Keck School Faculty

David Warburton, MD
David Warburton, MD
Professor of Pediatrics
Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles
Professor David Warburton is a world leader in child health and regenerative medicine. Born and medically educated in London, at Harvard and Brown, he has made a broad translational impact in pediatrics. His major contributions range from clinical studies establishing management practices of extreme prematurity, to infants of diabetics, to basic mechanisms of organ morphogenesis, repair and regeneration. He is thus a seminal figure in neonatal- perinatal medicine, developmental biology, stem cell biology and regenerative medicine. His most highly cited work established and leads the field of molecular embryology of the lung, showing how growth factors and matrix molecules direct formation and repair of the gas exchange surface. Active UK collaborations include Liverpool, Cardiff and London, supported by UK Foreign and Commonwealth Office, MRC, BBSRC and build on his NIH and CIRM funded programs. He mentors UK Doctoral and Postdoctoral Fellows (Basic Science and Clinical), supported by funders ranging from MRC and Wellcome Trust to Royal College of Surgeons of England. An elected Fellow of the Royal Colleges of Surgeons, Physicians as well as Paediatrics and Child Health, he regularly gives keynotes at major US and world scientific meetings as well as teaching in Liverpool, Cardiff, Birmingham and London. In Los Angeles, he hosts UK and other foreign scientific delegations including the Ministers of Science, Heads of Welsh and Scottish Parliaments, Lords Mayor of Manchester and London and HRH Prince Andrew. His personal contribution and enthusiastic support for UK/US Science collaboration has been recognized by several awards including, in 2009, the Order of the British Empire. His commitment to the development of science for human benefit is evident from his many scientific and clinical discoveries, his personal mentoring through to his public advising.

Approaching Clinical Trials in Childhood ILD (chILD) and Pediatric Pulmonary Fibrosis Am J Respir Crit Care Med. 2019 Jul 19. . View in PubMed

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation Sci Rep. 2019 Mar 28; 9(1):5296. . View in PubMed

Differential epithelial growth in tissue-engineered larynx and trachea generated from postnatal and fetal progenitor cells Biochem Biophys Res Commun. 2019 Mar 05; 510(2):205-210. . View in PubMed

Discordant roles for FGF ligands in lung branching morphogenesis between human and mouse J Pathol. 2019 Feb; 247(2):254-265. . View in PubMed

Collagenolytic Activity Is Associated with Scar Resolution in Zebrafish Hearts after Cryoinjury J Cardiovasc Dev Dis. 2017 Feb 24; 4(1). . View in PubMed

Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes Am J Physiol Lung Cell Mol Physiol. 2017 Feb 01; 312(2):L196-L207. . View in PubMed

Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality EMBO Mol Med. 2016 11; 8(11):1340-1359. . View in PubMed

Can Alveolar Macrophages Made from Stem Cells Achieve Functional Rescue of Lung Diseases? Am J Respir Crit Care Med. 2016 06 01; 193(11):1187-8.. View in PubMed

A novel profibrotic mechanism mediated by TGFß-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells J Pathol. 2015 Jul; 236(3):384-94. . View in PubMed

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis Nat Commun. 2015 Apr 13; 6:6798. . View in PubMed

A Grhl2-dependent gene network controls trophoblast branching morphogenesis Development. 2015 Mar 15; 142(6):1125-36. . View in PubMed

Differential regenerative capacity of neonatal mouse hearts after cryoinjury Dev Biol. 2015 Mar 01; 399(1):91-99. . View in PubMed

Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission BMC Biol. 2014 Nov 11; 12:92. . View in PubMed

Branching patterns emerge in a mathematical model of the dynamics of lung development J Physiol. 2014 Jan 15; 592(2):313-24. . View in PubMed

Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling Dev Biol. 2013 Oct 01; 382(1):110-23. . View in PubMed

Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse modelUrology. 2013 Jul; 82(1):253. e9-15. . View in PubMed

Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage PLoS One. 2013; 8(8):e71679. . View in PubMed

