Keck School Faculty

Mark Krailo

Mark Krailo

Professor of Research Population and Public Health Sciences
Medicine
Children's Oncology Group Health Sciences Campus Monrovia

: Board of Governor's Award, University of Windsor, 2000

: Ontario Graduate Scholarship, 2000

: University of Windsor Entrance Award , 2000

: Ford Scholarship, 2000

: National Research Council Postgraduate Scholarship , 2000

: Ontario Scholarship , 2000

: University of Windsor Entrance Award, 2000

: National Research Council Postgraduate Scholarship, 2000

: Ontario Scholarship, 2000

Outcomes of children with well-differentiated fetal hepatoblastoma treated with surgery only: Report from Children's Oncology Group Trial, AHEP0731 J Pediatr Surg. 2022 Oct; 57(10):251-256. . View in PubMed

Phase 2 study of anti-disialoganglioside antibody, dinutuximab, in combination with GM-CSF in patients with recurrent osteosarcoma: A report from the Children's Oncology Group Eur J Cancer. 2022 Sep; 172:264-275. . View in PubMed

Intensive Multimodality Therapy for Extraocular Retinoblastoma: A Children's Oncology Group Trial (ARET0321) J Clin Oncol. 2022 Jul 12; JCO2102337. . View in PubMed

Response to commentary re: Clinicopathologic predictors of outcomes in children with stage I testicular germ cell tumors: A pooled post hoc analysis of trials from the Children's oncology group J Pediatr Urol. 2022 Jul 08. . View in PubMed

Utility of frozen section in pediatric and adolescent malignant ovarian nonseminomatous germ cell tumors: A report from the children's oncology group Gynecol Oncol. 2022 Jun 21. . View in PubMed

Clinicopathologic predictors of outcomes in children with stage I testicular germ cell tumors: A pooled post hoc analysis of trials from the Children's Oncology Group J Pediatr Urol. 2022 May 07. . View in PubMed

Predicted leukocyte telomere length and risk of germ cell tumours Br J Cancer. 2022 07; 127(2):301-312. . View in PubMed

Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma Eur J Cancer. 2022 07; 170:209-235. . View in PubMed

Sodium thiosulfate for prevention of cisplatin-induced hearing loss: updated survival from ACCL0431 Lancet Oncol. 2022 05; 23(5):570-572. . View in PubMed

Doxorubicin in combination with cisplatin, 5-flourouracil, and vincristine is feasible and effective in unresectable hepatoblastoma: A Children's Oncology Group study Cancer. 2022 03 01; 128(5):1057-1065. . View in PubMed

Reply to J-G. Wang et al. J Clin Oncol. 2022 05 01; 40(13):1507-1508. . View in PubMed

Phase I/II trial of vorinostat and radiation and maintenance vorinostat in children with diffuse intrinsic pontine glioma: A Children's Oncology Group report Neuro Oncol. 2022 04 01; 24(4):655-664. . View in PubMed

Small Cell Undifferentiated Histology Does Not Adversely Affect Outcome in Hepatoblastoma: A Report From the Children's Oncology Group (COG) AHEP0731 Study Committee J Clin Oncol. 2022 02 10; 40(5):459-467. . View in PubMed

Imaging Appearance of Nongerminoma Pediatric Ovarian Germ Cell Tumors Does Not Discriminate Benign from Malignant Histology J Pediatr Adolesc Gynecol. 2021 Jun; 34(3):383-386. . View in PubMed

Current surgical management of children with osteosarcoma and pulmonary metastatic disease: A survey of the American Pediatric Surgical Association J Pediatr Surg. 2021 Feb; 56(2):282-285. . View in PubMed

A Multi-institutional Pooled Analysis Demonstrates That Circulating miR-371a-3p Alone is Sufficient for Testicular Malignant Germ Cell Tumor Diagnosis Clin Genitourin Cancer. 2021 12; 19(6):469-479. . View in PubMed

Outcome of patients with relapsed or progressive Ewing sarcoma enrolled on cooperative group phase 2 clinical trials: A report from the Children's Oncology Group Pediatr Blood Cancer. 2021 12; 68(12):e29333. . View in PubMed

