Keck School Faculty

Michael Noel Koss, MD
Michael Noel Koss, MD
Clinical Professor of Pathology (Part-Time)
Pathology
HC4 1450 San Pablo Street Health Sciences Campus Los Angeles
Dr. Koss, a former officer in the United States Armed Forces, has co-authored over a hundred peer reviewed articles and numerous other non-peer reviewed articles, book chapters, letters to the editor, abstracts and four books. He has been invited to guest lecture across the globe and has been a co-investigator on two separate five-year research studies. Dr. Koss is a former Chairman of the Pulmonary and Mediastinal Pathology Department at the Armed Services Institute of Pathology and is currently a Professor of Pathology at the LAC+USC Medical Center.

Evaluation of Cyclin D1 as a Discriminatory Immunohistochemical Biomarker for Idiopathic Pulmonary Fibrosis Appl Immunohistochem Mol Morphol. 2019 Feb; 27(2):e11-e15. . View in PubMed

Evaluation of Cyclin D1 as a Discriminatory Immunohistochemical Biomarker for Idiopathic Pulmonary Fibrosis Appl Immunohistochem Mol Morphol. 2018 Aug 08. . View in PubMed

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 Mar 01; 128(3):970-984. . View in PubMed

Further Studies of Unsuspected Emphysema in Nonsmoking Patients With Asthma With Persistent Expiratory Airflow Obstruction Chest. 2018 Mar; 153(3):618-629. . View in PubMed

Further Studies of Unsuspected Emphysema in Nonsmoking Patients With Asthma With Persistent Expiratory Airflow Obstruction Chest. 2018 03; 153(3):618-629. . View in PubMed

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 03 01; 128(3):970-984. . View in PubMed

A middle-aged man with cough, chest pain, and pulmonary artery filling defect: primary pulmonary artery sarcoma Chest. 2014 Feb; 145(2):407-410. . View in PubMed

Handling and interpretation of the medical renal biopsy Methods Mol Biol. 2014; 1180:323-36. . View in PubMed

Anti-VEGF for the management of diabetic macular edema J Immunol Res. 2014; 2014:632307. . View in PubMed

Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression Genome Res. 2012 Jul; 22(7):1197-211. . View in PubMed

Near fatal asthma: clinical and airway biopsy characteristics Pulm Med. 2012; 2012:829608. . View in PubMed

B Cell and BAFF dependence of IFN-a-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice J Immunol. 2011 Apr 15; 186(8):4984-93. . View in PubMed

Chronic interstitial pneumonitis in end-stage sarcoidosis Eur Respir J. 2010 Mar; 35(3):695-7. . View in PubMed

Foxp3 staining in BK virus allograft nephropathy and comparison with acute cellular rejection Transplant Proc. 2009 Dec; 41(10):4188-92. . View in PubMed

Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease J Immunol. 2009 Nov 01; 183(9):6021-9. . View in PubMed

IgG4-related interstitial lung disease: a new and evolving concept Curr Opin Pulm Med. 2009 Sep; 15(5):513-6. . View in PubMed

Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway J Immunol. 2009 Feb 15; 182(4):2532-41. . View in PubMed

ASSOCIATION BETWEEN DE NOVO DONOR SPECIFIC HLA ANTIBODY, C4D STAINING IN RENAL GRAFT BIOPSY AND GRAFT OUTCOME: A SINGLE CENTER EXPERIENCE J Nephrol Ren Transplant. 2009; 2(2):69-74. . View in PubMed

Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer Mol Cancer. 2008 Jul 10; 7:62. . View in PubMed

Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity J Immunol. 2008 Jul 01; 181(1):833-41. . View in PubMed

DNA methylation profile of 28 potential marker loci in malignant mesothelioma Lung Cancer. 2007 Nov; 58(2):220-30. . View in PubMed

Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma Mol Cancer. 2007 Oct 29; 6:70. . View in PubMed

Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF J Immunol. 2006 Aug 15; 177(4):2671-80. . View in PubMed

Microscopic pulmonary embolisation of an indwelling central venous catheter with granulomatous inflammatory response Eur Respir J. 2005 Aug; 26(2):351-3. . View in PubMed

BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus Arthritis Rheum. 2005 Jul; 52(7):2080-91. . View in PubMed

Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung Lung Cancer. 2005 Feb; 47(2):193-204. . View in PubMed

