Keck School Faculty

Gopalan Sethuraman

Gopalan Sethuraman

Associate Professor of Research Neurology

A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer's disease Stat Med. 2018 09 20; 37(21):3047-3055. . View in PubMed

Representativeness of European clinical trial populations in mild Alzheimer's disease dementia: a comparison of 18-month outcomes with real-world data from the GERAS observational study Alzheimers Res Ther. 2018 04 03; 10(1):36. . View in PubMed

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients Alzheimers Dement. 2016 Feb; 12(2):110-120. . View in PubMed

Delayed-start analysis: Mild Alzheimer's disease patients in solanezumab trials, 35 years. Alzheimers Dement (N Y). 2015 Sep; 1(2):111-121. . View in PubMed

Adverse events and dropouts in Alzheimer's disease studies: what can we learn? Alzheimers Dement. 2015 Jan; 11(1):24-31.. View in PubMed

Alzheimers Res Ther. 2015; 7(1):36. . View in PubMed

Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings Curr Med Res Opin. 2014 Oct; 30(10):2021-32. . View in PubMed

Assessment of type I error rate associated with dose-group switching in a longitudinal Alzheimer trial J Biopharm Stat. 2014; 24(3):660-84. . View in PubMed

A phase 3 trial of semagacestat for treatment of Alzheimer's disease N Engl J Med. 2013 Jul 25; 369(4):341-50. . View in PubMed

Safety profile of Alzheimer's disease populations in Alzheimer's Disease Neuroimaging Initiative and other 18-month studies Alzheimers Dement. 2012 Sep; 8(5):407-16. . View in PubMed

Safety and biomarker effects of solanezumab in patients with Alzheimer's disease Alzheimers Dement. 2012 Jul; 8(4):261-71. . View in PubMed

Enriching amnestic mild cognitive impairment populations for clinical trials: optimal combination of biomarkers to predict conversion to dementia J Alzheimers Dis. 2012; 32(2):373-85. . View in PubMed

Validation of ELISA methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer's disease studies J Alzheimers Dis. 2011; 26(3):531-41. . View in PubMed

Olanzapine long-acting injection: a 24-week, randomized, double-blind trial of maintenance treatment in patients with schizophrenia Am J Psychiatry. 2010 Feb; 167(2):181-9. . View in PubMed

In search of moderators and mediators of hyperglycemia with atypical antipsychotic treatment J Psychiatr Res. 2009 Jul; 43(11):997-1002. . View in PubMed

Characteristics of two alternative schizophrenia remission definitions: relationship to clinical and quality of life outcomes Schizophr Res. 2006 Sep; 86(1-3):300-8. . View in PubMed

Response to Kujawa et alletter-to-the-editor. Schizophr Res. 2006 May; 84(1):172-3. . View in PubMed

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex Ann Neurol. 2006 Mar; 59(3):490-8. . View in PubMed

Is quality of life among minimally symptomatic patients with schizophrenia better following withdrawal or continuation of antipsychotic treatment? J Clin Psychopharmacol. 2006 Feb; 26(1):40-4.. View in PubMed

A retrospective comparison of cumulative time spent in remission during treatment with olanzapine or risperidone among patients with schizophrenia Schizophr Res. 2005 Nov 15; 79(2-3):337-40. . View in PubMed

Impulsive aggression with irritability and responsive to divalproex: a pediatric bipolar spectrum disorder phenotype? J Affect Disord. 2005 Nov; 88(3):279-85.. View in PubMed

The illusion of mental health: in the mind of which beholder? J Pers Assess. 2005 Aug; 85(1):92-7.. View in PubMed

An Indian child with Kindler syndrome resulting from a new homozygous nonsense mutation (C468X) in the KIND1 gene Clin Exp Dermatol. 2005 May; 30(3):286-8. . View in PubMed

A pilot safety study of repetitive transcranial magnetic stimulation (rTMS) in Tourette's syndrome Cogn Behav Neurol. 2004 Jun; 17(2):109-17. . View in PubMed

The use of dietary supplements by veterans with cancer J Altern Complement Med. 2004 Jun; 10(3):560-4. . View in PubMed

Breast milk feeding rates of mothers of multiples compared to mothers of singletons Ambul Pediatr. 2004 May-Jun; 4(3):226-31. . View in PubMed

Association of cortical disinhibition with tic, ADHD, and OCD severity in Tourette syndrome Mov Disord. 2004 Apr; 19(4):416-25. . View in PubMed

Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trial J Am Acad Child Adolesc Psychiatry. 2004 Feb; 43(2):206-14. . View in PubMed

Donors with central nervous system malignancies: are they truly safe? Transplantation. 2003 Jul 27; 76(2):340-3.. View in PubMed

Psychosocial outcomes of a pilot multidisciplinary program for weight management Am J Health Behav. 2003 Jul-Aug; 27(4):348-54. . View in PubMed