Temozolomide with irinotecan versus temozolomide, irinotecan plus bevacizumab for recurrent medulloblastoma of childhood: Report of a COG randomized Phase II screening trial Pediatr Blood Cancer. 2021 08; 68(8):e29031. . View in PubMed

The International Collaboration for Research methods Development in Oncology (CReDO) workshops: shaping the future of global oncology research Lancet Oncol. 2021 08; 22(8):e369-e376. . View in PubMed

Patterns of Translocation Testing in Patients Enrolling in a Cooperative Group Trial for Newly Diagnosed Metastatic Ewing Sarcoma Arch Pathol Lab Med. 2021 12 01; 145(12):1564-1568. . View in PubMed

Treatment of Pediatric Adrenocortical Carcinoma With Surgery, Retroperitoneal Lymph Node Dissection, and Chemotherapy: The Children's Oncology Group ARAR0332 Protocol J Clin Oncol. 2021 08 01; 39(22):2463-2473. . View in PubMed

Reply to J-G. Wang et al. J Clin Oncol. 2021 09 20; 39(27):3088-3089. . View in PubMed

Outcomes of adolescent males with extracranial metastatic germ cell tumors: A report from the Malignant Germ Cell Tumor International Consortium Cancer. 2021 01 15; 127(2):193-202. . View in PubMed

Phase III Trial Adding Vincristine-Topotecan-Cyclophosphamide to the Initial Treatment of Patients With Nonmetastatic Ewing Sarcoma: A Children's Oncology Group Report J Clin Oncol. 2021 12 20; 39(36):4029-4038. . View in PubMed

Developing and Using a Data Commons for Understanding the Molecular Characteristics of Germ Cell Tumors Methods Mol Biol. 2021; 2195:263-275. . View in PubMed

Information fraction estimation based on the number of events within the standard treatment regimen Biom J. 2020 Jul 06. . View in PubMed

Evaluation of the diagnostic biopsy approach for children with hepatoblastoma: A report from the children's oncology group AHEP 0731 liver tumor committee J Pediatr Surg. 2020 Apr; 55(4):655-659. . View in PubMed

A single-arm study of systemic and sub-Tenon chemotherapy for Groups C and D intraocular retinoblastoma: A Children's Oncology Group study (ARET 0231) Pediatr Blood Cancer. 2020 09; 67(9):e28502. . View in PubMed

The importance of age as prognostic factor for the outcome of patients with hepatoblastoma: Analysis from the Children's Hepatic tumors International Collaboration (CHIC) database Pediatr Blood Cancer. 2020 08; 67(8):e28350. . View in PubMed

Development of a Data Model and Data Commons for Germ Cell Tumors JCO Clin Cancer Inform. 2020 06; 4:555-566. . View in PubMed

Reply to SA. Upadhyaya. J Clin Oncol. 2020 10 01; 38(28):3353-3354. . View in PubMed

Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children's Oncology Group Trial ACNS0333 J Clin Oncol. 2020 04 10; 38(11):1175-1185. . View in PubMed

Quality of Life of Patients With Osteosarcoma in the European American Osteosarcoma Study-1 (EURAMOS-1): Development and Implementation of a Questionnaire Substudy JMIR Res Protoc. 2019 Sep 26; 8(8):e14406. . View in PubMed

Correction: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Br J Cancer. 2019 Apr; 120(8):869. . View in PubMed

Rejoinder Clin Trials. 2019 12; 16(6):613-615. . View in PubMed

Bias in retrospective analyses of biomarker effect using data from an outcome-adaptive randomized trial Clin Trials. 2019 12; 16(6):599-609. . View in PubMed

Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method Pharm Stat. 2019 11; 18(6):659-670. . View in PubMed

Phase II trial of the glycoprotein non-metastatic B-targeted antibody-drug conjugate, glembatumumab vedotin (CDX-011), in recurrent osteosarcoma AOST1521: A report from the Children's Oncology Group Eur J Cancer. 2019 11; 121:177-183. . View in PubMed