Nonspecific interstitial pneumonia: a provisional category of idiopathic interstitial pneumonia Curr Opin Pulm Med. 2004 Sep; 10(5):441-6. . View in PubMed

Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma Am J Surg Pathol. 2004 Jul; 28(7):921-7. . View in PubMed

Malignant and benign lymphoid lesions of the lung Ann Diagn Pathol. 2004 Jun; 8(3):167-87. . View in PubMed

CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome J Immunol. 2004 Feb 01; 172(3):1531-9. . View in PubMed

Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice J Immunol. 2003 Aug 01; 171(3):1564-71. . View in PubMed

Lack of TNF alpha supports persistence of a plasmid encoding the bovine leukaemia virus in TNF(-/-) mice Vet Immunol Immunopathol. 2003 Mar 20; 92(1-2):15-22. . View in PubMed

Extensive squamous metaplasia with cytologic atypia in diffuse alveolar damage mimicking squamous cell carcinoma: a report of 2 cases Hum Pathol. 2002 Oct; 33(10):1052-4. . View in PubMed

Bronchiolitis: update 2001 Curr Opin Pulm Med. 2002 Mar; 8(2):112-6. . View in PubMed

Morphometry confirms the presence of considerable nuclear size overlap between "small cells" and "large cells" in high-grade pulmonary neuroendocrine neoplasms Am J Clin Pathol. 2001 Oct; 116(4):466-72. . View in PubMed

Idiopathic pulmonary fibrosis and malignancy Curr Opin Pulm Med. 2001 Sep; 7(5):278-82. . View in PubMed

Mitotic counting in surgical pathology: sampling bias, heterogeneity and statistical uncertainty Histopathology. 2001 Jul; 39(1):1-8. . View in PubMed

Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12 Mol Diagn. 2001 Jun; 6(2):109-15. . View in PubMed

Primary anaplastic large cell lymphoma of the lung: a clinicopathologic study of five patients Mod Pathol. 2000 Dec; 13(12):1285-92. . View in PubMed

A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium Am J Surg Pathol. 2000 Jul; 24(7):906-16. . View in PubMed

Nodular lymphoid hyperplasia of the lung: a clinicopathologic study of 14 cases Am J Surg Pathol. 2000 Apr; 24(4):587-97. . View in PubMed

Pornography and sexual aggression: are there reliable effects and can we understand them? Annu Rev Sex Res. 2000; 11:26-91.. View in PubMed

Carcinosarcomas of the lung: a clinicopathologic study of 66 patients Am J Surg Pathol. 1999 Dec; 23(12):1514-26. . View in PubMed

Alveolar adenoma: a histochemical, immunohistochemical, and ultrastructural analysis of 17 cases Hum Pathol. 1999 Feb; 30(2):158-67. . View in PubMed

Pleuro-pulmonary endometriosis and pulmonary ectopic deciduosis: a clinicopathologic and immunohistochemical study of 10 cases with emphasis on diagnostic pitfalls Hum Pathol. 1998 Dec; 29(12):1495-503. . View in PubMed

Constrictive (obliterative) bronchiolitis: diagnosis, etiology, and a critical review of the literature Ann Diagn Pathol. 1998 Oct; 2(5):321-34. . View in PubMed

Constrictive (obliterative) bronchiolitis Curr Opin Pulm Med. 1998 Sep; 4(5):288-93. . View in PubMed

A limited renal injury may cause a permanent form of neurogenic hypertension Am J Hypertens. 1998 Jun; 11(6 Pt 1):723-8. . View in PubMed

Adenocarcinoma simulating mesothelioma: a clinicopathologic and immunohistochemical study of 29 cases Ann Diagn Pathol. 1998 Apr; 2(2):93-102. . View in PubMed

Nonspecific interstitial pneumonitis mimicking Pneumocystis carinii pneumonia Am J Respir Crit Care Med. 1997 Sep; 156(3 Pt 1):912-7. . View in PubMed

Mutations in the p53 gene in pulmonary blastomas: immunohistochemical and molecular studies Hum Pathol. 1996 Nov; 27(11):1117-23. . View in PubMed

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis Am J Pathol. 1996 Oct; 149(4):1241-56. . View in PubMed

Pleomorphic (giant and spindle cell) carcinoma is genetically distinct from adenocarcinoma and squamous cell carcinoma by K-ras-2 and p53 analysis Am J Clin Pathol. 1996 Oct; 106(4):487-92. . View in PubMed

