Lori Walker, MD

Clinical Assistant Professor of Family Medicine (Practitioner) (Part-Time)

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Overview

Lori Walker, MD received her medical degree from the Charles R. Drew University of California, Los Angeles. She served her residency in Internal Medicine at the Martin Luther King Hospital and is board-certified in Internal Medicine. She is a member of the American College of Physicians.

Publications

  • Perivascular adipose tissue remodeling impairs vasoreactivity in thermoneutral-housed rats bioRxiv. 2024 May 13. . View in PubMed
  • Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure Circ Res. 2024 03 15; 134(6):675-694. . View in PubMed
  • Enhancing circadian rhythms-the circadian MEGA bundle as novel approach to treat critical illness Ann Transl Med. 2023 Jun 30; 11(9):319. . View in PubMed
  • Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H804-H820. . View in PubMed
  • Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart Circulation. 2022 08 30; 146(9):699-714. . View in PubMed
  • Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy Stem Cell Reports. 2021 03 09; 16(3):519-533. . View in PubMed
  • Physiology of the Right Ventricle Across the Lifespan Front Physiol. 2021; 12:642284. . View in PubMed
  • Ex vivo Methods for Measuring Cardiac Muscle Mechanical Properties Front Physiol. 2020; 11:616996. . View in PubMed
  • (-)-Epicatechin Modulates Mitochondrial Redox in Vascular Cell Models of Oxidative Stress Oxid Med Cell Longev. 2020; 2020:6392629. . View in PubMed
  • Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins Proc Natl Acad Sci U S A. 2020 07 28; 117(30):18079-18090. . View in PubMed
  • LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion Proc Natl Acad Sci U S A. 2019 01 08; 116(2):556-565. . View in PubMed
  • The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation PLoS One. 2019; 14(8):e0220573. . View in PubMed
  • Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the EndotheliumCell Rep. 2019 08 06; 28(6):1471-1484. e11. . View in PubMed
  • Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy Am J Physiol Heart Circ Physiol. 2019 12 01; 317(6):H1221-H1230. . View in PubMed
  • Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats Physiol Rep. 2018 07; 6(13):e13754. . View in PubMed
  • Exercise and Pharmacology as Medicine for Cardiovascular Diseases: From Bench to Bedside and Back Exerc Sport Sci Rev. 2018 01; 46(1):2-3. . View in PubMed
  • Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction PLoS One. 2018; 13(7):e0199705. . View in PubMed
  • Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner World J Cardiol. 2017 Aug 26; 9(8):673-684. . View in PubMed
  • Genetic ablation of interleukin-18 does not attenuate hypobaric hypoxia-induced right ventricular hypertrophy Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15; 310(6):L542-50. . View in PubMed
  • Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation Nat Commun. 2016 Mar 04; 7:10830. . View in PubMed
  • Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model Oxid Med Cell Longev. 2016; 2016:8524267. . View in PubMed
  • High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling Nat Commun. 2015 Sep 10; 6:8243. . View in PubMed
  • Differential Tissue-Specific Function of Adora2b in Cardioprotection J Immunol. 2015 Aug 15; 195(4):1732-43. . View in PubMed
  • Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15; 308(2):L158-67. . View in PubMed
  • Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation J Immunol Methods. 2014 Jan 31; 403(1-2):66-71. . View in PubMed
  • Contractile protein phosphorylation predicts human heart disease phenotypes Am J Physiol Heart Circ Physiol. 2013 Jun 15; 304(12):H1644-50. . View in PubMed
  • The right ventricle: biologic insights and response to disease: updated Curr Cardiol Rev. 2013 Feb 01; 9(1):73-81. . View in PubMed
  • Serendipitous discovery of a novel protein signaling mechanism in heart failure Biochem Biophys Res Commun. 2012 May 11; 421(3):431-5. . View in PubMed
  • Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia Nat Med. 2012 Apr 15; 18(5):774-82. . View in PubMed
  • Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism Circ Res. 2012 Mar 02; 110(5):739-48. . View in PubMed
  • Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction Physiol Genomics. 2011 Oct 06; 43(19):1087-95. . View in PubMed
  • Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H832-40. . View in PubMed
  • Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support Circ Heart Fail. 2011 Jul; 4(4):425-32. . View in PubMed
  • Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H138-46. . View in PubMed
  • Tissue procurement strategies affect the protein biochemistry of human heart samples J Muscle Res Cell Motil. 2011 Mar; 31(5-6):309-14. . View in PubMed
  • Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice J Mol Cell Cardiol. 2010 Jun; 48(6):1180-6. . View in PubMed
  • Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation J Biol Chem. 2009 Feb 20; 284(8):5097-106. . View in PubMed
  • The right ventricle: biologic insights and response to disease Curr Cardiol Rev. 2009 Jan; 5(1):22-8. . View in PubMed
  • Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation J Mol Cell Cardiol. 2006 Apr; 40(4):465-73. . View in PubMed
  • Depressed cardiac myofilament function in human diabetes mellitus Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2478-83. . View in PubMed
  • Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure Circ Res. 2004 Aug 20; 95(4):424-32. . View in PubMed