Results from the UK Children's Cancer and Leukaemia Group study of extracranial germ cell tumours in children and adolescents (GCIII) Eur J Cancer. 2019 09; 118:49-57. . View in PubMed

Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial Lancet Oncol. 2019 05; 20(5):719-727. . View in PubMed

Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort Eur J Cancer. 2019 03; 109:36-50. . View in PubMed

A phase II study of eribulin in recurrent or refractory osteosarcoma: A report from the Children's Oncology Group Pediatr Blood Cancer. 2019 02; 66(2):e27524. . View in PubMed

Factors influencing survival after recurrence in osteosarcoma: A report from the Children's Oncology Group Pediatr Blood Cancer. 2019 01; 66(1):e27444. . View in PubMed

A Phase II Study of Alisertib in Children with Recurrent/Refractory Solid Tumors or Leukemia: Children's Oncology Group Phase I and Pilot Consortium (ADVL0921) Clin Cancer Res. 2019 06 01; 25(11):3229-3238. . View in PubMed

Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children's Oncology Group Cardiooncology. 2019; 5:15. . View in PubMed

Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children's Oncology Group ARAR0331 Study J Clin Oncol. 2019 12 10; 37(35):3369-3376. . View in PubMed

High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008 J Clin Oncol. 2019 12 01; 37(34):3192-3202. . View in PubMed

Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy: A Children's Oncology Group Study J Clin Oncol. 2019 11 01; 37(31):2883-2891. . View in PubMed

Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group J Clin Oncol. 2019 02 10; 37(5):396-402. . View in PubMed

a-Fetoprotein as a predictor of outcome for children with germ cell tumors: A report from the Malignant Germ Cell International Consortium Cancer. 2019 10 15; 125(20):3649-3656. . View in PubMed

Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials Cancer Med. 2018 May 30. . View in PubMed

Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 10; 119(7):864-872. . View in PubMed

Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? Gynecol Oncol. 2018 08; 150(2):253-260.. View in PubMed

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Br J Cancer. 2018 08; 119(5):615-621. . View in PubMed

Treatment of refractory germ cell tumors in children with paclitaxel, ifosfamide, and carboplatin: A report from the Children's Oncology Group AGCT0521 study Pediatr Blood Cancer. 2018 08; 65(8):e27111. . View in PubMed

Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium Eur J Cancer. 2018 07; 98:30-37. . View in PubMed

Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study Pediatr Blood Cancer. 2018 04; 65(4). . View in PubMed

Adolescents and Young Adults With a "Rare" Cancer: Getting Past Semantics to Optimal Care for Patients With Germ Cell Tumors Oncologist. 2018 02; 23(2):272. . View in PubMed

Ovarian Yolk Sac Tumors; Does Age Matter? Int J Gynecol Cancer. 2018 01; 28(1):77-84.. View in PubMed

Family history of cancer in children and adolescents with germ cell tumours: a report from the Children's Oncology Group Br J Cancer. 2018 01; 118(1):121-126. . View in PubMed

Klinefelter syndrome in males with germ cell tumors: A report from the Children's Oncology Group Cancer. 2018 10 01; 124(19):3900-3908. . View in PubMed

The prognostic significance of circulating serum amyloid A and CXC chemokine ligand 4 in osteosarcoma Pediatr Blood Cancer. 2017 Dec; 64(12). . View in PubMed

Characterization of Pulmonary Metastases in Children With Hepatoblastoma Treated on Children's Oncology Group Protocol AHEP0731 (The Treatment of Children With All Stages of Hepatoblastoma): A Report From the Children's Oncology Group J Clin Oncol. 2017 Oct 20; 35(30):3465-3473. . View in PubMed

Clinical trial enrollment of adolescents and young adults with sarcoma Cancer. 2017 Sep 15; 123(18):3434-3440. . View in PubMed

Systemic neoadjuvant chemotherapy for Group B intraocular retinoblastoma (ARET0331): A report from the Children's Oncology Group Pediatr Blood Cancer. 2017 Jul; 64(7). . View in PubMed

Upfront window vincristine/irinotecan treatment of high-risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 study committee Cancer. 2017 Jun 15; 123(12):2360-2367. . View in PubMed

Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children's Oncology Group J Clin Oncol. 2017 Apr 10; 35(11):1203-1210. . View in PubMed

Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children's Oncology Group J Expo Sci Environ Epidemiol. 2017 07; 27(4):359-364. . View in PubMed

Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group Genes Chromosomes Cancer. 2017 07; 56(7):548-558. . View in PubMed

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial Lancet Oncol. 2017 01; 18(1):63-74. . View in PubMed

Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration Lancet Oncol. 2017 01; 18(1):122-131. . View in PubMed

A novel prognostic model for osteosarcoma using circulating CXCL10 and FLT3LG Cancer. 2017 Jan 01; 123(1):144-154. . View in PubMed

Identification of Patients With Localized Ewing Sarcoma at Higher Risk for Local Failure: A Report From the Children's Oncology Group Int J Radiat Oncol Biol Phys. 2017 12 01; 99(5):1286-1294. . View in PubMed

Caphosol for prevention of oral mucositis in pediatric myeloablative haematopoietic cell transplantation Br J Cancer. 2017 01 03; 116(1):21-27. . View in PubMed

Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial Lancet Oncol. 2016 Oct; 17(10):1396-1408. . View in PubMed

Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group Pediatr Blood Cancer. 2016 Mar; 63(3):493-8. . View in PubMed

Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions: A report from the Children's Oncology Group J Surg Oncol. 2016 Mar; 113(4):351-4. . View in PubMed

Rapid Protocol Enrollment in Osteosarcoma: A Report From the Children's Oncology Group Pediatr Blood Cancer. 2016 Feb; 63(2):370-1. . View in PubMed

Cancer. 2016 Jan 15; 122(2):230-7. . View in PubMed

Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group Ann Surg Oncol. 2016 10; 23(11):3541-3547. . View in PubMed

Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Group Bone Tumor Committee Pediatr Blood Cancer. 2016 10; 63(10):1737-43. . View in PubMed

Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children's Oncology Group Pediatr Blood Cancer. 2016 10; 63(10):1771-9. . View in PubMed

Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS0423 study Neuro Oncol. 2016 10; 18(10):1442-50. . View in PubMed

Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort: A Children's Oncology Group Study Ophthalmology. 2016 08; 123(8):1817-1823. . View in PubMed

Can Big Data Shed Light on the Origins of Pediatric Cancer? Pediatrics. 2016 06; 137(6).. View in PubMed

Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move Forward J Clin Oncol. 2016 09 01; 34(25):3031-8. . View in PubMed

Identification of Discrete Prognostic Groups in Ewing Sarcoma Pediatr Blood Cancer. 2016 Jan; 63(1):47-53. . View in PubMed

Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group Clin Cancer Res. 2016 07 15; 22(14):3643-50. . View in PubMed

p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma Cancer Res. 2016 07 01; 76(13):4002-11. . View in PubMed

Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group Pediatr Blood Cancer. 2016 Jan; 63(1):54-61. . View in PubMed

The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model Eur J Cancer. 2016 Jan; 52:92-101. . View in PubMed

Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration J Clin Oncol. 2015 Sep 20; 33(27):3018-28. . View in PubMed

Rare Tumors in Children: Progress Through Collaboration J Clin Oncol. 2015 Sep 20; 33(27):3047-54. . View in PubMed

Feasibility Study of a Novel Experimental Induction Protocol Combining B43-PAP (Anti-CD19) Immunotoxin With Standard Induction Chemotherapy in Children and Adolescents With Relapsed B-Lineage ALL: A Report From the Children's Oncology Group J Immunother. 2015 Sep; 38(7):299-305. . View in PubMed

Impact of central surgical review in a study of malignant germ cell tumors J Pediatr Surg. 2015 Sep; 50(9):1502-5. . View in PubMed

Phase 2 trial of sorafenib in children and young adults with refractory solid tumors: A report from the Children's Oncology Group Pediatr Blood Cancer. 2015 Sep; 62(9):1562-6. . View in PubMed

A pilot study using carboplatin, vincristine, and temozolomide in children with progressive/symptomatic low-grade glioma: a Children's Oncology Group study† Neuro Oncol. 2015 Aug; 17(8):1132-8. . View in PubMed

