Keck School Faculty

Kevin Verne Lemley, MD, PhD
Kevin Verne Lemley, MD, PhD
Professor of Pediatrics (Clinical Scholar)
Pediatrics
CHL Mail Stop 40 Off Campus Los Angeles
My main research interests are in podocyte pathobiology and stereologic methods. My clinical interests are in diabetic kidney disease, nephrotic syndrome, genetic kidney diseases. My health systems interests are in the use of clinical pathways/protocols, outcomes assessment and quality audit, and lean systems.

Machine Learning Comes to Nephrology J Am Soc Nephrol. 2019 Oct; 30(10):1780-1781. . View in PubMed

Text Messaging for Disease Monitoring in Childhood Nephrotic Syndrome Kidney Int Rep. 2019 Aug; 4(8):1066-1074. . View in PubMed

Statistical methods for building better biomarkers of chronic kidney disease Stat Med. 2019 May 20; 38(11):1903-1917. . View in PubMed

Plasma Zonulin Levels in Childhood Nephrotic Syndrome Front Pediatr. 2019; 7:197. . View in PubMed

ErratumEffect of Losartan on Prevention and Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes. Diabetes 2013;62:3224-3231. Diabetes. 2018 03; 67(3):532. . View in PubMed

A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome Kidney Int. 2018 02; 93(2):439-449. . View in PubMed

Interstitial fibrosis scored on whole-slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies Nephrol Dial Transplant. 2018 02 01; 33(2):310-318. . View in PubMed

Urine metabolites are associated with glomerular lesions in type 2 diabetes Metabolomics. 2018 06 08; 14(6):84. . View in PubMed

White blood cell fractions correlate with lesions of diabetic kidney disease and predict loss of kidney function in Type 2 diabetes Nephrol Dial Transplant. 2018 06 01; 33(6):1001-1009. . View in PubMed

Combined use of electron microscopy and intravital imaging captures morphological and functional features of podocyte detachment Pflugers Arch. 2017 Aug; 469(7-8):965-974. . View in PubMed

Mechanical challenges to the glomerulus and podocyte loss: evolution of a paradigm Pflugers Arch. 2017 Aug; 469(7-8):959-963. . View in PubMed

Potential relevance of shear stress for slit diaphragm and podocyte function Kidney Int. 2017 06; 91(6):1283-1286. . View in PubMed

Mechanical challenges to the glomerular filtration barrier: adaptations and pathway to sclerosis Pediatr Nephrol. 2017 03; 32(3):405-417. . View in PubMed

White blood cell fractions correlate with lesions of diabetic kidney disease and predict loss of kidney function in Type 2 diabetes Nephrol Dial Transplant. 2017 12 01; 32(12):2145. . View in PubMed

Fetal Serum ß2-Microglobulin and Postnatal Renal Function in Lower Urinary Tract Obstruction Treated with Vesicoamniotic Shunt Fetal Diagn Ther. 2017; 42(1):17-27. . View in PubMed

Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes Diabetes. 2016 Dec; 65(12):3744-3753. . View in PubMed

Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects J Am Soc Nephrol. 2016 Mar; 27(3):814-23. . View in PubMed

Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes Clin J Am Soc Nephrol. 2016 Feb 05; 11(2):254-61. . View in PubMed

Complete Remission in the Nephrotic Syndrome Study Network Clin J Am Soc Nephrol. 2016 Jan 07; 11(1):81-9. . View in PubMed

Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes J Diabetes Complications. 2016 07; 30(5):873-9. . View in PubMed

The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome Pediatrics. 2016 07; 138(1). . View in PubMed

Morphometry Predicts Early GFR Change in Primary Proteinuric Glomerulopathies: A Longitudinal Cohort Study Using Generalized Estimating Equations PLoS One. 2016; 11(6):e0157148. . View in PubMed

Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes Kidney Int. 2016 Jan; 89(1):226-34. . View in PubMed

Glomerular pathology and the progression of chronic kidney disease Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1385-8. . View in PubMed

Nephrotic syndrome: Efficacy of rituximab in challenging nephrotic syndrome Nat Rev Nephrol. 2015 May; 11(5):257-8. . View in PubMed

Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes Semin Nephrol. 2015 May; 35(3):266-78. . View in PubMed

A potential role for mechanical forces in the detachment of podocytes and the progression of CKD J Am Soc Nephrol. 2015 Feb; 26(2):258-69. . View in PubMed

Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota Pediatr Res. 2015 Jan; 77(1-2):252-5. . View in PubMed

The importance of clinical pathways and protocols in pediatric nephrology Pediatr Nephrol. 2014 Oct; 29(10):1903-14. . View in PubMed

An unusual case of hypercalcemia in a patient with renal insufficiency Pediatr Nephrol. 2014 Sep; 29(9):1529-33. . View in PubMed

LMX1B mutations with nails and kneecaps: a new paradigm? Nephrol Dial Transplant. 2014 Jan; 29(1):9-12.. View in PubMed

