Keck School Faculty

David Warburton, MD
David Warburton, MD
Professor of Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles
Professor David Warburton is a world leader in child health and regenerative medicine. Born and medically educated in London, at Harvard and Brown, he has made a broad translational impact in pediatrics. His major contributions range from clinical studies establishing management practices of extreme prematurity, to infants of diabetics, to basic mechanisms of organ morphogenesis, repair and regeneration. He is thus a seminal figure in neonatal- perinatal medicine, developmental biology, stem cell biology and regenerative medicine. His most highly cited work established and leads the field of molecular embryology of the lung, showing how growth factors and matrix molecules direct formation and repair of the gas exchange surface. Active UK collaborations include Liverpool, Cardiff and London, supported by UK Foreign and Commonwealth Office, MRC, BBSRC and build on his NIH and CIRM funded programs. He mentors UK Doctoral and Postdoctoral Fellows (Basic Science and Clinical), supported by funders ranging from MRC and Wellcome Trust to Royal College of Surgeons of England. An elected Fellow of the Royal Colleges of Surgeons, Physicians as well as Paediatrics and Child Health, he regularly gives keynotes at major US and world scientific meetings as well as teaching in Liverpool, Cardiff, Birmingham and London. In Los Angeles, he hosts UK and other foreign scientific delegations including the Ministers of Science, Heads of Welsh and Scottish Parliaments, Lords Mayor of Manchester and London and HRH Prince Andrew. His personal contribution and enthusiastic support for UK/US Science collaboration has been recognized by several awards including, in 2009, the Order of the British Empire. His commitment to the development of science for human benefit is evident from his many scientific and clinical discoveries, his personal mentoring through to his public advising.

Discordant roles for FGF ligands in lung branching morphogenesis between human and mouse J Pathol. 2018 Oct 25. . View in PubMed

Impact of Seasonal Winter Air Pollution on Health across the Lifespan in Mongolia and Some Putative Solutions Ann Am Thorac Soc. 2018 Apr; 15(Supplement_2):S86-S90. . View in PubMed

Fiber pattern removal and image reconstruction method for snapshot mosaic hyperspectral endoscopic images Biomed Opt Express. 2018 Feb 01; 9(2):780-790. . View in PubMed

Human lung branching morphogenesis is orchestrated by the spatiotemporal distribution of ACTA2, SOX2, and SOX9 Am J Physiol Lung Cell Mol Physiol. 2018 01 01; 314(1):L144-L149. . View in PubMed

LungMAP: The Molecular Atlas of Lung Development Program Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L733-L740. . View in PubMed

Collagenolytic Activity Is Associated with Scar Resolution in Zebrafish Hearts after Cryoinjury J Cardiovasc Dev Dis. 2017 Feb 24; 4(1). . View in PubMed

Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes Am J Physiol Lung Cell Mol Physiol. 2017 Feb 01; 312(2):L196-L207. . View in PubMed

Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung Thorax. 2017 05; 72(5):451-459. . View in PubMed

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization Am J Pathol. 2016 Dec; 186(12):3261-3272. . View in PubMed

Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease J Clin Med. 2016 Feb 19; 5(2). . View in PubMed

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization Am J Pathol. 2016 12; 186(12):3261-3272. . View in PubMed

Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality EMBO Mol Med. 2016 11; 8(11):1340-1359. . View in PubMed

Can Alveolar Macrophages Made from Stem Cells Achieve Functional Rescue of Lung Diseases? Am J Respir Crit Care Med. 2016 06 01; 193(11):1187-8.. View in PubMed

Increased alveolar soluble annexin V promotes lung inflammation and fibrosis Eur Respir J. 2015 Nov; 46(5):1417-29. . View in PubMed

Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung J Theor Biol. 2015 Oct 07; 382:378-85. . View in PubMed

A novel profibrotic mechanism mediated by TGFß-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells J Pathol. 2015 Jul; 236(3):384-94. . View in PubMed

Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development BMC Biol. 2015 Jun 20; 13:42. . View in PubMed

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis Nat Commun. 2015 Apr 13; 6:6798. . View in PubMed

A Grhl2-dependent gene network controls trophoblast branching morphogenesis Development. 2015 Mar 15; 142(6):1125-36. . View in PubMed

Differential regenerative capacity of neonatal mouse hearts after cryoinjury Dev Biol. 2015 Mar 01; 399(1):91-99. . View in PubMed

Morphogenetic Implications of Peristalsis-Driven Fluid Flow in the Embryonic Lung PLoS One. 2015; 10(7):e0132015. . View in PubMed

Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission BMC Biol. 2014 Nov 11; 12:92. . View in PubMed

Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis Am J Physiol Lung Cell Mol Physiol. 2014 Mar 01; 306(5):L405-19. . View in PubMed

Branching patterns emerge in a mathematical model of the dynamics of lung development J Physiol. 2014 Jan 15; 592(2):313-24. . View in PubMed

Lung mesenchymal expression of Sox9 plays a critical role in tracheal development BMC Biol. 2013 Nov 25; 11:117. . View in PubMed

Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling Dev Biol. 2013 Oct 01; 382(1):110-23. . View in PubMed

Environmental pollution in Mongolia: effects across the lifespan Environ Res. 2013 Jul; 124:65-6. . View in PubMed

Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse modelUrology. 2013 Jul; 82(1):253. e9-15. . View in PubMed

Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage PLoS One. 2013; 8(8):e71679. . View in PubMed

New ideas in lung regeneration: a personal view from Estoril Expert Rev Respir Med. 2012 Nov; 6(5):507-8. . View in PubMed

FGF9-Pitx2-FGF10 signaling controls cecal formation in mice Dev Biol. 2012 Sep 15; 369(2):340-8. . View in PubMed

Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium J Cell Sci. 2012 Sep 01; 125(Pt 17):4036-48. . View in PubMed

Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice Am J Physiol Lung Cell Mol Physiol. 2012 Jul; 303(2):L89-96. . View in PubMed

Modulating the alveolar milieu to enhance resolution of fibrotic lung injury Proc Am Thorac Soc. 2012 Jul; 9(3):117-9. . View in PubMed

Injection of amniotic fluid stem cells delays progression of renal fibrosis J Am Soc Nephrol. 2012 Apr; 23(4):661-73. . View in PubMed

Embryonic epithelial Pten deletion through Nkx21-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-122. . View in PubMed

Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation PLoS One. 2012; 7(7):e40314. . View in PubMed

Mesenchymal-specific inhibition of vascular endothelial growth factor (VEGF) attenuates growth in neonatal mice J Surg Res. 2012 Jan; 172(1):40-7. . View in PubMed

Cell-based therapies for lung disease Br Med Bull. 2012; 101:147-61. . View in PubMed

MIR-99a and MIR-99b modulate TGF-ß induced epithelial to mesenchymal plasticity in normal murine mammary gland cells PLoS One. 2012; 7(1):e31032. . View in PubMed

Isolation and characterization of distal lung progenitor cells Methods Mol Biol. 2012; 879:109-22. . View in PubMed

Impact of stem cells in craniofacial regenerative medicine Front Physiol. 2012; 3:188. . View in PubMed

Developmental responses to lung injury: repair or fibrosis Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S2. . View in PubMed

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L391-401. . View in PubMed

A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways Development. 2011 Jun; 138(11):2359-68. . View in PubMed

Carbon monoxide pollution and lung function in urban compared with rural Mongolian children Respirology. 2011 May; 16(4):653-8. . View in PubMed

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium Development. 2011 Apr; 138(7):1395-407. . View in PubMed

Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung Dev Biol. 2011 Feb 01; 350(1):112-26. . View in PubMed

Cell polarity and spindle orientation in the distal epithelium of embryonic lung Dev Dyn. 2011 Feb; 240(2):441-5. . View in PubMed

A modified technique for partial pneumonectomy in the mouse J Invest Surg. 2011; 24(2):81-6. . View in PubMed

FGF10 controls the patterning of the tracheal cartilage rings via Shh Development. 2011 Jan; 138(2):273-82. . View in PubMed

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair PLoS One. 2011; 6(8):e23139. . View in PubMed

Entrained pulmonary clocks: epithelium and vasculature keeping pace Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L453-4. . View in PubMed

Mouse embryonic lung culture, a system to evaluate the molecular mechanisms of branching J Vis Exp. 2010 Jun 30; (40). . View in PubMed

Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications J Urol. 2010 Mar; 183(3):1193-200. . View in PubMed

A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma Am J Respir Crit Care Med. 2010 Feb 15; 181(4):328-36. . View in PubMed

Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation Methods Mol Biol. 2010; 633:71-9. . View in PubMed

Genes and signals regulating murine trophoblast cell development Mech Dev. 2010 Jan-Feb; 127(1-2):1-20. . View in PubMed

Lung organogenesis Curr Top Dev Biol. 2010; 90:73-158. . View in PubMed

Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease? Proc Am Thorac Soc. 2009 Dec 01; 6(7):614-7.. View in PubMed

Introduction: Ninth Lund COPD Symposium Proc Am Thorac Soc. 2009 Dec 01; 6(7):557. . View in PubMed

