Keck School Faculty

Jeffrey S. Upperman, MD
Jeffrey S. Upperman, MD
Professor of Surgery
Pediatrics
CHL MailStop72 Off Campus Los Angeles
I chose to work in pediatric surgery because...

I developed a love of surgery during my medical training and pediatric surgery became a perfect match between my love of children and my enjoyment of performing surgery. If I were to point to a specific point in my life where I made the decision to become a pediatric surgeon it was during assisting a more senior surgeon on one of my first procedures to correct a congenital anomaly in an infant. I accompanied the senior surgeon out to see the family after the procedure. Watching him be able to go up to this family and say the words, "Your baby is going to be OK" and see the joy spread over that family really typified for me what we refer to around here as providing the "80-year cure."

I joined Childrens Hospital Los Angeles because...

I decided to come to Los Angeles to be a part of a state-of-the-science, tertiary care, healthcare center that was a leader in pediatric disease and treatment. I had experience working for the Childrens Hospital of Pittsburgh and had recently been deployed from my military obligation as a Major in the United States Army Medical Corps serving in Operation Iraqi Freedom 2 and was looking for other challenges. I decided to explore potential opportunities in Southern California and was recruited to work at Childrens Hospital Los Angeles.

I come to work every day because...

I view what I do as the ultimate community service. Coming to work every day, of course, pays the bills, but I am the kind of person who wants to be of service to the largest group of people possible.

Management and outcomes of peripancreatic fluid collections and pseudocysts following non-operative management of pancreatic injuries in children Pediatr Surg Int. 2019 Aug; 35(8):861-867. . View in PubMed

Interactive Education is Associated With Lower Incidence of Pedestrian-Related Injury in Children J Surg Res. 2019 Jul 03; 244:57-62. . View in PubMed

Parenteral Nutrition Prolongs Hospital Stay in Children with Nonoperative Blunt Pancreatic Injury: A Propensity Score Weighted Analysis J Pediatr Surg. 2019 Jun 28. . View in PubMed

Multidisciplinary Simulation-Based Team Training for Trauma Resuscitation: A Scoping Review J Surg Educ. 2019 May 17. . View in PubMed

Formative research experiences in pediatric surgeons: a mixed methods study of Pediatric Trauma Society members Pediatr Surg Int. 2019 Apr; 35(4):495-499. . View in PubMed

Pediatric firearm injuries in Los Angeles County: Younger children are more likely to be the victims of unintentional firearm injury J Pediatr Surg. 2019 Feb; 54(2):350-353. . View in PubMed

Formative research experiences in pediatric surgeons: a mixed methods study of Pediatric Trauma Society members Pediatr Surg Int. 2019 Jan 19. . View in PubMed

Impact of simulation-based training on perceived provider confidence in acute multidisciplinary pediatric trauma resuscitation Pediatr Surg Int. 2018 Dec; 34(12):1353-1362. . View in PubMed

Pediatric firearm injuries in Los Angeles County: Younger children are more likely to be the victims of unintentional firearm injury J Pediatr Surg. 2018 Oct 22. . View in PubMed

Impact of simulation-based training on perceived provider confidence in acute multidisciplinary pediatric trauma resuscitation Pediatr Surg Int. 2018 Oct 15. . View in PubMed

Improving Disaster Preparedness of Families With a Parenteral Nutrition-dependent Child J Pediatr Gastroenterol Nutr. 2018 Aug; 67(2):237-241. . View in PubMed

Heads Up, Phones Down: A Pedestrian Safety Intervention on Distracted Crosswalk Behavior J Community Health. 2018 Aug; 43(4):810-815. . View in PubMed

Pediatric Online Disaster Preparedness Training for Medical and Non-Medical Personnel: A Multi-Level Modeling Analysis Prehosp Disaster Med. 2018 Aug; 33(4):349-354. . View in PubMed

Improving Disaster Preparedness of Families with a Parenteral Nutrition-Dependent Child J Pediatr Gastroenterol Nutr. 2018 Jun 12. . View in PubMed

Considering the Ability of General Surgeons to Add Value to Pediatric Surgery JAMA Surg. 2018 Jun 01; 153(6):558. . View in PubMed

Heads Up, Phones Down: A Pedestrian Safety Intervention on Distracted Crosswalk Behavior J Community Health. 2018 Feb 28. . View in PubMed

Pediatric dog bites: a population-based profile Inj Prev. 2018 Feb 08. . View in PubMed

Considering the Ability of General Surgeons to Add Value to Pediatric Surgery JAMA Surg. 2018 Jan 17. . View in PubMed

Congenital H-type tracheoesophageal fistula: A multicenter review of outcomes in a rare disease J Pediatr Surg. 2017 Nov; 52(11):1711-1714. . View in PubMed

