Keck School Faculty

Gordana Raca, MD, PhD
Gordana Raca, MD, PhD
Associate Professor of Clinical Pathology
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles

Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen) Genet Med. 2019 Nov 06. . View in PubMed

Technical laboratory standards for interpretation and reporting of acquired copy-number abnormalities and copy-neutral loss of heterozygosity in neoplastic disorders: a joint consensus recommendation from the American College of Medical Genetics and Genomics (ACMG) and the Cancer Genomics Consortium (CGC) Genet Med. 2019 09; 21(9):1903-1916. . View in PubMed

A semiautomated whole-exome sequencing workflow leads to increased diagnostic yield and identification of novel candidate variants Cold Spring Harb Mol Case Stud. 2019 04; 5(2). . View in PubMed

Standard operating procedure for curation and clinical interpretation of variants in cancer Genome Med. 2019 11 29; 11(1):76. . View in PubMed

Assessing copy number aberrations and copy neutral loss of heterozygosity across the genome as best practice: An evidence based review of clinical utility from the cancer genomics consortium (CGC) working group for myelodysplastic syndrome, myelodysplastic/myeloproliferative and myeloproliferative neoplasms Cancer Genet. 2018 12; 228-229:197-217. . View in PubMed

Assessing copy number abnormalities and copy-neutral loss-of-heterozygosity across the genome as best practice in diagnostic evaluation of acute myeloid leukemia: An evidence-based review from the cancer genomics consortium (CGC) myeloid neoplasms working group Cancer Genet. 2018 12; 228-229:218-235. . View in PubMed

OncoKids: A Comprehensive Next-Generation Sequencing Panel for Pediatric Malignancies J Mol Diagn. 2018 11; 20(6):765-776. . View in PubMed

Adapting crowdsourced clinical cancer curation in CIViC to the ClinGen minimum variant level data community-driven standards Hum Mutat. 2018 11; 39(11):1721-1732. . View in PubMed

Myeloid lineage switch following chimeric antigen receptor T-cell therapy in a patient with TCF3-ZNF384 fusion-positive B-lymphoblastic leukemia Pediatr Blood Cancer. 2018 09; 65(9):e27265. . View in PubMed

Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies Blood Adv. 2018 01 23; 2(2):146-150. . View in PubMed

A neoplasm with FIP1L1-PDGFRA fusion presenting as pediatric T-cell lymphoblastic leukemia/lymphoma without eosinophilia Cancer Genet. 2017 Oct; 216-217:91-99. . View in PubMed

Diagnostic evaluation of RNA sequencing for the detection of genetic abnormalities associated with Ph-like acute lymphoblastic leukemia (ALL) Leuk Lymphoma. 2017 04; 58(4):950-958. . View in PubMed

Segmental Chromosomal Aberrations in Localized Neuroblastoma Can be Detected in Formalin-Fixed Paraffin-Embedded Tissue Samples and Are Associated With Recurrence Pediatr Blood Cancer. 2016 Jun; 63(6):1019-23. . View in PubMed

Congenital B-lymphoblastic leukemia with a cryptic MLL rearrangement and post-treatment evolution to mixed phenotype acute leukemia Leuk Res Rep. 2016; 6:29-32. . View in PubMed

Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma Oncotarget. 2015 Dec 22; 6(41):43881-96. . View in PubMed

T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia Oncotarget. 2015 Oct 20; 6(32):33410-25. . View in PubMed

Predicting Prognosis in Chronic Lymphocytic Leukemia in the Contemporary Era JAMA Oncol. 2015 Oct; 1(7):965-74. . View in PubMed

Next-generation sequencing reveals clinically actionable molecular markers in myeloid sarcoma Leukemia. 2015 Oct; 29(10):2113-6. . View in PubMed

Prognosis in Chronic Lymphocytic Leukemia-Reply JAMA Oncol. 2015 Oct; 1(7):988-9. . View in PubMed

RCSD1-ABL2 fusion resulting from a complex chromosomal rearrangement in high-risk B-cell acute lymphoblastic leukemia Leuk Lymphoma. 2015 Apr; 56(4):1145-7. . View in PubMed

MYC Amplification in Angiosarcoma Arising from an Arteriovenous Graft Site Case Rep Pathol. 2015; 2015:537297. . View in PubMed

RCSD1-ABL1 Translocation Associated with IKZF1 Gene Deletion in B-Cell Acute Lymphoblastic Leukemia Case Rep Hematol. 2015; 2015:353247. . View in PubMed

Genomic aberrations in myeloid sarcoma without blood or bone marrow involvement: characterization of formalin-fixed paraffin-embedded samples by chromosomal microarrays Leuk Res. 2014 Sep; 38(9):1091-6. . View in PubMed

Complex or monosomal karyotype and not blast percentage is associated with poor survival in acute myeloid leukemia and myelodysplastic syndrome patients with inv(3)(q21q262)/t(3;3)(q21;q26. 2): a Bone Marrow Pathology Group study. Haematologica. 2014 May; 99(5):821-9. . View in PubMed

