Keck School Faculty

Biagio Saitta, PhD
Biagio Saitta, PhD
Associate Professor of Research Medicine
Medicine
MMR 518/528 1333 San Pablo Street Off Campus Los Angeles
Dr. Saitta is a molecular and stem cell biologist who studies regulation of extracellular matrix genes during cartilage and bone development. His recent studies explore the impact of the kidney’s metabolic pathways on the development and maintenance of bone. His projects and collaborations combine work in basic gene regulation and in regenerative medicine, which includes work with human stem cells. He is studying their common biochemical and signaling pathways toward translational applications for therapies of human disorders involving kidney and bone.

Dr. Saitta earned his PhD in Biological Sciences from the University of Messina, followed by fellowships in Molecular Pharmacology at the Mario Negri Institute in Milano and in Developmental and Molecular Biology at the Institute of the Council of National Research (CNR) in Palermo, Italy. He was a postdoctoral fellow and junior faculty member at Thomas Jefferson University in Philadelphia studying the transcriptional regulation of collagen genes. He then joined the Coriell Institute for Medical Research as an Associate Professor at UMDNJ, to develop a research program utilizing mesenchymal stem cells isolated from neonatal cord blood. Afterwards Dr. Saitta relocated to Cedars-Sinai Medical Center, as a Research Adj. Associate Professor of Pediatrics at UCLA, and there he developed a novel in vitro model of chondrogenesis using human induced pluripotent stem cells generated from reprogrammed cells of patients with skeletal dysplasia. Dr. Saitta joined the University of Southern California in the Department of Orthopaedic Surgery and the Broad CIRM Center as a Research Scientist studying the maintenance of the articular cartilage phenotype using human embryonic stem cells. He began collaborative efforts with the USC/UKRO Kidney Research Center and joined the group as Associate Professor of Research Medicine in November, 2017.

East Coast Connective Tissue Meeting, Philadelphia: Outstanding Presentation Award , 1993

Measurement of CP-Violating and Mixing-Induced Observables in B_{s}^{0}? Decays. Phys Rev Lett. 2019 Aug 23; 123(8):081802.. View in PubMed

First Observation of the Radiative Decay? . Phys Rev Lett. 2019 Jul 19; 123(3):031801.. View in PubMed

Measurement of the Mass Difference Between Neutral Charm-Meson Eigenstates Phys Rev Lett. 2019 Jun 14; 122(23):231802. . View in PubMed

Lentiviral Gene Therapy for Bone Repair Using Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Hum Gene Ther. 2019 Apr 22. . View in PubMed

First Measurement of Charm Production in its Fixed-Target Configuration at the LHC Phys Rev Lett. 2019 Apr 05; 122(13):132002. . View in PubMed

Lentiviral Gene Therapy For Bone Repair Using Human Umbilical Cord Blood Derived-Mesenchymal Stem Cells Hum Gene Ther. 2019 Feb 16. . View in PubMed

Measurement of the Charm-Mixing Parameter y_{CP} Phys Rev Lett. 2019 Jan 11; 122(1):011802. . View in PubMed

Ex vivo kidney slice preparations as a model system to study signaling cascades in kidney epithelial cells Methods Cell Biol. 2019; 153:185-203. . View in PubMed

CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGFß and BMP through SMAD signaling Osteoarthritis Cartilage. 2019 Jan; 27(1):158-171. . View in PubMed

Measurement of Antiproton Production in p-He Collisions at sqrt[s_{NN}]=110? GeV. Phys Rev Lett. 2018 Nov 30; 121(22):222001.. View in PubMed

First Observation of the Doubly Charmed Baryon Decay? _{c}^{+}p^{+}. Phys Rev Lett. 2018 Oct 19; 121(16):162002.. View in PubMed

Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes Nat Commun. 2018 Sep 07; 9(1):3634. . View in PubMed

Phys Rev Lett. 2018 Aug 31; 121(9):091801. . View in PubMed

Measurement of the O_{c}^{0} Baryon Lifetime Phys Rev Lett. 2018 Aug 31; 121(9):092003. . View in PubMed

Measurement of the Lifetime of the Doubly Charmed Baryon? _{cc}^{++}. Phys Rev Lett. 2018 Aug 03; 121(5):052002.. View in PubMed

