Keck School Faculty

Hiroyuki Shimada, MD, PhD
Hiroyuki Shimada, MD, PhD
Professor of Pathology (Clinical Scholar)
Pediatrics
CHL Mail Stop 43 Off Campus Los Angeles

University of Chicago: Eleanor Humphreys Visiting Professorship, 2005

Society for Pediatric Pathology: Lotte Strauss Prize, 1989

Associations of social frailty with loss of muscle mass and muscle weakness among community-dwelling older adults Geriatr Gerontol Int. 2019 Jan; 19(1):76-80. . View in PubMed

Associations of social frailty with loss of muscle mass and muscle weakness among community-dwelling older adults Geriatr Gerontol Int. 2018 Dec 21. . View in PubMed

Capsular bag irrigation using 0025% povidone-iodine in balanced salt solution PLUS for the treatment of postoperative endophthalmitis. Int Ophthalmol. 2018 Dec; 38(6):2267-2268. . View in PubMed

Aging-related anorexia and its association with disability and frailty J Cachexia Sarcopenia Muscle. 2018 Oct; 9(5):834-843. . View in PubMed

Association between insulin resistance and objective measurement of physical activity in community-dwelling older adults without diabetes mellitus Diabetes Res Clin Pract. 2018 Sep; 143:267-274. . View in PubMed

Changes in objectively measured outdoor time and physical, psychological, and cognitive function among older adults with cognitive impairments Arch Gerontol Geriatr. 2018 Sep - Oct; 78:190-195. . View in PubMed

Association of walk ratio during normal gait speed and fall in community-dwelling elderly people Gait Posture. 2018 Aug 25; 66:151-154. . View in PubMed

Aging-related anorexia and its association with disability and frailty J Cachexia Sarcopenia Muscle. 2018 Aug 14. . View in PubMed

Capsular bag irrigation using 0025% povidone-iodine in balanced salt solution PLUS for the treatment of postoperative endophthalmitis. Int Ophthalmol. 2018 Aug; 38(4):1787-1790. . View in PubMed

Association between insulin resistance and objective measurement of physical activity in community-dwelling older adults without diabetes mellitus Diabetes Res Clin Pract. 2018 Jul 26. . View in PubMed

Changes in objectively measured outdoor time and physical, psychological, and cognitive function among older adults with cognitive impairments Arch Gerontol Geriatr. 2018 Jun 11; 78:190-195. . View in PubMed

A paradoxical thrombogenic mutation in factor II at the target site of arthropod bleeding toxin Eur J Med Genet. 2018 Jun 04. . View in PubMed

Chapter 2 Epidemiology of sarcopenia Geriatr Gerontol Int. 2018 May; 18 Suppl 1:13-22. . View in PubMed

Assessing competence at a higher level among older adults: development of the Japan Science and Technology Agency Index of Competence (JST-IC) Aging Clin Exp Res. 2018 Apr; 30(4):383-393. . View in PubMed

Associations of Near-Miss Traffic Incidents with Attention and Executive Function among Older Japanese Drivers Gerontology. 2018 Feb 09. . View in PubMed

Behavioral protective factors of increased depressive symptoms in community-dwelling older adults: A prospective cohort study Int J Geriatr Psychiatry. 2018 Feb; 33(2):e234-e241. . View in PubMed

Association of walk ratio during normal gait speed and fall in community-dwelling elderly people Gait Posture. 2018 10; 66:151-154. . View in PubMed

Behavioral protective factors of increased depressive symptoms in community-dwelling older adults: A prospective cohort study Int J Geriatr Psychiatry. 2018 02; 33(2):e234-e241. . View in PubMed

Analysis of risk factors for mild cognitive impairment based on word list memory test results and questionnaire responses in healthy Japanese individuals registered in an online database PLoS One. 2018; 13(5):e0197466. . View in PubMed

Associations of Near-Miss Traffic Incidents with Attention and Executive Function among Older Japanese Drivers Gerontology. 2018; 64(5):495-502. . View in PubMed

Association between body composition parameters and risk of mild cognitive impairment in older Japanese adults Geriatr Gerontol Int. 2017 Nov; 17(11):2053-2059. . View in PubMed

Association of MYCN copy number with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group Cancer. 2017 Nov 01; 123(21):4224-4235. . View in PubMed

Capsular bag irrigation using 0025% povidone-iodine in balanced salt solution PLUS for the treatment of postoperative endophthalmitis. Int Ophthalmol. 2017 Oct 12. . View in PubMed

27-gauge and 25-gauge vitrectomy day surgery for idiopathic epiretinal membrane BMC Ophthalmol. 2017 Oct 10; 17(1):188. . View in PubMed

Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126 Oncotarget. 2017 Aug 08; 8(32):52193-52210. . View in PubMed

Age-dependent changes in physical performance and body composition in community-dwelling Japanese older adults J Cachexia Sarcopenia Muscle. 2017 Aug; 8(4):607-614. . View in PubMed

Capsular bag irrigation using 0025% povidone-iodine in balanced salt solution PLUS for the treatment of postoperative endophthalmitis. Int Ophthalmol. 2017 Jul 08. . View in PubMed

[Alzheimer's Therapeutic Research Institute] Brain Nerve. 2017 Jul; 69(7):856-861. . View in PubMed

Association of Social Frailty With Both Cognitive and Physical Deficits Among Older People J Am Med Dir Assoc. 2017 Jul 01; 18(7):603-607. . View in PubMed

[DIAN/DIAN-J/DIAN-TU] Brain Nerve. 2017 Jul; 69(7):701-709. . View in PubMed

Association between sedentary time and kidney function in community-dwelling elderly Japanese people Geriatr Gerontol Int. 2017 May; 17(5):730-736. . View in PubMed

Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects with probable Alzheimer's disease, subjects with amnestic mild cognitive impairment and healthy volunteers Ann Nucl Med. 2017 Apr; 31(3):260-272. . View in PubMed

Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells Cancer Res. 2017 09 15; 77(18):5142-5157. . View in PubMed

Aß levels in the jugular vein and high molecular weight Aß oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease PLoS One. 2017; 12(4):e0174630. . View in PubMed

Age-related changes in prefrontal oxygenation during memory encoding and retrieval Geriatr Gerontol Int. 2016 Dec; 16(12):1296-1304. . View in PubMed

Cancer association as a risk factor for anti-HMGCR antibody-positive myopathy Neurol Neuroimmunol Neuroinflamm. 2016 Dec; 3(6):e290. . View in PubMed

Neurology. 2016 Jul 19; 87(3):299-308. . View in PubMed

[Exercise and Physical Activity for Dementia Prevention] Brain Nerve. 2016 Jul; 68(7):799-808. . View in PubMed

[Significance and progress of DIAN/A4/API] Nihon Rinsho. 2016 Mar; 74(3):417-22. . View in PubMed

Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality EMBO Mol Med. 2016 11; 8(11):1340-1359. . View in PubMed

A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma Pediatr Blood Cancer. 2016 08; 63(8):1349-56. . View in PubMed

Characteristics of Hyperautofluorescent Choroidal Vessels Using Fundus Camera Type Short-Wavelength Autofluorescence Ophthalmologica. 2016; 236(3):175-180. . View in PubMed

[Incidence of Postoperative Retinal Detachment after 25-gauge Vitrectomy for Macular Diseases] Nippon Ganka Gakkai Zasshi. 2015 Jun; 119(6):402-9. . View in PubMed

Geriatr Gerontol Int. 2015 Apr; 15(4):422-7. . View in PubMed

131I-metaiodobenzylguanidine with intensive chemotherapy and autologous stem cell transplantation for high-risk neuroblastomaA new approaches to neuroblastoma therapy (NANT) phase II study. Biol Blood Marrow Transplant. 2015 Apr; 21(4):673-81. . View in PubMed

Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed Neurobiol Aging. 2015 Feb; 36(2):942-7. . View in PubMed

A second pedigree with amyloid-less familial Alzheimer's disease harboring an identical mutation in the amyloid precursor protein gene (E693delta) Intern Med. 2015; 54(2):205-8. . View in PubMed

Cerebral infarction in the left hemisphere compared with the right hemisphere increases the risk of aspiration pneumonia Osaka City Med J. 2014 Dec; 60(2):81-6. . View in PubMed

Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group Pediatr Dev Pathol. 2014 Nov-Dec; 17(6):441-9. . View in PubMed

Acquisition process of typing skill using hierarchical materials in the Japanese language Atten Percept Psychophys. 2014 Aug; 76(6):1838-46. . View in PubMed

Association of knee-extension strength with instrumental activities of daily living in community-dwelling older adults Geriatr Gerontol Int. 2014 Jul; 14(3):674-80. . View in PubMed

A case of anti-N-methyl-d-aspartate receptor encephalitis with multiple sclerosis-like demyelinated lesions Mult Scler Relat Disord. 2014 May; 3(3):391-7. . View in PubMed

Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion Int J Hematol. 2014 Jan; 99(1):21-31. . View in PubMed

Basic setup and disinfection Dev Ophthalmol. 2014; 54:63-70. . View in PubMed

A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly Front Aging Neurosci. 2014; 6:69. . View in PubMed

