Keck School Faculty

Joy Goldstein

Joy Goldstein

Volunteer Faculty
Medicine
4640 West Sunset Blvd Off Campus Los Angeles

Contact

CYP2C8 Is a Novel Target of Peroxisome Proliferator-Activated Receptor a in Human Liver Mol Pharmacol. 2016 Jan; 89(1):154-64. . View in PubMed

Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9 J Biol Chem. 2015 Jan 23; 290(4):2264-78. . View in PubMed

Med25 is required for estrogen receptor alpha (ERa)-mediated regulation of human CYP2C9 expression Biochem Pharmacol. 2014 Aug 15; 90(4):425-31. . View in PubMed

The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping Pharmacogenet Genomics. 2014 Aug; 24(8):381-6. . View in PubMed

Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping Mol Pharmacol. 2014 Aug; 86(2):125-37. . View in PubMed

RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor Drug Metab Dispos. 2013 Feb; 41(2):398-405. . View in PubMed

Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients Transplantation. 2012 Nov 15; 94(9):971-7. . View in PubMed

Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver Mol Pharmacol. 2012 Sep; 82(3):529-40. . View in PubMed

Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis Br J Clin Pharmacol. 2012 Sep; 74(3):445-55. . View in PubMed

P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice Free Radic Biol Med. 2012 May 01; 52(9):1666-79. . View in PubMed

Comparison of CYP3A4 and CYP3A5: the effects of cytochrome b5 and NADPH-cytochrome P450 reductase on testosterone hydroxylation activities Drug Metab Pharmacokinet. 2012; 27(6):663-7. . View in PubMed

Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients Transplantation. 2011 Dec 27; 92(12):1342-7. . View in PubMed

Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure Nucleic Acids Res. 2011 Oct; 39(19):8392-403. . View in PubMed

NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes Pharmacol Res. 2011 May; 63(5):405-13. . View in PubMed

Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver Mol Cell Biol. 2011 Feb; 31(3):466-81. . View in PubMed

The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver Drug Metab Dispos. 2010 Jul; 38(7):1177-82. . View in PubMed

Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes Drug Metab Dispos. 2010 Apr; 38(4):591-9. . View in PubMed

CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases Eur J Clin Pharmacol. 2009 Sep; 65(9):947-53. . View in PubMed

The transcriptional regulation of the human CYP2C genes Curr Drug Metab. 2009 Jul; 10(6):567-78. . View in PubMed

Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene J Pharmacol Exp Ther. 2009 Apr; 329(1):192-201. . View in PubMed

Kidney function influences warfarin responsiveness and hemorrhagic complications J Am Soc Nephrol. 2009 Apr; 20(4):912-21. . View in PubMed

VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans Pharmacogenomics. 2008 Oct; 9(10):1445-58. . View in PubMed

Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha Mol Pharmacol. 2008 Sep; 74(3):913-23. . View in PubMed

Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans Pharmacogenomics. 2008 May; 9(5):511-26. . View in PubMed

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes Mol Pharmacol. 2008 Mar; 73(3):1029-36. . View in PubMed

Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues Drug Metab Dispos. 2007 Apr; 35(4):682-8. . View in PubMed

The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system Pharmacogenet Genomics. 2007 Mar; 17(3):169-80. . View in PubMed

A new CYP3A5 variant, CYP3A5*11, is shown to be defective in nifedipine metabolism in a recombinant cDNA expression system Drug Metab Dispos. 2007 Jan; 35(1):67-71. . View in PubMed

Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor Drug Metab Dispos. 2006 Dec; 34(12):2003-10. . View in PubMed

Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: IExpression and role of cytochromes P450. J Pharmacol Exp Ther. 2006 Oct; 319(1):488-96. . View in PubMed

Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition J Clin Pharmacol. 2006 May; 46(5):515-26. . View in PubMed

Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians J Pharmacol Exp Ther. 2005 Dec; 315(3):1085-90. . View in PubMed

Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha Mol Pharmacol. 2005 Sep; 68(3):747-57. . View in PubMed

The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter J Pharmacol Exp Ther. 2005 Sep; 314(3):1125-33. . View in PubMed

Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests Pharmacogenomics. 2005 Jun; 6(4):357-71. . View in PubMed

Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype J Pharmacol Exp Ther. 2005 Apr; 313(1):302-9. . View in PubMed

Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension Pharmacogenet Genomics. 2005 Jan; 15(1):7-13. . View in PubMed

CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products J Pharmacol Exp Ther. 2004 Sep; 310(3):845-54. . View in PubMed

Discovery of new potentially defective alleles of human CYP2C9 Pharmacogenetics. 2004 Aug; 14(8):527-37. . View in PubMed

The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29 Mol Pharmacol. 2004 Jun; 65(6):1397-404. . View in PubMed

Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities Mol Pharmacol. 2004 May; 65(5):1148-58. . View in PubMed

CYP2C9 genetic polymorphisms and warfarin Clin Appl Thromb Hemost. 2004 Apr; 10(2):149-54. . View in PubMed

Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor J Pharmacol Exp Ther. 2004 Feb; 308(2):495-501. . View in PubMed

Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylaseIts down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice. J Biol Chem. 2004 Jan 30; 279(5):3434-8. . View in PubMed

Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter Mol Pharmacol. 2003 Aug; 64(2):316-24. . View in PubMed

Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups Pharmacogenetics. 2003 Aug; 13(8):461-72. . View in PubMed

Losartan and E3174 pharmacokinetics in cytochrome P450 2C9*1/*1, *1/*2, and *1/*3 individuals Pharmacotherapy. 2003 Jun; 23(6):720-5. . View in PubMed

Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes Eur J Clin Pharmacol. 2003 Apr; 58(12):791-4. . View in PubMed

Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans J Clin Pharmacol. 2003 Jan; 43(1):84-91. . View in PubMed

Identification and functional characterization of new potentially defective alleles of human CYP2C19 Pharmacogenetics. 2002 Dec; 12(9):703-11. . View in PubMed

Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes Clin Pharmacol Ther. 2002 Nov; 72(5):562-71. . View in PubMed

Evaluation of potential losartan-phenytoin drug interactions in healthy volunteers Clin Pharmacol Ther. 2002 Sep; 72(3):238-46. . View in PubMed

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site Mol Pharmacol. 2002 Sep; 62(3):737-46. . View in PubMed

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data Pharmacogenetics. 2002 Apr; 12(3):251-63. . View in PubMed

CYP2C9 polymorphisms and CYP2C9*2 genotyping primers Br J Clin Pharmacol. 2002 Apr; 53(4):409-10. . View in PubMed

Analysis of the CYP2C19 polymorphism in a North-eastern Thai population Pharmacogenetics. 2002 Apr; 12(3):221-5. . View in PubMed

In vitro human metabolism and interactions of repellent N,N-diethyl-m-toluamide Drug Metab Dispos. 2002 Mar; 30(3):289-94. . View in PubMed

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