Keck School Faculty

David V. Conti

David V. Conti

Professor of Population and Public Health Sciences
Associate Director for Data Science Integration
Center for Genetic Epidemiology
SSB 202 2001 N. Soto Street Health Sciences Campus Los Angeles

A genetic association study of tobacco withdrawal endophenotypes in African Americans Exp Clin Psychopharmacol. 2022 Oct; 30(5):673-681. . View in PubMed

Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study Cancer Res. 2022 Sep 16; 82(18):3201-3208. . View in PubMed

Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach Hum Mol Genet. 2022 Sep 10; 31(18):3133-3143. . View in PubMed

Characteristics associated with COVID-19 vaccination status among staff and faculty of a large, diverse University in Los Angeles: The Trojan Pandemic Response Initiative Prev Med Rep. 2022 Jun; 27:101802. . View in PubMed

Prenatal exposure to multiple organochlorine compounds and childhood body mass index Environ Epidemiol. 2022 Jun; 6(3):e201. . View in PubMed

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium HGG Adv. 2022 Apr 14; 3(2):100099. . View in PubMed

The International Family Study of Nonsyndromic Orofacial Clefts: Design and Methods Cleft Palate Craniofac J. 2022 Apr; 59(4_suppl2):S37-S47. . View in PubMed

Plasma concentrations of lipophilic persistent organic pollutants and glucose homeostasis in youth populations Environ Res. 2022 09; 212(Pt B):113296. . View in PubMed

A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry Eur Urol. 2022 05; 81(5):458-462. . View in PubMed

Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis Environ Health Perspect. 2022 04; 130(4):46001. . View in PubMed

Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies Obes Rev. 2022 01; 23 Suppl 1:e13383. . View in PubMed

Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q242 Region. Cancer Epidemiol Biomarkers Prev. 2022 05 04; 31(5):1077-1089. . View in PubMed

Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk J Natl Cancer Inst. 2022 08 08; 114(8):1135-1148. . View in PubMed

Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health Elife. 2022 01 25; 11. . View in PubMed

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations Elife. 2022 07 08; 11. . View in PubMed

Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children JAMA Netw Open. 2022 07 01; 5(7):e2220176. . View in PubMed

Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer J Natl Cancer Inst. 2022 05 09; 114(5):771-774. . View in PubMed

Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking Cancers (Basel). 2021 Oct 27; 13(21). . View in PubMed

Prenatal and childhood exposure to air pollution and traffic and the risk of liver injury in European children Environ Epidemiol. 2021 Jun; 5(3):e153. . View in PubMed

Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 Mar; 53(3):413. . View in PubMed

Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi-phased study of prostate cancer Cancer Commun (Lond). 2021 12; 41(12):1387-1397. . View in PubMed

Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts Environ Int. 2021 12; 157:106853. . View in PubMed

Association of Genetic Risk Score With NAFLD in An Ethnically Diverse Cohort Hepatol Commun. 2021 10; 5(10):1689-1703. . View in PubMed

Exposure to Perfluoroalkyl Substances and Glucose Homeostasis in Youth Environ Health Perspect. 2021 09; 129(9):97002. . View in PubMed

In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood Hepatology. 2021 09; 74(3):1546-1559. . View in PubMed

Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk Eur Urol. 2021 08; 80(2):134-138. . View in PubMed

Genetic architectures of proximal and distal colorectal cancer are partly distinct Gut. 2021 07; 70(7):1325-1334. . View in PubMed

Rare Variants in the DNA Repair Pathway and the Risk of Colorectal Cancer Cancer Epidemiol Biomarkers Prev. 2021 05; 30(5):895-903. . View in PubMed

Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 SubjectsGastroenterology. 2021 03; 160(4):1164-1178. e6. . View in PubMed

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 01; 53(1):65-75. . View in PubMed

Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry Am J Hum Genet. 2021 04 01; 108(4):564-582. . View in PubMed

Sign-based Shrinkage Based on an Asymmetric LASSO Penalty J Data Sci. 2021; 19(3):429-449. . View in PubMed