Brain activation during dual-task walking and executive function among older adults with mild cognitive impairment: a fNIRS study Aging Clin Exp Res. 2013 Oct; 25(5):539-44. . View in PubMed

[The DIAN study] Brain Nerve. 2013 Oct; 65(10):1179-84. . View in PubMed

A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment PLoS One. 2013; 8(4):e61483. . View in PubMed

Characteristics of cognitive function in early and late stages of amnestic mild cognitive impairment Geriatr Gerontol Int. 2013 Jan; 13(1):83-9. . View in PubMed

[Are gait parameters related to knee pain, urinary incontinence and a history of falls in community-dwelling elderly women? ]. Nihon Ronen Igakkai Zasshi. 2013; 50(4):528-35.. View in PubMed

Brain atrophy and trunk stability during dual-task walking among older adults J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(7):790-5. . View in PubMed

Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project Eur J Cancer. 2012 May; 48(8):1185-91. . View in PubMed

A galectin-3-dependent pathway upregulates interleukin-6 in the microenvironment of human neuroblastoma Cancer Res. 2012 May 01; 72(9):2228-38. . View in PubMed

[Pathology of peripheral neuroblastic tumors] Zhonghua Bing Li Xue Za Zhi. 2012 Apr; 41(4):283-8. . View in PubMed

A significant relationship between plasma vitamin C concentration and physical performance among Japanese elderly women J Gerontol A Biol Sci Med Sci. 2012 Mar; 67(3):295-301. . View in PubMed

[Predictors of interruptions to living at home in elderly people enrolled in a home visit rehabilitation service] Nihon Ronen Igakkai Zasshi. 2012; 49(2):214-21. . View in PubMed

A lower prevalence of self-reported fear of falling is associated with memory decline among older adults Gerontology. 2012; 58(5):413-8. . View in PubMed

[Prevention of cognitive decline] Nihon Ronen Igakkai Zasshi. 2012; 49(1):60-2. . View in PubMed

[Factors associated with fear of falling among community-dwelling elderly adults without reduced performance in instrumental activities of daily living] Nihon Ronen Igakkai Zasshi. 2012; 49(4):457-62. . View in PubMed

[Clinical characteristics of argyrophillic grain disease and senile dementia of the neurofibrillary tangle type] Nihon Ronen Igakkai Zasshi. 2012; 49(3):281-3. . View in PubMed

[A case of Churg-Strauss syndrome with subarachnoid hemorrhage and left phrenic nerve paralysis] Nihon Kokyuki Gakkai Zasshi. 2011 Sep; 49(9):642-6. . View in PubMed

[A case of melioidosis occurring after a long-term stay in Vietnam that developed pulmonary cavitation and relapsed with multiple pulmonary nodules] Nihon Kokyuki Gakkai Zasshi. 2011 Jun; 49(6):443-8. . View in PubMed

[Clinical features of reversed halo sign in cryptogenic organizing pneumonia] Nihon Kokyuki Gakkai Zasshi. 2011 Feb; 49(2):75-80. . View in PubMed

[Fall and fracture of the elderly people] Nihon Ronen Igakkai Zasshi. 2011; 48(6):655-8. . View in PubMed

A new infusion sustainer that stabilizes perfusion during sutureless 25-gauge vitrectomy Int Ophthalmol. 2010 Dec; 30(6):735-8. . View in PubMed

Association between a history of falls and the ability to multi-task in community-dwelling older people Aging Clin Exp Res. 2010 Oct-Dec; 22(5-6):427-32. . View in PubMed

Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma N Engl J Med. 2010 Sep 30; 363(14):1324-34. . View in PubMed

[Life-space of community-dwelling older adults using preventive health care services in Japan and the validity of composite scoring methods for assessment] Nihon Koshu Eisei Zasshi. 2010 Jul; 57(7):526-37. . View in PubMed

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo J Neurosci. 2010 Apr 07; 30(14):4845-56. . View in PubMed

[Effects of SERMs on bone healthSERM and metabolic markers of bone]. Clin Calcium. 2010 Mar; 20(3):365-71. . View in PubMed

A case of multisystem Langerhans cell histiocytosis with primary hypothyroidism followed by type 1 diabetes mellitus Pediatr Blood Cancer. 2009 Aug; 53(2):232-4. . View in PubMed

Bimanual anterior vitrectomy using a 25-gauge high-speed cutter to manage vitreous loss during phacoemulsification Int Ophthalmol. 2009 Aug; 29(4):253-5. . View in PubMed