Phys Rev Lett. 2018 Jun 29; 120(26):261801. . View in PubMed

Evidence for the Rare Decay S^{+}? pµ^{+}µ^{-}. Phys Rev Lett. 2018 Jun 01; 120(22):221803.. View in PubMed

Phys Rev Lett. 2018 Apr 27; 120(17):171802. . View in PubMed

Measurement of the Ratio of Branching Fractions B(B_{c}^{+}? _{µ}). Phys Rev Lett. 2018 Mar 23; 120(12):121801.. View in PubMed

Eur Phys J C Part Fields. 2018; 78(12):1019. . View in PubMed

Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes Nat Commun. 2018 09 07; 9(1):3634. . View in PubMed

First Observation of the Rare Purely Baryonic Decay B^{0}? pp[over ¯]. Phys Rev Lett. 2017 Dec 08; 119(23):232001.. View in PubMed

Measurement of B_{s}^{0} and D_{s}^{-} Meson Lifetimes Phys Rev Lett. 2017 Sep 08; 119(10):101801. . View in PubMed

First Observation of a Baryonic B_{s}^{0} Decay Phys Rev Lett. 2017 Jul 28; 119(4):041802. . View in PubMed

Phys Rev Lett. 2017 Jun 30; 118(26):261803. . View in PubMed

Phys Rev Lett. 2017 May 12; 118(19):191801. . View in PubMed

Measurement of the b-Quark Production Cross Section in 7 and 13 TeV pp Collisions Phys Rev Lett. 2017 Feb 03; 118(5):052002. . View in PubMed

First Experimental Study of Photon Polarization in Radiative B_{s}^{0} Decays Phys Rev Lett. 2017 Jan 13; 118(2):021801. . View in PubMed

Measurement of the phase difference between short- and long-distance amplitudes in the [Formula: see text] decay Eur Phys J C Part Fields. 2017; 77(3):161. . View in PubMed

Phys Rev Lett. 2016 Dec 23; 117(26):261801. . View in PubMed

Evidence for Exotic Hadron Contributions to? pp^{-} Decays. Phys Rev Lett. 2016 Aug 19; 117(8):082003.. View in PubMed

Measurement of the CP Asymmetry in B_{s}^{0}-B[over ¯]_{s}^{0} Mixing Phys Rev Lett. 2016 Aug 05; 117(6):061803. . View in PubMed

Phys Rev Lett. 2016 Jun 17; 116(24):241801. . View in PubMed

Phys Rev Lett. 2016 May 13; 116(19):191601. . View in PubMed

A precise measurement of the [Formula: see text] meson oscillation frequency Eur Phys J C Part Fields. 2016; 76(7):412. . View in PubMed

Evidence for the Strangeness-Changing Weak Decay? _{b}^{0}p^{-}. Phys Rev Lett. 2015 Dec 11; 115(24):241801.. View in PubMed

Measurement of the ratio of branching fractions B(B[over ¯]^{0}? [over ¯]_{µ}). Phys Rev Lett. 2015 Sep 11; 115(11):111803.. View in PubMed

First observation of top quark production in the forward region Phys Rev Lett. 2015 Sep 11; 115(11):112001. . View in PubMed

Measurement of CP Violation in B0? K{S}^{0} Decays. Phys Rev Lett. 2015 Jul 17; 115(3):031601.. View in PubMed

Measurement of Bc+ Production in Proton-Proton Collisions at v[s]=8? TeV. Phys Rev Lett. 2015 Apr 03; 114(13):132001.. View in PubMed

Measurement of the semileptonic CP asymmetry in B0-B[over ¯]0 mixing Phys Rev Lett. 2015 Jan 30; 114(4):041601. . View in PubMed

Measurement of the [Formula: see text] production cross-section in proton-proton collisions via the decay [Formula: see text] Eur Phys J C Part Fields. 2015; 75(7):311. . View in PubMed

Phys Rev Lett. 2014 Nov 21; 113(21):211801. . View in PubMed

Measurement of the B¯s° meson lifetime in Ds? decays. Phys Rev Lett. 2014 Oct 24; 113(17):172001.. View in PubMed

First observation of a baryonic Bc+ decay Phys Rev Lett. 2014 Oct 10; 113(15):152003. . View in PubMed