Prenatal metal mixtures and child blood pressure in the Rhea mother-child cohort in Greece Environ Health. 2021 01 06; 20(1):1. . View in PubMed

Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women Nat Commun. 2021 07 07; 12(1):4198. . View in PubMed

An integrated risk and epidemiological model to estimate risk-stratified COVID-19 outcomes for Los Angeles County: March 1, 2020-March 1, 2021 PLoS One. 2021; 16(6):e0253549. . View in PubMed

Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry J Natl Cancer Inst. 2021 09 04; 113(9):1168-1176. . View in PubMed

Bayesian variable selection with a pleiotropic loss function in Mendelian randomization Stat Med. 2021 10 15; 40(23):5025-5045. . View in PubMed

Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer J Natl Cancer Inst. 2021 05 04; 113(5):616-625. . View in PubMed

A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis Am J Epidemiol. 2021 06 01; 190(6):1148-1158. . View in PubMed

Estimation of COVID-19 risk-stratified epidemiological parameters and policy implications for Los Angeles County through an integrated risk and stochastic epidemiological model medRxiv. 2020 Dec 14. . View in PubMed

The role of smoke from cooking indoors over an open flame and parental smoking on the risk of cleft lip and palate: A case- control study in 7 low-resource countries J Glob Health. 2020 Dec; 10(2):020410. . View in PubMed

Author Correction: Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL Sci Rep. 2020 Jan 15; 10(1):748. . View in PubMed

Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults Environ Int. 2020 12; 145:106091. . View in PubMed

Replication and Genetic Risk Score Analysis for Pancreatic Cancer in a Diverse Multiethnic Population Cancer Epidemiol Biomarkers Prev. 2020 12; 29(12):2686-2692. . View in PubMed

A Cross-Sectional Study Examining the Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in a University Student Population J Adolesc Health. 2020 12; 67(6):763-768. . View in PubMed

The genetic diversity of multiple sclerosis risk among Hispanic and African American populations living in the United States Mult Scler. 2020 10; 26(11):1329-1339. . View in PubMed

Variability in Cytogenetic Testing for Multiple Myeloma: A Comprehensive Analysis From Across the United States JCO Oncol Pract. 2020 10; 16(10):e1169-e1180. . View in PubMed

A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry Eur Urol. 2020 09; 78(3):316-320. . View in PubMed

The Four-Kallikrein Panel Is Effective in Identifying Aggressive Prostate Cancer in a Multiethnic Population Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1381-1388. . View in PubMed

Interaction effect of alcohol consumption and Alzheimer disease polygenic risk score on the brain cortical thickness of cognitively normal subjects Alcohol. 2020 06; 85:1-12. . View in PubMed

Correction to: Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study Cancer Causes Control. 2020 06; 31(6):607. . View in PubMed

Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk Cancer Med. 2020 05; 9(10):3563-3573. . View in PubMed

Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study Cancer Causes Control. 2020 05; 31(5):451-462. . View in PubMed

Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset CancerGastroenterology. 2020 04; 158(5):1274-1286. e12. . View in PubMed

Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk Cancer Epidemiol Biomarkers Prev. 2020 04; 29(4):860-870. . View in PubMed

Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach Environ Int. 2020 01; 134:105220. . View in PubMed

A genome-wide association study of prostate cancer in Latinos Int J Cancer. 2020 04 01; 146(7):1819-1826. . View in PubMed

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children JAMA Netw Open. 2020 03 02; 3(3):e201007. . View in PubMed

Pathogenic Variants in Cancer Predisposition Genes and Prostate Cancer Risk in Men of African Ancestry JCO Precis Oncol. 2020; 4:32-43. . View in PubMed

A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry Blood Adv. 2020 01 14; 4(1):181-190. . View in PubMed

A latent unknown clustering integrating multi-omics data (LUCID) with phenotypic traits Bioinformatics. 2020 02 01; 36(3):842-850. . View in PubMed