Acute procedural interventions after pediatric blunt abdominal trauma: A prospective multicenter evaluation J Trauma Acute Care Surg. 2017 Oct; 83(4):597-602. . View in PubMed

Focused assessment with sonography for trauma in children after blunt abdominal trauma: A multi-institutional analysis J Trauma Acute Care Surg. 2017 Aug; 83(2):218-224. . View in PubMed

Acute procedural interventions after pediatric blunt abdominal trauma: A prospective multicenter evaluation J Trauma Acute Care Surg. 2017 10; 83(4):597-602. . View in PubMed

Focused assessment with sonography for trauma in children after blunt abdominal trauma: A multi-institutional analysis J Trauma Acute Care Surg. 2017 08; 83(2):218-224. . View in PubMed

Factors associated with preparedness of the US healthcare system to respond to a pediatric surge during an infectious disease pandemic: Is our nation prepared? Am J Disaster Med. 2017; 12(4):203-226.. View in PubMed

Mixed-Methods Pilot Study: Disaster Preparedness of Families With Children Followed in an Intestinal Rehabilitation Clinic Nutr Clin Pract. 2016 Apr; 31(2):257-65. . View in PubMed

Management of pediatric blunt renal trauma: A systematic review J Trauma Acute Care Surg. 2016 Mar; 80(3):519-28. . View in PubMed

Observed child restraint misuse in a large, urban community: Results from three years of inspection events J Safety Res. 2016 Feb; 56:17-22. . View in PubMed

Limiting chest computed tomography in the evaluation of pediatric thoracic trauma J Trauma Acute Care Surg. 2016 08; 81(2):271-7. . View in PubMed

Defining the Role of a Pediatric Surgery Fellowship Program Director: Results of a National Cross-sectional Survey Am Surg. 2016 Jan; 82(1):E9-12. . View in PubMed

Implementation and analysis of initial trauma registry in Iquitos, Peru Health Promot Perspect. 2016; 6(4):174-179. . View in PubMed

Mullerian-Type Ciliated Cyst of the Thigh with PAX-8 and WT1 Positivity: A Case Report and Review of the Literature Case Rep Med. 2016; 2016:2487820. . View in PubMed

A School-Hospital Partnership Increases Knowledge of Pedestrian and Motor Vehicle Safety J Community Health. 2015 Dec; 40(6):1057-64. . View in PubMed

Critical Violent Injury in the United States: A Review and Call to Action Crit Care Med. 2015 Nov; 43(11):2460-7. . View in PubMed

Admission hematocrit predicts the need for transfusion secondary to hemorrhage in pediatric blunt trauma patients J Trauma Acute Care Surg. 2015 Oct; 79(4):555-62. . View in PubMed

Academic-Community Partnership to Develop a Novel Disaster Training Tool for School Nurses: Emergency Triage Drill Kit NASN Sch Nurse. 2015 Sep; 30(5):265-8. . View in PubMed

Assessing medical care availability for student athletes of a large urban high school district J Pediatr Surg. 2015 Jul; 50(7):1192-5. . View in PubMed

Assessment of parental knowledge and attitudes toward pediatric sports-related concussions Sports Health. 2015 Mar; 7(2):124-9. . View in PubMed

Assessing American Red Cross First Aid mobile app user trends: Implications for resilience Am J Disaster Med. 2015; 10(4):273-83. . View in PubMed

Pediatric disaster preparedness and response and the nation's children's hospitals Am J Disaster Med. 2015; 10(2):83-91. . View in PubMed

Engagement and education: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement Chest. 2014 Oct; 146(4 Suppl):e118S-33S. . View in PubMed

A mixed-methods pilot study of disaster preparedness and resiliency among faith-based organizations Prehosp Disaster Med. 2014 Apr; 29(2):127-33. . View in PubMed

Evaluation of a child passenger safety class in increasing parental knowledge Accid Anal Prev. 2014 Feb; 63:37-40. . View in PubMed

Meeting children's needs: a mixed-methods approach to a regionalized pediatric surge plan-the Los Angeles County experience Am J Disaster Med. 2014; 9(3):161-9. . View in PubMed

Competency-based pediatric disaster training Am J Disaster Med. 2014; 9(1):5-16. . View in PubMed

Cell phones and young drivers: a systematic review regarding the association between psychological factors and prevention Traffic Inj Prev. 2014; 15(3):234-42. . View in PubMed

Disaster preparedness education in South Los Angeles faith-based organizations: a pilot study in promoting personal and community preparedness and resiliency Am J Disaster Med. 2014; 9(4):287-96. . View in PubMed

Consider the children: pediatric disaster planning Nurs Manage. 2013 Nov; 44(11):44-51. . View in PubMed

Delayed family reunification of pediatric disaster survivors increases mortality and inpatient hospital costs: a simulation study J Surg Res. 2013 Sep; 184(1):430-7. . View in PubMed

