Keck School Faculty

Hisham Abdel-Azim

Hisham Abdel-Azim

Associate Professor of Pediatrics (Clinical Scholar)
CHL Mail Stop 62 Off Campus Los Angeles

Pharmacokinetics and safety of posaconazole intravenous solution and powder for oral suspension in children with neutropenia: an open-label, sequential dose-escalation trial Int J Antimicrob Agents. 2020 Sep; 56(3):106084. . View in PubMed

A Personalized Prediction Model for Outcomes after Allogeneic Hematopoietic Cell Transplant in Myelodysplastic Syndromes Patients Biol Blood Marrow Transplant. 2020 Aug 08. . View in PubMed

Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide Biol Blood Marrow Transplant. 2020 Aug; 26(8):1459-1468. . View in PubMed

Practice patterns and incidence of adenovirus infection in allogeneic hematopoietic cell transplant recipients: Multicenter survey of transplant centers in the United States Transpl Infect Dis. 2020 Aug; 22(4):e13283. . View in PubMed

Reduced intensity conditioning for acute myeloid leukemia using melphalan- vs busulfan-based regimens: a CIBMTR report Blood Adv. 2020 Jul 14; 4(13):3180-3190. . View in PubMed

Integrin a6 mediates the drug resistance of acute lymphoblastic B-cell leukemia Blood. 2020 Jul 09; 136(2):210-223. . View in PubMed

Composite GRFS and CRFS Outcomes After Adult Alternative Donor HCT J Clin Oncol. 2020 Jun 20; 38(18):2062-2076. . View in PubMed

Comparison of total body irradiation versus non- total body irradiation containing regimens for de novo acute myeloid leukemia in children Haematologica. 2020 Jun 18. . View in PubMed

The Role of Donor Lymphocyte Infusion (DLI) in Post-Hematopoietic Cell Transplant (HCT) Relapse for Chronic Myeloid Leukemia (CML) in the Tyrosine Kinase Inhibitor (TKI) Era Biol Blood Marrow Transplant. 2020 Jun; 26(6):1137-1143. . View in PubMed

Bilateral retinal detachment after chimeric antigen receptor T-cell therapy Blood Adv. 2020 May 26; 4(10):2158-2162. . View in PubMed

The Impact of Donor Type on Outcomes and Cost of Allogeneic Hematopoietic Cell Transplantation for Pediatric Leukemia: A Merged Center for International Blood and Marrow Transplant Research and Pediatric Health Information System Analysis Biol Blood Marrow Transplant. 2020 May 25. . View in PubMed

A Phase 3, Single-Arm, Prospective Study of Remestemcel-L, Ex Vivo Culture-Expanded Adult Human Mesenchymal Stromal Cells for the Treatment of Pediatric Patients Who Failed to Respond to Steroid Treatment for Acute Graft-versus-Host Disease Biol Blood Marrow Transplant. 2020 May; 26(5):845-854. . View in PubMed

Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research Haematologica. 2020 May; 105(5):1329-1338. . View in PubMed

CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression Leukemia. 2020 Mar 24. . View in PubMed

Integrin Antibody Decreases Deformability of Patient-Derived Pre-B Acute Lymphocytic Leukemia Cells as Measured by High-Frequency Acoustic Tweezers J Ultrasound Med. 2020 Mar; 39(3):589-595. . View in PubMed

Maintenance Tyrosine Kinase Inhibitors Following Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia: A Center for International Blood and Marrow Transplant Research Study Biol Blood Marrow Transplant. 2020 Mar; 26(3):472-479. . View in PubMed

Weighty choices: selecting optimal G-CSF doses for stem cell mobilization to optimize yield Blood Adv. 2020 Feb 25; 4(4):706-716. . View in PubMed

Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement Lancet Haematol. 2020 Jan; 7(1):e61-e72. . View in PubMed

Strategies to generate functionally normal neutrophils to reduce infection and infection-related mortality in cancer chemotherapy Pharmacol Ther. 2019 12; 204:107403. . View in PubMed

Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation Biol Blood Marrow Transplant. 2019 09; 25(9):1875-1883. . View in PubMed