Publisher Correction: Shared heritability and functional enrichment across six solid cancers Nat Commun. 2019 Sep 23; 10(1):4386. . View in PubMed

Correction to: Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer Hum Genet. 2019 Jul; 138(7):789-791. . View in PubMed

Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer Gastroenterology. 2019 Apr; 156(5):1455-1466. . View in PubMed

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer Hum Genet. 2019 Apr; 138(4):307-326. . View in PubMed

Correction: Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease Br J Cancer. 2019 Apr; 120(8):867. . View in PubMed

Genome-wide association study of circulating folate one-carbon metabolites Genet Epidemiol. 2019 12; 43(8):1030-1045. . View in PubMed

Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method Pharm Stat. 2019 11; 18(6):659-670. . View in PubMed

Reply to Xiaoling Lin, Brian THelfand, and Jianfeng Xu's Letter to the Editor re: Daniel A. Leongamornlert, Edward J. Saunders, Sarah Wakerell, et al. Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel. Eur Urol 2019;76:329-37. Eur Urol. 2019 11; 76(5):e130-e131. . View in PubMed

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes Genet Epidemiol. 2019 10; 43(7):844-863. . View in PubMed

Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel Eur Urol. 2019 09; 76(3):329-337. . View in PubMed

Alterations in folate-dependent one-carbon metabolism as colon cell transition from normal to cancerous J Nutr Biochem. 2019 07; 69:1-9. . View in PubMed

DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin Leuk Lymphoma. 2019 06; 60(6):1429-1437. . View in PubMed

Telomerase Variants in Patients with Cirrhosis Awaiting Liver Transplantation Hepatology. 2019 06; 69(6):2652-2663. . View in PubMed

Perfluoroalkyl substances, metabolomic profiling, and alterations in glucose homeostasis among overweight and obese Hispanic children: A proof-of-concept analysis Environ Int. 2019 05; 126:445-453. . View in PubMed

Epstein-Barr virus load is higher in long-term Hodgkin lymphoma survivors compared to their unaffected twins and unrelated controls Br J Haematol. 2019 04; 185(2):377-380. . View in PubMed

Genet Epidemiol. 2019 03; 43(2):150-165. . View in PubMed

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos J Allergy Clin Immunol. 2019 03; 143(3):957-969. . View in PubMed

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2019 02; 51(2):363. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 01; 51(1):76-87. . View in PubMed

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study Cancer Epidemiol Biomarkers Prev. 2019 01; 28(1):208-216. . View in PubMed

Shared heritability and functional enrichment across six solid cancers Nat Commun. 2019 01 25; 10(1):431. . View in PubMed

HiLDA: a statistical approach to investigate differences in mutational signatures PeerJ. 2019; 7:e7557. . View in PubMed

Exploratory metabolomic study to identify blood-based biomarkers as a potential screen for colorectal cancer Mol Omics. 2019 02 11; 15(1):21-29. . View in PubMed

Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study Int J Epidemiol. 2019 06 01; 48(3):899-907. . View in PubMed

A Unified Model for the Analysis of Gene-Environment Interaction Am J Epidemiol. 2019 04 01; 188(4):760-767. . View in PubMed

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry Nat Commun. 2019 01 17; 10(1):382. . View in PubMed

Novel Common Genetic Susceptibility Loci for Colorectal Cancer J Natl Cancer Inst. 2019 02 01; 111(2):146-157. . View in PubMed

Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL Sci Rep. 2019 06 28; 9(1):9371. . View in PubMed

Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer JAMA Netw Open. 2019 09 04; 2(9):e1912259. . View in PubMed

Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis Ann Clin Transl Neurol. 2018 Nov; 5(11):1362-1371. . View in PubMed

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease Br J Cancer. 2018 07; 119(1):96-104. . View in PubMed

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2018 07; 50(7):928-936. . View in PubMed

Genetic risk of prostate cancer in Ugandan men Prostate. 2018 04; 78(5):370-376. . View in PubMed

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants Nat Commun. 2018 06 11; 9(1):2256. . View in PubMed

