Keck School Faculty

Kimberly Gokoffski
Kimberly Gokoffski
Assistant Professor of Clinical Ophthalmology
HC4 4900 1450 San Pablo Street Health Sciences Campus Los Angeles
My research interests are focused on the clinical need for optic nerve regeneration. Optic neuropathies are diseases in which the optic nerve (ON) – the cable that transmits information from the eye to the brain – is damaged. Advanced optic neuropathies, like glaucoma, result in irreversible vision loss because the cells that make up the ON are not capable of self-renewal. To restore vision in patients with optic neuropathies, we need to regenerate the ON. The current rate-limiting step to ON regeneration is directing stem cells that have been implanted in the eye to grow an axon out of the eye to the brain — a distance that spans 5cm in humans.

The goal of my research is 1.) to elucidate the molecular signals that guide axon growth and 2.) to test whether an applied electrical field can be used to direct the growth of implanted stem cells. The results from this project will be developed into a technology to facilitate ON regeneration and restore vision in patients blinded by optic neuropathies.

North American Neuro-Ophthalmology Society: Thomas Carlow Young Investigator Award, 2017

Department of Ophthalmology, UC Davis: 1st Place Resident Research Presentation, Alumni Day, 2012

UC Irvine: Graduated with Distinction in Research, 2009

UC Irvine: Graduated with Distinction in Community Service, 2009

UC Irvine: Developmental and Systems Biology Training Grant, 2008

Center for Complex Biological Systems: Student Project Grant, 2007

International Conference in Systems Biology: Travel Award, 2006

UC Irvine: Paul H. Silverman Award for Research in Stem Cells, 2005-2007

UC Irvine: School of Biological Sciences Travel Award, 2002

UC Irvine: Alpha Omega Alpha Honors Society Community Service Award, 2001

UC Irvine: Center for Complex Biological Systems Student Project Grant, 2001

NIH: NINDS/AUPN/ANA Medical Students Mentoring Workshop Scholarship, 2001

UC Irvine: NIH Neurosciences Training Grant, 2001

UC Irvine: MSTP 2nd Place Oral Presentation Award, 2001

University of Kansas: Research Experience for Undergraduates (REU) Fellowship, 2001

University of Pittsburgh: Summer Undergraduate Research Program (SURP) Fellowship, 2001

Seasonal incidence of biopsy-proven giant cell arteritis: a 20-year retrospective study of the University of California Davis Medical System Clin Exp Rheumatol. 2019 Jan 07. . View in PubMed

Ophthalmic Artery Occlusion after Cocaine Use J Emerg Med. 2015 Jul; 49(1):61-2. . View in PubMed

Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate Development. 2011 Oct; 138(19):4131-42. . View in PubMed

Spatial dynamics of multistage cell lineages in tissue stratification Biophys J. 2010 Nov 17; 99(10):3145-54. . View in PubMed

Cell lineages and the logic of proliferative control PLoS Biol. 2009 Jan 20; 7(1):e15. . View in PubMed

Feedback regulation in multistage cell lineages Math Biosci Eng. 2009 Jan; 6(1):59-82. . View in PubMed

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