Frank Gonzalez

Assistant Professor of Clinical Pediatrics

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Publications

  • Fenofibrate-promoted hepatomegaly and liver regeneration are PPARa-dependent and partially related to the YAP pathway Acta Pharm Sin B. 2024 Jul; 14(7):2992-3008. . View in PubMed
  • Hepatocyte-specific CCAAT/enhancer binding protein a restricts liver fibrosis progression J Clin Invest. 2024 Apr 01; 134(7). . View in PubMed
  • Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine Int J Biol Sci. 2024; 20(6):2187-2201. . View in PubMed
  • Cardiomyocyte peroxisome proliferator-activated receptor a prevents septic cardiomyopathy via improving mitochondrial function Acta Pharmacol Sin. 2023 Nov; 44(11):2184-2200. . View in PubMed
  • Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs ACS Pharmacol Transl Sci. 2023 Mar 10; 6(3):422-446. . View in PubMed
  • Intestinal peroxisome proliferator-activated receptor a-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis Hepatology. 2023 01 01; 77(1):239-255. . View in PubMed
  • Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer Nat Commun. 2023 02 10; 14(1):755. . View in PubMed
  • Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence Int J Biol Sci. 2023; 19(7):2067-2080. . View in PubMed
  • Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice Nat Commun. 2023 04 01; 14(1):1829. . View in PubMed
  • Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer NPJ Precis Oncol. 2022 Oct 07; 6(1):70. . View in PubMed
  • Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation iScience. 2022 May 20; 25(5):104196. . View in PubMed
  • Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis Food Chem Toxicol. 2022 Feb; 160:112807. . View in PubMed
  • The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice J Biol Chem. 2022 11; 298(11):102530. . View in PubMed
  • Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity Hepatology. 2022 08; 76(2):387-403. . View in PubMed
  • Postprandial Plasma Lipidomics Reveal Specific Alteration of Hepatic-derived Diacylglycerols in Nonalcoholic Fatty Liver Disease Gastroenterology. 2022 06; 162(7):1990-2003. . View in PubMed
  • Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights Drug Metab Dispos. 2022 05; 50(5):685-693. . View in PubMed
  • Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation Biochim Biophys Acta Mol Cell Biol Lipids. 2022 02; 1867(2):159089. . View in PubMed
  • YAP-TEAD mediates PPAR a-induced hepatomegaly and liver regeneration in mice Hepatology. 2022 01; 75(1):74-88. . View in PubMed
  • The role of mouse and human peroxisome proliferator-activated receptor-a in modulating the hepatic effects of perfluorooctane sulfonate in mice Toxicology. 2022 01 15; 465:153056. . View in PubMed
  • Disruption of peroxisome proliferator-activated receptor a in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway Int J Biol Sci. 2022; 18(6):2317-2328. . View in PubMed
  • Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewalCell Stem Cell. 2022 09 01; 29(9):1366-1381. e9. . View in PubMed
  • Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in mouse liver Mol Cell Endocrinol. 2022 11 01; 557:111722. . View in PubMed
  • Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting Cell Rep. 2022 10 25; 41(4):111547. . View in PubMed
  • Critical role of peroxisome proliferator-activated receptor a in promoting platelet hyperreactivity and thrombosis under hyperlipidemia Haematologica. 2022 06 01; 107(6):1358-1373. . View in PubMed
  • Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis Cell Host Microbe. 2022 03 09; 30(3):289-300. . View in PubMed
  • Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins Nat Commun. 2022 11 26; 13(1):7303. . View in PubMed
  • John’s Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NF? B antagonism. FASEB J. 2021 11; 35(11):e21968.. View in PubMed
  • The pathophysiological function of non-gastrointestinal farnesoid X receptor Pharmacol Ther. 2021 10; 226:107867. . View in PubMed
  • Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma Hepatology. 2021 10; 74(4):1932-1951. . View in PubMed
  • Oleuropein-Induced Acceleration of Cytochrome P450-Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor a Drug Metab Dispos. 2021 09; 49(9):833-843. . View in PubMed
  • Intestinal MYC modulates obesity-related metabolic dysfunction Nat Metab. 2021 07; 3(7):923-939. . View in PubMed
