Keck School Faculty

Mark Krailo, PhD
Mark Krailo, PhD
Professor of Research Preventive Medicine
Preventive Medicine
Children's Oncology Group Health Sciences Campus Monrovia

: Board of Governor's Award, University of Windsor, 2000

: Ontario Graduate Scholarship, 2000

: University of Windsor Entrance Award , 2000

: Ford Scholarship, 2000

: National Research Council Postgraduate Scholarship , 2000

: Ontario Scholarship , 2000

Correction: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Br J Cancer. 2019 Mar 18. . View in PubMed

A Phase 2 Study of Alisertib in Children with Recurrent/Refractory Solid Tumors or Leukemia: Children's Oncology Group Phase 1 and Pilot Consortium ADVL0921) Clin Cancer Res. 2019 Feb 18. . View in PubMed

A phase II study of eribulin in recurrent or refractory osteosarcoma: A report from the Children's Oncology Group Pediatr Blood Cancer. 2019 Feb; 66(2):e27524. . View in PubMed

Factors influencing survival after recurrence in osteosarcoma: A report from the Children's Oncology Group Pediatr Blood Cancer. 2019 Jan; 66(1):e27444. . View in PubMed

Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group J Clin Oncol. 2018 Dec 21; JCO1800790. . View in PubMed

A phase II study of eribulin in recurrent or refractory osteosarcoma: A report from the Children's Oncology Group Pediatr Blood Cancer. 2018 Oct 30; e27524. . View in PubMed

Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 Oct 05. . View in PubMed

Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 Oct; 119(7):864-872. . View in PubMed

Factors influencing survival after recurrence in osteosarcoma: A report from the Children's Oncology Group Pediatr Blood Cancer. 2018 Sep 25; e27444. . View in PubMed

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Br J Cancer. 2018 Aug 21. . View in PubMed

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Br J Cancer. 2018 Aug; 119(5):615-621. . View in PubMed

Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium Eur J Cancer. 2018 Jul; 98:30-37. . View in PubMed

Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium Eur J Cancer. 2018 May 30; 98:30-37. . View in PubMed

Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium Eur J Cancer. 2018 May 30; 98:30-37. . View in PubMed

Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study Pediatr Blood Cancer. 2018 Apr; 65(4). . View in PubMed

Adolescents and Young Adults With a "Rare" Cancer: Getting Past Semantics to Optimal Care for Patients With Germ Cell Tumors Oncologist. 2018 Feb; 23(2):272. . View in PubMed

Family history of cancer in children and adolescents with germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 01; 118(1):121-126. . View in PubMed

Family history of cancer in children and adolescents with germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 Jan; 118(1):121-126. . View in PubMed

Characterization of Pulmonary Metastases in Children With Hepatoblastoma Treated on Children's Oncology Group Protocol AHEP0731 (The Treatment of Children With All Stages of Hepatoblastoma): A Report From the Children's Oncology Group J Clin Oncol. 2017 Oct 20; 35(30):3465-3473. . View in PubMed

Clinical trial enrollment of adolescents and young adults with sarcoma Cancer. 2017 Sep 15; 123(18):3434-3440. . View in PubMed

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial Lancet Oncol. 2017 01; 18(1):63-74. . View in PubMed

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial Lancet Oncol. 2017 Jan; 18(1):63-74. . View in PubMed

Identification of Patients With Localized Ewing Sarcoma at Higher Risk for Local Failure: A Report From the Children's Oncology Group Int J Radiat Oncol Biol Phys. 2017 12 01; 99(5):1286-1294. . View in PubMed

Caphosol for prevention of oral mucositis in pediatric myeloablative haematopoietic cell transplantation Br J Cancer. 2017 01 03; 116(1):21-27. . View in PubMed

A novel prognostic model for osteosarcoma using circulating CXCL10 and FLT3LG Cancer. 2017 Jan 01; 123(1):144-154. . View in PubMed

Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Group Bone Tumor Committee Pediatr Blood Cancer. 2016 Oct; 63(10):1737-43. . View in PubMed

Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children's Oncology Group Pediatr Blood Cancer. 2016 Oct; 63(10):1771-9. . View in PubMed

Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial Lancet Oncol. 2016 Oct; 17(10):1396-1408. . View in PubMed

Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions: A report from the Children's Oncology Group J Surg Oncol. 2016 Mar; 113(4):351-4. . View in PubMed

Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children's Oncology Group Pediatr Blood Cancer. 2016 10; 63(10):1771-9. . View in PubMed

Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Group Bone Tumor Committee Pediatr Blood Cancer. 2016 10; 63(10):1737-43. . View in PubMed

Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort: A Children's Oncology Group Study Ophthalmology. 2016 08; 123(8):1817-1823. . View in PubMed

Can Big Data Shed Light on the Origins of Pediatric Cancer? Pediatrics. 2016 06; 137(6).. View in PubMed

Identification of Discrete Prognostic Groups in Ewing Sarcoma Pediatr Blood Cancer. 2016 Jan; 63(1):47-53. . View in PubMed

Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group Clin Cancer Res. 2016 07 15; 22(14):3643-50. . View in PubMed

Feasibility Study of a Novel Experimental Induction Protocol Combining B43-PAP (Anti-CD19) Immunotoxin With Standard Induction Chemotherapy in Children and Adolescents With Relapsed B-Lineage ALL: A Report From the Children's Oncology Group J Immunother. 2015 Sep; 38(7):299-305. . View in PubMed

Impact of central surgical review in a study of malignant germ cell tumors J Pediatr Surg. 2015 Sep; 50(9):1502-5. . View in PubMed

A pilot study using carboplatin, vincristine, and temozolomide in children with progressive/symptomatic low-grade glioma: a Children's Oncology Group study† Neuro Oncol. 2015 Aug; 17(8):1132-8. . View in PubMed

Gene Expression Profiling of Ewing Sarcoma Tumors Reveals the Prognostic Importance of Tumor-Stromal Interactions: A Report from the Children's Oncology Group J Pathol Clin Res. 2015 Apr; 1(2):83-94. . View in PubMed

A summary of the osteosarcoma banking efforts: a report from the Children's Oncology Group and the QuadW Foundation Pediatr Blood Cancer. 2015 Mar; 62(3):450-5. . View in PubMed

Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group Cancer. 2015 Feb 01; 121(3):467-75. . View in PubMed

EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment Ann Oncol. 2015 Feb; 26(2):407-14. . View in PubMed

Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children's Oncology Group Report Sarcoma. 2015; 2015:927123. . View in PubMed

HER-2 expression is not prognostic in osteosarcoma; a Children's Oncology Group prospective biology study Pediatr Blood Cancer. 2014 Sep; 61(9):1558-64. . View in PubMed

Congenital abnormalities and hepatoblastoma: a report from the Children's Oncology Group (COG) and the Utah Population Database (UPDB) Am J Med Genet A. 2014 Sep; 164A(9):2250-5. . View in PubMed

Adolescents and young adults with a "rare" cancer: getting past semantics to optimal care for patients with germ cell tumors Oncologist. 2014 Jul; 19(7):689-92. . View in PubMed

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children's oncology group study Pediatr Blood Cancer. 2014 Apr; 61(4):749-52. . View in PubMed

Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group PLoS One. 2014; 9(8):e104378. . View in PubMed

High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: a report from the Children's Oncology Group Pediatr Blood Cancer. 2013 Dec; 60(12):2042-6. . View in PubMed

Feasibility and dose discovery analysis of zoledronic acid with concurrent chemotherapy in the treatment of newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group Eur J Cancer. 2013 Jul; 49(10):2384-91. . View in PubMed

Children's Oncology Group's 2013 blueprint for research: rare tumors Pediatr Blood Cancer. 2013 Jun; 60(6):1016-21. . View in PubMed

A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multiagent chemotherapy for patients with newly diagnosed metastatic Ewing sarcoma family of tumors: A Children's Oncology Group (COG) Phase II study NCT00061893 Pediatr Blood Cancer. 2013 Mar; 60(3):409-14. . View in PubMed

A Decade in Banking Ewing Sarcoma: A Report from the Children's Oncology Group Front Oncol. 2013; 3:57. . View in PubMed

"Accelerated ear-age": a new measure of chemotherapy-induced ototoxicity Pediatr Blood Cancer. 2012 Nov; 59(5):947-9. . View in PubMed

A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: a report from the Children's Oncology Group Eur J Cancer. 2012 Mar; 48(4):579-85. . View in PubMed

Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study Int J Mol Epidemiol Genet. 2012; 3(4):286-93. . View in PubMed

Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group Pediatr Blood Cancer. 2011 Dec 01; 57(6):939-42. . View in PubMed

Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the Children's Oncology Group Study ASCT0031 Biol Blood Marrow Transplant. 2011 Dec; 17(12):1804-13. . View in PubMed

Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children's Oncology Group J Clin Oncol. 2011 Aug 20; 29(24):3301-6. . View in PubMed

Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group Clin Cancer Res. 2011 Jan 01; 17(1):56-66. . View in PubMed

Infrequent tumor initiative of the Children's Oncology Group: initial lessons learned and their impact on future plans J Clin Oncol. 2010 Nov 20; 28(33):5011-6. . View in PubMed

Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Groups Study, ASCT0031 Bone Marrow Transplant. 2010 Nov; 45(11):1653-7. . View in PubMed

A novel toxicity scoring system treating toxicity response as a quasi-continuous variable in Phase I clinical trials Contemp Clin Trials. 2010 Sep; 31(5):473-82. . View in PubMed

A phase II trial and pharmacokinetic study of oxaliplatin in children with refractory solid tumors: a Children's Oncology Group study Pediatr Blood Cancer. 2010 Sep; 55(3):440-5. . View in PubMed

Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group J Clin Oncol. 2010 Apr 20; 28(12):1989-94. . View in PubMed

Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group Cancer. 2009 Dec 15; 115(24):5828-35. . View in PubMed

Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group Cancer. 2009 Nov 15; 115(22):5339-48. . View in PubMed

Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study J Clin Oncol. 2009 May 20; 27(15):2536-41. . View in PubMed

Effect of time to resumption of chemotherapy after definitive surgery on prognosis for non-metastatic osteosarcoma J Bone Joint Surg Am. 2009 Mar 01; 91(3):604-12. . View in PubMed

Chemoimmunotherapy reinduction with epratuzumab in children with acute lymphoblastic leukemia in marrow relapse: a Children's Oncology Group Pilot Study J Clin Oncol. 2008 Aug 01; 26(22):3756-62. . View in PubMed

A Phase 1 and pharmacokinetic clinical trial of paclitaxel for the treatment of refractory leukemia in children: a Children's Oncology Group study Pediatr Blood Cancer. 2008 Apr; 50(4):788-92. . View in PubMed

Biomarkers in newly diagnosed pediatric-extensive chronic graft-versus-host disease: a report from the Children's Oncology Group Blood. 2008 Mar 15; 111(6):3276-85. . View in PubMed

A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study Pediatr Blood Cancer. 2008 Feb; 50(2):254-8. . View in PubMed

A phase I study of 90yttrium-ibritumomab-tiuxetan in children and adolescents with relapsed/refractory CD20-positive non-Hodgkin's lymphoma: a Children's Oncology Group study Clin Cancer Res. 2007 Sep 15; 13(18 Pt 2):5652s-5660s. . View in PubMed

Analysis of biologic surrogate markers from a Children's Oncology Group Phase I trial of gefitinib in pediatric patients with solid tumors Pediatr Blood Cancer. 2007 Sep; 49(3):352-7. . View in PubMed

Altered Toll-like receptor 9 responses in circulating B cells at the onset of extensive chronic graft-versus-host disease Biol Blood Marrow Transplant. 2007 Apr; 13(4):386-97. . View in PubMed

Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: a report from the Children's Oncology Group Cancer Lett. 2007 Mar 18; 247(2):204-12. . View in PubMed

A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study Clin Cancer Res. 2007 Mar 15; 13(6):1789-93. . View in PubMed

A phase I clinical trial of the hu1418-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children's Oncology Group. Clin Cancer Res. 2006 Mar 15; 12(6):1750-9. . View in PubMed

In utero exposure to female hormones and germ cell tumors in children Cancer. 2006 Mar 01; 106(5):1169-77. . View in PubMed

Environmental exposure to residential pesticides, chemicals, dusts, fumes, and metals, and risk of childhood germ cell tumors Int J Hyg Environ Health. 2006 Jan; 209(1):31-40. . View in PubMed

A Phase I study of concurrent RMP-7 and carboplatin with radiation therapy for children with newly diagnosed brainstem gliomas Cancer. 2005 Nov 01; 104(9):1968-74. . View in PubMed

A phase I clinical, pharmacologic, and biologic study of thrombopoietin and granulocyte colony-stimulating factor in children receiving ifosfamide, carboplatin, and etoposide chemotherapy for recurrent or refractory solid tumors: a Children's Oncology Group experience Clin Cancer Res. 2005 Apr 01; 11(7):2644-50. . View in PubMed

Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the Children's Cancer Group (CCG) experience Pediatr Blood Cancer. 2005 Apr; 44(4):338-47. . View in PubMed

A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumorsA Children's Oncology Group study. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):672-7. . View in PubMed

Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: results from a Children's Oncology Group phase 1 study Blood. 2004 Nov 01; 104(9):2655-60. . View in PubMed

Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy Ann Surg. 2003 Oct; 238(4):563-7; discussion 567-8. . View in PubMed

Fibrolamellar hepatocellular carcinoma in children and adolescents Cancer. 2003 Apr 15; 97(8):2006-12. . View in PubMed

Childhood cancer patients' access to cooperative group cancer programs: a population-based study Cancer. 2003 Mar 01; 97(5):1339-45. . View in PubMed

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone N Engl J Med. 2003 Feb 20; 348(8):694-701. . View in PubMed

Burkitt's and Burkitt-like lymphoma in children and adolescents: a review of the Children's Cancer Group experience Br J Haematol. 2003 Feb; 120(4):660-70. . View in PubMed

A phase I study of topotecan as a radiosensitizer for brainstem glioma of childhood: first report of the Children's Cancer Group-0952 Neuro Oncol. 2003 01; 5(1):8-13. . View in PubMed

Hepatocellular carcinoma in children and adolescents: results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study J Clin Oncol. 2002 Jun 15; 20(12):2789-97. . View in PubMed

Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: A Pediatric Oncology Group/Children's Cancer Group Intergroup Study J Clin Oncol. 1999 Jul; 17(7):2137-43. . View in PubMed

Chromosome abnormalities of eighty-one pediatric germ cell tumors: sex-, age-, site-, and histopathology-related differences--a Children's Cancer Group study Genes Chromosomes Cancer. 1999 Jun; 25(2):134-46. . View in PubMed

Cancer in adolescents and young adults Cancer. 1993 May 15; 71(10 Suppl):3206-9. . View in PubMed

American Cancer Society Workshop on Adolescents and Young Adults with CancerWorkgroup #4: Clinical research implications. Cancer. 1993 Apr 01; 71(7):2423. . View in PubMed

Efficacy and toxicity of 12 courses of ABVD chemotherapy followed by low-dose regional radiation in advanced Hodgkin's disease in children: a report from the Children's Cancer Study Group J Clin Oncol. 1990 Dec; 8(12):1971-80. . View in PubMed

Adjuvant chemotherapy following cystectomy benefits patients with deeply invasive bladder cancer Semin Urol. 1990 Nov; 8(4):279-84. . View in PubMed

A phase II study of diaziquone in children with recurrent or progressive primary brain tumors: a report from the Childrens Cancer Study Group J Neurooncol. 1990 Aug; 9(1):69-76. . View in PubMed

Germ cell tumors in infancy and childhood: a 45-year experience Pediatr Pathol. 1990; 10(1-2):231-41. . View in PubMed

Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma Cancer. 1989 Sep 01; 64(5):1082-95. . View in PubMed

Immature teratomas: identification of patients at risk for malignant recurrence J Natl Cancer Inst. 1989 Jun 07; 81(11):870-4. . View in PubMed

A phase II study of diaziquone in childhood leukemia: a report from the Children's Cancer Study Group Am J Pediatr Hematol Oncol. 1988; 10(1):18-22. . View in PubMed

Biochemical pharmacology of high dose 1-beta-D-arabinofuranosylcytosine in childhood acute leukemia Cancer Res. 1987 Dec 15; 47(24 Pt 1):6786-92. . View in PubMed

AIDS-related malignant lymphoma: results of prospective treatment trials J Clin Oncol. 1987 Sep; 5(9):1322-8. . View in PubMed

A randomized study comparing high-dose methotrexate with moderate-dose methotrexate as components of adjuvant chemotherapy in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group Med Pediatr Oncol. 1987; 15(2):69-77. . View in PubMed

Fitting models of carcinogenesis to a case-control study of breast cancer J Chronic Dis. 1987; 40 Suppl 2:181S-189S. . View in PubMed

A comparison of imaging, clinical, and pathologic aspects of space-occupying lesions within the brain in patients with acquired immune deficiency syndrome Am J Physiol Imaging. 1986; 1(3):134-41. . View in PubMed

Comparison of the antiemetic effect of high-dose intravenous metoclopramide and high-dose intravenous haloperidol in a randomized double-blind crossover study J Clin Oncol. 1984 Jul; 2(7):782-7. . View in PubMed

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