Keck School Faculty

Chaim O. Jacob, MD, PhD
Chaim O. Jacob, MD, PhD
Professor of Medicine
Medicine
HMR 705 Health Sciences Campus Los Angeles
Dr. Jacob's research interests include genetics and pathogenesis of systemic lupus erythematosus (SLE). He continues his groundbreaking work in discovering and characterizing new genes important to the development of SLE.

Dr. Jacob earned his medical degree from Tel Aviv University, Sackler School of Medicine. He then went on to complete graduate school at The Weizmann Institute of Science, followed by a Rheumatology Fellowship at Stanford University School of Medicine.

The Henry Kunkel Society: Elected Member, 2009

National Arthritis Foundation: Klinenberg Award, 2001-2002

Southern California Chapter of Arthritis Foundation: Klinenberg Award, 2000

Irvington House Institute for Medical Research: Fellow, 1988-1990

The Reticulo Endothelial Society: Presidential Award, 1987

: J.F. Kennedy Memorial Prize, 1985

Development of murine systemic lupus erythematosus in the absence of BAFF Arthritis Rheumatol. 2019 Sep 07. . View in PubMed

Constitutive reduction in the checkpoint inhibitor, CTLA-4, does not accelerate SLE in NZM 2328 mice Lupus Sci Med. 2019; 6(1):e000313. . View in PubMed

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus Hum Mol Genet. 2018 Jul 01; 27(13):2392-2404. . View in PubMed

TLR7-Mediated Lupus Nephritis Is Independent of Type I IFN Signaling J Immunol. 2018 07 15; 201(2):393-405. . View in PubMed

Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans Hum Mol Genet. 2018 11 01; 27(21):3813-3824. . View in PubMed

Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice Arthritis Rheumatol. 2017 08; 69(8):1647-1660. . View in PubMed

Transancestral mapping and genetic load in systemic lupus erythematosus Nat Commun. 2017 07 17; 8:16021. . View in PubMed

Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production Ann Rheum Dis. 2016 Nov; 75(11):2007-2013. . View in PubMed

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture Arthritis Rheumatol. 2016 Apr; 68(4):932-43. . View in PubMed

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity Elife. 2016 Feb 15; 5. . View in PubMed

Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans Arthritis Rheumatol. 2016 05; 68(5):1197-1209. . View in PubMed

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA Ann Rheum Dis. 2016 Jan; 75(1):242-52. . View in PubMed

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus Clin Immunol. 2015 Dec; 161(2):157-62. . View in PubMed

Erratum: IgG1 protects against renal disease in a mouse model of cryoglobulinaemia Nature. 2015 Oct 29; 526(7575):728. . View in PubMed

Differential Development of Systemic Lupus Erythematosus in NZM 2328 Mice Deficient in Discrete Pairs of BAFF Receptors Arthritis Rheumatol. 2015 Sep; 67(9):2523-35. . View in PubMed

Systemic lupus erythematosus-associated neutrophil cytosolic factor 2 mutation affects the structure of NADPH oxidase complex J Biol Chem. 2015 May 15; 290(20):12595-602. . View in PubMed

Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression Am J Hum Genet. 2015 May 07; 96(5):731-9. . View in PubMed

Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR J Immunol. 2015 May 01; 194(9):4055-7. . View in PubMed

Genes Immun. 2015 Mar; 16(2):142-50. . View in PubMed

IgG1 protects against renal disease in a mouse model of cryoglobulinaemia Nature. 2015 Jan 22; 517(7535):501-4. . View in PubMed

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share Hum Mol Genet. 2015 Jan 15; 24(2):582-96. . View in PubMed

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus Genes Immun. 2015 Jan-Feb; 16(1):15-23. . View in PubMed

Lupus nephritis susceptibility loci in women with systemic lupus erythematosus J Am Soc Nephrol. 2014 Dec; 25(12):2859-70. . View in PubMed

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region Genes Immun. 2014 Sep; 15(6):347-54. . View in PubMed

Lupus risk variants in the PXK locus alter B-cell receptor internalization Front Genet. 2014; 5:450. . View in PubMed

ABIN1 dysfunction as a genetic basis for lupus nephritis J Am Soc Nephrol. 2013 Nov; 24(11):1743-54. . View in PubMed

Development of systemic lupus erythematosus in NZM 2328 mice in the absence of any single BAFF receptor Arthritis Rheum. 2013 Apr; 65(4):1043-54. . View in PubMed

