Keck School Faculty

Hooman Allayee

Hooman Allayee

Professor of Population and Public Health Sciences
CSC CSC202 Health Sciences Campus Los Angeles

Trimethylamine N-Oxide Response to a Mixed Macronutrient Tolerance Test in a Cohort of Healthy United States Adults Int J Mol Sci. 2023 Jan 20; 24(3). . View in PubMed

Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach Mol Metab. 2022 10; 64:101557. . View in PubMed

Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis Front Physiol. 2022; 13:909870. . View in PubMed

Near-roadway air pollution, immune cells and adipokines among obese young adults Environ Health. 2022 03 19; 21(1):36. . View in PubMed

Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women Clin Epigenetics. 2022 07 18; 14(1):90. . View in PubMed

Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure Science. 2022 09 23; 377(6613):1399-1406. . View in PubMed

Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial J Nutr. 2022 07 06; 152(7):1655-1665. . View in PubMed

PNPLA3 Genotype, Arachidonic Acid Intake, and Unsaturated Fat Intake Influences Liver Fibrosis in Hispanic Youth with Obesity Nutrients. 2021 May 12; 13(5). . View in PubMed

CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation Mucosal Immunol. 2021 07; 14(4):899-911. . View in PubMed

Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression Metabolism. 2021 03; 116:154457. . View in PubMed

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction Eur Heart J. 2021 03 01; 42(9):919-933. . View in PubMed

APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population Elife. 2021 09 29; 10. . View in PubMed

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality Eur Heart J. 2021 05 07; 42(18):1742-1756. . View in PubMed

Noise Exposure and Distortion Product Otoacoustic Emission Suprathreshold Amplitudes: A Genome-Wide Association Study Audiol Neurootol. 2021; 26(6):445-453. . View in PubMed

Genetic evidence for independent causal relationships between metabolic biomarkers and risk of coronary artery diseases J Lipid Res. 2021; 62:100064. . View in PubMed

Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection J Lipid Res. 2021; 62:100061. . View in PubMed

Gene-Environment Interactions for Cardiovascular Disease Curr Atheroscler Rep. 2021 10 14; 23(12):75. . View in PubMed

The Genetics of Variation of the Wave 1 Amplitude of the Mouse Auditory Brainstem Response J Assoc Res Otolaryngol. 2020 08; 21(4):323-336. . View in PubMed

Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles Environ Int. 2020 03; 136:105510. . View in PubMed

Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma Nat Commun. 2020 04 15; 11(1):1776. . View in PubMed

Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice G3 (Bethesda). 2020 07 07; 10(7):2529-2541. . View in PubMed

Adult mouse hippocampal transcriptome changes associated with long-term behavioral and metabolic effects of gestational air pollution toxicity Transl Psychiatry. 2020 07 07; 10(1):218. . View in PubMed

Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data Circulation. 2020 08 11; 142(6):546-555. . View in PubMed

A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity PLoS Genet. 2019 12; 15(12):e1008528. . View in PubMed

Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report Arterioscler Thromb Vasc Biol. 2019 06; 39(6):1045-1054. . View in PubMed

Subsequent Event Risk in Individuals With Established Coronary Heart Disease Circ Genom Precis Med. 2019 04; 12(4):e002470. . View in PubMed

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events Circ Genom Precis Med. 2019 04; 12(4):e002471. . View in PubMed

Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease Menopause. 2019 01; 26(1):7-15. . View in PubMed

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes Nat Commun. 2019 02 12; 10(1):713. . View in PubMed

Effect of ApoE4 Genotype on the Association Between Metabolic Phenotype and Subclinical Atherosclerosis in Postmenopausal Women Am J Cardiol. 2019 10 01; 124(7):1031-1037. . View in PubMed

Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease J Am Heart Assoc. 2019 05 21; 8(10):e011922. . View in PubMed

Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice Sci Rep. 2019 02 12; 9(1):1816. . View in PubMed

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk JCI Insight. 2018 03 22; 3(6). . View in PubMed

Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration Nat Genet. 2017 Sep; 49(9):1346-1353. . View in PubMed

Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions Circulation. 2017 Jun 13; 135(24):2336-2353. . View in PubMed

The Genetic Architecture of Coronary Artery Disease: Current Knowledge and Future Opportunities Curr Atheroscler Rep. 2017 Feb; 19(2):6. . View in PubMed

The in vivo T helper type 17 and regulatory T cell immune responses to Aggregatibacter actinomycetemcomitans Mol Oral Microbiol. 2017 12; 32(6):490-499. . View in PubMed

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study Lancet Diabetes Endocrinol. 2017 07; 5(7):534-543. . View in PubMed

