Hooman Allayee, PhD

Professor of Population and Public Health Sciences

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Overview

Dr. Allayee is Professor of Populations & Public Health Sciences and Biochemistry & Molecular Medicine at the Keck School of Medicine of USC. His research program is focused on using multi-disciplinary genetics/genomics approaches to understand complex disorders, with an emphasis on cardiovascular, metabolic, and inflammatory diseases. In particular, his laboratory employs systems genetics strategies to dissect the architecture of complex diseases where a variety of intermediate phenotypes at the molecular, proteomic, and metabolomic levels are integrated into the genetic analyses. Current projects involve large-scale population studies in humans, gene-environment interactions, functional experiments using molecular genetics techniques, and the generation and characterization of mouse models. Prior to joining USC, Dr. Allayee completed NIH Postdoctoral Fellowships at Harbor-UCLA Medical Center and the David Geffen School of Medicine UCLA.

Publications

  • Comprehensive clinical and genetic analyses of circulating bile acids and their associations with diabetes and its indices Diabetes. 2024 May 03. . View in PubMed
  • Associations of dietary sugars with liver stiffness in Latino adolescents with obesity differ on PNPLA3 and liver disease severity Liver Int. 2024 Apr 18. . View in PubMed
  • Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women J Clin Endocrinol Metab. 2024 Mar 28. . View in PubMed
  • Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort Metabolites. 2024 Mar 20; 14(3). . View in PubMed
  • Publisher Correction: A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk Nat Med. 2024 Mar 06. . View in PubMed
  • A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk Nat Med. 2024 Feb; 30(2):424-434. . View in PubMed
  • Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity J Allergy Clin Immunol. 2024 Jan 19. . View in PubMed
  • Genetics unravels protein-metabolite relationships Trends Endocrinol Metab. 2024 03; 35(3):183-184. . View in PubMed
  • Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction Circ Res. 2024 02 16; 134(4):371-389. . View in PubMed
  • Effect of Genetic and Dietary Perturbation of Glycine Metabolism on Atherosclerosis in Humans and Mice medRxiv. 2023 Dec 11. . View in PubMed
  • Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial Nutrients. 2023 Jul 27; 15(15). . View in PubMed
  • Trimethylamine N-Oxide Response to a Mixed Macronutrient Tolerance Test in a Cohort of Healthy United States Adults Int J Mol Sci. 2023 Jan 20; 24(3). . View in PubMed
  • Systems genetics approaches for understanding complex traits with relevance for human disease Elife. 2023 11 14; 12. . View in PubMed
  • Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach Mol Metab. 2022 10; 64:101557. . View in PubMed
  • Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis Front Physiol. 2022; 13:909870. . View in PubMed
  • Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure Science. 2022 09 23; 377(6613):1399-1406. . View in PubMed
  • Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial J Nutr. 2022 07 06; 152(7):1655-1665. . View in PubMed
  • Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women Clin Epigenetics. 2022 07 18; 14(1):90. . View in PubMed
  • Near-roadway air pollution, immune cells and adipokines among obese young adults Environ Health. 2022 03 19; 21(1):36. . View in PubMed
  • PNPLA3 Genotype, Arachidonic Acid Intake, and Unsaturated Fat Intake Influences Liver Fibrosis in Hispanic Youth with Obesity Nutrients. 2021 May 12; 13(5). . View in PubMed
  • CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation Mucosal Immunol. 2021 07; 14(4):899-911. . View in PubMed
  • Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression Metabolism. 2021 03; 116:154457. . View in PubMed
  • Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection J Lipid Res. 2021; 62:100061. . View in PubMed
  • Gene-Environment Interactions for Cardiovascular Disease Curr Atheroscler Rep. 2021 10 14; 23(12):75. . View in PubMed
  • APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population Elife. 2021 09 29; 10. . View in PubMed
  • Noise Exposure and Distortion Product Otoacoustic Emission Suprathreshold Amplitudes: A Genome-Wide Association Study Audiol Neurootol. 2021; 26(6):445-453. . View in PubMed