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups Ann Rheum Dis. 2013 Mar; 72(3):437-44. . View in PubMed

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production PLoS Genet. 2013; 9(2):e1003222. . View in PubMed

Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4 PLoS Genet. 2013; 9(7):e1003554. . View in PubMed

PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes PLoS One. 2013; 8(8):e69404. . View in PubMed

Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression PLoS Genet. 2013; 9(10):e1003870. . View in PubMed

MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus PLoS Genet. 2013; 9(2):e1003336. . View in PubMed

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations Arthritis Rheum. 2012 Nov; 64(11):3687-94. . View in PubMed

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus Arthritis Rheum. 2012 Nov; 64(11):3695-705. . View in PubMed

A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus Genes Immun. 2012 Jul; 13(5):380-7. . View in PubMed

Evaluation of TRAF6 in a large multiancestral lupus cohort Arthritis Rheum. 2012 Jun; 64(6):1960-9. . View in PubMed

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus Ann Rheum Dis. 2012 May; 71(5):694-9. . View in PubMed

Genetics of rheumatoid arthritis: an impressionist perspective Rheum Dis Clin North Am. 2012 May; 38(2):243-57. . View in PubMed

Dispensability of APRIL to the development of systemic lupus erythematosus in NZM 2328 mice Arthritis Rheum. 2012 May; 64(5):1610-9. . View in PubMed

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study Am J Hum Genet. 2012 Apr 06; 90(4):648-60. . View in PubMed

Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis Genes Immun. 2012 Apr; 13(3):232-8. . View in PubMed

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus Arthritis Rheum. 2012 Feb; 64(2):485-92. . View in PubMed

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):E59-67. . View in PubMed

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap PLoS Genet. 2011 Dec; 7(12):e1002406. . View in PubMed

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study Arthritis Rheum. 2011 Nov; 63(11):3493-501. . View in PubMed

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus Ann Rheum Dis. 2011 Oct; 70(10):1752-7. . View in PubMed

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups Arthritis Rheum. 2011 Sep; 63(9):2755-63. . View in PubMed

Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus Arthritis Rheum. 2011 Jul; 63(7):2049-57. . View in PubMed

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort Genes Immun. 2011 Jun; 12(4):270-9. . View in PubMed

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility PLoS Genet. 2011 May; 7(5):e1002079. . View in PubMed

B Cell and BAFF dependence of IFN-a-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice J Immunol. 2011 Apr 15; 186(8):4984-93. . View in PubMed

Reflections on Darwinian Evolution - Is there a Jewish Perspective? Rambam Maimonides Med J. 2011 Apr; 2(2):e0044.. View in PubMed

Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production PLoS Genet. 2011 Mar; 7(3):e1001323. . View in PubMed

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus Nat Genet. 2011 Mar; 43(3):253-8. . View in PubMed

Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes PLoS Genet. 2011 Feb; 7(2):e1001311. . View in PubMed

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study Am J Hum Genet. 2011 Jan 07; 88(1):83-91. . View in PubMed

On anti-tumor necrosis factor-induced systemic lupus erythematosus J Rheumatol. 2010 Jan; 37(1):3-5. . View in PubMed

The role of genetic variation near interferon-kappa in systemic lupus erythematosus J Biomed Biotechnol. 2010; 2010. . View in PubMed

Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease J Immunol. 2009 Nov 01; 183(9):6021-9. . View in PubMed

A polymorphism within IL21R confers risk for systemic lupus erythematosus Arthritis Rheum. 2009 Aug; 60(8):2402-7. . View in PubMed

Evaluation of C1q genomic region in minority racial groups of lupus Genes Immun. 2009 Jul; 10(5):517-24. . View in PubMed

Identification of new SLE-associated genes with a two-step Bayesian study design Genes Immun. 2009 Jul; 10(5):446-56. . View in PubMed

Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing Genes Immun. 2009 Jul; 10(5):457-69. . View in PubMed

Admixture in Hispanic Americans: its impact on ITGAM association and implications for admixture mapping in SLE Genes Immun. 2009 Jul; 10(5):539-45. . View in PubMed

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6256-61. . View in PubMed

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups Arthritis Rheum. 2009 Apr; 60(4):1085-95. . View in PubMed

Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE) Hum Mol Genet. 2009 Mar 15; 18(6):1171-80. . View in PubMed

Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway J Immunol. 2009 Feb 15; 182(4):2532-41. . View in PubMed