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial J Clin Oncol. 2015 Jul 10; 33(20):2279-87. . View in PubMed

Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group J Pediatr Surg. 2015 Jun; 50(6):1000-3. . View in PubMed

Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group Pediatr Blood Cancer. 2015 May; 62(5):759-65. . View in PubMed

Gene Expression Profiling of Ewing Sarcoma Tumors Reveals the Prognostic Importance of Tumor-Stromal Interactions: A Report from the Children's Oncology Group J Pathol Clin Res. 2015 Apr; 1(2):83-94. . View in PubMed

A summary of the osteosarcoma banking efforts: a report from the Children's Oncology Group and the QuadW Foundation Pediatr Blood Cancer. 2015 Mar; 62(3):450-5. . View in PubMed

Systemic levels of neuropeptide Y and dipeptidyl peptidase activity in patients with Ewing sarcoma--associations with tumor phenotype and survival Cancer. 2015 Mar 01; 121(5):697-707. . View in PubMed

Phase II study of cixutumumab in combination with temsirolimus in pediatric patients and young adults with recurrent or refractory sarcoma: a report from the Children's Oncology Group Pediatr Blood Cancer. 2015 Mar; 62(3):440-4. . View in PubMed

Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group Cancer. 2015 Feb 01; 121(3):467-75. . View in PubMed

EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment Ann Oncol. 2015 Feb; 26(2):407-14. . View in PubMed

Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States J Clin Oncol. 2015 Jan 10; 33(2):195-201. . View in PubMed

Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children's Oncology Group Report Sarcoma. 2015; 2015:927123. . View in PubMed

Predictive properties of DNA methylation patterns in primary tumor samples for osteosarcoma relapse status Epigenetics. 2015; 10(1):31-9. . View in PubMed

Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: a report from the Children's Oncology Group Pediatr Blood Cancer. 2014 Nov; 61(11):2018-23. . View in PubMed

The Children's Oncology Group Childhood Cancer Research Network (CCRN): case catchment in the United States Cancer. 2014 Oct 01; 120(19):3007-15. . View in PubMed

Reply to GMangili et al and C. Lhommé et al. J Clin Oncol. 2014 Sep 01; 32(25):2816-7. . View in PubMed

HER-2 expression is not prognostic in osteosarcoma; a Children's Oncology Group prospective biology study Pediatr Blood Cancer. 2014 Sep; 61(9):1558-64. . View in PubMed

Congenital abnormalities and hepatoblastoma: a report from the Children's Oncology Group (COG) and the Utah Population Database (UPDB) Am J Med Genet A. 2014 Sep; 164A(9):2250-5. . View in PubMed

Toward a drug development path that targets metastatic progression in osteosarcoma Clin Cancer Res. 2014 Aug 15; 20(16):4200-9. . View in PubMed

Adolescents and young adults with a "rare" cancer: getting past semantics to optimal care for patients with germ cell tumors Oncologist. 2014 Jul; 19(7):689-92. . View in PubMed

Response to "High BMI at diagnosis is associated with inferior survival in patients with osteosarcoma" Pediatr Blood Cancer. 2014 May; 61(5):951. . View in PubMed

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children's oncology group study Pediatr Blood Cancer. 2014 Apr; 61(4):749-52. . View in PubMed

Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: a report from the Children's Oncology Group Pediatr Blood Cancer. 2014 Mar; 61(3):452-6. . View in PubMed

Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Children's Oncology Group J Clin Oncol. 2014 Feb 10; 32(5):465-70. . View in PubMed

Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group PLoS One. 2014; 9(8):e104378. . View in PubMed

High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: a report from the Children's Oncology Group Pediatr Blood Cancer. 2013 Dec; 60(12):2042-6. . View in PubMed

Outcomes for patients with congenital hepatoblastoma Pediatr Blood Cancer. 2013 Nov; 60(11):1817-25. . View in PubMed

Parental tobacco and alcohol use and risk of hepatoblastoma in offspring: a report from the children's oncology group Cancer Epidemiol Biomarkers Prev. 2013 Oct; 22(10):1837-43. . View in PubMed

