View in PubMed

Cholesterol modification of Hedgehog family proteins J Clin Invest. 2002 Sep; 110(5):591-6. . View in PubMed

A mitogen gradient of dorsal midline Wnts organizes growth in the CNS Development. 2002 May; 129(9):2087-98. . View in PubMed

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse Dev Biol. 2002 Apr 15; 244(2):305-18. . View in PubMed

Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes Mech Dev. 2002 Feb; 111(1-2):75-87. . View in PubMed

Hedgehog is required for murine yolk sac angiogenesis Development. 2002 Jan; 129(2):361-72. . View in PubMed

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