Evaluation of 71 Coronary Artery Disease Risk Variants in a Multiethnic Cohort Front Cardiovasc Med. 2018; 5:19. . View in PubMed

Germline variation at 8q24 and prostate cancer risk in men of European ancestry Nat Commun. 2018 11 05; 9(1):4616. . View in PubMed

Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study J Clin Oncol. 2018 05 20; 36(15):1513-1520. . View in PubMed

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium PLoS Genet. 2017 Apr; 13(4):e1006719. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1016-1026. . View in PubMed

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers Cancer Epidemiol Biomarkers Prev. 2017 01; 26(1):126-135. . View in PubMed

Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans Int J Cancer. 2017 06 15; 140(12):2728-2733. . View in PubMed

Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry J Natl Cancer Inst. 2017 08 01; 109(8). . View in PubMed

Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia Int J Cancer. 2017 11 01; 141(9):1794-1802. . View in PubMed

Prostate Cancer Susceptibility in Men of African Ancestry at 8q24 J Natl Cancer Inst. 2016 Jul; 108(7). . View in PubMed

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation Nat Commun. 2016 Apr 07; 7:10979. . View in PubMed

JAM: A Scalable Bayesian Framework for Joint Analysis of Marginal SNP Effects Genet Epidemiol. 2016 Apr; 40(3):188-201. . View in PubMed

GWASeq: targeted re-sequencing follow up to GWAS BMC Genomics. 2016 Mar 03; 17:176. . View in PubMed

Smokescreen: a targeted genotyping array for addiction research BMC Genomics. 2016 Feb 27; 17:145. . View in PubMed

Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk Hum Mol Genet. 2016 Jan 15; 25(2):371-81. . View in PubMed

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1609-1618. . View in PubMed

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer Cancer Epidemiol. 2016 10; 44:1-4. . View in PubMed

Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries Nicotine Tob Res. 2016 09; 18(9):1837-1844. . View in PubMed

Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study Genet Epidemiol. 2016 07; 40(5):394-403. . View in PubMed

Genome-wide association study of colorectal cancer in Hispanics Carcinogenesis. 2016 06; 37(6):547-556. . View in PubMed

Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants PLoS One. 2016; 11(7):e0157521. . View in PubMed

The contribution of rare variation to prostate cancer heritability Nat Genet. 2016 Jan; 48(1):30-5. . View in PubMed

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations Cancer Res. 2016 09 01; 76(17):5103-14. . View in PubMed

Reducing GWAS Complexity Cell Cycle. 2016; 15(1):22-4. . View in PubMed

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer J Natl Cancer Inst. 2015 Nov; 107(11). . View in PubMed

Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Oct 26; 6:8739. . View in PubMed

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans Hum Mol Genet. 2015 Oct 01; 24(19):5589-602. . View in PubMed

Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions Hum Mol Genet. 2015 Oct 01; 24(19):5603-18. . View in PubMed

Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population J Clin Oncol. 2015 Sep 10; 33(26):2901-7. . View in PubMed

Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer Carcinogenesis. 2015 Sep; 36(9):999-1007. . View in PubMed

Genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Jul 07; 6:7138. . View in PubMed

Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2737-48. . View in PubMed

Generalizability of established prostate cancer risk variants in men of African ancestry Int J Cancer. 2015 Mar 01; 136(5):1210-7. . View in PubMed

Enlight: web-based integration of GWAS results with biological annotations Bioinformatics. 2015 Jan 15; 31(2):275-6. . View in PubMed

UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):94-104. . View in PubMed

Place of birth,age of immigration,and disability in Hispanics with multiple sclerosis Mult Scler Relat Disord. 2015 Jan; 4(1):25-30. . View in PubMed

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD Am J Psychiatry. 2015 Jan; 172(1):82-93. . View in PubMed

Genetic ancestry influences asthma susceptibility and lung function among Latinos J Allergy Clin Immunol. 2015 Jan; 135(1):228-35. . View in PubMed

Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption PLoS One. 2015; 10(7):e0126113. . View in PubMed

Organic cation transporter variation and response to smoking cessation therapies Nicotine Tob Res. 2014 Dec; 16(12):1638-46. . View in PubMed

A novel colorectal cancer risk locus at 4q322 identified from an international genome-wide association study. Carcinogenesis. 2014 Nov; 35(11):2512-9. . View in PubMed

The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease Cancer Res. 2014 Oct 15; 74(20):5808-18. . View in PubMed

A comprehensive examination of breast cancer risk loci in African American women Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. . View in PubMed

Gender difference in interactions between MAOA promoter uVNTR polymorphism and negative familial stressors on body mass index among Chinese adolescents Pediatr Obes. 2014 Oct; 9(5):e80-90. . View in PubMed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer Nat Genet. 2014 Oct; 46(10):1103-9. . View in PubMed

Genome-wide interaction study of smoking and bladder cancer risk Carcinogenesis. 2014 Aug; 35(8):1737-44. . View in PubMed

Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai Int J Cancer. 2014 Jul 15; 135(2):335-47. . View in PubMed

A meta-analysis of Hodgkin lymphoma reveals 19p133 TCF3 as a novel susceptibility locus. Nat Commun. 2014 Jun 12; 5:3856. . View in PubMed

Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome Drug Alcohol Depend. 2014 May 01; 138:109-17. . View in PubMed

Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia Gut. 2014 May; 63(5):800-7. . View in PubMed

Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q231. Hum Mol Genet. 2014 Apr 15; 23(8):2198-209. . View in PubMed

A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age Cancer Epidemiol Biomarkers Prev. 2014 Apr; 23(4):658-69. . View in PubMed

Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer Hum Mol Genet. 2013 Dec 15; 22(24):5075-82. . View in PubMed

Integrative variable selection via Bayesian model uncertainty Stat Med. 2013 Dec 10; 32(28):4938-53. . View in PubMed

Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion Addiction. 2013 Dec; 108(12):2202-11. . View in PubMed

Sneaker "jack" males outcompete dominant "hooknose" males under sperm competition in Chinook salmon (Oncorhynchus tshawytscha) Ecol Evol. 2013 Dec; 3(15):4987-97. . View in PubMed

Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer Cancer Epidemiol Biomarkers Prev. 2013 Nov; 22(11):2037-46. . View in PubMed

Spinal cord lesions and disability in Hispanics with multiple sclerosis J Neurol. 2013 Nov; 260(11):2770-6. . View in PubMed

A scalable, knowledge-based analysis framework for genetic association studies BMC Bioinformatics. 2013 Oct 23; 14:312. . View in PubMed

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture PLoS Genet. 2013 Oct; 9(10):e1003864. . View in PubMed

The DRD4 exon III VNTR, bupropion, and associations with prospective abstinence Nicotine Tob Res. 2013 Jul; 15(7):1190-200. . View in PubMed

Genome-wide association study of obsessive-compulsive disorder Mol Psychiatry. 2013 Jul; 18(7):788-98. . View in PubMed

Efficient two-step testing of gene-gene interactions in genome-wide association studies Genet Epidemiol. 2013 Jul; 37(5):440-51. . View in PubMed

Biomarkers for smoking cessation Clin Pharmacol Ther. 2013 Jun; 93(6):526-38. . View in PubMed

Next generation sequencing and a new era of medicine Gut. 2013 Jun; 62(6):920-32. . View in PubMed

Genome-wide association study of Tourette's syndrome Mol Psychiatry. 2013 Jun; 18(6):721-8. . View in PubMed

Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers--The Shanghai Bladder Cancer Study Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):937-45. . View in PubMed

Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysisGastroenterology. 2013 Apr; 144(4):799-807. e24. . View in PubMed

Confounding and heterogeneity in genetic association studies with admixed populations Am J Epidemiol. 2013 Feb 15; 177(4):351-60. . View in PubMed

