Keck School Faculty

Hugo Rosen, MD
Hugo Rosen, MD
Professor and Chair, Department of Medicine;Kenneth T. Norris, Jr., Chair in Medicine
Medicine
1450 San Pablo St. Off Campus Los Angeles
Hugo R. Rosen, MD is the Norris Chair of Medicine and Professor of Medicine, Immunology, and Molecular Microbiology.

Rosen is a prolific physician-scientist with more than 180 original peer-reviewed manuscripts investigating the cellular and molecular underpinnings of a wide spectrum of innate and adaptive immune responses and developing novel paradigms in liver diseases. He has been the principal investigator of multiple National Institutes of Health grants (including two active RO1 grants), Center Grants, three T32 training grants and five VA Merit grants. He is an elected member of the American Society of Clinical Investigation (elected in 2008) and the American Association of Physicians. He has also received research funding from the American Society of Transplantation and American Association for the Study of Liver Diseases, having been named “Fellow” in the inaugural class of both societies. He currently serves as deputy editor of the journal Hepatology. He completed his internship and residency in internal medicine at Beth Israel Deaconess Medical Center, Harvard Medical School, followed by a fellowship in gastroenterology and transplant hepatology at UCLA. He will manage patients with acute and chronic liver disease at the Medical Center of USC and LAC+USC Medical Center.

Revisiting the Paradox of ISG expression as a predictor of HCV treatment response, a decade later Hepatology. 2018 Jul 28. . View in PubMed

Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment Hepatol Commun. 2018 04; 2(4):364-375. . View in PubMed

Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection Hepatology. 2018 01; 67(1):71-85. . View in PubMed

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection Sci Rep. 2017 Nov 20; 7(1):15843. . View in PubMed

NAM 2017 report: A national plan to eliminate hepatitis B and C in the United States by 2030 and the AASLD's response Hepatology. 2017 10; 66(4):1020-1022. . View in PubMed

Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation Hepatology. 2017 07; 66(1):271-279. . View in PubMed

Neutrophil-to-lymphocyte ratio correlates with proinflammatory neutrophils and predicts death in low model for end-stage liver disease patients with cirrhosis Liver Transpl. 2017 02; 23(2):155-165. . View in PubMed

"Hep C, where art thou": What are the remaining (fundable) questions in hepatitis C virus research? Hepatology. 2017 01; 65(1):341-349.. View in PubMed

Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy PLoS One. 2017; 12(10):e0186213. . View in PubMed

Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission J Immunol. 2017 01 15; 198(2):972. . View in PubMed

Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of AlcoholClin Gastroenterol Hepatol. 2016 May; 14(5):762-8. e1. . View in PubMed

Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner Nat Commun. 2016 Apr 21; 7:11291. . View in PubMed

Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver FailureClin Gastroenterol Hepatol. 2016 Apr; 14(4):606-612. e3. . View in PubMed

J Immunol. 2016 Mar 01; 196(5):2283-92. . View in PubMed

HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production J Leukoc Biol. 2016 Mar; 99(3):495-503. . View in PubMed

CD4+ and CD8+ T Cell Activation in Children with Hepatitis CJ Pediatr. 2016 Mar; 170:142-8. e1. . View in PubMed

Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability J Leukoc Biol. 2016 09; 100(3):545-57. . View in PubMed

Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease PLoS One. 2016; 11(7):e0159217. . View in PubMed

Hepatitis C viral infection is associated with activated cytolytic natural killer cells expressing high levels of T cell immunoglobulin- and mucin-domain-containing molecule-3 Clin Immunol. 2015 May; 158(1):114-25. . View in PubMed

Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver MBio. 2015 Feb 24; 6(2):e02510. . View in PubMed

Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replicationGastroenterology. 2015 Feb; 148(2):392-402. e13. . View in PubMed

Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission J Immunol. 2015 10 15; 195(8):3737-47. . View in PubMed

Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression PLoS One. 2014; 9(5):e95627. . View in PubMed

Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection PLoS One. 2014; 9(7):e103219. . View in PubMed

High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase Hepatology. 2013 Nov; 58(5):1632-43. . View in PubMed

Emerging concepts in immunity to hepatitis C virus infection J Clin Invest. 2013 Oct; 123(10):4121-30. . View in PubMed

