Keck School Faculty

Debbie Mitra, PhD
Debbie Mitra, PhD
Assistant Professor of Research Ophthalmology
HC4 1450 San Pablo Street HC4 6525 Off Campus Los Angeles
Dr. Debbie Mitra obtained her PhD in Chemical Biology from McGill University in Montreal, Canada. She completed a postdoctoral fellowship at the Center for Nanotechnology at the University of Wisconsin-Madison, WI where she conducted research in the fabrication of DNA microarrays and nanotechnology applications in the photolithographic synthesis of oligonucleotides using a Maskless Array Synthesizer for gene assembly. During this time Mitra was the co-inventor of a novel methodology in the fabrication of RNA based microarrays, patented in 2009. She completed a second postdoctoral fellowship at the University of Ottawa, Canada in the field of tissue engineering of artificial corneas fabricated from chemically cross-linked collagen-based materials that mimic the extracellular matrix (ECM) and act as regenerative templates. Mitra is the project manager for the novel stem cell-based therapy for dry AMD-phase 1 clinical trial, funded by the California Institute for Regenerative Medicine. She is also the research-administrative liaison for the USC Roski Eye Institute and the Director of Science and Technology for the USC Institute for Biomedical Therapeutics. Her research interests include regenerative medicine, tissue engineering, DNA nanotechnology and chemistry.

A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration Sci Transl Med. 2018 Apr 04; 10(435). . View in PubMed

Epoxy cross-linked collagen and collagen-laminin Peptide hydrogels as corneal substitutes J Funct Biomater. 2013 Aug 28; 4(3):162-77. . View in PubMed

Crosslinked collagen hydrogels as corneal implants: effects of sterically bulky vsnon-bulky carbodiimides as crosslinkers. Acta Biomater. 2013 Aug; 9(8):7796-805. . View in PubMed

Synthetic neoglycopolymer-recombinant human collagen hybrids as biomimetic crosslinking agents in corneal tissue engineering Biomaterials. 2009 Oct; 30(29):5403-8. . View in PubMed

Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays J Am Chem Soc. 2009 Jun 24; 131(24):8496-502. . View in PubMed

A novel approach to the synthesis of DNA and RNA lariats J Org Chem. 2007 Dec 07; 72(25):9491-500. . View in PubMed

Self-assembly of cyclic metal-DNA nanostructures using ruthenium tris(bipyridine)-branched oligonucleotides Angew Chem Int Ed Engl. 2004 Nov 05; 43(43):5804-8. . View in PubMed

Solid-Phase Synthesis of Transition Metal Linked, Branched Oligonucleotides This work was supported by NSERC (Canada), CFI (Canada) and FCAR (Quebec)The authors gratefully acknowledge Prof. M. J. Damha and his laboratory, McGill University, for helpful discussion. Angew Chem Int Ed Engl. 2001 Dec 17; 40(24):4629-4632. . View in PubMed

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