  • Genetic evidence for independent causal relationships between metabolic biomarkers and risk of coronary artery diseases J Lipid Res. 2021; 62:100064. . View in PubMed
  • Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality Eur Heart J. 2021 05 07; 42(18):1742-1756. . View in PubMed
  • Genome-wide analysis identifies novel susceptibility loci for myocardial infarction Eur Heart J. 2021 03 01; 42(9):919-933. . View in PubMed
  • The Genetics of Variation of the Wave 1 Amplitude of the Mouse Auditory Brainstem Response J Assoc Res Otolaryngol. 2020 08; 21(4):323-336. . View in PubMed
  • Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles Environ Int. 2020 03; 136:105510. . View in PubMed
  • Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice G3 (Bethesda). 2020 07 07; 10(7):2529-2541. . View in PubMed
  • Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data Circulation. 2020 08 11; 142(6):546-555. . View in PubMed
  • Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma Nat Commun. 2020 04 15; 11(1):1776. . View in PubMed
  • Adult mouse hippocampal transcriptome changes associated with long-term behavioral and metabolic effects of gestational air pollution toxicity Transl Psychiatry. 2020 07 07; 10(1):218. . View in PubMed
  • A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity PLoS Genet. 2019 12; 15(12):e1008528. . View in PubMed
  • Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report Arterioscler Thromb Vasc Biol. 2019 06; 39(6):1045-1054. . View in PubMed
  • Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events Circ Genom Precis Med. 2019 04; 12(4):e002471. . View in PubMed
  • Subsequent Event Risk in Individuals With Established Coronary Heart Disease Circ Genom Precis Med. 2019 04; 12(4):e002470. . View in PubMed
  • Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer’s disease Menopause. 2019 01; 26(1):7-15. . View in PubMed
  • Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice Sci Rep. 2019 02 12; 9(1):1816. . View in PubMed
  • Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes Nat Commun. 2019 02 12; 10(1):713. . View in PubMed
  • Effect of ApoE4 Genotype on the Association Between Metabolic Phenotype and Subclinical Atherosclerosis in Postmenopausal Women Am J Cardiol. 2019 10 01; 124(7):1031-1037. . View in PubMed
  • Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease J Am Heart Assoc. 2019 05 21; 8(10):e011922. . View in PubMed
  • Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk JCI Insight. 2018 03 22; 3(6). . View in PubMed
  • Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration Nat Genet. 2017 Sep; 49(9):1346-1353. . View in PubMed
  • Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions Circulation. 2017 Jun 13; 135(24):2336-2353. . View in PubMed
  • The Genetic Architecture of Coronary Artery Disease: Current Knowledge and Future Opportunities Curr Atheroscler Rep. 2017 Feb; 19(2):6. . View in PubMed
  • The in vivo T helper type 17 and regulatory T cell immune responses to Aggregatibacter actinomycetemcomitans Mol Oral Microbiol. 2017 12; 32(6):490-499. . View in PubMed
  • Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study Lancet Diabetes Endocrinol. 2017 07; 5(7):534-543. . View in PubMed
  • Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden FASEB J. 2017 04; 31(4):1508-1515. . View in PubMed
  • Proceedings of the 11th Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN 2017) J Nutrigenet Nutrigenomics. 2017; 10(5-6):155-162. . View in PubMed
  • Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity J Nutrigenet Nutrigenomics. 2017; 10(1-2):43-62. . View in PubMed
  • Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. . View in PubMed
  • Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis Neurology. 2016 Aug 16; 87(7):699-708. . View in PubMed
  • Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association Circ Cardiovasc Genet. 2016 Jun; 9(3):291-313. . View in PubMed
  • Expanding role of gut microbiota in lipid metabolism Curr Opin Lipidol. 2016 Apr; 27(2):141-7. . View in PubMed
  • Choline metabolites: gene by diet interactions Curr Opin Lipidol. 2016 Feb; 27(1):33-9. . View in PubMed
  • Does near-roadway air pollution contribute to childhood obesity? Pediatr Obes. 2016 Feb; 11(1):1-3.. View in PubMed
  • Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease Nat Commun. 2016 Jan 29; 7:10558. . View in PubMed
  • Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium Diabetes. 2016 07; 65(7):2072-80. . View in PubMed