Nicotinic acetylcholine receptor variation and response to smoking cessation therapies Pharmacogenet Genomics. 2013 Feb; 23(2):94-103. . View in PubMed

Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry PLoS One. 2013; 8(4):e60464. . View in PubMed

Vitamin D levels in Hispanics with multiple sclerosis J Neurol. 2012 Dec; 259(12):2565-70. . View in PubMed

Gender-stratified gene and gene-treatment interactions in smoking cessation Pharmacogenomics J. 2012 Dec; 12(6):521-32. . View in PubMed

Analysis and optimal design for association studies using next-generation sequencing with case-control pools Genet Epidemiol. 2012 Dec; 36(8):870-81. . View in PubMed

Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine AIDS. 2012 Oct 23; 26(16):2097-106. . View in PubMed

Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes Pharmacogenomics J. 2012 Aug; 12(4):349-58. . View in PubMed

DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers Pharmacogenet Genomics. 2012 Jul; 22(7):551-4. . View in PubMed

Cigarette smoking and subtypes of bladder cancer Int J Cancer. 2012 Feb 15; 130(4):896-901. . View in PubMed

Meta-analysis of new genome-wide association studies of colorectal cancer risk Hum Genet. 2012 Feb; 131(2):217-34. . View in PubMed

Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials Neuropsychopharmacology. 2012 Feb; 37(3):641-50. . View in PubMed

A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p2132. Blood. 2012 Jan 12; 119(2):469-75. . View in PubMed

Incorporating prior biologic information for high-dimensional rare variant association studies Hum Hered. 2012; 74(3-4):184-95. . View in PubMed

Genome-wide search for gene-gene interactions in colorectal cancer PLoS One. 2012; 7(12):e52535. . View in PubMed

Joint analysis for integrating two related studies of different data types and different study designs using hierarchical modeling approaches Hum Hered. 2012; 74(2):83-96. . View in PubMed

Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development BMC Med Genet. 2011 Dec 05; 12:156. . View in PubMed

Incorporating model uncertainty in detecting rare variants: the Bayesian risk index Genet Epidemiol. 2011 Nov; 35(7):638-49. . View in PubMed

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations Nat Genet. 2011 Jul 31; 43(9):887-92. . View in PubMed

Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma Nat Med. 2011 Jul 24; 17(8):941-3. . View in PubMed

The impact of change in visual field on health-related quality of life the los angeles latino eye study Ophthalmology. 2011 Jul; 118(7):1310-7. . View in PubMed

Lower risk in parous women suggests that hormonal factors are important in bladder cancer etiology Cancer Epidemiol Biomarkers Prev. 2011 Jun; 20(6):1156-70. . View in PubMed

Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status Breast Cancer Res Treat. 2011 Jun; 127(3):819-29. . View in PubMed

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk Hum Mol Genet. 2011 Jun 01; 20(11):2263-72. . View in PubMed

Genetic contribution of the leukotriene pathway to coronary artery disease Hum Genet. 2011 Jun; 129(6):617-27. . View in PubMed

Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California Am J Epidemiol. 2011 May 01; 173(9):1039-48. . View in PubMed

Relationships between IGF-1 and IGFBP-1 and adiposity in obese African-American and Latino adolescents Obesity (Silver Spring). 2011 May; 19(5):933-8. . View in PubMed

Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study Cancer Epidemiol Biomarkers Prev. 2011 May; 20(5):758-66. . View in PubMed

Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study Cancer Causes Control. 2011 Apr; 22(4):541-52. . View in PubMed

Sample size requirements to detect gene-environment interactions in genome-wide association studies Genet Epidemiol. 2011 Apr; 35(3):201-10. . View in PubMed

Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study Carcinogenesis. 2011 Feb; 32(2):197-202. . View in PubMed

Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study Cancer Epidemiol Biomarkers Prev. 2010 Dec; 19(12):3150-6. . View in PubMed

Hypertension, diuretics and antihypertensives in relation to bladder cancer Carcinogenesis. 2010 Nov; 31(11):1964-71. . View in PubMed