Evidence for CP violation in B+? ppK+ decays. Phys Rev Lett. 2014 Oct 03; 113(14):141801.. View in PubMed

First measurement of the charge asymmetry in beauty-quark pair production Phys Rev Lett. 2014 Aug 22; 113(8):082003. . View in PubMed

Phys Rev Lett. 2014 Mar 21; 112(11):111802. . View in PubMed

Measurement of CP violation in the phase space of B±? p+ p- p± decays. Phys Rev Lett. 2014 Jan 10; 112(1):011801.. View in PubMed

Measurement of [Formula: see text] polarisation in [Formula: see text] collisions at [Formula: see text] = 7 TeV Eur Phys J C Part Fields. 2014; 74(5):2872. . View in PubMed

Measurement of charged particle multiplicities and densities in [Formula: see text] collisions at [Formula: see text]TeV in the forward region Eur Phys J C Part Fields. 2014; 74(5):2888. . View in PubMed

Measurement of the [Formula: see text] meson lifetime using [Formula: see text] decays Eur Phys J C Part Fields. 2014; 74(5):2839. . View in PubMed

Measurement of D0-D0 mixing parameters and search for CP violation using D0? K+ p- decays. Phys Rev Lett. 2013 Dec 20; 111(25):251801.. View in PubMed

Measurement of form-factor-independent observables in the decay B0? K(*0)µ(+)µ(-). Phys Rev Lett. 2013 Nov 08; 111(19):191801.. View in PubMed

Phys Rev Lett. 2013 Oct 11; 111(15):151801. . View in PubMed

Measurement of CP violation in the phase space of B±? K± K+ K- decays. Phys Rev Lett. 2013 Sep 06; 111(10):101801.. View in PubMed

Phys Rev Lett. 2013 Sep 06; 111(10):101805. . View in PubMed

First measurement of the CP-violating phase in Bs(0)? decays. Phys Rev Lett. 2013 Jun 14; 110(24):241802.. View in PubMed

First observation of CP violation in the decays of B(s)0 mesons Phys Rev Lett. 2013 May 31; 110(22):221601. . View in PubMed

Determination of the X(3872) meson quantum numbers Phys Rev Lett. 2013 May 31; 110(22):222001. . View in PubMed

Phys Rev Lett. 2013 May 03; 110(18):182001. . View in PubMed

Human umbilical cord blood-derived mesenchymal stem cells in the cultured rabbit intervertebral disc: a novel cell source for disc repair Am J Phys Med Rehabil. 2013 May; 92(5):420-9. . View in PubMed

Phys Rev Lett. 2013 Apr 12; 110(15):151803. . View in PubMed

Phys Rev Lett. 2013 Jan 18; 110(3):031801. . View in PubMed

First evidence for the decay B(s)(0)? µ+ µ-. Phys Rev Lett. 2013 Jan 11; 110(2):021801.. View in PubMed

Measurement of the forward energy flow in pp collisions at [Formula: see text] Eur Phys J C Part Fields. 2013; 73(5):2421. . View in PubMed

Eur Phys J C Part Fields. 2013; 73(11):2631. . View in PubMed

Measurements of B(c)+ production and mass with the B(c)+? p+ decay. Phys Rev Lett. 2012 Dec 07; 109(23):232001.. View in PubMed

Phys Rev Lett. 2012 Oct 12; 109(15):152002. . View in PubMed

First observation of the decay B(c)+? p(+) p- p+. Phys Rev Lett. 2012 Jun 22; 108(25):251802.. View in PubMed

Determination of the sign of the decay width difference in the B(s)(0) system Phys Rev Lett. 2012 Jun 15; 108(24):241801. . View in PubMed

First evidence of direct CP violation in charmless two-body decays of Bs0 mesons Phys Rev Lett. 2012 May 18; 108(20):201601. . View in PubMed

Differential branching fraction and angular analysis of the decay B0? K*0 µ+ µ-. Phys Rev Lett. 2012 May 04; 108(18):181806.. View in PubMed

Phys Rev Lett. 2012 Apr 20; 108(16):161801. . View in PubMed

Phys Rev Lett. 2012 Mar 16; 108(11):111602. . View in PubMed

Measurement of the CP-violating phase? . Phys Rev Lett. 2012 Mar 09; 108(10):101803.. View in PubMed

