Keck School Faculty

Axel Montagne, PhD
Axel Montagne, PhD
Assistant Professor of Research Physiology & Neuroscience;Assistant Director, Functional Biological Imaging Core
Zilkha Neurogenetic Institute
ZNI 301, 1501 San Pablo Street Health Sciences Campus Los Angeles

Blood-Brain Barrier: From Physiology to Disease and Back Physiol Rev. 2019 01 01; 99(1):21-78. . View in PubMed

Blood-Brain Barrier: From Physiology to Disease and Back Physiol Rev. 2019 Jan 01; 99(1):21-78. . View in PubMed

Vascular dysfunction-The disregarded partner of Alzheimer's disease Alzheimers Dement. 2019 Jan; 15(1):158-167. . View in PubMed

The role of brain vasculature in neurodegenerative disorders Nat Neurosci. 2018 Oct; 21(10):1318-1331. . View in PubMed

Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage J Cereb Blood Flow Metab. 2018 Jun; 38(6):973-979. . View in PubMed

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 Mar; 24(3):326-337. . View in PubMed

Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage J Cereb Blood Flow Metab. 2018 Jan 01; 271678X18768670. . View in PubMed

Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169.. View in PubMed

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease Nat Rev Neurosci. 2017 07; 18(7):419-434. . View in PubMed

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling PLoS One. 2017; 12(4):e0176225. . View in PubMed

Brain imaging of neurovascular dysfunction in Alzheimer's disease Acta Neuropathol. 2016 May; 131(5):687-707. . View in PubMed

Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI Magn Reson Med. 2016 May; 75(5):1967-77. . View in PubMed

Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons Mol Neurobiol. 2016 09; 53(7):5000-12. . View in PubMed

Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research JAMA Neurol. 2016 Jan; 73(1):13-4. . View in PubMed

ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies BMC Med Imaging. 2015 Jun 16; 15:19. . View in PubMed

Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activator Stroke. 2015 Jun; 46(6):1641-50. . View in PubMed

Vascular plasticity and cognition during normal aging and dementia JAMA Neurol. 2015 May; 72(5):495-6. . View in PubMed

7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. . View in PubMed

Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed

Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis Neuropharmacology. 2014 Oct; 85:158-65. . View in PubMed

GpIba-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice Blood. 2014 May 22; 123(21):3354-63. . View in PubMed

Molecular magnetic resonance imaging of brain-immune interactions Front Cell Neurosci. 2014; 8:389. . View in PubMed

Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy Stroke. 2013 Dec; 44(12):3482-9. . View in PubMed

Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes Stroke. 2013 Jul; 44(7):1988-96. . View in PubMed

Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-D-aspartate glutamate receptors improves hemorrhagic stroke outcome Neuropharmacology. 2013 Apr; 67:267-71. . View in PubMed

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity Cell Death Differ. 2012 Dec; 19(12):1983-91. . View in PubMed

Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders Neuroimage. 2012 Nov 01; 63(2):760-70. . View in PubMed

Memantine improves safety of thrombolysis for stroke Stroke. 2012 Oct; 43(10):2774-81. . View in PubMed

Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals J Neurosci. 2012 Apr 11; 32(15):5186-99. . View in PubMed

Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence J Cereb Blood Flow Metab. 2011 Nov; 31(11):2119-34. . View in PubMed

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo Mol Neurodegener. 2011 Oct 05; 6:68. . View in PubMed

Tissue plasminogen activator prevents white matter damage following stroke J Exp Med. 2011 Jun 06; 208(6):1229-42. . View in PubMed

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity Cell Death Differ. 2010 May; 17(5):860-71. . View in PubMed

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