  • Lower omental t-regulatory cell count is associated with higher fasting glucose and lower ß-cell function in adults with obesity Obesity (Silver Spring). 2016 06; 24(6):1274-82. . View in PubMed
  • The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits J Lipid Res. 2016 06; 57(6):925-42. . View in PubMed
  • Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation J Am Heart Assoc. 2016 07 28; 5(8). . View in PubMed
  • The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction G3 (Bethesda). 2016 10 13; 6(10):3219-3228. . View in PubMed
  • Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 – Fields of Precision Nutrition J Nutrigenet Nutrigenomics. 2016; 9(1):12-27. . View in PubMed
  • Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 – Ethics, Challenges and Endeavors of Precision Nutrition J Nutrigenet Nutrigenomics. 2016; 9(1):28-46. . View in PubMed
  • An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease Genome Biol. 2016 08 11; 17(1):171. . View in PubMed
  • Contribution of Gut Bacteria to Lipid Levels: Another Metabolic Role for Microbes? Circ Res. 2015 Oct 09; 117(9):750-4.. View in PubMed
  • The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants G3 (Bethesda). 2015 Sep 04; 5(11):2329-39. . View in PubMed
  • Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study Early Hum Dev. 2015 Aug; 91(8):483-9. . View in PubMed
  • The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice Stem Cell Reports. 2015 Jul 14; 5(1):125-38. . View in PubMed
  • Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss PLoS Genet. 2015 Jun; 11(6):e1005293. . View in PubMed
  • Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss PLoS Genet. 2015 Apr; 11(4):e1005094. . View in PubMed
  • Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2737-48. . View in PubMed
  • Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics Obesity (Silver Spring). 2015 Mar; 23(3):543-51. . View in PubMed
  • Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction Nature. 2015 Feb 05; 518(7537):102-6. . View in PubMed
  • Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation Nat Genet. 2015 11; 47(11):1282-1293. . View in PubMed
  • Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans Diabetologia. 2014 Jul; 57(7):1391-9. . View in PubMed
  • Macrophages and fibrosis in adipose tissue are linked to liver damage and metabolic risk in obese children Obesity (Silver Spring). 2014 Jun; 22(6):1512-9. . View in PubMed
  • Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine Arterioscler Thromb Vasc Biol. 2014 Jun; 34(6):1307-13. . View in PubMed
  • J Nutr. 2014 Feb; 144(2):123-31. . View in PubMed
  • Modifying influence of dietary sugar in the relationship between cortisol and visceral adipose tissue in minority youth Obesity (Silver Spring). 2014 Feb; 22(2):474-81. . View in PubMed
  • Adipose tissue 11ßHSD1 gene expression, ßcell function and ectopic fat in obese African Americans versus Hispanics Obesity (Silver Spring). 2014 Jan; 22(1):14-8. . View in PubMed
  • Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. . View in PubMed
  • Genetic and clinical markers of elevated liver fat content in overweight and obese Hispanic children Obesity (Silver Spring). 2013 Dec; 21(12):E790-7. . View in PubMed
  • Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia Hum Mol Genet. 2013 Aug 15; 22(16):3381-93. . View in PubMed
  • Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk Circ Cardiovasc Genet. 2013 Aug; 6(4):372-80. . View in PubMed
  • ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma Clin Exp Allergy. 2013 May; 43(5):512-20. . View in PubMed
  • Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2) J Biol Chem. 2013 Apr 26; 288(17):11940-8. . View in PubMed
  • Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis J Am Coll Cardiol. 2013 Mar 05; 61(9):957-70. . View in PubMed
  • Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods Contemp Clin Trials. 2013 Mar; 34(2):326-35. . View in PubMed
  • Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation Cell Metab. 2013 Jan 08; 17(1):49-60. . View in PubMed
  • Seventy-five genetic loci influencing the human red blood cell Nature. 2012 Dec 20; 492(7429):369-75. . View in PubMed
  • Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2803-12. . View in PubMed
  • Metabolic syndrome is linked to chromosome 7q21 and associated with genetic variants in CD36 and GNAT3 in Mexican Americans Obesity (Silver Spring). 2012 Oct; 20(10):2083-92. . View in PubMed
  • Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits Mamm Genome. 2012 Oct; 23(9-10):680-92. . View in PubMed
  • CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults Hum Genomics. 2012 Aug 02; 6:9. . View in PubMed
  • Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography Circ Cardiovasc Genet. 2012 Aug 01; 5(4):441-9. . View in PubMed
  • Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans J Nutr. 2012 Aug; 142(8):1417-28. . View in PubMed
  • Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study Am J Clin Nutr. 2012 Jul; 96(1):80-9. . View in PubMed
  • Genetic-related and carbohydrate-related factors affecting liver fat accumulation Curr Opin Clin Nutr Metab Care. 2012 Jul; 15(4):392-6. . View in PubMed
  • Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs Am J Clin Nutr. 2012 Apr; 95(4):959-65. . View in PubMed
  • Clinical and genetic association of serum ceruloplasmin with cardiovascular risk Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):516-22. . View in PubMed
  • New gene functions in megakaryopoiesis and platelet formation Nature. 2011 Nov 30; 480(7376):201-8. . View in PubMed
  • Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-? B stress pathway. Diabetes. 2011 Nov; 60(11):2802-9.. View in PubMed
  • Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome BMC Med Genet. 2011 Sep 29; 12:127. . View in PubMed
  • A novel g-1258G>A mutation in a conserved putative regulatory element of PAX9 is associated with autosomal dominant molar hypodontia. Clin Genet. 2011 Sep; 80(3):265-72. . View in PubMed
  • Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism Epidemiology. 2011 Jul; 22(4):476-85. . View in PubMed
  • Genetic contribution of the leukotriene pathway to coronary artery disease Hum Genet. 2011 Jun; 129(6):617-27. . View in PubMed
  • ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation J Lipid Res. 2011 May; 52(5):991-1003. . View in PubMed
  • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease Nature. 2011 Apr 07; 472(7341):57-63. . View in PubMed
  • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease Nat Genet. 2011 Mar 06; 43(4):333-8. . View in PubMed
  • Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project PLoS Genet. 2011 Feb 10; 7(2):e1001300. . View in PubMed
  • Genetic risk score and risk of myocardial infarction in Hispanics Circulation. 2011 Feb 01; 123(4):374-80. . View in PubMed
  • Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies Lancet. 2011 Jan 29; 377(9763):383-92. . View in PubMed
  • Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load Biodemography Soc Biol. 2011; 57(1):33-52. . View in PubMed
  • Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents Diabetes. 2010 Dec; 59(12):3127-30. . View in PubMed
  • Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption Am J Clin Nutr. 2010 Dec; 92(6):1522-7. . View in PubMed
  • Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy J Lipid Res. 2010 Oct; 51(10):3055-61. . View in PubMed
  • Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose Diabetes. 2009 Dec; 58(12):2946-53. . View in PubMed
  • Functional analysis of 5-lipoxygenase promoter repeat variants Hum Mol Genet. 2009 Dec 01; 18(23):4521-9. . View in PubMed
  • Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. . View in PubMed
  • Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay Genet Test Mol Biomarkers. 2009 Jun; 13(3):361-5. . View in PubMed
  • Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans Obesity (Silver Spring). 2009 Apr; 17(4):729-36. . View in PubMed
  • A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus Hum Mol Genet. 2009 Feb 01; 18(3):569-79. . View in PubMed
  • Polyunsaturated fatty acids and cardiovascular disease: implications for nutrigenetics J Nutrigenet Nutrigenomics. 2009; 2(3):140-8. . View in PubMed
  • Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction Am J Clin Nutr. 2008 Oct; 88(4):934-40. . View in PubMed
  • Identification of ALOX5 as a gene regulating adiposity and pancreatic function Diabetologia. 2008 Jun; 51(6):978-88. . View in PubMed
  • Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease Hum Genet. 2008 May; 123(4):399-408. . View in PubMed
  • Allgrove syndrome in a Mexican American family is caused by an ancestral mutation derived from North Africa Clin Genet. 2008 Apr; 73(4):385-7. . View in PubMed
  • Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans Diabetes. 2008 Apr; 57(4):1048-56. . View in PubMed
  • Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk JAMA. 2008 Mar 19; 299(11):1265-76. . View in PubMed
  • Prevalence of common disease-associated variants in Asian Indians BMC Genet. 2008 Feb 04; 9:13. . View in PubMed
  • Non-conventional genetic risk factors for cardiovascular disease World Rev Nutr Diet. 2008; 98:62-76. . View in PubMed
  • FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice Toxicol Sci. 2007 Dec; 100(2):474-85. . View in PubMed
  • The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics Chest. 2007 Sep; 132(3):868-74. . View in PubMed
  • Genetics of gestational diabetes mellitus and type 2 diabetes Diabetes Care. 2007 Jul; 30 Suppl 2:S134-40. . View in PubMed
  • Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans Diabetes. 2007 May; 56(5):1481-5. . View in PubMed
  • A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q243. Hum Genet. 2007 Jan; 120(5):653-62. . View in PubMed
  • Effect of obesity on clinical presentation and response to treatment in asthma J Asthma. 2006 Sep; 43(7):553-8. . View in PubMed
  • Using inbred mouse strains to identify genes for complex diseases Front Biosci. 2006 May 01; 11:1216-26. . View in PubMed
  • Nonconventional genetic risk factors for cardiovascular disease Curr Atheroscler Rep. 2006 May; 8(3):184-92. . View in PubMed
  • Influence of leukotriene pathway polymorphisms on response to montelukast in asthma Am J Respir Crit Care Med. 2006 Feb 15; 173(4):379-85. . View in PubMed
  • Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits Nat Genet. 2005 Nov; 37(11):1224-33. . View in PubMed
  • A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background Genomics. 2005 Sep; 86(3):259-70. . View in PubMed
  • The Collaborative Cross, a community resource for the genetic analysis of complex traits Nat Genet. 2004 Nov; 36(11):1133-7. . View in PubMed
  • Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1935-41. . View in PubMed
  • Vascular cross-talk: a conversation Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1748-9. . View in PubMed
  • Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia Circ Res. 2004 Apr 16; 94(7):993-9. . View in PubMed
  • Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis N Engl J Med. 2004 Jan 01; 350(1):29-37. . View in PubMed
  • 5-lipoxygenase and atherosclerosis Curr Opin Lipidol. 2003 Oct; 14(5):447-57. . View in PubMed
  • Using mice to dissect genetic factors in atherosclerosis Arterioscler Thromb Vasc Biol. 2003 Sep 01; 23(9):1501-9. . View in PubMed
  • Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia Circ Res. 2003 Jun 13; 92(11):1262-7. . View in PubMed
  • Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q Am J Hum Genet. 2003 Apr; 72(4):903-17. . View in PubMed
  • Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice Circ Res. 2002 Jul 26; 91(2):120-6. . View in PubMed
  • Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia Circ Res. 2002 May 03; 90(8):926-31. . View in PubMed
  • Understanding atherosclerosis through mouse genetics Curr Opin Lipidol. 2002 Apr; 13(2):181-9. . View in PubMed
  • Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p Hypertension. 2001 Oct; 38(4):773-8. . View in PubMed
  • BiochemistryAn absorbing study of cholesterol. Science. 2000 Dec 01; 290(5497):1709-11. . View in PubMed
  • Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A Int J Obes Relat Metab Disord. 2000 Nov; 24(11):1381-91. . View in PubMed
  • Identification of TNFRSF1B as a novel modifier gene in familial combined hyperlipidemia Hum Mol Genet. 2000 Sep 01; 9(14):2067-74. . View in PubMed
  • A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2 J Lipid Res. 2000 Apr; 41(4):573-82. . View in PubMed
  • Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia J Lipid Res. 2000 Feb; 41(2):245-52. . View in PubMed
  • Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2730-6. . View in PubMed
  • A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11 Am J Hum Genet. 1999 Aug; 65(2):397-412. . View in PubMed
  • Novel genes for familial combined hyperlipidemia Curr Opin Lipidol. 1999 Apr; 10(2):113-22. . View in PubMed
  • Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype Am J Hum Genet. 1998 Aug; 63(2):577-85. . View in PubMed
  • Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice J Clin Invest. 1994 Aug; 94(2):877-84. . View in PubMed