A three-dimensional mathematical and computational model of necrotizing enterocolitis J Theor Biol. 2013 Apr 07; 322:17-32. . View in PubMed

Emergency management of pancreatic injury in a 5-year-old Adv Emerg Nurs J. 2013 Apr-Jun; 35(2):122-8. . View in PubMed

Congenital heart disease and heterotaxy: upper gastrointestinal fluoroscopy can be misleading and surgery in an asymptomatic patient is not beneficial J Pediatr Surg. 2013 Jan; 48(1):164-9. . View in PubMed

Can a pediatric trauma center improve the response to a mass casualty incident? J Trauma Acute Care Surg. 2012 Oct; 73(4):885-9.. View in PubMed

Laparoscopic versus open distal pancreatectomy in the management of traumatic pancreatic disruption J Laparoendosc Adv Surg Tech A. 2012 Jul-Aug; 22(6):595-8. . View in PubMed

Community engagement and pediatric disaster readiness in a large urban disaster resource hospital network: the case of "The Great California ShakeOut" Disaster Med Public Health Prep. 2012 Jun; 6(2):182-6. . View in PubMed

Bicycle helmet legislation and injury patterns in trauma patients under age 18 J Surg Res. 2012 Apr; 173(2):327-31. . View in PubMed

Education in a pediatric emergency mass critical care setting Pediatr Crit Care Med. 2011 Nov; 12(6 Suppl):S135-40. . View in PubMed

P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis Lab Invest. 2011 Nov; 91(11):1668-79. . View in PubMed

Availability of a pediatric trauma center in a disaster surge decreases triage time of the pediatric surge population: a population kinetics model Theor Biol Med Model. 2011 Oct 12; 8:38. . View in PubMed

Factors associated with willingness to respond to a disaster: a study of healthcare workers in a tertiary setting Prehosp Disaster Med. 2011 Aug; 26(4):244-50. . View in PubMed

Pediatric applied trauma research network: a call to action J Trauma. 2010 Nov; 69(5):1304-7. . View in PubMed

Pediatric applied trauma research network: a call to action J Pediatr Surg. 2010 Nov; 45(11):2278-82. . View in PubMed

Disaster and mass casualty events in the pediatric population Semin Pediatr Surg. 2010 Nov; 19(4):265-70. . View in PubMed

Disaster preparedness among medical students: a survey assessment Am J Disaster Med. 2010 Sep-Oct; 5(5):275-84. . View in PubMed

Attitudes of genetic counselors towards genetic susceptibility testing in children J Genet Couns. 2010 Aug; 19(4):402-16. . View in PubMed

Pediatric nurse practitioner implementation of a pediatric trauma continuity clinic utilizing the "medical home" model J Trauma Nurs. 2010 Apr-Jun; 17(2):64-6; quiz 67-8. . View in PubMed

Health informatics for pediatric disaster preparedness planning Appl Clin Inform. 2010; 1(3):256-64. . View in PubMed

Pediatric disaster preparedness of a hospital network in a large metropolitan region Am J Disaster Med. 2010 Jan-Feb; 5(1):27-34. . View in PubMed

Disaster Olympix: a unique nursing emergency preparedness exercise J Trauma Nurs. 2010 Jan-Mar; 17(1):5-10. . View in PubMed

Design and evaluation of a disaster preparedness logistics tool Am J Disaster Med. 2009 Nov-Dec; 4(6):309-20. . View in PubMed

Clinical clearance of the cervical spine in blunt trauma patients younger than 3 years: a multi-center study of the american association for the surgery of trauma J Trauma. 2009 Sep; 67(3):543-9; discussion 549-50. . View in PubMed

A survey of academic surgeons: work, stress, and research Surgery. 2009 Sep; 146(3):462-8. . View in PubMed

Introduction pediatric disaster and emergency services national summit J Trauma. 2009 Aug; 67(2 Suppl):S71-2. . View in PubMed

Pediatric disaster preparedness in the medical setting: integrating mental health Am J Disaster Med. 2009 May-Jun; 4(3):137-46. . View in PubMed

A parental educational intervention to facilitate informed consent for emergency operations in children J Surg Res. 2009 Apr; 152(2):258-63. . View in PubMed

Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis Infect Immun. 2009 03; 77(3):1031-43. . View in PubMed

Emergency drills and exercises in healthcare organizations: assessment of pediatric population involvement using after-action reports Am J Disaster Med. 2009 Jan-Feb; 4(1):23-32. . View in PubMed

Disaster drill exercise documentation and management: are we drilling to standard? J Emerg Nurs. 2008 Dec; 34(6):504-8.. View in PubMed

Necrotizing enterocolitis--bench to bedside: novel and emerging strategies Semin Pediatr Surg. 2008 Nov; 17(4):255-65. . View in PubMed