Eur Phys J C Part Fields. 2012; 72(8):2100. . View in PubMed

Measurement of relative branching fractions of B decays to? mesons. Eur Phys J C Part Fields. 2012; 72(8):2118.. View in PubMed

Eur Phys J C Part Fields. 2012; 72(6):2025. . View in PubMed

Phys Rev Lett. 2011 Nov 18; 107(21):211801. . View in PubMed

Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model Dev Biol. 2007 May 01; 305(1):172-86. . View in PubMed

Identification of cord blood-derived mesenchymal stem/stromal cell populations with distinct growth kinetics, differentiation potentials, and gene expression profiles Stem Cells Dev. 2007 Feb; 16(1):53-73. . View in PubMed

Inhibition of collagen gene expression in systemic sclerosis dermal fibroblasts by mithramycin Ann Rheum Dis. 2005 Dec; 64(12):1685-91. . View in PubMed

Inhibition of collagen gene expression in systemic sclerosis dermal fibroblasts by mithramycinAnn. Rheum. Dis. 2005; (64):1685-1691. . View in PubMed

B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts Biochem J. 2004 Mar 01; 378(Pt 2):609-16. . View in PubMed

CCAAT binding transcription factor binds and regulates human COL1A1 promoter activity in human dermal fibroblasts: demonstration of increased binding in systemic sclerosis fibroblasts Arthritis Rheum. 2000 Oct; 43(10):2219-29. . View in PubMed

Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I Arthritis Rheum. 2000 Jul; 43(7):1624-32. . View in PubMed

A novel de novo mutation in the triple helix of the COL6A3 gene in a two-generation Italian family affected by Bethlem myopathyA diagnostic approach in the mutations' screening of type VI collagen. Neuromuscul Disord. 1999 Jun; 9(4):264-71. . View in PubMed

A heterozygous splice site mutation in COL6A1 leading to an in-frame deletion of the alpha1(VI) collagen chain in an italian family affected by bethlem myopathy Biochem Biophys Res Commun. 1999 May 19; 258(3):802-7. . View in PubMed

B-MYB transactivates its own promoter through SP1-binding sites Oncogene. 1999 Feb 11; 18(6):1333-9. . View in PubMed

Alterations in the regulation of expression of the alpha 1(I) collagen gene (COL1A1) in systemic sclerosis (scleroderma) Springer Semin Immunopathol. 1999; 21(4):397-414. . View in PubMed

Identification of a polymorphic CA repeat in the COL6A2 gene on human chromosome 21q223. Hum Hered. 1996 Jul-Aug; 46(4):239-40. . View in PubMed

Characterization of the human alpha 1(VI) collagen promoter and its comparison with human alpha 2(VI) promoters Eur J Biochem. 1995 Dec 01; 234(2):542-9. . View in PubMed

Head to tail organization of the human COL6A1 and COL6A2 genes by fiber-FISH Genomics. 1995 Oct 10; 29(3):801-3. . View in PubMed

Human alpha 2(VI) collagen geneHeterogeneity at the 5'-untranslated region generated by an alternate exon. J Biol Chem. 1992 Mar 25; 267(9):6188-96. . View in PubMed

Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter Genomics. 1991 Sep; 11(1):174-8. . View in PubMed

Human nidogen gene: structural and functional characterization of the 5'-flanking region J Invest Dermatol. 1991 Aug; 97(2):281-5. . View in PubMed

Human alpha 3(VI) collagen geneCharacterization of exons coding for the amino-terminal globular domain and alternative splicing in normal and tumor cells. J Biol Chem. 1991 May 05; 266(13):8626-33. . View in PubMed

Alternative splicing of the human alpha 2(VI) collagen gene generates multiple mRNA transcripts which predict three protein variants with distinct carboxyl termini J Biol Chem. 1990 Apr 15; 265(11):6473-80. . View in PubMed

Isolation of a putative collagen-like gene from the sea urchin Paracentrotus lividus Biochem Biophys Res Commun. 1989 Feb 15; 158(3):633-9. . View in PubMed

alpha alpha alpha anti-42 Haplotype and heterozygous beta null thalassemia in a Sicilian family. Hum Genet. 1985; 70(4):318-20. . View in PubMed

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