  • The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer Nat Rev Gastroenterol Hepatol. 2021 05; 18(5):335-347. . View in PubMed
  • Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3 Cell Death Dis. 2021 02 11; 12(2):174. . View in PubMed
  • Hypoxia via ERK Signaling Inhibits Hepatic PPARa to Promote Fatty Liver Cell Mol Gastroenterol Hepatol. 2021; 12(2):585-597. . View in PubMed
  • Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment Bioorg Med Chem. 2021 01 01; 29:115851. . View in PubMed
  • FXR-Deoxycholic Acid-TNF-a Axis Modulates Acetaminophen-Induced Hepatotoxicity Toxicol Sci. 2021 05 27; 181(2):273-284. . View in PubMed
  • Feedback repression of PPARa signaling by Let-7 microRNA Cell Rep. 2021 08 10; 36(6):109506. . View in PubMed
  • Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis Nat Commun. 2021 01 12; 12(1):290. . View in PubMed
  • Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling Nat Commun. 2021 05 12; 12(1):2745. . View in PubMed
  • Improved detection and precise relative quantification of the urinary cancer metabolite biomarkers – Creatine riboside, creatinine riboside, creatine and creatinine by UPLC-ESI-MS/MS: Application to the NCI-Maryland cohort population controls and lung cancer cases J Pharm Biomed Anal. 2020 Nov 30; 191:113596. . View in PubMed
  • Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice Toxicol Lett. 2020 Oct 15; 333:290-302. . View in PubMed
  • PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice Int J Mol Sci. 2020 Mar 17; 21(6). . View in PubMed
  • MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis Mol Pharmacol. 2020 12; 98(6):686-694. . View in PubMed
  • Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation Drug Metab Dispos. 2020 09; 48(9):830-839. . View in PubMed
  • Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice J Endocrinol. 2020 05; 245(2):301-314. . View in PubMed
  • Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1 J Med Chem. 2020 11 25; 63(22):14087-14117. . View in PubMed
  • PPARa mediates night neon light-induced weight gain: role of lipid homeostasis Theranostics. 2020; 10(25):11497-11506. . View in PubMed
  • Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting Nat Commun. 2020 11 17; 11(1):5847. . View in PubMed
  • Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis Free Radic Biol Med. 2020 02 20; 148:33-41. . View in PubMed
  • Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites Hum Genomics. 2020 03 11; 14(1):10. . View in PubMed
  • SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis Nat Commun. 2020 01 13; 11(1):240. . View in PubMed
  • A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice Carcinogenesis. 2020 04 22; 41(2):159-170. . View in PubMed
  • A novel miR-1291-ERRa-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis Theranostics. 2020; 10(16):7193-7210. . View in PubMed
  • Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence Aging (Albany NY). 2020 04 14; 12(8):6733-6755. . View in PubMed
  • Herbal drug discovery for the treatment of nonalcoholic fatty liver disease Acta Pharm Sin B. 2020 Jan; 10(1):3-18. . View in PubMed
  • Hepatic metabolic adaptation in a murine model of glutathione deficiency Chem Biol Interact. 2019 Apr 25; 303:1-6. . View in PubMed
  • A systemic workflow for profiling metabolome and lipidome in tissue J Chromatogr A. 2019 Mar 29; 1589:105-115. . View in PubMed
  • Withaferin A Improves Nonalcoholic Steatohepatitis in Mice J Pharmacol Exp Ther. 2019 11; 371(2):360-374. . View in PubMed
  • Hepatocyte peroxisome proliferator-activated receptor a regulates bile acid synthesis and transport Biochim Biophys Acta Mol Cell Biol Lipids. 2019 10; 1864(10):1396-1411. . View in PubMed
  • Parkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on a-synuclein protein levels Biochem Pharmacol. 2019 10; 168:429-437. . View in PubMed
  • Intestinal PPARa Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6Gastroenterology. 2019 09; 157(3):744-759. e4. . View in PubMed
  • Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation Hepatology. 2019 07; 70(1):154-167. . View in PubMed
  • J Pharmacol Exp Ther. 2019 03; 368(3):514-523. . View in PubMed
  • Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling Mol Cell Proteomics. 2019 03; 18(3):520-533. . View in PubMed
  • Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes-Associated Protein Activation in Mice Hepatology. 2019 01; 69(1):343-358. . View in PubMed