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden FASEB J. 2017 04; 31(4):1508-1515. . View in PubMed

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity J Nutrigenet Nutrigenomics. 2017; 10(1-2):43-62. . View in PubMed

Proceedings of the 11th Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN 2017) J Nutrigenet Nutrigenomics. 2017; 10(5-6):155-162. . View in PubMed

Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. . View in PubMed

Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis Neurology. 2016 Aug 16; 87(7):699-708. . View in PubMed

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association Circ Cardiovasc Genet. 2016 Jun; 9(3):291-313. . View in PubMed

Expanding role of gut microbiota in lipid metabolism Curr Opin Lipidol. 2016 Apr; 27(2):141-7. . View in PubMed

Does near-roadway air pollution contribute to childhood obesity? Pediatr Obes. 2016 Feb; 11(1):1-3.. View in PubMed

Choline metabolites: gene by diet interactions Curr Opin Lipidol. 2016 Feb; 27(1):33-9. . View in PubMed

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease Nat Commun. 2016 Jan 29; 7:10558. . View in PubMed

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium Diabetes. 2016 07; 65(7):2072-80. . View in PubMed

Lower omental t-regulatory cell count is associated with higher fasting glucose and lower ß-cell function in adults with obesity Obesity (Silver Spring). 2016 06; 24(6):1274-82. . View in PubMed

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits J Lipid Res. 2016 06; 57(6):925-42. . View in PubMed

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation J Am Heart Assoc. 2016 07 28; 5(8). . View in PubMed

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease Genome Biol. 2016 08 11; 17(1):171. . View in PubMed

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition J Nutrigenet Nutrigenomics. 2016; 9(1):12-27. . View in PubMed

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 - Ethics, Challenges and Endeavors of Precision Nutrition J Nutrigenet Nutrigenomics. 2016; 9(1):28-46. . View in PubMed

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction G3 (Bethesda). 2016 10 13; 6(10):3219-3228. . View in PubMed

Contribution of Gut Bacteria to Lipid Levels: Another Metabolic Role for Microbes? Circ Res. 2015 Oct 09; 117(9):750-4.. View in PubMed

The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants G3 (Bethesda). 2015 Sep 04; 5(11):2329-39. . View in PubMed

Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study Early Hum Dev. 2015 Aug; 91(8):483-9. . View in PubMed

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice Stem Cell Reports. 2015 Jul 14; 5(1):125-38. . View in PubMed

Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss PLoS Genet. 2015 Jun; 11(6):e1005293. . View in PubMed

Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss PLoS Genet. 2015 Apr; 11(4):e1005094. . View in PubMed

Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2737-48. . View in PubMed

Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics Obesity (Silver Spring). 2015 Mar; 23(3):543-51. . View in PubMed

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction Nature. 2015 Feb 05; 518(7537):102-6. . View in PubMed

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation Nat Genet. 2015 11; 47(11):1282-1293. . View in PubMed

Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans Diabetologia. 2014 Jul; 57(7):1391-9. . View in PubMed

Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine Arterioscler Thromb Vasc Biol. 2014 Jun; 34(6):1307-13. . View in PubMed

Macrophages and fibrosis in adipose tissue are linked to liver damage and metabolic risk in obese children Obesity (Silver Spring). 2014 Jun; 22(6):1512-9. . View in PubMed

Modifying influence of dietary sugar in the relationship between cortisol and visceral adipose tissue in minority youth Obesity (Silver Spring). 2014 Feb; 22(2):474-81. . View in PubMed

J Nutr. 2014 Feb; 144(2):123-31. . View in PubMed

Adipose tissue 11ßHSD1 gene expression, ßcell function and ectopic fat in obese African Americans versus Hispanics Obesity (Silver Spring). 2014 Jan; 22(1):14-8. . View in PubMed

Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. . View in PubMed

Genetic and clinical markers of elevated liver fat content in overweight and obese Hispanic children Obesity (Silver Spring). 2013 Dec; 21(12):E790-7. . View in PubMed

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia Hum Mol Genet. 2013 Aug 15; 22(16):3381-93. . View in PubMed

Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk Circ Cardiovasc Genet. 2013 Aug; 6(4):372-80. . View in PubMed

ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma Clin Exp Allergy. 2013 May; 43(5):512-20. . View in PubMed

Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2) J Biol Chem. 2013 Apr 26; 288(17):11940-8. . View in PubMed

Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis J Am Coll Cardiol. 2013 Mar 05; 61(9):957-70. . View in PubMed

Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods Contemp Clin Trials. 2013 Mar; 34(2):326-35. . View in PubMed

