Keck School Faculty

Benjamin Hurrell

Benjamin Hurrell

Assistant Professor of Research Molecular Microbiology and Immunology
Molecular Microbiology and Immunology
NRT 5509 1450 Biggy Street Health Sciences Campus Los Angeles


Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cellsJ Allergy Clin Immunol. 2023 02; 151(2):526-538. e8. . View in PubMed

Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivityJ Allergy Clin Immunol. 2022 05; 149(5):1628-1642. e10. . View in PubMed

LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivityJ Allergy Clin Immunol. 2022 01; 149(1):223-236. e6. . View in PubMed

Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23 Nat Commun. 2022 03 17; 13(1):1440. . View in PubMed

PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability Nat Commun. 2022 08 31; 13(1):5118. . View in PubMed

CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation Mucosal Immunol. 2021 07; 14(4):899-911. . View in PubMed

IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivityJ Allergy Clin Immunol. 2021 04; 147(4):1281-1295. e5. . View in PubMed

CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma Nat Commun. 2021 05 05; 12(1):2526. . View in PubMed

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-a Production and Restricts Progression of Metastatic Melanoma Front Immunol. 2021; 12:733136. . View in PubMed

Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector functionJ Allergy Clin Immunol. 2020 02; 145(2):502-517. e5. . View in PubMed

Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma Nat Commun. 2020 04 15; 11(1):1776. . View in PubMed

TLR7 Sensing by Neutrophils Is Critical for the Control of Cutaneous Leishmaniasis Cell Rep. 2020 06 09; 31(10):107746. . View in PubMed

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity Nat Commun. 2020 08 10; 11(1):3998. . View in PubMed

Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity Front Immunol. 2020; 11:542818. . View in PubMed

DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus Nat Commun. 2020 09 18; 11(1):4718. . View in PubMed

TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway HyperreactivityCell Rep. 2019 12 24; 29(13):4509-4524. e5. . View in PubMed

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes Nat Commun. 2019 02 12; 10(1):713. . View in PubMed

Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation Front Immunol. 2019; 10:2051. . View in PubMed

Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma Front Immunol. 2018; 9:2694. . View in PubMed

Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils J Leukoc Biol. 2017 11; 102(5):1187-1198. . View in PubMed

IL-4Ra Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice Front Immunol. 2017; 8:1265. . View in PubMed

Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing Front Immunol. 2017; 8:1558. . View in PubMed

The Nlrp3 inflammasome, IL-1ß, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice Eur J Immunol. 2016 Apr; 46(4):897-911. . View in PubMed

Different Leishmania Species Drive Distinct Neutrophil Functions Trends Parasitol. 2016 05; 32(5):392-401. . View in PubMed

Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner Sci Rep. 2016 12 15; 6:39117. . View in PubMed

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion PLoS Pathog. 2015 May; 11(5):e1004929. . View in PubMed

Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003601. . View in PubMed

Crosstalk between neutrophils and dendritic cells: a context-dependent process J Leukoc Biol. 2013 Oct; 94(4):671-5. . View in PubMed

sc ctsi logoPowered by SC CTSI