Natural killer cells: multifaceted players with key roles in hepatitis C immunity Immunol Rev. 2013 Sep; 255(1):68-81. . View in PubMed

Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation J Hepatol. 2013 May; 58(5):969-76. . View in PubMed

Galectin-9 functionally impairs natural killer cells in humans and mice J Virol. 2013 May; 87(9):4835-45. . View in PubMed

Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease J Biol Chem. 2013 Apr 26; 288(17):11761-70. . View in PubMed

Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes Hepatology. 2013 Apr; 57(4):1314-24. . View in PubMed

Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts Ann Intern Med. 2013 Feb 19; 158(4):235-45. . View in PubMed

Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells PLoS Pathog. 2013; 9(4):e1003316. . View in PubMed

Race- and gender-related variation in natural killer p46 expression associated with differential anti-hepatitis C virus immunity Hepatology. 2012 Oct; 56(4):1214-22. . View in PubMed

Interleukin (IL)-17/IL-22-producing T cells enriched within the liver of patients with chronic hepatitis C viral (HCV) infection Dig Dis Sci. 2012 Feb; 57(2):381-9. . View in PubMed

Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species Hepatology. 2012 Feb; 55(2):343-53. . View in PubMed

Identification of osteopontin as a novel marker for early hepatocellular carcinoma Hepatology. 2012 Feb; 55(2):483-90. . View in PubMed

Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C Hepatology. 2011 Nov; 54(5):1559-69. . View in PubMed

Clinical practiceChronic hepatitis C infection. N Engl J Med. 2011 Jun 23; 364(25):2429-38. . View in PubMed

Genetic diversity of near genome-wide hepatitis C virus sequences during chronic infection: evidence for protein structural conservation over time PLoS One. 2011 May 05; 6(5):e19562. . View in PubMed

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity J Clin Invest. 2010 Dec; 120(12):4546-57. . View in PubMed

Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro Hepatology. 2010 Nov; 52(5):1581-9. . View in PubMed

Innate immune function in placenta and cord blood of hepatitis C--seropositive mother-infant dyads PLoS One. 2010 Aug 30; 5(8):e12232. . View in PubMed

Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity PLoS Pathog. 2010 Jul 29; 6(7):e1001018. . View in PubMed

Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus J Infect Dis. 2010 May 01; 201(9):1371-80. . View in PubMed

Functional characterization of core genes from patients with acute hepatitis C virus infection J Infect Dis. 2010 Mar 15; 201(6):912-22. . View in PubMed

A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection PLoS One. 2010 Mar 04; 5(3):e9504. . View in PubMed

Comprehensive assessment of chemokine expression profiles by flow cytometry J Clin Invest. 2010 Mar; 120(3):907-23. . View in PubMed

Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope Hepatology. 2010 Jan; 51(1):54-62. . View in PubMed

Human liver transplantation as a model to study hepatitis C virus pathogenesis Liver Transpl. 2009 Nov; 15(11):1395-411. . View in PubMed

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus Nature. 2009 Oct 08; 461(7265):798-801. . View in PubMed

Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection Clin Immunol. 2009 Sep; 132(3):401-11. . View in PubMed

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells J Virol. 2009 Sep; 83(18):9122-30. . View in PubMed

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients Hepatology. 2008 Dec; 48(6):1769-78. . View in PubMed

Genetic markers of IgG influence the outcome of infection with hepatitis C virus J Infect Dis. 2008 Nov 01; 198(9):1334-6. . View in PubMed

Prospective analysis of effector and regulatory CD4+ T cells in chronic HCV patients undergoing combination antiviral therapy J Hepatol. 2008 Sep; 49(3):329-38. . View in PubMed

Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C J Hepatol. 2008 Aug; 49(2):184-91. . View in PubMed

Transplantation immunology: what the clinician needs to know for immunotherapy Gastroenterology. 2008 May; 134(6):1789-801. . View in PubMed

Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differences J Immunol. 2008 Mar 15; 180(6):3637-41. . View in PubMed

Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help J Virol. 2008 Feb; 82(4):1827-37. . View in PubMed

Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection J Infect Dis. 2008 Jan 01; 197(1):46-57. . View in PubMed

Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence Liver Transpl. 2008 Jan; 14(1):31-40. . View in PubMed

Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance J Infect Dis. 2007 Nov 15; 196(10):1474-82. . View in PubMed

Mechanisms of Disease: HCV-induced liver injury Nat Clin Pract Gastroenterol Hepatol. 2007 Nov; 4(11):622-34. . View in PubMed

Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection J Virol. 2007 Sep; 81(17):9292-8. . View in PubMed

Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction J Virol. 2007 Sep; 81(17):9249-58. . View in PubMed

Selective decrease in hepatitis C virus-specific immunity among African Americans and outcome of antiviral therapy Hepatology. 2007 Aug; 46(2):350-8. . View in PubMed

Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells Hepatology. 2007 Jun; 45(6):1422-32. . View in PubMed

Assessment of FIBROSpect II to detect hepatic fibrosis in chronic hepatitis C patientsAm J Med. 2007 Mar; 120(3):280. e9-14. . View in PubMed

A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):985-90. . View in PubMed

Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence Hepatology. 2006 Nov; 44(5):1098-109. . View in PubMed

Acute rejection in HCV-infected liver transplant recipients: The great conundrum Liver Transpl. 2006 Nov; 12(11 Suppl 2):S38-47. . View in PubMed

Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine design J Infect Dis. 2006 Aug 15; 194(4):454-63. . View in PubMed

Identification of a hepatitis C virus-reactive T cell receptor that does not require CD8 for target cell recognition Hepatology. 2006 May; 43(5):973-81. . View in PubMed

Diagnosis and management of allograft failure Clin Liver Dis. 2006 May; 10(2):407-35, x. . View in PubMed

Natural killer cells: primary target for hepatitis C virus immune evasion strategies? Liver Transpl. 2006 Mar; 12(3):363-72.. View in PubMed

Liver retransplantation for hepatitis C virus recurrence: a survey of liver transplant programs in the United States Clin Gastroenterol Hepatol. 2005 Jul; 3(7):700-4. . View in PubMed

Immune evasion versus recovery after acute hepatitis C virus infection from a shared source J Exp Med. 2005 Jun 06; 201(11):1725-31. . View in PubMed

Reconstitution of hepatitis C virus-specific T-cellmediated immunity after liver transplantation Hepatology. 2005 Jan; 41(1):72-81. . View in PubMed

An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection Hepatology. 2004 Nov; 40(5):1062-71. . View in PubMed

Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease Hepatology. 2004 Aug; 40(2):335-45. . View in PubMed

Comparative analysis of outcome following liver transplantation in US veterans Am J Transplant. 2004 May; 4(5):788-95. . View in PubMed

Changing compliance to the American College of Gastroenterology guidelines for the management of variceal hemorrhage: a regional survey Am J Gastroenterol. 2004 Apr; 99(4):645-9. . View in PubMed

Treatment of hepatitis C in solid organ transplantation Drugs. 2004; 64(5):489-98. . View in PubMed

DNA vaccination protects mice against challenge with Listeria monocytogenes expressing the hepatitis C virus NS3 protein Infect Immun. 2003 Nov; 71(11):6372-80. . View in PubMed

Graft failure from severe recurrent primary sclerosing cholangitis following orthotopic liver transplantation J Clin Gastroenterol. 2003 Oct; 37(4):344-7. . View in PubMed

Validation and refinement of survival models for liver retransplantation Hepatology. 2003 Aug; 38(2):460-9. . View in PubMed

Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection Hepatology. 2003 Mar; 37(3):577-89. . View in PubMed

A longitudinal analysis of T-cell epitope-coding regions of hepatitis C virus after liver transplantation Transplantation. 2002 Jul 27; 74(2):209-16. . View in PubMed

Hepatitis C quasispecies and severity of recurrence: cause, consequence, or coincidence? Liver Transpl. 2002 Jul; 8(7):646-8.. View in PubMed

Early hepatitis C viral kinetics correlate with long-term outcome in patients receiving high dose induction followed by combination interferon and ribavirin therapy J Hepatol. 2002 Jul; 37(1):124-30. . View in PubMed

Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection Dig Dis Sci. 2002 Jun; 47(6):1195-205. . View in PubMed

Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages Hepatology. 2002 Jan; 35(1):190-8. . View in PubMed

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