Function2Gene: a gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge BMC Bioinformatics. 2008 Jul 17; 9:311. . View in PubMed

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nat Genet. 2008 Feb; 40(2):204-10. . View in PubMed

Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform Arthritis Rheum. 2007 Dec; 56(12):4164-73. . View in PubMed

Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF J Immunol. 2006 Aug 15; 177(4):2671-80. . View in PubMed

The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain J Biol Chem. 2005 Mar 11; 280(10):9618-26. . View in PubMed

A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes Nat Genet. 2004 Aug; 36(8):837-41. . View in PubMed

Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice J Immunol. 2003 Aug 01; 171(3):1564-71. . View in PubMed

Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis J Immunol. 2003 May 01; 170(9):4818-25. . View in PubMed

Characterization of the FcgammaRIIA promoter and 5'UTR sequences in patients with systemic lupus erythematosus Genes Immun. 2002 Oct; 3 Suppl 1:S47-50. . View in PubMed

In vivo staphylococcal superantigen-driven polyclonal Ig responses in mice: dependence upon CD4(+) cells and human MHC class II Int Immunol. 2001 Oct; 13(10):1291-300. . View in PubMed

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33 Diabetes. 2000 Mar; 49(3):492-9. . View in PubMed

Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families Hum Mol Genet. 1999 Apr; 8(4):639-44. . View in PubMed

Synergistic effect between IL-10 and bcl-2 genotypes in determining susceptibility to systemic lupus erythematosus Arthritis Rheum. 1998 Apr; 41(4):596-602. . View in PubMed

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups Hum Mol Genet. 1997 Aug; 6(8):1275-82. . View in PubMed

Impaired nonrestricted cytolytic activity in systemic lupus erythematosus: involvement of a pathway independent of Fas, tumor necrosis factor, and extracellular ATP that is associated with little detectable perforin Arthritis Rheum. 1997 Jun; 40(6):1130-7. . View in PubMed

Mutational analysis of TNF-alpha gene reveals a regulatory role for the 3'-untranslated region in the genetic predisposition to lupus-like autoimmune disease J Immunol. 1996 Apr 15; 156(8):3043-50. . View in PubMed

Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages J Immunol. 1995 Nov 15; 155(10):4909-16. . View in PubMed

The cytokine network in the pathogenesis of systemic lupus erythematosus and possible therapeutic implications Springer Semin Immunopathol. 1994; 16(2-3):181-200. . View in PubMed

Novel DNA polymorphism in the mouse tumor necrosis factor receptors type 1 and type 2 Immunogenetics. 1993; 37(3):199-203. . View in PubMed

Tumor necrosis factor and interferon gamma: relevance for immune regulation and genetic predisposition to autoimmune disease Semin Immunol. 1992 Jun; 4(3):147-54. . View in PubMed

Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development Int Immunol. 1992 May; 4(5):611-4. . View in PubMed

Studies on the role of tumor necrosis factor in murine and human autoimmunity J Autoimmun. 1992 Apr; 5 Suppl A:133-43. . View in PubMed

Definition of microsatellite size variants for Tnfa and Hsp70 in autoimmune and nonautoimmune mouse strains Immunogenetics. 1992; 36(3):182-8. . View in PubMed

Tumor necrosis factor alpha in murine systemic lupus erythematosus disease models: implications for genetic predisposition and immune regulation Cytokine. 1991 Nov; 3(6):551-61. . View in PubMed

Regulation of MHC class II antigen expressionOpposing effects of tumor necrosis factor-alpha on IFN-gamma-induced HLA-DR and Ia expression depends on the maturation and differentiation stage of the cell. J Immunol. 1991 Feb 01; 146(3):899-905. . View in PubMed

MHC class II-associated variation in the production of tumor necrosis factor in mice and humans: relevance to the pathogenesis of autoimmune diseases Immunol Res. 1991; 10(2):156-68. . View in PubMed

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus Proc Natl Acad Sci U S A. 1990 Feb; 87(3):1233-7. . View in PubMed

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1 Proc Natl Acad Sci U S A. 1990 Feb; 87(3):968-72. . View in PubMed

Heterogeneous effects of IFN-gamma in adjuvant arthritis J Immunol. 1989 Mar 01; 142(5):1500-5. . View in PubMed

A molecular basis for MHC class II--associated autoimmunity Science. 1988 May 20; 240(4855):1003-9. . View in PubMed

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon J Exp Med. 1987 Sep 01; 166(3):798-803. . View in PubMed

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