Keck School Faculty

Linda J. Hovanessian Larsen, MD
Linda J. Hovanessian Larsen, MD
Professor of Clinical Radiology;Director, Division of Women's Imaging;Director, Radiology Research in Women's Health
NOR 1441 Eastlake Ave Health Sciences Campus Los Angeles
Dr. Linda Hovanessian Larsen is a Professor of Clinical Radiology and Chief of Breast Imaging at USC Keck School of Medicine. She has dedicated her career to improving the early detection and diagnosis of breast cancer and to delivering compassionate, equitable, and high-quality care to the community.
Dr Larsen first began her career working at the University of Miami Medical Center, specializing in breast imaging. She joined the faculty of the USC Keck School of Medicine in 1998, and became the Director of Outpatient Mammography for the LAC+USC Medical Center. From the beginning, Dr. Larsen has advocated the multidisciplinary team approach and worked closely with the breast surgeons, oncologists, and pathologists to provide outstanding, equitable healthcare for each patient.
In 2003, she became the Chief of Women’s Imaging (now Breast Imaging), and currently oversees the Norris Breast Center, LAC+USC County Mammography, and mammography at the affiliated Ambulatory Care Clinics.
Dr. Larsen has served on administrative and clinical committees for the DOR, and has spearheaded many of the Breast Imaging research projects. She incorporated the USC DOR into the American College of Radiology Imaging Network (ACRIN), which is a national multicenter organization supported in part by the National Cancer Institute. Dr. Larsen’s main area of research concentrates on innovative breast imaging techniques, including digital breast tomosynthesis, automated whole breast ultrasound, and contrast enhanced breast ultrasound. She has received grant awards from the Susan G Komen Breast Cancer Foundation, the Whittier Foundation, and participates in NCI-ACRIN, I-SPY 2, and SWOG multicenter trials. Her most rewarding project was an NIH funded grant for the Susan Love foundation, which evaluated a low-cost ultrasound device used to triage palpable breast lumps in women living in low income countries that do not readily have access to healthcare.
Dr. Larsen is a widely recognized leader in the field of breast imaging, lecturing locally and nationally on breast cancer screening, diagnosis, and advanced imaging techniques. She enjoys reaching out to women in the community and educating them about the best tools available for early detection of breast cancer. However, by far, her most favorite teaching involves medical students, residents, and fellows on the clinical service. She believes the diverse patient populations and clinical experiences at LAC+USC Mammography and the Norris Breast Center together provide an unparalleled foundation for an outstanding education in breast imaging.

Factors associated with MRI detection of occult lesions in newly diagnosed breast cancers J Surg Oncol. 2020 Mar; 121(4):589-598. . View in PubMed

Contrast-Enhanced Ultrasound Imaging of Breast Masses: Adjunct Tool to Decrease the Number of False-Positive Biopsy Results J Ultrasound Med. 2019 Sep; 38(9):2259-2273. . View in PubMed

Clinical findings and outcomes of MRI staging of breast cancer in a diverse population Breast Cancer Res Treat. 2019 Apr; 174(2):315-324. . View in PubMed

Accuracy of Contrast-Enhanced Ultrasound Compared With Magnetic Resonance Imaging in Assessing the Tumor Response After Neoadjuvant Chemotherapy for Breast Cancer J Ultrasound Med. 2017 May; 36(5):901-911. . View in PubMed

ED breast cases and other breast emergencies Emerg Radiol. 2016 Feb; 23(1):67-77. . View in PubMed

Modified Bi-Rads Scoring of Breast Imaging Findings Improves Clinical Judgment Breast J. 2015 Nov-Dec; 21(6):642-50. . View in PubMed

A Phase II Study of 3'-Deoxy-3'-18F-Fluorothymidine PET in the Assessment of Early Response of Breast Cancer to Neoadjuvant Chemotherapy: Results from ACRIN 6688 J Nucl Med. 2015 Nov; 56(11):1681-9. . View in PubMed

Double-Blind Randomized 12-Month Soy Intervention Had No Effects on Breast MRI Fibroglandular Tissue Density or Mammographic Density Cancer Prev Res (Phila). 2015 Oct; 8(10):942-51. . View in PubMed

High-frequency ultrasound imaging for breast cancer biopsy guidance J Med Imaging (Bellingham). 2015 Oct; 2(4):047001. . View in PubMed

Malignancy rates after surgical excision of discordant breast biopsies J Surg Res. 2015 May 01; 195(1):152-7. . View in PubMed

The role of axillary ultrasound in the detection of metastases from primary breast cancers Am J Surg. 2013 Mar; 205(3):242-4; discussion 244-5. . View in PubMed

Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: a randomized trial Contraception. 2012 Sep; 86(3):238-43. . View in PubMed

Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk JAMA. 2012 Apr 04; 307(13):1394-404. . View in PubMed

Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation Breast Cancer Res Treat. 2012 Apr; 132(2):653-60. . View in PubMed

Shear-wave elastography improves the specificity of breast US: the BE1 multinational study of 939 masses Radiology. 2012 Feb; 262(2):435-49. . View in PubMed

Breast cancer: comparative effectiveness of positron emission mammography and MR imaging in presurgical planning for the ipsilateral breast Radiology. 2011 Jan; 258(1):59-72. . View in PubMed

Reasons women at elevated risk of breast cancer refuse breast MR imaging screening: ACRIN 6666 Radiology. 2010 Jan; 254(1):79-87. . View in PubMed

Progesterone and estrogen receptors in pregnant and premenopausal non-pregnant normal human breast Breast Cancer Res Treat. 2009 Nov; 118(1):161-8. . View in PubMed

Granulomatous lobular mastitis: imaging, diagnosis, and treatment AJR Am J Roentgenol. 2009 Aug; 193(2):574-81. . View in PubMed

Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer JAMA. 2008 May 14; 299(18):2151-63. . View in PubMed

Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography J Ultrasound Med. 2008 Mar; 27(3):435-51. . View in PubMed

Imaging characteristics of malignant lesions of the male breast Radiographics. 2006 Jul-Aug; 26(4):993-1006. . View in PubMed

Greatly increased occurrence of breast cancers in areas of mammographically dense tissue Breast Cancer Res. 2005; 7(5):R605-8. . View in PubMed

Retroperitoneal cystic lymphangioma: MR findings Magn Reson Imaging. 1990; 8(1):91-3. . View in PubMed

Central and renal hemodynamic effects of a new agonist at peripheral dopamine- and beta-2 adrenoreceptors (dopexamine) in patients with heart failure Am Heart J. 1989 Mar; 117(3):607-14. . View in PubMed

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