Effect of losartan on prevention and progression of early diabetic nephropathy in American Indians with type 2 diabetes Diabetes. 2013 Sep; 62(9):3224-31. . View in PubMed

Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE) Clin J Am Soc Nephrol. 2013 Aug; 8(8):1449-59. . View in PubMed

Comparison of serum cystatin C, serum creatinine, measured GFR, and estimated GFR to assess the risk of kidney failure in American Indians with diabetic nephropathy Am J Kidney Dis. 2013 Jul; 62(1):33-41. . View in PubMed

Estimation of glomerular podocyte number: a selection of valid methods J Am Soc Nephrol. 2013 Jul; 24(8):1193-202. . View in PubMed

The authors reply Kidney Int. 2013 Jun; 83(6):1203. . View in PubMed

Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach Kidney Int. 2013 Apr; 83(4):749-56. . View in PubMed

The podocyte's response to stress: the enigma of foot process effacement Am J Physiol Renal Physiol. 2013 Feb 15; 304(4):F333-47. . View in PubMed

A novel source of cultured podocytes PLoS One. 2013; 8(12):e81812. . View in PubMed

Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy Kidney Int. 2012 Nov; 82(9):1010-7. . View in PubMed

Injection of amniotic fluid stem cells delays progression of renal fibrosis J Am Soc Nephrol. 2012 Apr; 23(4):661-73. . View in PubMed

Early renal function decline in type 2 diabetes Clin J Am Soc Nephrol. 2012 Jan; 7(1):78-84. . View in PubMed

Protecting podocytes: how good do we need to be? Kidney Int. 2012 Jan; 81(1):9-11.. View in PubMed

Pediatrics: Extracellular volume in children with chronic kidney disease Nat Rev Nephrol. 2011 May 24; 7(7):366-8. . View in PubMed

Podocyte detachment in type 2 diabetic nephropathy Am J Nephrol. 2011; 33 Suppl 1:21-4. . View in PubMed

When to initiate ACEI/ARB therapy in patients with type 1 and 2 diabetes Pediatr Nephrol. 2010 Oct; 25(10):2021-34. . View in PubMed

Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis PLoS One. 2010 Feb 24; 5(2):e9357. . View in PubMed

Pediatrics: how 'minimal' are the adult consequences of childhood MCNS? Nat Rev Nephrol. 2010 Feb; 6(2):70-1.. View in PubMed

Kidney disease in nail-patella syndrome Pediatr Nephrol. 2009 Dec; 24(12):2345-54. . View in PubMed

Kidney transplantation in children and adolescents: an analysis of United Network for Organ Sharing Database Transplant Proc. 2009 Jun; 41(5):1533-5. . View in PubMed

Pediatric nephrology: Estimating GFR in children: Schwartz redux Nat Rev Nephrol. 2009 Jun; 5(6):310-1. . View in PubMed

The MIF receptor CD74 in diabetic podocyte injury J Am Soc Nephrol. 2009 Feb; 20(2):353-62. . View in PubMed

Diabetes and chronic kidney disease: lessons from the Pima Indians Pediatr Nephrol. 2008 Nov; 23(11):1933-40. . View in PubMed

Yet more ways to skin a cat: nephrin mutations outside the neonatal period J Am Soc Nephrol. 2008 Oct; 19(10):1837-8. . View in PubMed

Prediction of early progression in recently diagnosed IgA nephropathy Nephrol Dial Transplant. 2008 Jan; 23(1):213-22. . View in PubMed

An introduction to biomarkers: applications to chronic kidney disease Pediatr Nephrol. 2007 Nov; 22(11):1849-59. . View in PubMed

Neonatal nephrotic presentation of a child with heterozygous NPHS1 mutation Pediatr Nephrol. 2006 Jun; 21(6):864-6. . View in PubMed

Can theophylline prevent the development of renal dysfunction in neonates with severe asphyxia? Nat Clin Pract Nephrol. 2006 Apr; 2(4):196-7.. View in PubMed

Modeling GFR trajectories in diabetic nephropathy Am J Physiol Renal Physiol. 2005 Oct; 289(4):F863-70. . View in PubMed

Proteinuria or peptiduria: where's the beef? J Lab Clin Med. 2005 May; 145(5):228-30.. View in PubMed

Gene expression in the normal adult human kidney assessed by complementary DNA microarray Mol Biol Cell. 2004 Feb; 15(2):649-56. . View in PubMed

Determinants of glomerular hypofiltration in aging humans Kidney Int. 2003 Oct; 64(4):1417-24. . View in PubMed

Urinary excretion of viable podocytes in health and renal disease Am J Physiol Renal Physiol. 2003 Jul; 285(1):F40-8. . View in PubMed

The effect of dopamine on glomerular filtration rate in normotensive, oliguric premature neonates Pediatr Nephrol. 2003 Jul; 18(7):649-52. . View in PubMed