PLZF staining identifies peripheral T-cell lymphomas derived from innate-like T-cells with TRAV1-2-TRAJ33 TCR-a rearrangement Blood. 2014 Apr 24; 123(17):2742-3. . View in PubMed

MECP2 duplication: possible cause of severe phenotype in females Am J Med Genet A. 2014 Apr; 164A(4):1029-34. . View in PubMed

Whole-exome sequencing supports genetic heterogeneity in childhood apraxia of speech J Neurodev Disord. 2013 Oct 02; 5(1):29. . View in PubMed

The advantage of using SNP array in clinical testing for hematological malignancies--a comparative study of three genetic testing methods Cancer Genet. 2013 Sep-Oct; 206(9-10):317-26. . View in PubMed

Childhood Apraxia of Speech (CAS) in two patients with 16p112 microdeletion syndrome. Eur J Hum Genet. 2013 Apr; 21(4):455-9. . View in PubMed

The genomic landscape of hypodiploid acute lymphoblastic leukemia Nat Genet. 2013 Mar; 45(3):242-52. . View in PubMed

Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression Pediatr Blood Cancer. 2013 Feb; 60(2):332-5. . View in PubMed

Leuk Lymphoma. 2013 Feb; 54(2):403-5. . View in PubMed

MLL Rearrangment and EVI1 Deletion in BCR/ABL1 Positive Chronic Myeloid Leukemia J Assoc Genet Technol. 2013; 39(4):190-4. . View in PubMed

A Unique "Composite" PTLD with Diffuse Large B-Cell and T/Anaplastic Large Cell Lymphoma Components Occurring 17 Years after Transplant Case Rep Hematol. 2013; 2013:386147. . View in PubMed

Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization Genet Med. 2012 Nov; 14(11):928-36. . View in PubMed

Acute myeloid leukemia: the challenge of unfavorable cytogenetics Oncology (Williston Park). 2012 Aug; 26(8):724726-7. . View in PubMed

Typical renal-coloboma syndrome phenotype in a patient with a submicroscopic deletion of the PAX2 gene Am J Med Genet A. 2012 Jun; 158A(6):1437-41. . View in PubMed

Phenotype of FOXP2 haploinsufficiency in a mother and son Am J Med Genet A. 2012 Jan; 158A(1):174-81. . View in PubMed

DNA methylation assay for X-chromosome inactivation in female human iPS cells Stem Cell Rev Rep. 2011 Nov; 7(4):969-75. . View in PubMed

Array comparative genomic hybridization analysis in patients with anophthalmia, microphthalmia, and coloboma Genet Med. 2011 May; 13(5):437-42. . View in PubMed

Chromosomal abnormalities in 2 cases of testicular failure J Androl. 2011 May-Jun; 32(3):226-31. . View in PubMed

Duplication 5q and deletion 9p due to a t(5;9)(q34;p23) in 2 cousins with features of Hunter-McAlpine syndrome and hypothyroidism Cytogenet Genome Res. 2011; 132(4):233-8. . View in PubMed

Next generation sequencing in research and diagnostics of ocular birth defects Mol Genet Metab. 2010 Jun; 100(2):184-92. . View in PubMed

Clinical and molecular characterization of overlapping interstitial Xp21-p22 duplications in two unrelated individuals Am J Med Genet A. 2010 Apr; 152A(4):904-15. . View in PubMed

Mild clinical presentation in a child with prenatally diagnosed 45,X/47,XX,+18 mosaicism Am J Med Genet A. 2009 Nov; 149A(11):2588-92. . View in PubMed

Array-based comparative genomic hybridization (aCGH) in the genetic evaluation of stillbirth Am J Med Genet A. 2009 Nov; 149A(11):2437-43. . View in PubMed

Detailed characterization of, and clinical correlations in, 10 patients with distal deletions of chromosome 9p Genet Med. 2008 Aug; 10(8):599-611. . View in PubMed

Intrachromosomal duplications of 22q11 are not a common cause of isolated coloboma and coloboma with other limited features of cat eye syndrome Am J Med Genet A. 2008 Feb 01; 146A(3):401-4. . View in PubMed

Paternal deletion 6q243: a new congenital anomaly syndrome associated with intrauterine growth failure, early developmental delay and characteristic facial appearance. Am J Med Genet A. 2008 Feb 01; 146A(3):354-60. . View in PubMed

NSD1 analysis for Sotos syndrome: insights and perspectives from the clinical laboratory Genet Med. 2005 Oct; 7(8):524-33. . View in PubMed

Deletion analysis of the imprinting center region in patients with Angelman syndrome and Prader-Willi syndrome by real-time quantitative PCR Genet Test. 2004; 8(4):387-94. . View in PubMed

Progressive dystonia in a 12-year-old boy Eur J Paediatr Neurol. 2003; 7(2):85-8. . View in PubMed

Expansion of the (CTG)(n) repeat in the 5'-UTR of a reporter gene impedes translation Nucleic Acids Res. 2000 Oct 15; 28(20):3943-9. . View in PubMed

Trinucleotide repeats affect DNA replication in vivo Nat Genet. 1997 Nov; 17(3):298-304. . View in PubMed

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