Bcr and Abr cooperate in negatively regulating acute inflammatory responses Mol Cell Biol. 2009 Nov; 29(21):5742-50. . View in PubMed

Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome Pediatr Res. 2009 Oct; 66(4):386-90. . View in PubMed

miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution Dev Biol. 2009 Sep 15; 333(2):238-50. . View in PubMed

Development, repair and fibrosis: what is common and why it matters Respirology. 2009 Jul; 14(5):656-65. . View in PubMed

Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha J Physiol. 2009 Apr 15; 587(Pt 8):1739-53. . View in PubMed

Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages Stem Cells. 2008 Nov; 26(11):2902-11. . View in PubMed

Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha Biochem Biophys Res Commun. 2008 Oct 24; 375(3):460-4. . View in PubMed

Developmental biology: order in the lung Nature. 2008 Jun 05; 453(7196):733-5. . View in PubMed

Centrifugal migration of mesenchymal cells in embryonic lung Dev Dyn. 2008 Mar; 237(3):750-7. . View in PubMed

Lung development and adult lung diseases Chest. 2007 Aug; 132(2):651-6. . View in PubMed

Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development Dev Biol. 2007 Jul 15; 307(2):237-47. . View in PubMed

Meeting report: the first international collaborative symposium on stem cell research, Seoul, Korea Stem Cells. 2007 May; 25(5):1337-8. . View in PubMed

Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development Dev Biol. 2006 Nov 15; 299(2):373-85. . View in PubMed

Lung development and susceptibility to chronic obstructive pulmonary disease Proc Am Thorac Soc. 2006 Nov; 3(8):668-72. . View in PubMed

Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung Dev Biol. 2006 Nov 01; 299(1):52-62. . View in PubMed

BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction J Biol Chem. 2006 Sep 29; 281(39):29349-56. . View in PubMed

Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung Dev Biol. 2006 May 01; 293(1):77-89. . View in PubMed

Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrity Am J Pathol. 2005 Oct; 167(4):921-2. . View in PubMed

A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis Dev Biol. 2005 Jun 15; 282(2):422-31. . View in PubMed

Infection-induced kinin B1 receptors in human pulmonary fibroblasts: role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling J Pharmacol Exp Ther. 2005 Jun; 313(3):1231-8. . View in PubMed

Molecular mechanisms of early lung specification and branching morphogenesis Pediatr Res. 2005 May; 57(5 Pt 2):26R-37R. . View in PubMed

Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L683-91. . View in PubMed

Fibroblast growth factor-10 serves a regulatory role in duodenal development J Pediatr Surg. 2005 Feb; 40(2):313-6. . View in PubMed

Colonic atresia without mesenteric vascular occlusionThe role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg. 2005 Feb; 40(2):390-6. . View in PubMed

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung Dev Biol. 2005 Jan 15; 277(2):316-31. . View in PubMed

Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L52-9. . View in PubMed

Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia J Pediatr Surg. 2004 Jun; 39(6):872-4. . View in PubMed

Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L658-67. . View in PubMed

Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice J Pediatr Surg. 2004 Mar; 39(3):360-5; discussion 360-5. . View in PubMed

Functional analysis of the human Sprouty2 gene promoter Gene. 2003 Dec 11; 322:175-85. . View in PubMed

Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cell line: signaling through CD14 and mitogen-activated protein kinase Pediatr Res. 2003 Sep; 54(3):297-305. . View in PubMed

Fibrillin controls TGF-beta activation Nat Genet. 2003 Mar; 33(3):331-2. . View in PubMed

Nongenomic estrogen action regulates tyrosine phosphatase activity and tuberin stability Mol Cell Endocrinol. 2003 Jan 31; 199(1-2):143-51. . View in PubMed

Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry Respir Res. 2003; 4:5. . View in PubMed

Differential expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in early and late gestational mouse skin and skin wounds Wound Repair Regen. 2002 Nov-Dec; 10(6):387-96. . View in PubMed

Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse J Pediatr Surg. 2002 Sep; 37(9):1263-8. . View in PubMed

Murine nitrofen-induced pulmonary hypoplasia does not involve induction of TGF-beta signaling J Pediatr Surg. 2002 Aug; 37(8):1123-7. . View in PubMed

Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny? Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S59-62.. View in PubMed

Molecular embryology of the lung: then, now, and in the future Am J Physiol. 1999 May; 276(5 Pt 1):L697-704. . View in PubMed

Molecular embryology of the lung: then, now, and in the future Am J Physiol. 1999 05; 276(5):L697-704. . View in PubMed

Commitment and differentiation of lung cell lineages Biochem Cell Biol. 1998; 76(6):971-95. . View in PubMed

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