Comparison of DNA topoisomerase II alpha expression in small cell and nonsmall cell carcinoma of the lungIn search of a mechanism of chemotherapeutic response. Cancer. 1996 Aug 15; 78(4):729-35. . View in PubMed

Association of p53 and WAF1 expression with apoptosis in diffuse alveolar damage Am J Pathol. 1996 Aug; 149(2):531-8. . View in PubMed

Analysis of p53, K-ras-2, and C-raf-1 in pulmonary neuroendocrine tumorsCorrelation with histological subtype and clinical outcome. Am J Pathol. 1996 May; 148(5):1531-41. . View in PubMed

A 19-year-old female with fever, acroparesthesia, and progressive deterioration of renal function Am J Nephrol. 1996; 16(5):417-24. . View in PubMed

Multifocal micronodular pneumocyte hyperplasia: a distinctive pulmonary manifestation of tuberous sclerosis Mod Pathol. 1995 Dec; 8(9):902-6. . View in PubMed

Liposarcoma of the anterior mediastinum and thymusA clinicopathologic study of 28 cases. Am J Surg Pathol. 1995 Jul; 19(7):782-91. . View in PubMed

Granular cell tumors of the lungClinicopathologic study of 20 cases. Am J Surg Pathol. 1995 Jun; 19(6):627-35. . View in PubMed

Extramedullary hematopoiesis presenting as posterior mediastinal mass: a study of four cases Mod Pathol. 1995 Apr; 8(3):249-51. . View in PubMed

Extramedullary plasmacytomas presenting as mediastinal masses: clinicopathologic study of two cases preceding the onset of multiple myeloma Mod Pathol. 1995 Apr; 8(3):257-9. . View in PubMed

Pathways involved in PTH-induced rise in cytosolic Ca2+ concentration of rat renal proximal tubule Am J Physiol. 1995 Feb; 268(2 Pt 2):F330-7. . View in PubMed

Malignant smooth muscle tumors presenting as mediastinal soft tissue massesA clinicopathologic study of 10 cases. Cancer. 1994 Oct 15; 74(8):2251-60. . View in PubMed

Epithelioid hemangioendothelioma of the anterior mediastinumClinicopathologic, immunohistochemical, and ultrastructural analysis of 12 cases. Am J Surg Pathol. 1994 Sep; 18(9):871-81. . View in PubMed

Pleomorphic (spindle/giant cell) carcinoma of the lungA clinicopathologic correlation of 78 cases. Cancer. 1994 Jun 15; 73(12):2936-45. . View in PubMed

Benign and malignant salivary gland-type mixed tumors of the lungClinicopathologic and immunohistochemical study of eight cases. Cancer. 1994 May 15; 73(10):2481-90. . View in PubMed

Primary adenoid cystic carcinoma of the lungA clinicopathologic and immunohistochemical study of 16 cases. Cancer. 1994 Mar 01; 73(5):1390-7. . View in PubMed

Endobronchial lipomas: a clinicopathologic study of four cases Mod Pathol. 1994 Feb; 7(2):212-4. . View in PubMed

Mediastinal paragangliomasA clinicopathologic and immunohistochemical study of 16 cases. Cancer. 1993 Oct 15; 72(8):2358-64. . View in PubMed

Pigmented pulmonary carcinoid tumorAn immunohistochemical and ultrastructural study. Arch Pathol Lab Med. 1993 Aug; 117(8):832-6. . View in PubMed

Metastatic mature teratoma in lung following testicular embryonal carcinoma and teratocarcinoma Arch Pathol Lab Med. 1993 Jun; 117(6):641-4. . View in PubMed

Mucinous (so-called colloid) carcinomas of lung Mod Pathol. 1992 Nov; 5(6):634-8. . View in PubMed

Acinic cell carcinoma of the lung ("Fechner tumor")A clinicopathologic, immunohistochemical, and ultrastructural study of five cases. Am J Surg Pathol. 1992 Nov; 16(11):1039-50. . View in PubMed

Lymphoid interstitial pneumonia not associated with HIV infection: role of Epstein-Barr virus Mod Pathol. 1992 Sep; 5(5):487-91. . View in PubMed

Correspondence re: TOhyama, T. Shimokama, Y. Yoshikawa et al. Splenic amyloidosis: correlations between chemical types of amyloid protein and morphological features. Mod Pathol 3:419, 1990. Mod Pathol. 1992 Jan; 5(1):97. . View in PubMed