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation Cell Metab. 2013 Jan 08; 17(1):49-60. . View in PubMed

Seventy-five genetic loci influencing the human red blood cell Nature. 2012 Dec 20; 492(7429):369-75. . View in PubMed

Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2803-12. . View in PubMed

Metabolic syndrome is linked to chromosome 7q21 and associated with genetic variants in CD36 and GNAT3 in Mexican Americans Obesity (Silver Spring). 2012 Oct; 20(10):2083-92. . View in PubMed

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits Mamm Genome. 2012 Oct; 23(9-10):680-92. . View in PubMed

CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults Hum Genomics. 2012 Aug 02; 6:9. . View in PubMed

Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans J Nutr. 2012 Aug; 142(8):1417-28. . View in PubMed

Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography Circ Cardiovasc Genet. 2012 Aug 01; 5(4):441-9. . View in PubMed

Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study Am J Clin Nutr. 2012 Jul; 96(1):80-9. . View in PubMed

Genetic-related and carbohydrate-related factors affecting liver fat accumulation Curr Opin Clin Nutr Metab Care. 2012 Jul; 15(4):392-6. . View in PubMed

Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs Am J Clin Nutr. 2012 Apr; 95(4):959-65. . View in PubMed

Clinical and genetic association of serum ceruloplasmin with cardiovascular risk Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):516-22. . View in PubMed

New gene functions in megakaryopoiesis and platelet formation Nature. 2011 Nov 30; 480(7376):201-8. . View in PubMed

Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-? B stress pathway. Diabetes. 2011 Nov; 60(11):2802-9.. View in PubMed

Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome BMC Med Genet. 2011 Sep 29; 12:127. . View in PubMed

A novel g-1258G>A mutation in a conserved putative regulatory element of PAX9 is associated with autosomal dominant molar hypodontia. Clin Genet. 2011 Sep; 80(3):265-72. . View in PubMed

Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism Epidemiology. 2011 Jul; 22(4):476-85. . View in PubMed

Genetic contribution of the leukotriene pathway to coronary artery disease Hum Genet. 2011 Jun; 129(6):617-27. . View in PubMed

ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation J Lipid Res. 2011 May; 52(5):991-1003. . View in PubMed

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease Nature. 2011 Apr 07; 472(7341):57-63. . View in PubMed

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease Nat Genet. 2011 Mar 06; 43(4):333-8. . View in PubMed

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project PLoS Genet. 2011 Feb 10; 7(2):e1001300. . View in PubMed

Genetic risk score and risk of myocardial infarction in Hispanics Circulation. 2011 Feb 01; 123(4):374-80. . View in PubMed

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies Lancet. 2011 Jan 29; 377(9763):383-92. . View in PubMed

Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load Biodemography Soc Biol. 2011; 57(1):33-52. . View in PubMed

Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption Am J Clin Nutr. 2010 Dec; 92(6):1522-7. . View in PubMed

Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents Diabetes. 2010 Dec; 59(12):3127-30. . View in PubMed

Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy J Lipid Res. 2010 Oct; 51(10):3055-61. . View in PubMed

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose Diabetes. 2009 Dec; 58(12):2946-53. . View in PubMed

Functional analysis of 5-lipoxygenase promoter repeat variants Hum Mol Genet. 2009 Dec 01; 18(23):4521-9. . View in PubMed

Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. . View in PubMed

Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay Genet Test Mol Biomarkers. 2009 Jun; 13(3):361-5. . View in PubMed

Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans Obesity (Silver Spring). 2009 Apr; 17(4):729-36. . View in PubMed

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus Hum Mol Genet. 2009 Feb 01; 18(3):569-79. . View in PubMed

Polyunsaturated fatty acids and cardiovascular disease: implications for nutrigenetics J Nutrigenet Nutrigenomics. 2009; 2(3):140-8. . View in PubMed

Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction Am J Clin Nutr. 2008 Oct; 88(4):934-40. . View in PubMed

Identification of ALOX5 as a gene regulating adiposity and pancreatic function Diabetologia. 2008 Jun; 51(6):978-88. . View in PubMed

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease Hum Genet. 2008 May; 123(4):399-408. . View in PubMed

Allgrove syndrome in a Mexican American family is caused by an ancestral mutation derived from North Africa Clin Genet. 2008 Apr; 73(4):385-7. . View in PubMed

Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans Diabetes. 2008 Apr; 57(4):1048-56. . View in PubMed

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk JAMA. 2008 Mar 19; 299(11):1265-76. . View in PubMed

Prevalence of common disease-associated variants in Asian Indians BMC Genet. 2008 Feb 04; 9:13. . View in PubMed