Combination pharmacotherapy in children and adolescents with bipolar disorder Biol Psychiatry. 2003 Jun 01; 53(11):978-84. . View in PubMed

Gemcitabine and Cisplatin is a highly effective combination chemotherapy in patients with advanced cancer of the gallbladder Am J Clin Oncol. 2003 Apr; 26(2):174-7. . View in PubMed

Effect of weight change on bone mass in female adolescents J Am Diet Assoc. 2003 Mar; 103(3):369-72. . View in PubMed

Neuroendocrine and behavioral responses to dopaminergic agonists in adolescents with alcohol abuse Psychopharmacology (Berl). 2003 Mar; 166(2):95-101. . View in PubMed

Meta-analysis of EEG test performance shows wide variation among studies Neurology. 2003 Feb 25; 60(4):564-70. . View in PubMed

Tic reduction with pergolide in a randomized controlled trial in children Neurology. 2003 Feb 25; 60(4):606-11. . View in PubMed

Phase II trial of sequential therapy with fludarabine followed by cyclophosphamide, mitoxantrone, vincristine, and prednisone for low-grade follicular lymphomas Am J Hematol. 2002 Jul; 70(3):181-5. . View in PubMed

Pulmonary cysts consistent with lymphangioleiomyomatosis are common in women with tuberous sclerosis: genetic and radiographic analysis Chest. 2002 Mar; 121(3 Suppl):61S. . View in PubMed

Mutational and radiographic analysis of pulmonary disease consistent with lymphangioleiomyomatosis and micronodular pneumocyte hyperplasia in women with tuberous sclerosis Am J Respir Crit Care Med. 2001 Aug 15; 164(4):661-8. . View in PubMed

Lamotrigine therapy of epilepsy in tuberous sclerosis Epilepsia. 2001 Jul; 42(7):935-40. . View in PubMed

Venlafaxine treatment of patients with comorbid alcohol/cocaine abuse and attention-deficit/hyperactivity disorder: a pilot study J Clin Psychopharmacol. 2001 Feb; 21(1):116-8. . View in PubMed

Fenfluramine challenge in anxious children Hum Psychopharmacol. 2000 Dec; 15(8):619-629. . View in PubMed

Yohimbine challenge in children with anxiety disorders Am J Psychiatry. 2000 Aug; 157(8):1236-42. . View in PubMed

The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine Brain Res. 2000 Jun 09; 867(1-2):239-42. . View in PubMed

Tourette's syndrome improvement with pergolide in a randomized, double-blind, crossover trial Neurology. 2000 Mar 28; 54(6):1310-5. . View in PubMed

Parenteral clomipramine challenge in depressed adolescents: mood and neuroendocrine response Biol Psychiatry. 1998 Oct 01; 44(7):562-7. . View in PubMed

Intravenous clomipramine challenge in obsessive-compulsive disorder: predicting response to oral therapy at eight weeks Biol Psychiatry. 1998 Aug 01; 44(3):220-7. . View in PubMed

Clonidine challenge in childhood anxiety disorder J Am Acad Child Adolesc Psychiatry. 1998 Jun; 37(6):655-62. . View in PubMed

Relative efficacy of haloperidol and pimozide in children and adolescents with Tourette's disorder Am J Psychiatry. 1997 Aug; 154(8):1057-62. . View in PubMed

Dopamine agonist treatment of Tourette disorder in children: results of an open-label trial of pergolide Mov Disord. 1997 May; 12(3):402-7. . View in PubMed

Pulse intravenous clomipramine for depressed adolescents: double-blind, controlled trial Am J Psychiatry. 1997 May; 154(5):668-73. . View in PubMed

Platelet serotonin transporter in children and adolescents with obsessive-compulsive disorder or Tourette's syndrome J Am Acad Child Adolesc Psychiatry. 1996 Dec; 35(12):1647-56. . View in PubMed

Prolactin monitoring of haloperidol and pimozide treatment in children with Tourette's syndrome Biol Psychiatry. 1996 Nov 15; 40(10):1044-50. . View in PubMed

Head growth in cocaine-exposed infants: relationship to neonate hair level J Dev Behav Pediatr. 1995 Apr; 16(2):77-81. . View in PubMed

Lymphocyte glucocorticoid receptor: predictor of sertraline response in adolescent major depressive disorder (MDD) Psychopharmacol Bull. 1995; 31(2):339-45. . View in PubMed

Effects of pimozide on cognition in children with Tourette syndrome: interaction with comorbid attention deficit hyperactivity disorder Acta Psychiatr Scand. 1994 Jul; 90(1):4-9. . View in PubMed

Factors associated with visual loss in patients with advanced glaucomatous changes in the optic nerve head Am J Ophthalmol. 1993 Aug 15; 116(2):176-81. . View in PubMed

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