Keck School Faculty

David Warburton

David Warburton

Professor of Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles

A personal appreciation of Mary Ellen Avery for World Prematurity Day Am J Physiol Lung Cell Mol Physiol. 2022 Nov 01; 323(5):L640-L642. . View in PubMed

Extracellular Vesicles as Therapy for Congenital Diaphragmatic Hernia-associated Pulmonary Hypoplasia: Extra! Extra! Read All About Autophagy! Am J Respir Crit Care Med 2022 08 15; 206(4):373-375. . View in PubMed

Integrating quantitative and qualitative approaches to assess wintertime illness-related absenteeism and its direct and indirect costs among the private sector in Ulaanbaatar PLoS One. 2022; 17(2):e0263220. . View in PubMed

Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3ß-mediated restriction of epithelial IL-33 Nat Commun. 2021 02 05; 12(1):836. . View in PubMed

Editorial: Branching Morphogenesis During Embryonic Lung Development Front Cell Dev Biol. 2021; 9:728954. . View in PubMed

Winter Air Pollution from Domestic Coal Fired Heating in Ulaanbaatar, Mongolia, Is Strongly Associated with a Major Seasonal Cyclic Decrease in Successful Fecundity Int J Environ Res Public Health. 2021 03 09; 18(5). . View in PubMed

Conserved Mechanisms in the Formation of the Airways and Alveoli of the Lung Front Cell Dev Biol. 2021; 9:662059. . View in PubMed

YAP and TAZ in Lung Development: The Timing Is Important Am J Respir Cell Mol Biol. 2020 02; 62(2):141-142. . View in PubMed

Failure to Down-Regulate miR-154 Expression in Early Postnatal Mouse Lung Epithelium Suppresses Alveologenesis, with Changes in Tgf-ß Signaling Similar to those Induced by Exposure to Hyperoxia Cells. 2020 04 02; 9(4). . View in PubMed

Pre-processing visualization of hyperspectral fluorescent data with Spectrally Encoded Enhanced Representations Nat Commun. 2020 02 05; 11(1):726. . View in PubMed

Reply to de Steenhuijsen Piters and Bogaert: Bacterial DNA in Fetal Lung Samples May Be Explained by Sample Contamination Am J Respir Crit Care Med. 2020 05 15; 201(10):1311-1312. . View in PubMed

Human Fetal Lungs Harbor a Microbiome Signature Am J Respir Crit Care Med. 2020 04 15; 201(8):1002-1006. . View in PubMed

Mesenchyme-specific deletion of Tgf-ß1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia Lab Invest. 2019 09; 99(9):1363-1375. . View in PubMed

Discordant roles for FGF ligands in lung branching morphogenesis between human and mouse J Pathol. 2019 02; 247(2):254-265. . View in PubMed

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation Sci Rep. 2019 03 28; 9(1):5296. . View in PubMed

Approaching Clinical Trials in Childhood Interstitial Lung Disease and Pediatric Pulmonary Fibrosis Am J Respir Crit Care Med. 2019 11 15; 200(10):1219-1227. . View in PubMed

Differential epithelial growth in tissue-engineered larynx and trachea generated from postnatal and fetal progenitor cells Biochem Biophys Res Commun. 2019 03 05; 510(2):205-210. . View in PubMed

Normal lung development needs self-eating J Clin Invest. 2019 06 04; 129(7):2658-2659. . View in PubMed

Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung Am J Physiol Lung Cell Mol Physiol. 2019 09 01; 317(3):L347-L360. . View in PubMed

Fiber pattern removal and image reconstruction method for snapshot mosaic hyperspectral endoscopic images Biomed Opt Express. 2018 Feb 01; 9(2):780-790. . View in PubMed

Impact of Seasonal Winter Air Pollution on Health across the Lifespan in Mongolia and Some Putative Solutions Ann Am Thorac Soc. 2018 04; 15(Suppl 2):S86-S90. . View in PubMed

Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development Sci Rep. 2018 05 29; 8(1):8334. . View in PubMed

Human lung branching morphogenesis is orchestrated by the spatiotemporal distribution of ACTA2, SOX2, and SOX9 Am J Physiol Lung Cell Mol Physiol. 2018 01 01; 314(1):L144-L149. . View in PubMed

LungMAP: The Molecular Atlas of Lung Development Program Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L733-L740. . View in PubMed

SERCA directs cell migration and branching across species and germ layers Biol Open. 2017 Oct 15; 6(10):1458-1471. . View in PubMed

Collagenolytic Activity Is Associated with Scar Resolution in Zebrafish Hearts after Cryoinjury J Cardiovasc Dev Dis. 2017 Feb 24; 4(1). . View in PubMed

Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes Am J Physiol Lung Cell Mol Physiol. 2017 Feb 01; 312(2):L196-L207. . View in PubMed

The Oxygen Paradox, the French Paradox, and age-related diseases Geroscience. 2017 12; 39(5-6):499-550. . View in PubMed

Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung Thorax. 2017 05; 72(5):451-459. . View in PubMed

Retraction: Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epitheliumDevelopment doi: 10. 1242/dev. 058479. Development. 2017 10 15; 144(20):3849. . View in PubMed

Retraction: Eya1 protein phosphatase regulates tight junction formation in lung distal epitheliumJ. Cell. Sci. doi: 10. 1242/102848. J Cell Sci. 2017 10 15; 130(20):3601. . View in PubMed

Overview of Lung Development in the Newborn Human Neonatology. 2017; 111(4):398-401. . View in PubMed