Enterobacter sakazakii enhances epithelial cell injury by inducing apoptosis in a rat model of necrotizing enterocolitis J Infect Dis. 2008 Aug 15; 198(4):586-93. . View in PubMed

Hospital-based disaster preparedness for pediatric patients: how to design a realistic set of drill victims Am J Disaster Med. 2008 May-Jun; 3(3):171-80. . View in PubMed

Disaster management among pediatric surgeons: preparedness, training and involvement Am J Disaster Med. 2008 Jan-Feb; 3(1):5-14. . View in PubMed

Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect Biochem Biophys Res Commun. 2007 Aug 17; 360(1):238-43. . View in PubMed

Nitric oxide inhibits enterocyte migration through activation of RhoA-GTPase in a SHP-2-dependent manner Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1347-58. . View in PubMed

Mathematical modeling in necrotizing enterocolitis--a new look at an ongoing problem J Pediatr Surg. 2007 Mar; 42(3):445-53. . View in PubMed

Pediatric cystadenoma of the mesocolon J Pediatr Surg. 2006 Jan; 41(1):e63-4. . View in PubMed

Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway J Immunol. 2006 Jan 01; 176(1):580-8. . View in PubMed

Glutathione (GSH) levels in necrotizing enterocolitis (NEC) J Pediatr Surg. 2005 Nov; 40(11):1813; author reply 1813-4. . View in PubMed

High-mobility group box 1 protein is an inflammatory mediator in necrotizing enterocolitis: protective effect of the macrophage deactivator semapimod Am J Physiol Gastrointest Liver Physiol. 2005 Oct; 289(4):G643-52. . View in PubMed

Carbon monoxide protects against the development of experimental necrotizing enterocolitis Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G607-13. . View in PubMed

Mechanisms of nitric oxide-mediated intestinal barrier failure in necrotizing enterocolitis Semin Pediatr Surg. 2005 Aug; 14(3):159-66. . View in PubMed

Not your father's specialty: preparing residents and associates for collaborative leadership Bull Am Coll Surg. 2005 Jul; 90(7):15-9. . View in PubMed

Dominance of high-producing interleukin 6 and low-producing interleukin 10 and interferon gamma alleles in glucose-6-phosphate dehydrogenase-deficient trauma patients Shock. 2005 Mar; 23(3):197-201. . View in PubMed

Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis Semin Pediatr Surg. 2005 Feb; 14(1):49-57. . View in PubMed

Endotoxin differentially modulates the basolateral and apical sodium/proton exchangers (NHE) in enterocytes Surgery. 2004 Aug; 136(2):375-83. . View in PubMed

p38 MAP kinase mediates endotoxin-induced expression of cyclooxygenase-2 in enterocytes Surgery. 2004 Aug; 136(2):329-35. . View in PubMed

Images in clinical medicineCongenital lymphedema. N Engl J Med. 2004 Feb 05; 350(6):e5. . View in PubMed

All-terrain vehicle rules and regulations: impact on pediatric mortality J Pediatr Surg. 2003 Sep; 38(9):1284-6. . View in PubMed

H-type congenital tracheoesophageal fistula Am J Surg. 2003 Jun; 185(6):599-600. . View in PubMed

Mechanism of intestinal-derived fungal sepsis by gliotoxin, a fungal metabolite J Pediatr Surg. 2003 Jun; 38(6):966-70. . View in PubMed

NF-kappaB inhibition enhances peroxynitrite-induced enterocyte apoptosis J Surg Res. 2002 Jul; 106(1):7-14. . View in PubMed

Long-term follow-up of patients with necrotizing enterocolitis J Pediatr Surg. 2002 Jul; 37(7):1048-1050; discussion 1048-1050. . View in PubMed

Controversies in the management of necrotizing enterocolitis Surg Infect (Larchmt). 2001; 2(2):113-9; discussion 119-20. . View in PubMed

Inhibition of NF-kappaB by IkappaB prevents cytokine-induced NO production and promotes enterocyte apoptosis in vitro Shock. 2000 Sep; 14(3):366-73. . View in PubMed

Early functional outcome in children with pelvic fractures J Pediatr Surg. 2000 Jun; 35(6):1002-5. . View in PubMed

Effects of hypoxia on granulocytic-monocytic progenitors in ratsRole of bone marrow stroma. Am J Hematol. 2000 May; 64(1):20-5. . View in PubMed

Nitric oxide and intestinal barrier failure Semin Pediatr Surg. 1999 Aug; 8(3):148-54. . View in PubMed

Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock Ann Surg. 1998 Oct; 228(4):518-27. . View in PubMed

Differential effects of acute hypoxia and endotoxin on the secretion and expression of bone marrow interleukin-1 and interleukin-6 Shock. 1997 May; 7(5):324-31. . View in PubMed

Powered by SC CTSI
Go to Top