Discovery of complex pathways from observational data Stat Med. 2010 Aug 30; 29(19):1998-2011. . View in PubMed

Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry Carcinogenesis. 2010 Aug; 31(8):1412-6. . View in PubMed

Efficient genome-wide association testing of gene-environment interaction in case-parent trios Am J Epidemiol. 2010 Jul 01; 172(1):116-22. . View in PubMed

A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk Cancer Epidemiol Biomarkers Prev. 2010 Jul; 19(7):1812-21. . View in PubMed

A polytomous conditional likelihood approach for combining matched and unmatched case-control studies Stat Med. 2010 Apr 30; 29(9):1004-13. . View in PubMed

Genes involved with folate uptake and distribution and their association with colorectal cancer risk Cancer Causes Control. 2010 Apr; 21(4):597-608. . View in PubMed

Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence Cancer Res. 2010 Feb 15; 70(4):1496-504. . View in PubMed

Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence Thorax. 2010 Feb; 65(2):139-45. . View in PubMed

Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry Cancer Epidemiol Biomarkers Prev. 2010 Feb; 19(2):525-36. . View in PubMed

Complex system approaches to genetic analysis Bayesian approaches Adv Genet. 2010; 72:47-71. . View in PubMed

Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry Cancer Epidemiol Biomarkers Prev. 2010 Jan; 19(1):89-100. . View in PubMed

Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES) BMC Genet. 2009 Nov 10; 10:71. . View in PubMed

Methodological Issues in Multistage Genome-wide Association Studies Stat Sci. 2009 Nov 01; 24(4):414-429. . View in PubMed

Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):3057-61. . View in PubMed

Use of pathway information in molecular epidemiology Hum Genomics. 2009 Oct; 4(1):21-42. . View in PubMed

Dopamine genes and nicotine dependence in treatment-seeking and community smokers Neuropsychopharmacology. 2009 Sep; 34(10):2252-64. . View in PubMed

Effect of tidal volume in children with acute hypoxemic respiratory failure Intensive Care Med. 2009 Aug; 35(8):1428-37. . View in PubMed

A systems biology network model for genetic association studies of nicotine addiction and treatment Pharmacogenet Genomics. 2009 Jul; 19(7):538-51. . View in PubMed

Urinary tract infections and reduced risk of bladder cancer in Los Angeles Br J Cancer. 2009 Mar 10; 100(5):834-9. . View in PubMed

Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma Cancer Epidemiol Biomarkers Prev. 2009 Mar; 18(3):976-86. . View in PubMed

Detecting gene-environment interactions using a combined case-only and case-control approach Am J Epidemiol. 2009 Feb 15; 169(4):497-504. . View in PubMed

Water intake and bladder cancer risk in Los Angeles County Int J Cancer. 2008 Oct 01; 123(7):1649-56. . View in PubMed

Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation Hum Mol Genet. 2008 Sep 15; 17(18):2834-48. . View in PubMed

Snagger: a user-friendly program for incorporating additional information for tagSNP selection BMC Bioinformatics. 2008 Mar 27; 9:174. . View in PubMed

Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis Environ Health Perspect. 2008 Mar; 116(3):409-15. . View in PubMed

Prevalence of common disease-associated variants in Asian Indians BMC Genet. 2008 Feb 04; 9:13. . View in PubMed

Comprehensive evaluation of ESR2 variation and ovarian cancer risk Cancer Epidemiol Biomarkers Prev. 2008 Feb; 17(2):393-6. . View in PubMed

Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation Genet Epidemiol. 2007 Dec; 31(8):871-82. . View in PubMed

Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry Cancer Res. 2007 Dec 01; 67(23):11128-32. . View in PubMed

DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2363-72. . View in PubMed

The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics Chest. 2007 Sep; 132(3):868-74. . View in PubMed

Alcohol consumption and risk of bladder cancer in Los Angeles County Int J Cancer. 2007 Aug 15; 121(4):839-45. . View in PubMed

