Keck School Faculty

Benjamin Hurrell

Benjamin Hurrell

Assistant Professor of Research Molecular Microbiology and Immunology
Molecular Microbiology and Immunology
NRT 5509 1450 Biggy Street Health Sciences Campus Los Angeles

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Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivityJ Allergy Clin Immunol. 2022 05; 149(5):1628-1642. e10. . View in PubMed

LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivityJ Allergy Clin Immunol. 2022 01; 149(1):223-236. e6. . View in PubMed

Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23 Nat Commun. 2022 03 17; 13(1):1440. . View in PubMed

CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation Mucosal Immunol. 2021 07; 14(4):899-911. . View in PubMed

IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivityJ Allergy Clin Immunol. 2021 04; 147(4):1281-1295. e5. . View in PubMed

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-a Production and Restricts Progression of Metastatic Melanoma Front Immunol. 2021; 12:733136. . View in PubMed

CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma Nat Commun. 2021 05 05; 12(1):2526. . View in PubMed

Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector functionJ Allergy Clin Immunol. 2020 02; 145(2):502-517. e5. . View in PubMed

TLR7 Sensing by Neutrophils Is Critical for the Control of Cutaneous Leishmaniasis Cell Rep. 2020 06 09; 31(10):107746. . View in PubMed

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity Nat Commun. 2020 08 10; 11(1):3998. . View in PubMed

DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus Nat Commun. 2020 09 18; 11(1):4718. . View in PubMed

Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma Nat Commun. 2020 04 15; 11(1):1776. . View in PubMed

Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity Front Immunol. 2020; 11:542818. . View in PubMed

Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation Front Immunol. 2019; 10:2051. . View in PubMed

TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway HyperreactivityCell Rep. 2019 12 24; 29(13):4509-4524. e5. . View in PubMed

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes Nat Commun. 2019 02 12; 10(1):713. . View in PubMed

Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma Front Immunol. 2018; 9:2694. . View in PubMed

Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils J Leukoc Biol. 2017 11; 102(5):1187-1198. . View in PubMed

Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing Front Immunol. 2017; 8:1558. . View in PubMed

IL-4Ra Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice Front Immunol. 2017; 8:1265. . View in PubMed

The Nlrp3 inflammasome, IL-1ß, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice Eur J Immunol. 2016 Apr; 46(4):897-911. . View in PubMed

Different Leishmania Species Drive Distinct Neutrophil Functions Trends Parasitol. 2016 05; 32(5):392-401. . View in PubMed

Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner Sci Rep. 2016 12 15; 6:39117. . View in PubMed

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion PLoS Pathog. 2015 May; 11(5):e1004929. . View in PubMed

Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003601. . View in PubMed

Crosstalk between neutrophils and dendritic cells: a context-dependent process J Leukoc Biol. 2013 Oct; 94(4):671-5. . View in PubMed

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