Embryonic epithelial Pten deletion through Nkx21-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-122. . View in PubMed

Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation PLoS One. 2012; 7(7):e40314. . View in PubMed

Cell-based therapies for lung disease Br Med Bull. 2012; 101:147-61. . View in PubMed

Developmental responses to lung injury: repair or fibrosis Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S2. . View in PubMed

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L391-401. . View in PubMed

A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways Development. 2011 Jun; 138(11):2359-68. . View in PubMed

Carbon monoxide pollution and lung function in urban compared with rural Mongolian children Respirology. 2011 May; 16(4):653-8. . View in PubMed

Cell polarity and spindle orientation in the distal epithelium of embryonic lung Dev Dyn. 2011 Feb; 240(2):441-5. . View in PubMed

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair PLoS One. 2011; 6(8):e23139. . View in PubMed

A modified technique for partial pneumonectomy in the mouse J Invest Surg. 2011; 24(2):81-6. . View in PubMed

A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma Am J Respir Crit Care Med. 2010 Feb 15; 181(4):328-36. . View in PubMed

Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease? Proc Am Thorac Soc. 2009 Dec 01; 6(7):614-7.. View in PubMed

Bcr and Abr cooperate in negatively regulating acute inflammatory responses Mol Cell Biol. 2009 Nov; 29(21):5742-50. . View in PubMed

Development, repair and fibrosis: what is common and why it matters Respirology. 2009 Jul; 14(5):656-65. . View in PubMed

Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha Biochem Biophys Res Commun. 2008 Oct 24; 375(3):460-4. . View in PubMed

Developmental biology: order in the lung Nature. 2008 Jun 05; 453(7196):733-5. . View in PubMed

Centrifugal migration of mesenchymal cells in embryonic lung Dev Dyn. 2008 Mar; 237(3):750-7. . View in PubMed

BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction J Biol Chem. 2006 Sep 29; 281(39):29349-56. . View in PubMed

Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung Dev Biol. 2006 May 01; 293(1):77-89. . View in PubMed

A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis Dev Biol. 2005 Jun 15; 282(2):422-31. . View in PubMed

Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L683-91. . View in PubMed

Colonic atresia without mesenteric vascular occlusionThe role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg. 2005 Feb; 40(2):390-6. . View in PubMed

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung Dev Biol. 2005 Jan 15; 277(2):316-31. . View in PubMed

A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway J Surg Res. 2004 Aug; 120(2):201-9. . View in PubMed

BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells Am J Physiol Lung Cell Mol Physiol. 2004 Jan; 286(1):L81-6. . View in PubMed

Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cell line: signaling through CD14 and mitogen-activated protein kinase Pediatr Res. 2003 Sep; 54(3):297-305. . View in PubMed

Differential expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in early and late gestational mouse skin and skin wounds Wound Repair Regen. 2002 Nov-Dec; 10(6):387-96. . View in PubMed

Dynamics of metalloproteinase-2 and -9, TGF-beta, and uPA activities during normoxic vshyperoxic alveolarization. Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L747-54. . View in PubMed

Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny? Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S59-62.. View in PubMed

Bradykinin B1 receptor up-regulation by interleukin-1beta and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts J Pharmacol Exp Ther. 2001 Jul; 298(1):77-85. . View in PubMed

Abrogation of tumor necrosis factor-alpha converting enzyme inhibits embryonic lung morphogenesis in culture Int J Dev Biol. 2001 Jun; 45(4):623-31. . View in PubMed

EGF regulates early embryonic mouse gut development in chemically defined organ culture Pediatr Res. 2000 Dec; 48(6):794-802. . View in PubMed

A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function Biochem Biophys Res Commun. 2000 Jul 14; 273(3):1042-7. . View in PubMed

Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins Exp Cell Res. 2000 May 25; 257(1):22-32. . View in PubMed

Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation Biol Neonate. 2000 May; 77(4):217-23. . View in PubMed