Quantifying cellular and subcellular stretches in embryonic lung epithelia under peristalsis: where to look for mechanosensing Interface Focus. 2016 Oct 06; 6(5):20160031. . View in PubMed

The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR Sci Rep. 2016 Feb 25; 6:21975. . View in PubMed

Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease J Clin Med. 2016 Feb 19; 5(2). . View in PubMed

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization Am J Pathol. 2016 12; 186(12):3261-3272. . View in PubMed

Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality EMBO Mol Med. 2016 11; 8(11):1340-1359. . View in PubMed

Can Alveolar Macrophages Made from Stem Cells Achieve Functional Rescue of Lung Diseases? Am J Respir Crit Care Med. 2016 06 01; 193(11):1187-8.. View in PubMed

Quantifying stretch and secretion in the embryonic lung: Implications for morphogenesis Mech Dev. 2015 Nov; 138 Pt 3:356-63. . View in PubMed

Increased alveolar soluble annexin V promotes lung inflammation and fibrosis Eur Respir J. 2015 Nov; 46(5):1417-29. . View in PubMed

Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung J Theor Biol. 2015 Oct 07; 382:378-85. . View in PubMed

A novel profibrotic mechanism mediated by TGFß-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells J Pathol. 2015 Jul; 236(3):384-94. . View in PubMed

Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development BMC Biol. 2015 Jun 20; 13:42. . View in PubMed

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis Nat Commun. 2015 Apr 13; 6:6798. . View in PubMed

A Grhl2-dependent gene network controls trophoblast branching morphogenesis Development. 2015 Mar 15; 142(6):1125-36. . View in PubMed

Differential regenerative capacity of neonatal mouse hearts after cryoinjury Dev Biol. 2015 Mar 01; 399(1):91-99. . View in PubMed

Morphogenetic Implications of Peristalsis-Driven Fluid Flow in the Embryonic Lung PLoS One. 2015; 10(7):e0132015. . View in PubMed

Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission BMC Biol. 2014 Nov 11; 12:92. . View in PubMed

Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia BMC Pregnancy Childbirth. 2014 Apr 23; 14:146. . View in PubMed

Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis Am J Physiol Lung Cell Mol Physiol. 2014 Mar 01; 306(5):L405-19. . View in PubMed

Branching patterns emerge in a mathematical model of the dynamics of lung development J Physiol. 2014 Jan 15; 592(2):313-24. . View in PubMed

Lung mesenchymal expression of Sox9 plays a critical role in tracheal development BMC Biol. 2013 Nov 25; 11:117. . View in PubMed

Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer BMC Biol. 2013 Nov 13; 11:111. . View in PubMed

Stem cells: a recapitulation of development Respirology. 2013 Nov; 18(8):1167-76. . View in PubMed

Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling Dev Biol. 2013 Oct 01; 382(1):110-23. . View in PubMed

Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin a6ß1-ADAM17/tumor necrosis factor-a-converting enzyme (TACE) signaling pathway J Biol Chem. 2013 Aug 30; 288(35):25646-25657. . View in PubMed

Wingless: developmentally important genes that respond adversely to smoking Thorax. 2013 Aug; 68(8):703-4. . View in PubMed

Environmental pollution in Mongolia: effects across the lifespan Environ Res. 2013 Jul; 124:65-6. . View in PubMed

Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse modelUrology. 2013 Jul; 82(1):253. e9-15. . View in PubMed

2013 Jan 15; 304(2):L83-5. . View in PubMed

Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage PLoS One. 2013; 8(8):e71679. . View in PubMed

New ideas in lung regeneration: a personal view from Estoril Expert Rev Respir Med. 2012 Nov; 6(5):507-8. . View in PubMed

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation J Biol Chem. 2012 Oct 26; 287(44):37282-95. . View in PubMed

FGF9-Pitx2-FGF10 signaling controls cecal formation in mice Dev Biol. 2012 Sep 15; 369(2):340-8. . View in PubMed

Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium J Histochem Cytochem. 2012 Sep; 60(9):675-82. . View in PubMed

Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium J Cell Sci. 2012 Sep 01; 125(Pt 17):4036-48. . View in PubMed

Wound healing in development Birth Defects Res C Embryo Today. 2012 Sep; 96(3):213-22. . View in PubMed

Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice Am J Physiol Lung Cell Mol Physiol. 2012 Jul; 303(2):L89-96. . View in PubMed

Modulating the alveolar milieu to enhance resolution of fibrotic lung injury Proc Am Thorac Soc. 2012 Jul; 9(3):117-9. . View in PubMed

Injection of amniotic fluid stem cells delays progression of renal fibrosis J Am Soc Nephrol. 2012 Apr; 23(4):661-73. . View in PubMed

Embryonic epithelial Pten deletion through Nkx21-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-122. . View in PubMed

Cell-based therapies for lung disease Br Med Bull. 2012; 101:147-61. . View in PubMed

Impact of stem cells in craniofacial regenerative medicine Front Physiol. 2012; 3:188. . View in PubMed

Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation PLoS One. 2012; 7(7):e40314. . View in PubMed

Developmental responses to lung injury: repair or fibrosis Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S2. . View in PubMed

MIR-99a and MIR-99b modulate TGF-ß induced epithelial to mesenchymal plasticity in normal murine mammary gland cells PLoS One. 2012; 7(1):e31032. . View in PubMed

Mesenchymal-specific inhibition of vascular endothelial growth factor (VEGF) attenuates growth in neonatal mice J Surg Res. 2012 Jan; 172(1):40-7. . View in PubMed