National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification Pediatrics. 2003 Jun; 111(6 Pt 1):1416-21. . View in PubMed

Determinants of GFR depression in early membranous nephropathy Am J Physiol Renal Physiol. 2003 May; 284(5):F1014-22. . View in PubMed

A basis for accelerated progression of diabetic nephropathy in Pima Indians Kidney Int Suppl. 2003 Feb; (83):S38-42. . View in PubMed

Podocytes, parietal cells, and glomerular pathology: the role of cell cycle proteins Pediatr Nephrol. 2003 Jan; 18(1):3-8. . View in PubMed

Podocytopenia and disease severity in IgA nephropathy Kidney Int. 2002 Apr; 61(4):1475-85. . View in PubMed

Glomerular permselectivity at the onset of nephropathy in type 2 diabetes mellitus J Am Soc Nephrol. 2000 Nov; 11(11):2095-105. . View in PubMed

A 100% 2-year graft survival can be attained in high-risk 15-kg or smaller infant recipients of kidney allografts Arch Surg. 2000 Sep; 135(9):1063-8; discussion 1068-9. . View in PubMed

Evolution of incipient nephropathy in type 2 diabetes mellitus Kidney Int. 2000 Sep; 58(3):1228-37. . View in PubMed

Evaluation and management of proteinuria and nephrotic syndrome in children: recommendations from a pediatric nephrology panel established at the National Kidney Foundation conference on proteinuria, albuminuria, risk, assessment, detection, and elimination (PARADE) Pediatrics. 2000 Jun; 105(6):1242-9. . View in PubMed

A new, unique and simple method for ureteral implantation in kidney recipients with small, defunctionalized bladders Transplantation. 1999 Sep 27; 68(6):731-8. . View in PubMed

The role of the podocyte in glomerulosclerosis Curr Opin Nephrol Hypertens. 1999 Jul; 8(4):489-97. . View in PubMed

Transplantation of adult-sized kidneys into infants induces major blood flow changes Transplant Proc. 1999 Feb-Mar; 31(1-2):236-7. . View in PubMed

Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow Transplantation. 1998 Oct 15; 66(7):819-23. . View in PubMed

Progression of glomerular diseases: is the podocyte the culprit? Kidney Int. 1998 Sep; 54(3):687-97.. View in PubMed

Mechanisms of progressive glomerular injury in membranous nephropathy J Am Soc Nephrol. 1998 Aug; 9(8):1389-98. . View in PubMed

Superior outcomes in pediatric renal transplantation Arch Surg. 1997 Aug; 132(8):842-7; discussion 847-9. . View in PubMed

A frequent pathway to glomerulosclerosis: deterioration of tuft architecture-podocyte damage-segmental sclerosis Kidney Blood Press Res. 1996; 19(5):245-53. . View in PubMed

Structure-stabilizing forces in the glomerular tuft J Am Soc Nephrol. 1995 Apr; 5(10):1731-9. . View in PubMed

Glomerular hypertrophy after subtotal nephrectomy: relationship to early glomerular injury Virchows Arch. 1995; 426(5):509-17. . View in PubMed

The role of podocytes in the development of glomerular sclerosis Kidney Int Suppl. 1994 Feb; 45:S64-72. . View in PubMed

Glomerular size selectivity during protein overload in the rat Am J Physiol. 1993 Jun; 264(6 Pt 2):F1046-51. . View in PubMed

The glomerular mesangium: capillary support function and its failure under experimental conditions Clin Investig. 1992 Sep; 70(9):843-56. . View in PubMed

Changes in glomerular structure following acute mesangial failure in the isolated perfused kidney Kidney Int. 1992 Mar; 41(3):533-41. . View in PubMed

Anatomy of the renal interstitium Kidney Int. 1991 Mar; 39(3):370-81. . View in PubMed

Hypercalcemia, hypertension and acute renal insufficiency in an immobilized adolescent Child Nephrol Urol. 1991; 11(4):215-9. . View in PubMed

Glomerular injury in analbuminemic rats after subtotal nephrectomy Nephron. 1991; 59(1):104-9. . View in PubMed

Structure of the glomerular mesangium: a biomechanical interpretation Kidney Int Suppl. 1990 Nov; 30:S2-9. . View in PubMed

Mesangial cell-glomerular basement membrane connections counteract glomerular capillary and mesangium expansion Am J Nephrol. 1990; 10 Suppl 1:4-13. . View in PubMed

Cycles and separations: the histotopography of the urinary concentrating process Kidney Int. 1987 Feb; 31(2):538-48. . View in PubMed

The shape of renal vasa recta capillaries and its effect on calculation of single capillary blood flow Microvasc Res. 1986 Jul; 32(1):1-20. . View in PubMed

Prostaglandin synthesis inhibitors and vasa recta erythrocyte velocities in the rat Am J Physiol. 1984 Oct; 247(4 Pt 2):F562-7. . View in PubMed

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