Lower Graft-versus-Host Disease and Relapse Risk in Post-Transplant Cyclophosphamide-Based Haploidentical versus Matched Sibling Donor Reduced-Intensity Conditioning Transplant for Hodgkin Lymphoma Biol Blood Marrow Transplant. 2019 09; 25(9):1859-1868. . View in PubMed

Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation Bone Marrow Transplant. 2019 08; 54(8):1254-1265. . View in PubMed

Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia Biol Blood Marrow Transplant. 2019 02; 25(2):301-306. . View in PubMed

Comparative Analysis of Calcineurin Inhibitor-Based Methotrexate and Mycophenolate Mofetil-Containing Regimens for Prevention of Graft-versus-Host Disease after Reduced-Intensity Conditioning Allogeneic Transplantation Biol Blood Marrow Transplant. 2019 01; 25(1):73-85. . View in PubMed

Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy Nat Rev Clin Oncol. 2019 01; 16(1):45-63. . View in PubMed

Survival Trends in Infants Undergoing Allogeneic Hematopoietic Cell Transplant JAMA Pediatr. 2019 05 01; 173(5):e190081. . View in PubMed

Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia Blood Adv. 2019 10 22; 3(20):3123-3131. . View in PubMed

GRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia Blood Adv. 2019 05 14; 3(9):1441-1449. . View in PubMed

Outcomes of haploidentical vs matched sibling transplantation for acute myeloid leukemia in first complete remission Blood Adv. 2019 06 25; 3(12):1826-1836. . View in PubMed

The impact of the graft-versus-leukemia effect on survival in acute lymphoblastic leukemia Blood Adv. 2019 02 26; 3(4):670-680. . View in PubMed

Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008 J Exp Clin Cancer Res. 2018 Mar 27; 37(1):67. . View in PubMed

Country-Level Macroeconomic Indicators Predict Early Post-Allogeneic Hematopoietic Cell Transplantation Survival in Acute Lymphoblastic Leukemia: A CIBMTR Analysis Biol Blood Marrow Transplant. 2018 09; 24(9):1928-1935. . View in PubMed

Donor body mass index does not predict graft versus host disease following hematopoietic cell transplantation Bone Marrow Transplant. 2018 07; 53(7):932-937. . View in PubMed

Influence of Age on Acute and Chronic GVHD in Children Undergoing HLA-Identical Sibling Bone Marrow Transplantation for Acute Leukemia: Implications for Prophylaxis Biol Blood Marrow Transplant. 2018 03; 24(3):521-528. . View in PubMed

Donor Experiences of Second Marrow or Peripheral Blood Stem Cell Collection Mirror the First, but CD34+ Yields Are Less Biol Blood Marrow Transplant. 2018 01; 24(1):175-184. . View in PubMed

Characterizing Deformability of Drug Resistant Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells Using Acoustic Tweezers Sci Rep. 2018 10 24; 8(1):15708. . View in PubMed

Pre-B acute lymphoblastic leukemia expresses cell surface nucleolin as a 9-O-acetylated sialoglycoprotein Sci Rep. 2018 11 21; 8(1):17174. . View in PubMed

B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation Blood. 2018 06 28; 131(26):2967-2977. . View in PubMed

SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery Blood. 2018 10 25; 132(17):1737-1749. . View in PubMed

Outcomes following autologous hematopoietic stem cell transplant for patients with relapsed Wilms' tumor: a CIBMTR retrospective analysis Bone Marrow Transplant. 2017 Nov; 52(11):1549-1555. . View in PubMed

The PI3Kd Inhibitor Idelalisib Inhibits Homing in an in Vitro and in Vivo Model of B ALL Cancers (Basel). 2017 Sep 10; 9(9). . View in PubMed

Personalized Prognostic Risk Score for Long-Term Survival for Children with Acute Leukemia after Allogeneic Transplantation Biol Blood Marrow Transplant. 2017 Sep; 23(9):1523-1530. . View in PubMed

Humoral Immune Reconstitution Kinetics after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Maturation Block of IgM Memory B Cells May Lead to Impaired Antibody Immune Reconstitution Biol Blood Marrow Transplant. 2017 Sep; 23(9):1437-1446. . View in PubMed

Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report Biol Blood Marrow Transplant. 2017 Aug; 23(8):1342-1349. . View in PubMed

Phase I Study of Clofarabine and 2-Gy Total Body Irradiation as a Nonmyeloablative Preparative Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patients with Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia Consortium Study Biol Blood Marrow Transplant. 2017 Jul; 23(7):1134-1141. . View in PubMed

Role of aß T Cell Depletion in Prevention of Graft versus Host Disease Biomedicines. 2017 Jun 26; 5(3). . View in PubMed

Outcomes after Umbilical Cord Blood Transplantation for Myelodysplastic Syndromes Biol Blood Marrow Transplant. 2017 Jun; 23(6):971-979. . View in PubMed

GvHD after umbilical cord blood transplantation for acute leukemia: an analysis of risk factors and effect on outcomes Bone Marrow Transplant. 2017 Mar; 52(3):400-408. . View in PubMed

Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases Haematologica. 2017 11; 102(11):1823-1832. . View in PubMed

Reply: T-Cell Acute Lymphoblastic Leukemia, Minimal Residual Disease, and Lymphocyte Recovery Pediatr Blood Cancer. 2016 May; 63(5):945. . View in PubMed

The incidence, mortality and timing of Pneumocystis jiroveci pneumonia after hematopoietic cell transplantation: a CIBMTR analysis Bone Marrow Transplant. 2016 Apr; 51(4):573-80. . View in PubMed

Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia J Biol Chem. 2016 Feb 19; 291(8):4004-18. . View in PubMed

Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality EMBO Mol Med. 2016 11; 8(11):1340-1359. . View in PubMed

Human leukocyte antigen supertype matching after myeloablative hematopoietic cell transplantation with 7/8 matched unrelated donor allografts: a report from the Center for International Blood and Marrow Transplant Research Haematologica. 2016 10; 101(10):1267-1274. . View in PubMed

Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation Biol Blood Marrow Transplant. 2016 09; 22(9):1636-1645. . View in PubMed

Outcomes of Allogeneic Hematopoietic Cell Transplantation in Children and Young Adults with Chronic Myeloid Leukemia: A CIBMTR Cohort Analysis Biol Blood Marrow Transplant. 2016 06; 22(6):1056-1064. . View in PubMed

Transplant Outcomes for Children with T Cell Acute Lymphoblastic Leukemia in Second Remission: A Report from the Center for International Blood and Marrow Transplant Research Biol Blood Marrow Transplant. 2015 Dec; 21(12):2154-2159. . View in PubMed

A prognostic model predicting autologous transplantation outcomes in children, adolescents and young adults with Hodgkin lymphoma Bone Marrow Transplant. 2015 Nov; 50(11):1416-23. . View in PubMed

Unrelated donor hematopoietic stem cell transplantation for the treatment of non-malignant genetic diseases: An alemtuzumab based regimen is associated with cure of clinical disease; earlier clearance of alemtuzumab may be associated with graft rejection Am J Hematol. 2015 Nov; 90(11):1021-6. . View in PubMed

End of induction minimal residual disease alone is not a useful determinant for risk stratified therapy in pediatric T-cell acute lymphoblastic leukemia Pediatr Blood Cancer. 2015 Nov; 62(11):2040-3. . View in PubMed

Second Allogeneic Hematopoietic Cell Transplantation for Patients with Fanconi Anemia and Bone Marrow Failure Biol Blood Marrow Transplant. 2015 Oct; 21(10):1790-5. . View in PubMed

Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes: Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers Biol Blood Marrow Transplant. 2015 Oct; 21(10):1830-8. . View in PubMed

Graft versus tumor effect in the brain of a child with recurrent metastatic medulloblastoma Pediatr Blood Cancer. 2015 Sep; 62(9):1667-9. . View in PubMed

Improved outcomes associated with hematopoietic stem cell transplantation for patients with juvenile myelomonocytic leukemia Blood. 2015 Jul 23; 126(4):561-2. . View in PubMed

Transplantation Outcomes for Children with Hypodiploid Acute Lymphoblastic Leukemia Biol Blood Marrow Transplant. 2015 Jul; 21(7):1273-7. . View in PubMed