Isolation and characterization of distal lung progenitor cells Methods Mol Biol. 2012; 879:109-22. . View in PubMed

The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1212-21. . View in PubMed

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L391-401. . View in PubMed

VEGF optimizes the formation of tissue-engineered small intestine Regen Med. 2011 Sep; 6(5):559-67. . View in PubMed

A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways Development. 2011 Jun; 138(11):2359-68. . View in PubMed

Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs Am J Respir Cell Mol Biol. 2011 Jun; 44(6):870-8. . View in PubMed

Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L898-909. . View in PubMed

Stem cells and cell therapies in lung biology and lung diseases Proc Am Thorac Soc. 2011 Jun; 8(3):223-72. . View in PubMed

Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung Dev Biol. 2011 May 15; 353(2):242-58. . View in PubMed

Carbon monoxide pollution and lung function in urban compared with rural Mongolian children Respirology. 2011 May; 16(4):653-8. . View in PubMed

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium Development. 2011 Apr; 138(7):1395-407. . View in PubMed

Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung Dev Biol. 2011 Feb 01; 350(1):112-26. . View in PubMed

Cell polarity and spindle orientation in the distal epithelium of embryonic lung Dev Dyn. 2011 Feb; 240(2):441-5. . View in PubMed

A modified technique for partial pneumonectomy in the mouse J Invest Surg. 2011; 24(2):81-6. . View in PubMed

FGF10 controls the patterning of the tracheal cartilage rings via Shh Development. 2011 Jan; 138(2):273-82. . View in PubMed

Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty Cancer Biol Ther. 2011 Jan 01; 11(1):122-4. . View in PubMed

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair PLoS One. 2011; 6(8):e23139. . View in PubMed

Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis Eur Respir J. 2010 Oct; 36(4):907-14. . View in PubMed

Entrained pulmonary clocks: epithelium and vasculature keeping pace Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L453-4. . View in PubMed

On the derivation and clinical implications of "driver" mutations in lung cancer Am J Respir Crit Care Med. 2010 Jul 01; 182(1):4-5. . View in PubMed

Mouse embryonic lung culture, a system to evaluate the molecular mechanisms of branching J Vis Exp. 2010 Jun 30; (40). . View in PubMed

Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications J Urol. 2010 Mar; 183(3):1193-200. . View in PubMed

Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis PLoS One. 2010 Feb 24; 5(2):e9357. . View in PubMed

A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma Am J Respir Crit Care Med. 2010 Feb 15; 181(4):328-36. . View in PubMed

Lung organogenesis Curr Top Dev Biol. 2010; 90:73-158. . View in PubMed

O-GlcNAc mediated glycosylation down-regulation in mice with cyclophosphamide induced cystitis J Urol. 2010 Jan; 183(1):351-6. . View in PubMed

Genes and signals regulating murine trophoblast cell development Mech Dev. 2010 Jan-Feb; 127(1-2):1-20. . View in PubMed

Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation Methods Mol Biol. 2010; 633:71-9. . View in PubMed

Is COPD in adulthood really so far removed from early development? Eur Respir J. 2010 Jan; 35(1):12-3.. View in PubMed

Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease? Proc Am Thorac Soc. 2009 Dec 01; 6(7):614-7.. View in PubMed

Introduction: Ninth Lund COPD Symposium Proc Am Thorac Soc. 2009 Dec 01; 6(7):557. . View in PubMed

Bcr and Abr cooperate in negatively regulating acute inflammatory responses Mol Cell Biol. 2009 Nov; 29(21):5742-50. . View in PubMed

Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome Pediatr Res. 2009 Oct; 66(4):386-90. . View in PubMed

miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution Dev Biol. 2009 Sep 15; 333(2):238-50. . View in PubMed

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice Am J Respir Crit Care Med. 2009 Sep 01; 180(5):424-36. . View in PubMed

Development, repair and fibrosis: what is common and why it matters Respirology. 2009 Jul; 14(5):656-65. . View in PubMed

Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha J Physiol. 2009 Apr 15; 587(Pt 8):1739-53. . View in PubMed

The 2nd International Collaborative Symposium on Stem Cell Research Regen Med. 2009 Jan; 4(1):129-31. . View in PubMed

Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR J Physiol. 2008 Dec 15; 586(24):6007-19. . View in PubMed

Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages Stem Cells. 2008 Nov; 26(11):2902-11. . View in PubMed

Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha Biochem Biophys Res Commun. 2008 Oct 24; 375(3):460-4. . View in PubMed

Stem/progenitor cells in lung development, injury repair, and regeneration Proc Am Thorac Soc. 2008 Aug 15; 5(6):703-6. . View in PubMed

TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung Eur Respir J. 2008 Aug; 32(2):285-95. . View in PubMed

Developmental biology: order in the lung Nature. 2008 Jun 05; 453(7196):733-5. . View in PubMed

The human gamma-glutamyltransferase gene family Hum Genet. 2008 May; 123(4):321-32. . View in PubMed

TGF-beta signaling promotes survival and repair in rat alveolar epithelial type 2 cells during recovery after hyperoxic injury Am J Physiol Lung Cell Mol Physiol. 2008 Apr; 294(4):L739-48. . View in PubMed

Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation Am J Pathol. 2008 Mar; 172(3):571-82. . View in PubMed

Centrifugal migration of mesenchymal cells in embryonic lung Dev Dyn. 2008 Mar; 237(3):750-7. . View in PubMed

Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway Mech Dev. 2008 Mar-Apr; 125(3-4):314-24. . View in PubMed

The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol. 2008; 40(3):362-82.. View in PubMed

Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3 Int J Biochem Cell Biol. 2008; 40(3):484-95. . View in PubMed

Three-dimensional computed tomography imaging in an animal model of emphysema Eur Respir J. 2007 Dec; 30(6):1082-9. . View in PubMed

Renal differentiation of amniotic fluid stem cells Cell Prolif. 2007 Dec; 40(6):936-48. . View in PubMed

When the lung is stretched, could it be thrombospondin via TGFbeta1 peptide activation? J Physiol. 2007 Oct 15; 584(Pt 2):365.. View in PubMed

TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA EMBO J. 2007 Sep 05; 26(17):3957-67. . View in PubMed

Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells J Cell Physiol. 2007 Sep; 212(3):796-806. . View in PubMed

Lung development and adult lung diseases Chest. 2007 Aug; 132(2):651-6. . View in PubMed

Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development Dev Biol. 2007 Jul 15; 307(2):237-47. . View in PubMed

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells Gene. 2007 May 15; 393(1-2):70-80. . View in PubMed

Meeting report: the first international collaborative symposium on stem cell research, Seoul, Korea Stem Cells. 2007 May; 25(5):1337-8. . View in PubMed

Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development Dev Biol. 2006 Nov 15; 299(2):373-85. . View in PubMed

Lung development and susceptibility to chronic obstructive pulmonary disease Proc Am Thorac Soc. 2006 Nov; 3(8):668-72. . View in PubMed

Smad3 signaling involved in pulmonary fibrosis and emphysema Proc Am Thorac Soc. 2006 Nov; 3(8):696-702. . View in PubMed

Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung Dev Biol. 2006 Nov 01; 299(1):52-62. . View in PubMed

BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction J Biol Chem. 2006 Sep 29; 281(39):29349-56. . View in PubMed

Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction Wound Repair Regen. 2006 Sep-Oct; 14(5):516-25. . View in PubMed

Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung Dev Biol. 2006 May 01; 293(1):77-89. . View in PubMed

VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis Dev Biol. 2006 Feb 01; 290(1):177-88. . View in PubMed

The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia J Pediatr Surg. 2006 Jan; 41(1):132-6; discussion 132-6. . View in PubMed

Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrity Am J Pathol. 2005 Oct; 167(4):921-2. . View in PubMed

A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis Dev Biol. 2005 Jun 15; 282(2):422-31. . View in PubMed

Infection-induced kinin B1 receptors in human pulmonary fibroblasts: role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling J Pharmacol Exp Ther. 2005 Jun; 313(3):1231-8. . View in PubMed

Smad1 expression and function during mouse embryonic lung branching morphogenesis Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1033-9. . View in PubMed

Molecular mechanisms of early lung specification and branching morphogenesis Pediatr Res. 2005 May; 57(5 Pt 2):26R-37R. . View in PubMed

Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L683-91. . View in PubMed

In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage through MAP kinase signaling Am J Physiol Lung Cell Mol Physiol. 2005 Mar; 288(3):L569-75. . View in PubMed

Fibroblast growth factor-10 serves a regulatory role in duodenal development J Pediatr Surg. 2005 Feb; 40(2):313-6. . View in PubMed

Colonic atresia without mesenteric vascular occlusionThe role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg. 2005 Feb; 40(2):390-6. . View in PubMed

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung Dev Biol. 2005 Jan 15; 277(2):316-31. . View in PubMed

A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway J Surg Res. 2004 Aug; 120(2):201-9. . View in PubMed

Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L52-9. . View in PubMed

Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia J Pediatr Surg. 2004 Jun; 39(6):872-4. . View in PubMed

Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L658-67. . View in PubMed

Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice J Pediatr Surg. 2004 Mar; 39(3):360-5; discussion 360-5. . View in PubMed

Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins Am J Physiol Lung Cell Mol Physiol. 2004 Feb; 286(2):L293-300. . View in PubMed

Stem/progenitor cells in lung morphogenesis, repair, and regeneration Curr Top Dev Biol. 2004; 64:1-16. . View in PubMed

BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells Am J Physiol Lung Cell Mol Physiol. 2004 Jan; 286(1):L81-6. . View in PubMed

The molecular genetics of lung morphogenesis and injury repair Paediatr Respir Rev. 2004; 5 Suppl A:S283-7. . View in PubMed

Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse Dev Biol. 2004 Jan 01; 265(1):61-74. . View in PubMed

Functional analysis of the human Sprouty2 gene promoter Gene. 2003 Dec 11; 322:175-85. . View in PubMed

Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia Am J Pathol. 2003 Dec; 163(6):2575-84. . View in PubMed

TACE is required for fetal murine cardiac development and modeling Dev Biol. 2003 Sep 15; 261(2):371-80. . View in PubMed

Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cell line: signaling through CD14 and mitogen-activated protein kinase Pediatr Res. 2003 Sep; 54(3):297-305. . View in PubMed

Fibrillin controls TGF-beta activation Nat Genet. 2003 Mar; 33(3):331-2. . View in PubMed

Nongenomic estrogen action regulates tyrosine phosphatase activity and tuberin stability Mol Cell Endocrinol. 2003 Jan 31; 199(1-2):143-51. . View in PubMed

Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry Respir Res. 2003; 4:5. . View in PubMed

Dynamics of metalloproteinase-2 and -9, TGF-beta, and uPA activities during normoxic vshyperoxic alveolarization. Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L747-54. . View in PubMed

mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L700-6. . View in PubMed

Murine nitrofen-induced pulmonary hypoplasia does not involve induction of TGF-beta signaling J Pediatr Surg. 2002 Aug; 37(8):1123-7. . View in PubMed