  • Peroxisome proliferator-activated receptor a attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice Arch Toxicol. 2019 01; 93(1):149-161. . View in PubMed
  • Dietary Intake Regulates the Circulating Inflammatory Monocyte PoolCell. 2019 08 22; 178(5):1102-1114. e17. . View in PubMed
  • Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development Hepatol Commun. 2018 Dec; 2(12):1567-1582. . View in PubMed
  • Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis EBioMedicine. 2018 Nov; 37:322-333. . View in PubMed
  • Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643 J Gastroenterol Hepatol. 2018 May; 33(5):1138-1145. . View in PubMed
  • Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes Xenobiotica. 2018 Apr; 48(4):357-367. . View in PubMed
  • The role of hypoxia-inducible factors in metabolic diseases Nat Rev Endocrinol. 2018 12; 15(1):21-32. . View in PubMed
  • Extrahepatic PPARa modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice J Lipid Res. 2018 11; 59(11):2140-2152. . View in PubMed
  • Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism Hepatology. 2018 10; 68(4):1574-1588. . View in PubMed
  • Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation Drug Metab Dispos. 2018 09; 46(9):1310-1319. . View in PubMed
  • Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis Drug Metab Dispos. 2018 07; 46(7):1030-1040. . View in PubMed
  • Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2a Inhibitor PT2385 In Vivo and In Vitro Drug Metab Dispos. 2018 04; 46(4):336-345. . View in PubMed
  • Corrigendum to “Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha” [Mol Metab 7 (2018) 80-89] Mol Metab. 2018 03; 9:217-219. . View in PubMed
  • Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice Hepatology. 2018 03; 67(3):1071-1087. . View in PubMed
  • FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity J Am Soc Nephrol. 2018 01; 29(1):118-137. . View in PubMed
  • Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha Mol Metab. 2018 01; 7:80-89. . View in PubMed
  • Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice J Biol Chem. 2018 01 05; 293(1):1-17. . View in PubMed
  • Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4? . Mol Cell Biol. 2018 12 15; 38(24).. View in PubMed
  • Activation of intestinal hypoxia-inducible factor 2a during obesity contributes to hepatic steatosis Nat Med. 2017 Nov; 23(11):1298-1308. . View in PubMed
  • Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut MicrobiotaCell Metab. 2017 Oct 03; 26(4):672-685. e4. . View in PubMed
  • A Western diet-induced mouse model reveals a possible mechanism by which metformin decreases obesity Eur J Clin Pharmacol. 2017 Oct; 73(10):1337-1339. . View in PubMed
  • Potential role of CYP1B1 in the development and treatment of metabolic diseases Pharmacol Ther. 2017 Oct; 178:18-30. . View in PubMed
  • Nuclear Receptor PPARa Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKß-Deficient Mice Biomol Ther (Seoul). 2017 Sep 01; 25(5):504-510. . View in PubMed
  • Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated SepsisCell Metab. 2017 Apr 04; 25(4):856-867. e5. . View in PubMed
  • Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells Am J Physiol Gastrointest Liver Physiol. 2017 Mar 01; 312(3):G283-G299. . View in PubMed
  • Growth arrest and DNA damage-inducible 45a protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet Biochim Biophys Acta Mol Basis Dis. 2017 12; 1863(12):3170-3182. . View in PubMed
  • Inflammation is independent of steatosis in a murine model of steatohepatitis Hepatology. 2017 07; 66(1):108-123. . View in PubMed
  • J Hypertens. 2017 07; 35(7):1390-1401. . View in PubMed
  • 2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice Hypertension. 2017 06; 69(6):1104-1112. . View in PubMed
  • Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure Radiat Res. 2017 05; 187(5):612-629. . View in PubMed
  • An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice Diabetes. 2017 03; 66(3):613-626. . View in PubMed
  • Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption Toxicology. 2017 07 01; 386:133-142. . View in PubMed
  • Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease Dig Dis. 2017; 35(3):178-184. . View in PubMed
  • An HNF4a-microRNA-194/192 signaling axis maintains hepatic cell function J Biol Chem. 2017 06 23; 292(25):10574-10585. . View in PubMed
  • Editor’s Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway Toxicol Sci. 2017 08 01; 158(2):334-346. . View in PubMed
  • Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation Sci Rep. 2017 05 11; 7(1):1748. . View in PubMed
  • Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice PLoS One. 2017; 12(5):e0177953. . View in PubMed
  • Biochem Biophys Res Commun. 2017 09 16; 491(2):271-276. . View in PubMed
  • Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-ß/d Modulation of SP1 Promoter Occupancy J Biol Chem. 2016 Nov 25; 291(48):25255-25263. . View in PubMed
  • The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4 Biochem Pharmacol. 2016 Nov 01; 119:93-104. . View in PubMed
  • Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation Mol Endocrinol. 2016 Oct; 30(10):1070-1080. . View in PubMed
  • 6ß-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice Hypertension. 2016 May; 67(5):916-26. . View in PubMed
  • Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor a-Mediated Apoptosis Drug Metab Dispos. 2016 May; 44(5):720-31. . View in PubMed
  • HIF2a Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling Cell Metab. 2016 Mar 08; 23(3):505-16. . View in PubMed
  • Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression Toxicol Appl Pharmacol. 2016 Jan 15; 291:21-7. . View in PubMed
  • Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans J Lipid Res. 2016 12; 57(12):2130-2137. . View in PubMed
  • An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease Gastroenterology. 2016 11; 151(5):845-859. . View in PubMed
  • Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis Gut. 2016 07; 65(7):1186-201. . View in PubMed
  • Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice Hypertension. 2016 Jan; 67(1):206-13. . View in PubMed
  • Hepatocyte Nuclear Factor 4a Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver J Biol Chem. 2015 Dec 25; 290(52):30855-65. . View in PubMed
  • Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction Nat Commun. 2015 Dec 15; 6:10166. . View in PubMed
  • Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis Phytother Res. 2015 Oct; 29(10):1658-64. . View in PubMed
  • Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and HumansGastroenterology. 2015 Oct; 149(4):1030-41. e6. . View in PubMed
  • Maternal bile acid transporter deficiency promotes neonatal demise Nat Commun. 2015 Sep 29; 6:8186. . View in PubMed
  • Metabolic mapping of A3 adenosine receptor agonist MRS5980 Biochem Pharmacol. 2015 Sep 15; 97(2):215-23. . View in PubMed
  • Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity J Pharmacol Exp Ther. 2015 Sep; 354(3):459-70. . View in PubMed
  • Epigenetic control of EMT/MET dynamics: HNF4a impacts DNMT3s through miRs-29 Biochim Biophys Acta. 2015 Aug; 1849(8):919-29. . View in PubMed
  • Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet Biochim Biophys Acta. 2015 Jul; 1852(7):1242-52. . View in PubMed
  • Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation Environ Health Perspect. 2015 Jul; 123(7):679-88. . View in PubMed
  • Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity Expert Opin Drug Metab Toxicol. 2015 Jun; 11(6):869-81. . View in PubMed
  • 6ß-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice Hypertension. 2015 Jun; 65(6):1279-87. . View in PubMed
  • Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity J Hepatol. 2015 Jun; 62(6):1234-6. . View in PubMed
  • GC-MS metabolomics on PPARa-dependent exacerbation of colitis Mol Biosyst. 2015 May; 11(5):1329-37. . View in PubMed
  • Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism Lab Invest. 2015 May; 95(5):515-24. . View in PubMed
  • Activation of peroxisome proliferator-activated receptor a induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders J Biol Chem. 2015 Apr 17; 290(16):10309-24. . View in PubMed
  • Modulation of colon cancer by nutmeg J Proteome Res. 2015 Apr 03; 14(4):1937-46. . View in PubMed
  • Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine Drug Metab Dispos. 2015 Mar; 43(3):317-24. . View in PubMed
  • Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice Biochim Biophys Acta. 2015 Jan; 1851(1):19-29. . View in PubMed
  • Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration Toxicol Sci. 2015 Jan; 143(1):107-15. . View in PubMed
  • Application of mass spectrometry-based metabolomics in identification of early noninvasive biomarkers of alcohol-induced liver disease using mouse model Adv Exp Med Biol. 2015; 815:217-38. . View in PubMed
  • Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARa(PAC) mice due to dysregulated bile acid synthesis Oncotarget. 2015; 6(12):9686-700. . View in PubMed
  • Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer J Pharmacol Exp Ther. 2014 Dec; 351(3):559-67. . View in PubMed
  • Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways Drug Metab Dispos. 2014 Dec; 42(12):1982-90. . View in PubMed
  • Chem Biol Interact. 2014 Nov 05; 223:80-6. . View in PubMed
  • Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet Biochim Biophys Acta. 2014 Nov; 1841(11):1596-607. . View in PubMed
  • N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis Carcinogenesis. 2014 Oct; 35(10):2264-72. . View in PubMed
  • PPARa-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis Nat Commun. 2014 Sep 03; 5:4573. . View in PubMed
  • PPARa-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate Am J Physiol Gastrointest Liver Physiol. 2014 Sep 01; 307(5):G564-73. . View in PubMed
  • Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation Mol Cell Biol. 2014 Aug; 34(16):3013-23. . View in PubMed
  • LC-MS-based metabolomics: an update Arch Toxicol. 2014 Aug; 88(8):1491-502. . View in PubMed
  • Metabolic profiling of praziquantel enantiomers Biochem Pharmacol. 2014 Jul 15; 90(2):166-78. . View in PubMed
  • Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice Hypertension. 2014 Jul; 64(1):134-40. . View in PubMed
  • Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor ß/d (PPARß/d) in keratinocytes Carcinogenesis. 2014 Jul; 35(7):1602-12. . View in PubMed
  • PPARß/d activation of CD300a controls intestinal immunity Sci Rep. 2014 Jun 24; 4:5412. . View in PubMed
  • Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer Cancer Res. 2014 Jun 15; 74(12):3259-70. . View in PubMed
  • Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice Biochem Pharmacol. 2014 Jun 01; 89(3):399-412. . View in PubMed
  • Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity J Proteome Res. 2014 May 02; 13(5):2679-87. . View in PubMed
  • Potential role of the vitamin D receptor in control of cholesterol levels Gastroenterology. 2014 Apr; 146(4):899-902. . View in PubMed
  • Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes Drug Metab Dispos. 2014 Apr; 42(4):492-9. . View in PubMed
  • In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract Br J Pharmacol. 2014 Apr; 171(7):1735-46. . View in PubMed
  • Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-a function in vivo Am J Physiol Endocrinol Metab. 2014 Apr 01; 306(7):E824-37. . View in PubMed
  • Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2a and regulation of bile acid homeostasis Mol Cell Biol. 2014 Apr; 34(7):1208-20. . View in PubMed
  • Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice J Lipid Res. 2014 Mar; 55(3):455-65. . View in PubMed
  • Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice J Biol Chem. 2014 Feb 07; 289(6):3105-13. . View in PubMed
  • Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3 Hepatology. 2014 Feb; 59(2):695-704. . View in PubMed
  • Role of Myc in hepatocellular proliferation and hepatocarcinogenesis J Hepatol. 2014 Feb; 60(2):331-8. . View in PubMed
  • Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism PLoS One. 2014; 9(1):e84583. . View in PubMed
  • CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis Free Radic Biol Med. 2013 Dec; 65:1238-1245. . View in PubMed
  • Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum Arch Toxicol. 2013 Nov; 87(11):1975-1987. . View in PubMed
  • Potential role of CYP2D6 in the central nervous system Xenobiotica. 2013 Nov; 43(11):973-84. . View in PubMed
  • The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase J Biol Chem. 2013 Sep 27; 288(39):27898-911. . View in PubMed
  • Identification of 2-piperidone as a biomarker of CYP2E1 activity through metabolomic phenotyping Toxicol Sci. 2013 Sep; 135(1):37-47. . View in PubMed
  • Global metabolomics reveals urinary biomarkers of breast cancer in a mcf-7 xenograft mouse model Metabolites. 2013 Aug 07; 3(3):658-72. . View in PubMed
  • Metabolomics reveals that tumor xenografts induce liver dysfunction Mol Cell Proteomics. 2013 Aug; 12(8):2126-35. . View in PubMed
  • Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity Chem Res Toxicol. 2013 Jul 15; 26(7):1088-96. . View in PubMed
  • Cholestasis induces reversible accumulation of periplakin in mouse liver BMC Gastroenterol. 2013 Jul 13; 13:116. . View in PubMed
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