[Incidence of falls and fractures in disabled elderly people utilizing long-term care insurance] Nihon Ronen Igakkai Zasshi. 2009 Jul; 46(4):334-40. . View in PubMed

BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression Cancer Res. 2008 Aug 15; 68(16):6507-15. . View in PubMed

[Prevalence of geriatric syndrome and risk factors associated with obesity in community-dwelling elderly women] Nihon Ronen Igakkai Zasshi. 2008 Jul; 45(4):414-20. . View in PubMed

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia Ann Neurol. 2008 Mar; 63(3):377-87. . View in PubMed

[Factors burdening the caregiving relatives of community-dwelling disable Japanese people] Nihon Ronen Igakkai Zasshi. 2008 Jan; 45(1):59-67. . View in PubMed

An unusual case of neuroblastoma with angiomatoid features J Pediatr Surg. 2007 Dec; 42(12):e11-3. . View in PubMed

A case of composite neuroblastoma composed of histologically and biologically distinct clones Pediatr Dev Pathol. 2007 May-Jun; 10(3):229-32. . View in PubMed

[Sighting dominance in patients with macular disease] Nippon Ganka Gakkai Zasshi. 2007 Apr; 111(4):322-5. . View in PubMed

25-gauge scleral tunnel transconjunctival vitrectomy Am J Ophthalmol. 2006 Nov; 142(5):871-3. . View in PubMed

ABCC6 Mutation in Patients with Angioid Streaks Int J Biomed Sci. 2006 Feb; 2(1):7-12. . View in PubMed

[Chronic GVHD with polymyositis after non-myeloablative stem cell transplantation] Rinsho Ketsueki. 2005 Nov; 46(11):1213-7. . View in PubMed

[Preoperative factors for postoperative resolution of metamorphopsia in idiopathic macular hole surgery] Nippon Ganka Gakkai Zasshi. 2005 Sep; 109(9):591-5. . View in PubMed

[Evaluation of osteoporosis by markers of bone metabolism] Nihon Naika Gakkai Zasshi. 2005 Apr 10; 94(4):675-81. . View in PubMed

Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells Cancer Res. 2005 Feb 15; 65(4):1129-35. . View in PubMed

Assessment of NMYC amplification: a comparison of FISH, quantitative PCR monoplexing and traditional blotting methods used with formalin-fixed, paraffin-embedded neuroblastomas Anal Quant Cytol Histol. 2005 Feb; 27(1):5-14. . View in PubMed

A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis Arch Neurol. 2004 Nov; 61(11):1773-6. . View in PubMed

[Effects of introducing a risk manager for prevention of falls in a long-term care facility] Nihon Ronen Igakkai Zasshi. 2004 Jul; 41(4):414-9. . View in PubMed

[A randomized controlled trial of a treadmill training with the perturbation to improve the balance performance in the community dwelling elderly subjects] Nihon Ronen Igakkai Zasshi. 2004 May; 41(3):321-7. . View in PubMed

[Activity of the central nervous system and calcium] Clin Calcium. 2004 Jan; 14(1):106-9. . View in PubMed

[Surgical removal of juxtafoveal and extrafoveal choroidal neovascularization in age-related macular degeneration] Nippon Ganka Gakkai Zasshi. 2003 Nov; 107(11):695-701. . View in PubMed

[Surgical removal of choroidal neovascularization in angioid streaks] Nippon Ganka Gakkai Zasshi. 2003 Aug; 107(8):440-4. . View in PubMed

Anaplastic large cell lymphoma in Japanese children: retrospective analysis of 34 patients diagnosed at the National Research Institute for Child Health and Development Br J Haematol. 2003 Apr; 121(1):94-6. . View in PubMed

Antidisialoganglioside/granulocyte macrophage-colony-stimulating factor fusion protein facilitates neutrophil antibody-dependent cellular cytotoxicity and depends on FcgammaRII (CD32) and Mac-1 (CD11b/CD18) for enhanced effector cell adhesion and azurophil granule exocytosis Blood. 2002 Jun 01; 99(11):4166-73. . View in PubMed

Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors Genes Chromosomes Cancer. 2002 May; 34(1):33-41. . View in PubMed

alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin Int J Cancer. 2002 Apr 10; 98(5):690-7. . View in PubMed

[Relationship between lifestyle activities and physical functions in elderly persons utilizing care facilities] Nihon Ronen Igakkai Zasshi. 2002 Mar; 39(2):197-203. . View in PubMed

[Preoperative factors influencing visual acuity following vitrectomy for exudative age-related macular degeneration] Nippon Ganka Gakkai Zasshi. 2002 Jan; 106(1):16-22. . View in PubMed

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