Sound the tocsin! Beware adverse effects of lung inflammation early in gestation Am J Respir Crit Care Med. 2002 Mar 15; 165(6):741-2. . View in PubMed

Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny? Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S59-62.. View in PubMed

Migration and gelatinases in cultured fetal, adult, and hyperoxic alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol. 2001 Aug; 281(2):L427-34. . View in PubMed

Abrogation of tumor necrosis factor-alpha converting enzyme inhibits embryonic lung morphogenesis in culture Int J Dev Biol. 2001 Jun; 45(4):623-31. . View in PubMed

Nongenomic estrogen action in human lung myofibroblasts Biochem Biophys Res Commun. 2001 May 11; 283(3):661-7. . View in PubMed

Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis Am J Physiol Lung Cell Mol Physiol. 2001 May; 280(5):L1030-9. . View in PubMed

Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis Mech Dev. 2001 Apr; 102(1-2):81-94. . View in PubMed

Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis Dev Biol. 2001 Apr 01; 232(1):204-18. . View in PubMed

EGF regulates early embryonic mouse gut development in chemically defined organ culture Pediatr Res. 2000 Dec; 48(6):794-802. . View in PubMed

Telomerase in alveolar epithelial development and repair Am J Physiol Lung Cell Mol Physiol. 2000 Dec; 279(6):L1191-8. . View in PubMed

Smad7 and Smad6 differentially modulate transforming growth factor beta -induced inhibition of embryonic lung morphogenesis J Biol Chem. 2000 Aug 04; 275(31):23992-7. . View in PubMed

A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function Biochem Biophys Res Commun. 2000 Jul 14; 273(3):1042-7. . View in PubMed

Endothelial monocyte activating polypeptide II inhibits lung neovascularization and airway epithelial morphogenesis Mech Dev. 2000 Jul; 95(1-2):123-32. . View in PubMed

Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins Exp Cell Res. 2000 May 25; 257(1):22-32. . View in PubMed

Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis Mech Dev. 2000 May; 93(1-2):71-81. . View in PubMed

Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation Biol Neonate. 2000 May; 77(4):217-23. . View in PubMed

Cytokine response during hyperoxia: sequential production of pulmonary tumor necrosis factor and interleukin-6 in neonatal rats Isr Med Assoc J. 2000 May; 2(5):365-9. . View in PubMed

The molecular basis of lung morphogenesis Mech Dev. 2000 Mar 15; 92(1):55-81. . View in PubMed

Developmental differences in the expression and modulation of extracellular matrix proteases and inhibitors in mouse skin fibroblasts Wound Repair Regen. 1999 Nov-Dec; 7(6):467-76. . View in PubMed

Spatial-specific TGF-beta1 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung Eur J Cell Biol. 1999 Oct; 78(10):715-25. . View in PubMed

Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants Mech Dev. 1999 Aug; 86(1-2):63-74. . View in PubMed

Current concepts on lung development Curr Opin Pediatr. 1999 Jun; 11(3):188-92. . View in PubMed

Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis Curr Biol. 1999 Feb 25; 9(4):219-22. . View in PubMed

TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids Am J Physiol. 1999 12; 277(6):L1205-13. . View in PubMed

Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis Am J Physiol. 1999 08; 277(2):L412-22. . View in PubMed

Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas Am J Physiol. 1999 08; 277(2):F277-89. . View in PubMed

ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2 Am J Physiol. 1999 07; 277(1):L159-66. . View in PubMed

Molecular embryology of the lung: then, now, and in the future Am J Physiol. 1999 05; 276(5):L697-704. . View in PubMed

Abrogation of cyclin D1 expression predisposes lung cancer cells to serum deprivation-induced apoptosis Am J Physiol. 1999 04; 276(4):L679-87. . View in PubMed

EMAP II: a modulator of neovascularization in the developing lung Am J Physiol. 1999 02; 276(2):L365-75. . View in PubMed

The Shc 66 and 46 kD isoforms are differentially downregulated at parturition in the fetal mouse lung Pediatr Res. 1998 Dec; 44(6):850-9. . View in PubMed

Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired Nat Genet. 1998 Oct; 20(2):180-3. . View in PubMed

Immunohistochemical localization of TGF-beta type II receptor and TGF-beta3 during palatogenesis in vivo and in vitro Int J Dev Biol. 1998 Sep; 42(6):817-20. . View in PubMed

Effortful processing is a requirement for nicotine-induced improvements in memory Psychopharmacology (Berl). 1998 Aug; 138(3-4):362-8. . View in PubMed

Abrogation of betaglycan attenuates TGF-beta-mediated inhibition of embryonic murine lung branching morphogenesis in culture Mech Dev. 1998 Jul; 75(1-2):67-79. . View in PubMed

Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-beta type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA Mech Dev. 1998 Mar; 72(1-2):89-100. . View in PubMed

Contractility, transforming growth factor-beta, and plasmin in fetal skin fibroblasts: role in scarless wound healing Pediatr Res. 1998 Mar; 43(3):403-9. . View in PubMed

Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture Dev Biol. 1998 Feb 15; 194(2):182-95. . View in PubMed

Laminin 2 attachment selects myofibroblasts from fetal mouse lung Am J Physiol. 1998 09; 275(3):L622-30. . View in PubMed

Apoptosis and DNA damage in type 2 alveolar epithelial cells cultured from hyperoxic rats Am J Physiol. 1998 05; 274(5):L714-20. . View in PubMed