Pilot study of cisplatin, etoposide, bleomycin, and escalating dose cyclophosphamide therapy for children with high risk germ cell tumors: a report of the children's oncology group (COG) Pediatr Blood Cancer. 2013 Oct; 60(10):1602-5. . View in PubMed

Feasibility and dose discovery analysis of zoledronic acid with concurrent chemotherapy in the treatment of newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group Eur J Cancer. 2013 Jul; 49(10):2384-91. . View in PubMed

Maternal pregnancy events and exposures and risk of hepatoblastoma: a Children's Oncology Group (COG) study Cancer Epidemiol. 2013 Jun; 37(3):318-20. . View in PubMed

Children's Oncology Group's 2013 blueprint for research: rare tumors Pediatr Blood Cancer. 2013 Jun; 60(6):1016-21. . View in PubMed

A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multiagent chemotherapy for patients with newly diagnosed metastatic Ewing sarcoma family of tumors: A Children's Oncology Group (COG) Phase II study NCT00061893 Pediatr Blood Cancer. 2013 Mar; 60(3):409-14. . View in PubMed

Phase 2 trial of pemetrexed in children and adolescents with refractory solid tumors: a Children's Oncology Group study Pediatr Blood Cancer. 2013 Feb; 60(2):237-41. . View in PubMed

A Decade in Banking Ewing Sarcoma: A Report from the Children's Oncology Group Front Oncol. 2013; 3:57. . View in PubMed

Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group J Clin Oncol. 2012 Nov 20; 30(33):4148-54. . View in PubMed

"Accelerated ear-age": a new measure of chemotherapy-induced ototoxicity Pediatr Blood Cancer. 2012 Nov; 59(5):947-9. . View in PubMed

Outcome for adolescent and young adult patients with osteosarcoma: a report from the Children's Oncology Group Cancer. 2012 Sep 15; 118(18):4597-605. . View in PubMed

Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group J Clin Oncol. 2012 Jul 10; 30(20):2545-51. . View in PubMed

Parental infertility, infertility treatment and hepatoblastoma: a report from the Children's Oncology Group Hum Reprod. 2012 Jun; 27(6):1649-56. . View in PubMed

Phase 2 clinical trial of intrathecal topotecan in children with refractory leptomeningeal leukemia: a Children's Oncology Group trial (P9962) Pediatr Blood Cancer. 2012 Mar; 58(3):362-5. . View in PubMed

A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: a report from the Children's Oncology Group Eur J Cancer. 2012 Mar; 48(4):579-85. . View in PubMed

Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group J Clin Oncol. 2012 Jan 20; 30(3):256-62. . View in PubMed

Randomized trial of hydroxychloroquine for newly diagnosed chronic graft-versus-host disease in children: a Children's Oncology Group study Biol Blood Marrow Transplant. 2012 Jan; 18(1):84-91. . View in PubMed

Treatment of hepatoblastoma: the North American cooperative group experience Front Biosci (Elite Ed). 2012 01 01; 4(5):1717-23. . View in PubMed

Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study Int J Mol Epidemiol Genet. 2012; 3(4):286-93. . View in PubMed

Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the Children's Oncology Group Study ASCT0031 Biol Blood Marrow Transplant. 2011 Dec; 17(12):1804-13. . View in PubMed

Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group Pediatr Blood Cancer. 2011 Dec 01; 57(6):939-42. . View in PubMed

Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group Cancer. 2011 Nov 01; 117(21):4966-76. . View in PubMed

Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children's Oncology Group J Clin Oncol. 2011 Aug 20; 29(24):3301-6. . View in PubMed

The Children's Oncology Group routinely applies "lack of efficacy" interim monitoring to its randomized clinical trials Am J Bioeth. 2011 Mar; 11(3):18-9. . View in PubMed

Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group Clin Cancer Res. 2011 Jan 01; 17(1):56-66. . View in PubMed

Infrequent tumor initiative of the Children's Oncology Group: initial lessons learned and their impact on future plans J Clin Oncol. 2010 Nov 20; 28(33):5011-6. . View in PubMed

Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Groups Study, ASCT0031 Bone Marrow Transplant. 2010 Nov; 45(11):1653-7. . View in PubMed

Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors: a Children's Oncology Group study Pediatr Blood Cancer. 2010 Oct; 55(4):629-38. . View in PubMed

A phase II trial and pharmacokinetic study of oxaliplatin in children with refractory solid tumors: a Children's Oncology Group study Pediatr Blood Cancer. 2010 Sep; 55(3):440-5. . View in PubMed

A novel toxicity scoring system treating toxicity response as a quasi-continuous variable in Phase I clinical trials Contemp Clin Trials. 2010 Sep; 31(5):473-82. . View in PubMed

Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: effects on disease-free survival and immunomodulationa report from the Children's Oncology Group. Clin Cancer Res. 2010 Aug 01; 16(15):4024-30. . View in PubMed

Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group J Clin Oncol. 2010 Apr 20; 28(12):1989-94. . View in PubMed

Phase II trial of ixabepilone administered daily for five days in children and young adults with refractory solid tumors: a report from the children's oncology group Clin Cancer Res. 2010 Jan 15; 16(2):750-4. . View in PubMed

Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group Cancer. 2009 Dec 15; 115(24):5828-35. . View in PubMed

Predictive power of pretreatment prognostic factors in children with hepatoblastoma: a report from the Children's Oncology Group Pediatr Blood Cancer. 2009 Dec; 53(6):1016-22. . View in PubMed

Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group Cancer. 2009 Nov 15; 115(22):5339-48. . View in PubMed

Phase II evaluation of intravenous vinorelbine (Navelbine) in recurrent or refractory pediatric malignancies: a Children's Oncology Group study Pediatr Blood Cancer. 2009 Oct; 53(4):590-3. . View in PubMed

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Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study J Clin Oncol. 2008 Oct 20; 26(30):4921-7. . View in PubMed

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Phase I clinical and pharmacokinetic study of flavopiridol in children with refractory solid tumors: a Children's Oncology Group Study J Clin Oncol. 2005 Dec 20; 23(36):9179-86. . View in PubMed

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Phase I and pharmacokinetic study of gefitinib in children with refractory solid tumors: a Children's Oncology Group Study J Clin Oncol. 2005 Sep 01; 23(25):6172-80. . View in PubMed

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Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples Clin Cancer Res. 2003 Feb; 9(2):837-44. . View in PubMed

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Phase I trial of anti-B4-blocked ricin in pediatric patients with leukemia and lymphoma J Immunother. 2001 Nov-Dec; 24(6):511-6. . View in PubMed

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Phase I study of CI-958 in children and adolescents with recurrent solid tumors Cancer. 2001 Mar 15; 91(6):1166-9. . View in PubMed

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A phase I clinical, pharmacological, and biological trial of interleukin 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: enhanced hematological responses but a high incidence of grade III/IV constitutional toxicities Clin Cancer Res. 2001 Jan; 7(1):58-67. . View in PubMed

Prospective randomized trial between two doses of granulocyte colony-stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent or refractory solid tumors: a children's cancer group report J Pediatr Hematol Oncol. 2001 Jan; 23(1):30-8. . View in PubMed

Phase I study of chimeric human/murine anti-ganglioside G(D2) monoclonal antibody (ch1418) with granulocyte-macrophage colony-stimulating factor in children with neuroblastoma immediately after hematopoietic stem-cell transplantation: a Children's Cancer Group Study. J Clin Oncol. 2000 Dec 15; 18(24):4077-85. . View in PubMed

Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group J Clin Oncol. 2000 Jul; 18(14):2665-75. . View in PubMed

A phase I dose escalation of combination chemotherapy with granulocyte-macrophage-colony stimulating factor in patients with neuroblastoma Cancer. 2000 Jun 15; 88(12):2838-44. . View in PubMed

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Phase I trial of docetaxel with filgrastim support in pediatric patients with refractory solid tumors: a collaborative Pediatric Oncology Branch, National Cancer Institute and Children's Cancer Group trial Clin Cancer Res. 1999 Apr; 5(4):733-7. . View in PubMed

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