An immunohistochemical study of benign clear cell ('sugar') tumor of the lung Arch Pathol Lab Med. 1991 Oct; 115(10):1034-8. . View in PubMed

Hepatic amyloidosis: morphologic differences between systemic AL and AA types Hum Pathol. 1991 Sep; 22(9):904-7. . View in PubMed

Detection of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the lung Mod Pathol. 1991 Mar; 4(2):264-8. . View in PubMed

Bilateral renal cortical necrosis in two patients with Neisseria meningitidis sepsis Am J Nephrol. 1991; 11(5):411-5. . View in PubMed

Extrarenal renin-secreting tumors: insights into hypertension and ovarian renin production Medicine (Baltimore). 1989 Sep; 68(5):257-68. . View in PubMed

Pneumocystis carinii infection in the acquired immune deficiency syndrome Semin Diagn Pathol. 1989 Aug; 6(3):287-99. . View in PubMed

Ethnic distribution of amyloidosis: an autopsy study Mod Pathol. 1989 Jul; 2(4):372-7. . View in PubMed

Hepatic hyaline globules associated with passive congestion Arch Pathol Lab Med. 1988 May; 112(5):510-3. . View in PubMed

Heterotopic liver in an adrenal gland Pediatr Pathol. 1988; 8(5):535-40. . View in PubMed

Lymphoid interstitial pneumonia: clinicopathological and immunopathological findings in 18 cases Pathology. 1987 Apr; 19(2):178-85. . View in PubMed

Diagnosing Pneumocystis carinii Chest. 1987 Feb; 91(2):290-1. . View in PubMed

Lymphomatoid granulomatosis: a clinicopathologic study of 42 patients Pathology. 1986 Jul; 18(3):283-8. . View in PubMed

Malignant peripheral nerve sheath tumor arising in an adrenal ganglioneuroma in an adult male homosexual Cancer. 1986 May 15; 57(10):2022-5. . View in PubMed

Amyloidosis presenting in the lower respiratory tractClinicopathologic, radiologic, immunohistochemical, and histochemical studies on 48 cases. Arch Pathol Lab Med. 1986 Mar; 110(3):212-8. . View in PubMed

Incidence and mortality of adult respiratory distress syndrome: a prospective analysis from a large metropolitan hospital Crit Care Med. 1986 Jan; 14(1):1-4. . View in PubMed

Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome (AIDS)Diagnosis with bronchial brushings, biopsy, and bronchoalveolar lavage. Chest. 1985 May; 87(5):603-7. . View in PubMed

Necropsy findings in acquired immunodeficiency syndrome: a comparison of premortem diagnoses with postmortem findings Hum Pathol. 1984 Jul; 15(7):670-6. . View in PubMed

Immunopathologic and clinical studies in pulmonary hypertension associated with systemic lupus erythematosus Semin Arthritis Rheum. 1984 May; 13(4):349-59. . View in PubMed

Palpable leg purpura and renal failure in a 23-year-old man West J Med. 1984 Jan; 140(1):60-5. . View in PubMed

Bronchocentric granulomatosis: roentgenographic manifestations Am Rev Respir Dis. 1982 Jun; 125(6):751-6. . View in PubMed

Bronchocentric granulomatosis Hum Pathol. 1981 Jul; 12(7):632-8. . View in PubMed

Allergic granulomatosis (Churg-Strauss syndrome): pulmonary and renal morphologic findings Am J Surg Pathol. 1981 Jan; 5(1):21-8. . View in PubMed

Necrotizing sarcoid-like granulomatosis: clinical, pathologic, and immunopathologic findings Hum Pathol. 1980 Sep; 11(5 Suppl):510-9. . View in PubMed

Demonstration of amyloid fibrils in urinary sediment N Engl J Med. 1975 Nov 27; 293(22):1131-3. . View in PubMed

Pancreatic transplantation in diabetic rats: renal function, morphology, ultrastructure, and immunohistology Surgery. 1975 Aug; 78(2):142-8. . View in PubMed

Nephropathy associated with sickle cell anemia: an autologous immune complex nephritisI. Studies on nature of glomerular-bound antibody and antigen identification in a patient with sickle cell disease and immune deposit glomerulonephritis. Am J Med. 1975 Mar; 58(3):382-7. . View in PubMed

Glomerulonephritis associated with immune complex deposits and viral particles in spontaneous murine leukemiaAn electron microscopic study with immunofluorescence. Lab Invest. 1973 Aug; 29(2):159-65. . View in PubMed

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