Cytokine response during hyperoxia: sequential production of pulmonary tumor necrosis factor and interleukin-6 in neonatal rats Isr Med Assoc J. 2000 May; 2(5):365-9. . View in PubMed

Developmental differences in the expression and modulation of extracellular matrix proteases and inhibitors in mouse skin fibroblasts Wound Repair Regen. 1999 Nov-Dec; 7(6):467-76. . View in PubMed

Current concepts on lung development Curr Opin Pediatr. 1999 Jun; 11(3):188-92. . View in PubMed

Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis Curr Biol. 1999 Feb 25; 9(4):219-22. . View in PubMed

Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis Am J Physiol. 1999 08; 277(2):L412-22. . View in PubMed

Abrogation of cyclin D1 expression predisposes lung cancer cells to serum deprivation-induced apoptosis Am J Physiol. 1999 04; 276(4):L679-87. . View in PubMed

EMAP II: a modulator of neovascularization in the developing lung Am J Physiol. 1999 02; 276(2):L365-75. . View in PubMed

Effortful processing is a requirement for nicotine-induced improvements in memory Psychopharmacology (Berl). 1998 Aug; 138(3-4):362-8. . View in PubMed

Abrogation of betaglycan attenuates TGF-beta-mediated inhibition of embryonic murine lung branching morphogenesis in culture Mech Dev. 1998 Jul; 75(1-2):67-79. . View in PubMed

Contractility, transforming growth factor-beta, and plasmin in fetal skin fibroblasts: role in scarless wound healing Pediatr Res. 1998 Mar; 43(3):403-9. . View in PubMed

Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture Dev Biol. 1998 Feb 15; 194(2):182-95. . View in PubMed

Apoptosis and DNA damage in type 2 alveolar epithelial cells cultured from hyperoxic rats Am J Physiol. 1998 05; 274(5):L714-20. . View in PubMed

Commitment and differentiation of lung cell lineages Biochem Cell Biol. 1998; 76(6):971-95. . View in PubMed

Cell cycle in alveolar epithelial type II cells: integration of Matrigel and KGF Am J Physiol. 1997 Sep; 273(3 Pt 1):L572-80. . View in PubMed

Coordination of genetic, epigenetic, and environmental factors in lung development, injury, and repair Chest. 1997 Jun; 111(6 Suppl):119S-122S. . View in PubMed

Cyclin D1 antisense RNA destabilizes pRb and retards lung cancer cell growth Am J Physiol. 1997 11; 273(5):L941-9. . View in PubMed

Abrogation of transforming growth factor-beta type II receptor stimulates embryonic mouse lung branching morphogenesis in culture Dev Biol. 1996 Nov 25; 180(1):242-57. . View in PubMed

Dynamics of TGF-beta 3 peptide activity during rat alveolar epithelial cell proliferative recovery from acute hyperoxia Am J Physiol. 1996 Jul; 271(1 Pt 1):L54-60. . View in PubMed

Cell cycle arrest in G0/G1 phase by contact inhibition and TGF-beta 1 in mink Mv1Lu lung epithelial cells Am J Physiol. 1996 May; 270(5 Pt 1):L879-88. . View in PubMed

Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages J Histochem Cytochem. 1996 Feb; 44(2):113-23. . View in PubMed

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction Nat Genet. 1995 Dec; 11(4):415-21. . View in PubMed

Differential expression of cyclin D2 and cdc2 genes in proliferating and nonproliferating alveolar epithelial cells Am J Respir Cell Mol Biol. 1995 Jan; 12(1):95-103. . View in PubMed

Cell cycle-dependent expression of cyclin D1 and a 45 kD protein in human A549 lung carcinoma cells Am J Respir Cell Mol Biol. 1994 Apr; 10(4):437-47. . View in PubMed

Cyclin A expression in normal and transformed alveolar epithelial cells Am J Respir Cell Mol Biol. 1993 Aug; 9(2):115-25. . View in PubMed