Low-dose total-body irradiation and alemtuzumab-based reduced-intensity conditioning regimen results in durable engraftment and correction of clinical disease among children with chronic granulomatous disease Pediatr Transplant. 2015 Jun; 19(4):408-12. . View in PubMed

B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3 Oncotarget. 2015 May 10; 6(13):11378-94. . View in PubMed

Successful bone marrow transplantation of an adolescent young adult female with pregnancy-associated aplastic anemia J Pediatr Hematol Oncol. 2015 May; 37(4):319-21. . View in PubMed

A survey of infectious disease clinical practices among pediatric blood and marrow transplant programs in the United States Pediatr Blood Cancer. 2015 Apr; 62(4):731-5. . View in PubMed

Cytotoxicity of CD56-positive lymphocytes against autologous B-cell precursor acute lymphoblastic leukemia cells Leukemia. 2015 Apr; 29(4):788-97. . View in PubMed

A reduced-toxicity regimen is associated with durable engraftment and clinical cure of nonmalignant genetic diseases among children undergoing blood and marrow transplantation with an HLA-matched related donor Biol Blood Marrow Transplant. 2015 Mar; 21(3):440-4. . View in PubMed

Potential of autologous NK cell therapy to eradicate leukemia: "Education is [not] the best provision for old age" -Aristotle Oncoimmunology. 2015 Feb; 4(2):e984549. . View in PubMed

Phosphoflow-Based Evaluation of Mek Inhibitors as Small-Molecule Therapeutics for B-Cell Precursor Acute Lymphoblastic Leukemia PLoS One. 2015; 10(9):e0137917. . View in PubMed

Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia Blood. 2014 Dec 18; 124(26):3932-8. . View in PubMed

Bortezomib for effective treatment of a child with refractory autoimmune hemolytic anemia post allogeneic hematopoietic stem cell transplant Pediatr Blood Cancer. 2014 Dec; 61(12):2324-5. . View in PubMed

Overcoming psychosocial and developmental barriers to blood and marrow transplantation (BMT) in an adolescent/young adult (AYA) transgender patient with chronic myelogenous leukemia Pediatr Hematol Oncol. 2014 Nov; 31(8):765-7. . View in PubMed

Immunologic resolution of human chronic graft-versus-host disease Biol Blood Marrow Transplant. 2014 Oct; 20(10):1508-15. . View in PubMed

J Immunol. 2014 Jun 01; 192(11):5050-8. . View in PubMed

Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R . 2014 Jun; 13(6):1567-77. . View in PubMed

Transplantation for children with acute myeloid leukemia: a comparison of outcomes with reduced intensity and myeloablative regimens Blood. 2014 Mar 06; 123(10):1615-20. . View in PubMed

Galectin-3 in pre-B acute lymphoblastic leukemia Leukemia. 2013 Dec; 27(12):2385-8. . View in PubMed

ß-globin gene transfer to human bone marrow for sickle cell disease J Clin Invest. 2013 Jul 01. . View in PubMed

Circulating hematopoietic and endothelial progenitor cells in newborn infants: effects of gestational age, postnatal age and clinical stress in the first 3 weeks of life Early Hum Dev. 2013 Jun; 89(6):411-8. . View in PubMed

O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia J Exp Med. 2013 Apr 08; 210(4):805-19. . View in PubMed

Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans Blood. 2012 Nov 01; 120(18):3635-46. . View in PubMed

Clinical and genetic heterogeneity in Omenn syndrome and severe combined immune deficiency Pediatr Transplant. 2009 Mar; 13(2):244-50. . View in PubMed

Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis Pediatr Blood Cancer. 2009 Jan; 52(1):139-42. . View in PubMed

Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl Blood. 2008 Apr 15; 111(8):4064-74. . View in PubMed

Congenital bilateral upper eyelid coloboma J Perinatol. 2003 Mar; 23(2):166-7. . View in PubMed

Risk factors in intermediate and high-grade non-Hodgkin's lymphomas of adults: a need for a new staging system Anticancer Drugs. 1991 Aug; 2(4):383-8. . View in PubMed

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