Non-conventional genetic risk factors for cardiovascular disease World Rev Nutr Diet. 2008; 98:62-76. . View in PubMed

FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice Toxicol Sci. 2007 Dec; 100(2):474-85. . View in PubMed

The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics Chest. 2007 Sep; 132(3):868-74. . View in PubMed

Genetics of gestational diabetes mellitus and type 2 diabetes Diabetes Care. 2007 Jul; 30 Suppl 2:S134-40. . View in PubMed

Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans Diabetes. 2007 May; 56(5):1481-5. . View in PubMed

A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q243. Hum Genet. 2007 Jan; 120(5):653-62. . View in PubMed

Effect of obesity on clinical presentation and response to treatment in asthma J Asthma. 2006 Sep; 43(7):553-8. . View in PubMed

Using inbred mouse strains to identify genes for complex diseases Front Biosci. 2006 May 01; 11:1216-26. . View in PubMed

Nonconventional genetic risk factors for cardiovascular disease Curr Atheroscler Rep. 2006 May; 8(3):184-92. . View in PubMed

Influence of leukotriene pathway polymorphisms on response to montelukast in asthma Am J Respir Crit Care Med. 2006 Feb 15; 173(4):379-85. . View in PubMed

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits Nat Genet. 2005 Nov; 37(11):1224-33. . View in PubMed

A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background Genomics. 2005 Sep; 86(3):259-70. . View in PubMed

The Collaborative Cross, a community resource for the genetic analysis of complex traits Nat Genet. 2004 Nov; 36(11):1133-7. . View in PubMed

Vascular cross-talk: a conversation Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1748-9. . View in PubMed

Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1935-41. . View in PubMed

Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia Circ Res. 2004 Apr 16; 94(7):993-9. . View in PubMed

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis N Engl J Med. 2004 Jan 01; 350(1):29-37. . View in PubMed

5-lipoxygenase and atherosclerosis Curr Opin Lipidol. 2003 Oct; 14(5):447-57. . View in PubMed

Using mice to dissect genetic factors in atherosclerosis Arterioscler Thromb Vasc Biol. 2003 Sep 01; 23(9):1501-9. . View in PubMed

Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia Circ Res. 2003 Jun 13; 92(11):1262-7. . View in PubMed

Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q Am J Hum Genet. 2003 Apr; 72(4):903-17. . View in PubMed

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice Circ Res. 2002 Jul 26; 91(2):120-6. . View in PubMed

Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia Circ Res. 2002 May 03; 90(8):926-31. . View in PubMed

Understanding atherosclerosis through mouse genetics Curr Opin Lipidol. 2002 Apr; 13(2):181-9. . View in PubMed

Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p Hypertension. 2001 Oct; 38(4):773-8. . View in PubMed

BiochemistryAn absorbing study of cholesterol. Science. 2000 Dec 01; 290(5497):1709-11. . View in PubMed

Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A Int J Obes Relat Metab Disord. 2000 Nov; 24(11):1381-91. . View in PubMed

Identification of TNFRSF1B as a novel modifier gene in familial combined hyperlipidemia Hum Mol Genet. 2000 Sep 01; 9(14):2067-74. . View in PubMed

A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2 J Lipid Res. 2000 Apr; 41(4):573-82. . View in PubMed

Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia J Lipid Res. 2000 Feb; 41(2):245-52. . View in PubMed

Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2730-6. . View in PubMed

A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11 Am J Hum Genet. 1999 Aug; 65(2):397-412. . View in PubMed

Novel genes for familial combined hyperlipidemia Curr Opin Lipidol. 1999 Apr; 10(2):113-22. . View in PubMed

Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype Am J Hum Genet. 1998 Aug; 63(2):577-85. . View in PubMed

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice J Clin Invest. 1994 Aug; 94(2):877-84. . View in PubMed

Dr. Allayee is Professor of Populations & Public Health Sciences and Biochemistry & Molecular Medicine at the Keck School of Medicine of USC. His research program is focused on using multi-disciplinary genetics/genomics approaches to understand complex disorders, with an emphasis on cardiovascular, metabolic, and inflammatory diseases. In particular, his laboratory employs systems genetics strategies to dissect the architecture of complex diseases where a variety of intermediate phenotypes at the molecular, proteomic, and metabolomic levels are integrated into the genetic analyses. Current projects involve large-scale population studies in humans, gene-environment interactions, functional experiments using molecular genetics techniques, and the generation and characterization of mouse models. Prior to joining USC, Dr. Allayee completed NIH Postdoctoral Fellowships at Harbor-UCLA Medical Center and the David Geffen School of Medicine UCLA.
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