Keck School Faculty

Danieli B. Salinas, MD
Danieli B. Salinas, MD
Assistant Professor of Clinical Pediatrics
Pediatrics
4640 West Sunset Boulevard Off Campus Los Angeles
I am originally from Rio de Janeiro, Brazil and I came to the U.S. for Residency and Fellowship training in Pediatric Pulmonology with the goal of becoming a physician scientist. My passion is Cystic Fibrosis. I enjoy taking care of these complex children and I am fascinated by the science behind the consequences of this defective chloride channel. The fact that we still don’t have a cure for this disease and that there are nearly 2,000 different mutations producing a wide range of clinical presentations are my biggest motivation to work in this field. I hope to make contributions to improve the lives of people with this disease and I hope I can one day say CF stands for Cure Found! My major areas of research interest are predicting clinical outcomes in children with a positive newborn screening for Cystic Fibrosis.
a. Retrospective study based on the California database.
b. Hierarchical modeling of clinical prediction.
c. Developing a Sweat Rate test for infants for more accurately diagnose CF and predict clinical outcome.

Image-based ß-adrenergic sweat rate assay captures minimal cystic fibrosis transmembrane conductance regulator function Pediatr Res. 2019 Jul 25. . View in PubMed

Inconclusive diagnosis after a positive newborn bloodspot screening result for cystic fibrosis; clarification of the harmonised international definition J Cyst Fibros. 2019 Apr 24. . View in PubMed

The increasing challenge of genetic counseling for cystic fibrosis J Cyst Fibros. 2019 Mar; 18(2):167-174. . View in PubMed

Low Beta-Adrenergic Sweat Responses in Cystic Fibrosis and Cystic Fibrosis Transmembrane Conductance Regulator-Related Metabolic Syndrome Children Pediatr Allergy Immunol Pulmonol. 2017 Mar 01; 30(1):2-6. . View in PubMed

Applying Cystic Fibrosis Transmembrane Conductance Regulator Genetics and CFTR2 Data to Facilitate DiagnosesJ Pediatr. 2017 02; 181S:S27-S32. e1. . View in PubMed

Phenotypes of California CF Newborn Screen-Positive Children with CFTR 5T Allele by TG Repeat Length Genet Test Mol Biomarkers. 2016 Sep; 20(9):496-503. . View in PubMed

Benign and Deleterious Cystic Fibrosis Transmembrane Conductance Regulator Mutations Identified by Sequencing in Positive Cystic Fibrosis Newborn Screen Children from California PLoS One. 2016; 11(5):e0155624. . View in PubMed

Benign outcome among positive cystic fibrosis newborn screen children with non-CF-causing variants J Cyst Fibros. 2015 Nov; 14(6):714-9. . View in PubMed

Novel CFTR variants identified during the first 3 years of cystic fibrosis newborn screening in California J Mol Diagn. 2013 Sep; 15(5):710-22. . View in PubMed

Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis Am J Physiol Cell Physiol. 2006 Mar; 290(3):C741-9. . View in PubMed

Submucosal gland dysfunction as a primary defect in cystic fibrosis FASEB J. 2005 Mar; 19(3):431-3. . View in PubMed

CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L936-43. . View in PubMed

Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models J Biol Chem. 2004 Sep 24; 279(39):40629-33. . View in PubMed

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy J Gen Physiol. 2004 Aug; 124(2):125-37. . View in PubMed

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