Construction of a yeast artificial chromosome contig spanning the spinal muscular atrophy disease gene region Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6801-5. . View in PubMed

Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease Psychopharmacology (Berl). 1992; 108(4):485-94. . View in PubMed

Corticosteroids, thyrotropin-releasing hormone, and antioxidant enzymes in preterm lamb lungs Pediatr Res. 1991 Dec; 30(6):518-21. . View in PubMed

Augmentation of superoxide dismutase and catalase activity in alveolar type II cells Am J Respir Cell Mol Biol. 1991 Apr; 4(4):364-8. . View in PubMed

Elevated plasma norepinephrine levels in infants of substance-abusing mothers Am J Dis Child. 1991 Jan; 145(1):44-8. . View in PubMed

Biologic markers in risk assessment for environmental carcinogens Environ Health Perspect. 1991 Jan; 90:247-54. . View in PubMed

Cytogenetic methods for the mouse: preparation of chromosomes, karyotyping, and in situ hybridization Anal Biochem. 1990 Aug 15; 189(1):1-17. . View in PubMed

Effects of beta-2 agonist on hepatic glycogen metabolism in the fetal lamb Pediatr Res. 1988 Sep; 24(3):330-2. . View in PubMed

Combined effects of corticosteroid, thyroid hormones, and beta-agonist on surfactant, pulmonary mechanics, and beta-receptor binding in fetal lamb lung Pediatr Res. 1988 Aug; 24(2):166-70. . View in PubMed

Chronic glucose infusion inhibits development of beta-receptor binding in fetal lamb lung Pediatr Res. 1988 Aug; 24(2):171-4. . View in PubMed

Effects of beta-2 agonist on metabolic regulation in the fetal lamb lung J Pharmacol Exp Ther. 1987 Aug; 242(2):389-93. . View in PubMed

Effects of beta-2 agonist on tracheal fluid flow, surfactant and pulmonary mechanics in the fetal lamb J Pharmacol Exp Ther. 1987 Aug; 242(2):394-8. . View in PubMed

Beta-receptors and surface active material flux in fetal lamb lung: female advantage J Appl Physiol (1985). 1987 Aug; 63(2):828-33. . View in PubMed

Effects of glucose infusion on surfactant and glycogen regulation in fetal lamb lung J Appl Physiol (1985). 1987 Nov; 63(5):1750-6. . View in PubMed

Distal duplication 14q: report of three cases and further delineation of the syndrome Hum Genet. 1984; 68(2):159-64. . View in PubMed

Developmental pattern of maximal transdiaphragmatic pressure in infants during crying Pediatr Res. 1983 Sep; 17(9):707-9. . View in PubMed

Chronic hyperglycemia with secondary hyperinsulinemia inhibits the maturational response of fetal lamb lungs to cortisol J Clin Invest. 1983 Aug; 72(2):433-40. . View in PubMed

Chronic hyperglycemia reduces surface active material flux in tracheal fluid of fetal lambs J Clin Invest. 1983 Mar; 71(3):550-5. . View in PubMed

Effects of smoking on rapid information processing performance Neuropsychobiology. 1983; 9(4):223-9. . View in PubMed

Diagnosis of cutaneous T cell lymphoma by use of monoclonal antibodies reactive with tumor-associated antigens J Clin Invest. 1982 Dec; 70(6):1205-15. . View in PubMed

Do numerical polymorphisms exist at the human 5 S locus? Hum Genet. 1980; 54(1):83-5.. View in PubMed

A 9/11 translocation in a child with Ph1-negative chronic myelogenous leukemia J Pediatr. 1976 Apr; 88(4 Pt 1):599-601. . View in PubMed

Chromosome analysis of two related heteroploid mouse cell lines by quinacrine fluorescence J Cell Sci. 1973 Jan; 12(1):263-74. . View in PubMed

Application of new staining techniques to the study of human chromosomes Prog Med Genet. 1973; 9:1-47. . View in PubMed

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