Inhibition of vascular and epithelial differentiation in murine nitrofen-induced diaphragmatic hernia Am J Physiol. 1998 04; 274(4):L636-46. . View in PubMed

Nicotine stimulates branching and expression of SP-A and SP-C mRNAs in embryonic mouse lung culture Am J Physiol. 1998 01; 274(1):L165-70. . View in PubMed

Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis Dev Dyn. 1998 Jan; 211(1):11-25. . View in PubMed

Commitment and differentiation of lung cell lineages Biochem Cell Biol. 1998; 76(6):971-95. . View in PubMed

Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta Gene. 1997 Dec 05; 203(1):17-26. . View in PubMed

Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres Curr Biol. 1997 Nov 01; 7(11):901-4. . View in PubMed

Cell cycle in alveolar epithelial type II cells: integration of Matrigel and KGF Am J Physiol. 1997 Sep; 273(3 Pt 1):L572-80. . View in PubMed

TGF-beta isoforms differentially attenuate EGF mitogenicity and receptor activity in fetal lung mesenchymal cells Am J Physiol. 1997 Aug; 273(2 Pt 1):L374-81. . View in PubMed

Matrix Gla protein gene expression is induced by transforming growth factor-beta in embryonic lung culture Am J Physiol. 1997 Jul; 273(1 Pt 1):L282-7. . View in PubMed

Impaired lung branching morphogenesis in the absence of functional EGF receptor Dev Biol. 1997 Jun 15; 186(2):224-36. . View in PubMed

Coordination of genetic, epigenetic, and environmental factors in lung development, injury, and repair Chest. 1997 Jun; 111(6 Suppl):119S-122S. . View in PubMed

Cyclin D1 antisense RNA destabilizes pRb and retards lung cancer cell growth Am J Physiol. 1997 11; 273(5):L941-9. . View in PubMed

Abrogation of transforming growth factor-beta type II receptor stimulates embryonic mouse lung branching morphogenesis in culture Dev Biol. 1996 Nov 25; 180(1):242-57. . View in PubMed

Keratinocyte growth factor and embryonic rat lung morphogenesis Am J Respir Cell Mol Biol. 1996 Sep; 15(3):328-38. . View in PubMed

Dynamics of TGF-beta 3 peptide activity during rat alveolar epithelial cell proliferative recovery from acute hyperoxia Am J Physiol. 1996 Jul; 271(1 Pt 1):L54-60. . View in PubMed

Transforming growth factor-beta type-II receptor signalling: intrinsic/associated casein kinase activity, receptor interactions and functional effects of blocking antibodies Biochem J. 1996 May 15; 316 ( Pt 1):303-10. . View in PubMed

Increased expression of cyclin D1 and the Rb tumor suppressor gene in c-K-ras transformed rat enterocytes Oncogene. 1996 May 02; 12(9):1903-8. . View in PubMed

Cell cycle arrest in G0/G1 phase by contact inhibition and TGF-beta 1 in mink Mv1Lu lung epithelial cells Am J Physiol. 1996 May; 270(5 Pt 1):L879-88. . View in PubMed

Identification and characterization of three genes and two pseudogenes on chromosome 13 Hum Genet. 1996 Apr; 97(4):441-52. . View in PubMed

Factor XII-induced mitogenesis is mediated via a distinct signal transduction pathway that activates a mitogen-activated protein kinase Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):2174-9. . View in PubMed

Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages J Histochem Cytochem. 1996 Feb; 44(2):113-23. . View in PubMed

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction Nat Genet. 1995 Dec; 11(4):415-21. . View in PubMed

TTF-1 regulates lung epithelial morphogenesis Dev Biol. 1995 Dec; 172(2):694-8. . View in PubMed

Induction of A- and D-type cyclins and cdc2 kinase activity during recovery from short-term hyperoxic lung injury Am J Physiol. 1995 Apr; 268(4 Pt 1):L625-35. . View in PubMed

Differential expression of cyclin D2 and cdc2 genes in proliferating and nonproliferating alveolar epithelial cells Am J Respir Cell Mol Biol. 1995 Jan; 12(1):95-103. . View in PubMed

Improvements in performance without nicotine withdrawal Psychopharmacology (Berl). 1994 Aug; 115(4):539-42. . View in PubMed

No maternal age relationship for polyploidy Hum Genet. 1994 Jun; 93(6):725-6. . View in PubMed

Cell cycle-dependent expression of cyclin D1 and a 45 kD protein in human A549 lung carcinoma cells Am J Respir Cell Mol Biol. 1994 Apr; 10(4):437-47. . View in PubMed

Identification of a human epidermal growth factor receptor-associated protein kinase as a new member of the mitogen-activated protein kinase/extracellular signal-regulated protein kinase family J Biol Chem. 1993 Aug 25; 268(24):18213-7. . View in PubMed

Role of epidermal growth factor expression in early mouse embryo lung branching morphogenesis in culture: antisense oligodeoxynucleotide inhibitory strategy Dev Biol. 1993 Aug; 158(2):555-9. . View in PubMed

Cyclin A expression in normal and transformed alveolar epithelial cells Am J Respir Cell Mol Biol. 1993 Aug; 9(2):115-25. . View in PubMed

Construction of a yeast artificial chromosome contig spanning the spinal muscular atrophy disease gene region Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6801-5. . View in PubMed

Molecular embryology and the study of lung development Am J Respir Cell Mol Biol. 1993 Jul; 9(1):5-9. . View in PubMed

G1 expression and multistage dynamics of cyclin A in human osteosarcoma cells Oncogene. 1993 Jun; 8(6):1649-59. . View in PubMed

