Despite evidence from animal models supporting a developmental origins of adult disease hypothesis (DOHad), which proposes that adverse events during early life program an increased risk for numerous adult diseases, human studies of in utero or childhood environmental exposures have not been a primary focus until recently. My work in evaluating prenatal air pollution and prenatal tobacco smoke exposures provides evidence that early life exposures are important risk factors for cardio-respiratory health in children and young adults.
Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes Clin Epigenetics. 2018 Jul 20; 10(1):98. . View in PubMed
Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium Int J Epidemiol. 2018 Feb 01; 47(1):22-23u. . View in PubMed
Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group Environ Health Perspect. 2017 04; 125(4):511-526. . View in PubMed
Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure Environ Health Perspect. 2017 01; 125(1):104-110. . View in PubMed
Epigenetic regulation of AXL and risk of childhood asthma symptoms Clin Epigenetics. 2017; 9:121. . View in PubMed
Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation J Am Heart Assoc. 2016 Jul 28; 5(8). . View in PubMed
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis Am J Hum Genet. 2016 Apr 07; 98(4):680-96. . View in PubMed
Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood Environ Epigenet. 2016 Apr; 2(2):dvw005. . View in PubMed
Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study Environ Health Perspect. 2016 12; 124(12):1905-1912. . View in PubMed
Prenatal Air Pollution Exposure and Early Cardiovascular Phenotypes in Young Adults PLoS One. 2016; 11(3):e0150825. . View in PubMed
cit: hypothesis testing software for mediation analysis in genomic applications Bioinformatics. 2016 08 01; 32(15):2364-5. . View in PubMed
Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study J Thorac Dis. 2015 Jan; 7(1):46-58. . View in PubMed
NOS1 methylation and carotid artery intima-media thickness in children Circ Cardiovasc Genet. 2014 Apr; 7(2):116-22. . View in PubMed
HDL anti-oxidant function associates with LDL level in young adults Atherosclerosis. 2014 Jan; 232(1):165-70. . View in PubMed
Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation PLoS One. 2014; 9(6):e99716. . View in PubMed
Response to letter regarding article, “Childhood air pollutant exposure and carotid artery intima–media thickness in young adults” Circulation. 2013 Jun 04; 127(22):e659. . View in PubMed
Birth weight and carotid artery intima-media thicknessJ Pediatr. 2013 May; 162(5):906-11. e1-2. . View in PubMed
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships Hum Genet. 2012 Oct; 131(10):1565-89. . View in PubMed
Childhood air pollutant exposure and carotid artery intima-media thickness in young adults Circulation. 2012 Sep 25; 126(13):1614-20. . View in PubMed
Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease Environ Health Perspect. 2012 Sep; 120(9):1320-6. . View in PubMed
Air pollution and health: emerging information on susceptible populations Air Qual Atmos Health. 2012 Jun 01; 5(2):189-201. . View in PubMed
Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in childrenJ Allergy Clin Immunol. 2012 Jan; 129(1):232-9. e1-7. . View in PubMed
Carotid artery intima-media thickness in college students: race/ethnicity matters Atherosclerosis. 2011 Aug; 217(2):441-6. . View in PubMed
DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma Am J Respir Crit Care Med. 2011 Jul 15; 184(2):191-7. . View in PubMed
Heritability and role for the environment in DNA methylation in AXL receptor tyrosine kinase Epigenetics. 2011 Jul; 6(7):895-8. . View in PubMed
A pathway-based analysis of urinary arsenic metabolites and skin lesions Am J Epidemiol. 2011 Apr 01; 173(7):778-86. . View in PubMed
Investigating air pollution and atherosclerosis in humans: concepts and outlook Prog Cardiovasc Dis. 2011 Mar-Apr; 53(5):334-43. . View in PubMed
Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth Am J Respir Crit Care Med. 2011 Jan 15; 183(2):243-8. . View in PubMed
Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence Thorax. 2010 Feb; 65(2):139-45. . View in PubMed
Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation Am J Respir Crit Care Med. 2009 Sep 01; 180(5):462-7. . View in PubMed
Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function Am J Respir Crit Care Med. 2009 Apr 01; 179(7):601-7. . View in PubMed
GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study Environ Health. 2007 Dec 04; 6:39. . View in PubMed
Maternal arsenic exposure associated with low birth weight in Bangladesh J Occup Environ Med. 2007 Oct; 49(10):1097-104. . View in PubMed
Association between total ingested arsenic and toenail arsenic concentrations J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007 Oct; 42(12):1827-34. . View in PubMed
Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes Carcinogenesis. 2007 Jul; 28(7):1520-5. . View in PubMed
Dietary arsenic exposure in bangladesh Environ Health Perspect. 2007 Jun; 115(6):889-93. . View in PubMed
Gender-specific protective effect of hemoglobin on arsenic-induced skin lesions Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):902-7. . View in PubMed
