Keck School Faculty

Axel Montagne, PhD
Axel Montagne, PhD
Assistant Professor of Research Physiology & Neuroscience;Assistant Director, Functional Biological Imaging Core
Zilkha Neurogenetic Institute
ZNI 301, 1501 San Pablo Street Health Sciences Campus Los Angeles

Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging Geroscience. 2019 Dec 06. . View in PubMed

Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment Alzheimers Dement. 2019 Dec; 15(12):1568-1575. . View in PubMed

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss Nat Neurosci. 2019 07; 22(7):1089-1098. . View in PubMed

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 02; 25(2):270-276. . View in PubMed

Vascular dysfunction-The disregarded partner of Alzheimer's disease Alzheimers Dement. 2019 01; 15(1):158-167. . View in PubMed

Blood-Brain Barrier: From Physiology to Disease and Back Physiol Rev. 2019 01 01; 99(1):21-78. . View in PubMed

The role of brain vasculature in neurodegenerative disorders Nat Neurosci. 2018 10; 21(10):1318-1331. . View in PubMed

Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage J Cereb Blood Flow Metab. 2018 06; 38(6):973-979. . View in PubMed

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 03; 24(3):326-337. . View in PubMed

Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169.. View in PubMed

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease Nat Rev Neurosci. 2017 07; 18(7):419-434. . View in PubMed

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling PLoS One. 2017; 12(4):e0176225. . View in PubMed

Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI Magn Reson Med. 2016 May; 75(5):1967-77. . View in PubMed

Brain imaging of neurovascular dysfunction in Alzheimer's disease Acta Neuropathol. 2016 May; 131(5):687-707. . View in PubMed

Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons Mol Neurobiol. 2016 09; 53(7):5000-12. . View in PubMed

Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research JAMA Neurol. 2016 Jan; 73(1):13-4. . View in PubMed

ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies BMC Med Imaging. 2015 Jun 16; 15:19. . View in PubMed

Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activator Stroke. 2015 Jun; 46(6):1641-50. . View in PubMed

Vascular plasticity and cognition during normal aging and dementia JAMA Neurol. 2015 May; 72(5):495-6. . View in PubMed

7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. . View in PubMed

Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed

Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis Neuropharmacology. 2014 Oct; 85:158-65. . View in PubMed

GpIba-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice Blood. 2014 May 22; 123(21):3354-63. . View in PubMed

Molecular magnetic resonance imaging of brain-immune interactions Front Cell Neurosci. 2014; 8:389. . View in PubMed

Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy Stroke. 2013 Dec; 44(12):3482-9. . View in PubMed

Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes Stroke. 2013 Jul; 44(7):1988-96. . View in PubMed

Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-D-aspartate glutamate receptors improves hemorrhagic stroke outcome Neuropharmacology. 2013 Apr; 67:267-71. . View in PubMed

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity Cell Death Differ. 2012 Dec; 19(12):1983-91. . View in PubMed

Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders Neuroimage. 2012 Nov 01; 63(2):760-70. . View in PubMed

Memantine improves safety of thrombolysis for stroke Stroke. 2012 Oct; 43(10):2774-81. . View in PubMed

Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals J Neurosci. 2012 Apr 11; 32(15):5186-99. . View in PubMed

Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence J Cereb Blood Flow Metab. 2011 Nov; 31(11):2119-34. . View in PubMed

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo Mol Neurodegener. 2011 Oct 05; 6:68. . View in PubMed

Tissue plasminogen activator prevents white matter damage following stroke J Exp Med. 2011 Jun 06; 208(6):1229-42. . View in PubMed

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity Cell Death Differ. 2010 May; 17(5):860-71. . View in PubMed

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