Two potentially oncogenic cyclins, cyclin A and cyclin D1, share common properties of subunit configuration, tyrosine phosphorylation and physical association with the Rb protein Oncogene. 1993 May; 8(5):1377-84. . View in PubMed

Phospholipid and surfactant protein A concentrations in tracheal aspirates from infants requiring extracorporeal membrane oxygenation J Pediatr. 1992 Aug; 121(2):271-4. . View in PubMed

Identification of epidermal growth factor Thr-669 phosphorylation site peptide kinases as distinct MAP kinases and p34cdc2 Biochim Biophys Acta. 1992 Jun 29; 1135(3):335-42. . View in PubMed

Plasminogen activator inhibitor type 1 production by rat type II pneumocytes in culture Am J Respir Cell Mol Biol. 1992 Feb; 6(2):133-9. . View in PubMed

Epidermal growth factor transcription, translation, and signal transduction by rat type II pneumocytes in culture Am J Respir Cell Mol Biol. 1992 Jan; 6(1):44-9. . View in PubMed

Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease Psychopharmacology (Berl). 1992; 108(4):485-94. . View in PubMed

Facilitation of memory by post-trial administration of nicotine: evidence for an attentional explanation Psychopharmacology (Berl). 1992; 108(4):452-5. . View in PubMed

Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis Dev Biol. 1992 Jan; 149(1):123-33. . View in PubMed

Corticosteroids, thyrotropin-releasing hormone, and antioxidant enzymes in preterm lamb lungs Pediatr Res. 1991 Dec; 30(6):518-21. . View in PubMed

Protein phosphorylation and dephosphorylation in type II pneumocytes Am J Physiol. 1991 Jun; 260(6 Pt 1):L548-54. . View in PubMed

Role of inositol triphosphate isomer formation in type II pneumocyte signal transduction Am J Respir Cell Mol Biol. 1991 Jun; 4(6):514-8. . View in PubMed

Augmentation of superoxide dismutase and catalase activity in alveolar type II cells Am J Respir Cell Mol Biol. 1991 Apr; 4(4):364-8. . View in PubMed

Epigenetic autocrine and paracrine factors regulating lung morphogenesisA paradigm for lung repair. Chest. 1991 Mar; 99(3 Suppl):15S-18S. . View in PubMed

Ontogeny of antioxidant enzymes in the fetal lamb lung Exp Lung Res. 1991 Jan-Feb; 17(1):39-45. . View in PubMed

Biologic markers in risk assessment for environmental carcinogens Environ Health Perspect. 1991 Jan; 90:247-54. . View in PubMed

Elevated plasma norepinephrine levels in infants of substance-abusing mothers Am J Dis Child. 1991 Jan; 145(1):44-8. . View in PubMed

Polycyclic aromatic hydrocarbon-DNA adducts in spontaneously aborted fetal tissue Carcinogenesis. 1990 Sep; 11(9):1673-5. . View in PubMed

Cytogenetic methods for the mouse: preparation of chromosomes, karyotyping, and in situ hybridization Anal Biochem. 1990 Aug 15; 189(1):1-17. . View in PubMed

Paternal age and trisomy among spontaneous abortions Hum Genet. 1990 Aug; 85(3):355-61. . View in PubMed

Puff-by-puff sensory evaluation of a low to middle tar medium nicotine cigarette designed to maintain nicotine delivery to the smoker Psychopharmacology (Berl). 1990; 102(3):343-9. . View in PubMed

Serial section-reconstruction of anomalous tracheobronchial branching patterns from CT scan images: bridging bronchus associated with sling left pulmonary artery Pediatr Radiol. 1990; 20(6):444-6. . View in PubMed

Sublethal oxidant injury inhibits signal transduction in rat type II pneumocytes Am J Physiol. 1989 Oct; 257(4 Pt 1):L217-20. . View in PubMed

Effects of beta-2 agonist on hepatic glycogen metabolism in the fetal lamb Pediatr Res. 1988 Sep; 24(3):330-2. . View in PubMed

Combined effects of corticosteroid, thyroid hormones, and beta-agonist on surfactant, pulmonary mechanics, and beta-receptor binding in fetal lamb lung Pediatr Res. 1988 Aug; 24(2):166-70. . View in PubMed

Chronic glucose infusion inhibits development of beta-receptor binding in fetal lamb lung Pediatr Res. 1988 Aug; 24(2):171-4. . View in PubMed

Ontogeny of protein phosphatases 1 and 2A in developing rat lung Pediatr Res. 1988 Jul; 24(1):25-7. . View in PubMed

Growth failure in infants with bronchopulmonary dysplasia: nutrition and elevated resting metabolic expenditure Pediatrics. 1988 Mar; 81(3):379-84. . View in PubMed

Effects of beta-2 agonist on tracheal fluid flow, surfactant and pulmonary mechanics in the fetal lamb J Pharmacol Exp Ther. 1987 Aug; 242(2):394-8. . View in PubMed

Effects of beta-2 agonist on metabolic regulation in the fetal lamb lung J Pharmacol Exp Ther. 1987 Aug; 242(2):389-93. . View in PubMed

Beta-receptors and surface active material flux in fetal lamb lung: female advantage J Appl Physiol (1985). 1987 Aug; 63(2):828-33. . View in PubMed

Verapamil: a novel probe of surfactant secretion from rat type II pneumocytes J Appl Physiol (1985). 1989 Mar; 66(3):1304-8. . View in PubMed

P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes J Appl Physiol (1985). 1989 Feb; 66(2):901-5. . View in PubMed