Testing association between disease and multiple SNPs in a candidate gene Genet Epidemiol. 2007 Jul; 31(5):383-95. . View in PubMed

XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12):2384-90. . View in PubMed

Age-related smoking progression among adolescents in China J Adolesc Health. 2006 Nov; 39(5):686-93. . View in PubMed

Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma Cancer Epidemiol Biomarkers Prev. 2006 Nov; 15(11):2285-91. . View in PubMed

A testing framework for identifying susceptibility genes in the presence of epistasis Am J Hum Genet. 2006 Jan; 78(1):15-27. . View in PubMed

Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis BMC Genet. 2005 Dec 30; 6 Suppl 1:S147. . View in PubMed

Testing association and linkage using affected-sib-parent study designs Genet Epidemiol. 2005 Nov; 29(3):225-33. . View in PubMed

Intercellular adhesion molecule-1 and childhood asthma Hum Genet. 2005 Sep; 117(5):476-84. . View in PubMed

Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort J Clin Endocrinol Metab. 2005 Apr; 90(4):2198-204. . View in PubMed

SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for multilocus data Genet Epidemiol. 2004 Dec; 27(4):429-41. . View in PubMed

A survey of current Bayesian gene mapping methods Hum Genomics. 2004 Aug; 1(5):371-4. . View in PubMed

Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness Cancer Epidemiol Biomarkers Prev. 2004 Aug; 13(8):1331-6. . View in PubMed

Genetic dissection of complex traits with chromosome substitution strains of mice Science. 2004 Apr 16; 304(5669):445-8. . View in PubMed

Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the AR Prostate. 2004 Apr 01; 59(1):69-76. . View in PubMed

Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2 Eur J Hum Genet. 2004 Apr; 12(4):321-32. . View in PubMed

Commentary: the concept of 'Mendelian Randomization' Int J Epidemiol. 2004 Feb; 33(1):21-5. . View in PubMed

DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer Cancer Epidemiol Biomarkers Prev. 2004 Jan; 13(1):23-9. . View in PubMed

Comparison of missing data approaches in linkage analysis BMC Genet. 2003 Dec 31; 4 Suppl 1:S44. . View in PubMed

CYP3A4 and CYP3A5 genotypes, haplotypes, and risk of prostate cancer Cancer Epidemiol Biomarkers Prev. 2003 Sep; 12(9):928-32. . View in PubMed

Prostate cancer aggressiveness locus on chromosome segment 19q12-q131 identified by linkage and allelic imbalance studies. Genes Chromosomes Cancer. 2003 Apr; 36(4):332-9. . View in PubMed

Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations Am J Hum Genet. 2003 Feb; 72(2):351-63. . View in PubMed

Bayesian modeling of complex metabolic pathways Hum Hered. 2003; 56(1-3):83-93. . View in PubMed

Bayesian spatial modeling of haplotype associations Hum Hered. 2003; 56(1-3):32-40. . View in PubMed

Prostate cancer aggressiveness locus on chromosome 7q32-q33 identified by linkage and allelic imbalance studies Neoplasia. 2002 Sep-Oct; 4(5):424-31. . View in PubMed

Impact of preadjusting a quantitative phenotype prior to sib-pair linkage analysis when gene x environment interaction exists Genet Epidemiol. 2001; 21 Suppl 1:S837-42. . View in PubMed

Replication linkage study for prostate cancer susceptibility genes Prostate. 2000 Oct 01; 45(2):106-14. . View in PubMed

Genomewide scan for prostate cancer-aggressiveness loci Am J Hum Genet. 2000 Jul; 67(1):92-9. . View in PubMed

The Conti Lab performs research in genetic and environmental epidemiology with a particular interest in identifying and characterizing risk factors across populations. This includes development of statistical methods and applied collaborations. Methodological research aims to integrate multiple omic measurements, biological knowledge, and external prior information in statistical modeling, primarily focusing on the use of Bayesian hierarchical models. More recently, we have been developing a stochastic epidemic model for the COVID-19 pandemic in Los Angeles County. https://contilab.usc.edu
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