Effects of glucose infusion on surfactant and glycogen regulation in fetal lamb lung J Appl Physiol (1985). 1987 Nov; 63(5):1750-6. . View in PubMed

Triglycerides, free fatty acids, free fatty acids/albumin molar ratio, and cholesterol levels in serum of neonates receiving long-term lipid infusions: controlled trial of continuous and intermittent regimens J Pediatr. 1984 Mar; 104(3):429-35. . View in PubMed

Distal duplication 14q: report of three cases and further delineation of the syndrome Hum Genet. 1984; 68(2):159-64. . View in PubMed

Lipid-laden macrophages in tracheal aspirates of newborn infants receiving intravenous lipid infusions: a cytologic study Pediatr Pathol. 1984; 2(1):25-34. . View in PubMed

Furosemide acutely decreases airways resistance in chronic bronchopulmonary dysplasia J Pediatr. 1983 Oct; 103(4):624-9. . View in PubMed

Developmental pattern of maximal transdiaphragmatic pressure in infants during crying Pediatr Res. 1983 Sep; 17(9):707-9. . View in PubMed

Chronic hyperglycemia with secondary hyperinsulinemia inhibits the maturational response of fetal lamb lungs to cortisol J Clin Invest. 1983 Aug; 72(2):433-40. . View in PubMed

Chronic hyperglycemia reduces surface active material flux in tracheal fluid of fetal lambs J Clin Invest. 1983 Mar; 71(3):550-5. . View in PubMed

Effects of smoking on rapid information processing performance Neuropsychobiology. 1983; 9(4):223-9. . View in PubMed

The distribution of chromosomal genotypes associated with Turner's syndrome: livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural X abnormalities or mosaicism Hum Genet. 1983; 64(1):24-7. . View in PubMed

Diagnosis of cutaneous T cell lymphoma by use of monoclonal antibodies reactive with tumor-associated antigens J Clin Invest. 1982 Dec; 70(6):1205-15. . View in PubMed

Primary hyperinsulinemia reduces surface active material flux in tracheal fluid of fetal lambs Pediatr Res. 1981 Nov; 15(11):1422-4. . View in PubMed

Hyperviscosity in the newborn lamb produces pertubation in glucose homeostasis Pediatr Res. 1981 Oct; 15(10):1348-50. . View in PubMed

Endogenous posthepatic insulin secretion and metabolic clearance rates in the neonatal lamb Pediatr Res. 1980 Dec; 14(12):1391-4. . View in PubMed

Do numerical polymorphisms exist at the human 5 S locus? Hum Genet. 1980; 54(1):83-5.. View in PubMed

Regulation of rRNA gene expression in a human familial 14p+ marker chromosome Hum Genet. 1978 Sep 19; 43(3):289-97. . View in PubMed

A 9/11 translocation in a child with Ph1-negative chronic myelogenous leukemia J Pediatr. 1976 Apr; 88(4 Pt 1):599-601. . View in PubMed

The role of trypsin in the pre-treatment of chromosomes for Giemsa banding Hum Genet. 1976 Jan 28; 31(1):27-33. . View in PubMed

Spontaneous abortion as a screening deviceThe effect of fetal survival on the incidence of birth defects. Am J Epidemiol. 1975 Oct; 102(4):275-90. . View in PubMed

Application of new staining techniques to the study of human chromosomes Prog Med Genet. 1973; 9:1-47. . View in PubMed

Chromosome analysis of two related heteroploid mouse cell lines by quinacrine fluorescence J Cell Sci. 1973 Jan; 12(1):263-74. . View in PubMed

The cri du chat syndrome in adolescents and adults: clinical finding in 13 older patients with partial deletion of the short arm of chromosome No5(5p-). J Pediatr. 1970 Nov; 77(5):782-91. . View in PubMed

Partial deletion of the short arm of chromosome no4(4p-): clinical studies in five unrelated patients. J Pediatr. 1970 Nov; 77(5):792-801. . View in PubMed

Professor David Warburton is a world leader in child health and regenerative medicine. Born and medically educated in London, at Harvard and Brown, he has made a broad translational impact in pediatrics. His major contributions range from clinical studies establishing management practices of extreme prematurity, to infants of diabetics, to basic mechanisms of organ morphogenesis, repair and regeneration. He is thus a seminal figure in neonatal- perinatal medicine, developmental biology, stem cell biology and regenerative medicine. His most highly cited work established and leads the field of molecular embryology of the lung, showing how growth factors and matrix molecules direct formation and repair of the gas exchange surface. Active UK collaborations include Liverpool, Cardiff and London, supported by UK Foreign and Commonwealth Office, MRC, BBSRC and build on his NIH and CIRM funded programs. He mentors UK Doctoral and Postdoctoral Fellows (Basic Science and Clinical), supported by funders ranging from MRC and Wellcome Trust to Royal College of Surgeons of England. An elected Fellow of the Royal Colleges of Surgeons, Physicians as well as Paediatrics and Child Health, he regularly gives keynotes at major US and world scientific meetings as well as teaching in Liverpool, Cardiff, Birmingham and London. In Los Angeles, he hosts UK and other foreign scientific delegations including the Ministers of Science, Heads of Welsh and Scottish Parliaments, Lords Mayor of Manchester and London and HRH Prince Andrew. His personal contribution and enthusiastic support for UK/US Science collaboration has been recognized by several awards including, in 2009, the Order of the British Empire. His commitment to the development of science for human benefit is evident from his many scientific and clinical discoveries, his personal mentoring through to his public advising.
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