Keck School Faculty

Mitchell E. Geffner, MD
Mitchell E. Geffner, MD
Professor of Pediatrics;Division Chief - Endocrinology
Pediatrics
CHL Mail Stop 61 Off Campus Los Angeles

Changes in Visceral and Subcutaneous Fat in Youth With Type 2 Diabetes in the TODAY Study Diabetes Care. 2019 Jun 05. . View in PubMed

Cardiometabolic health in Turner syndrome Am J Med Genet C Semin Med Genet. 2019 Mar; 181(1):52-58. . View in PubMed

Emergency management of adrenal insufficiency in children: advocating for treatment options in outpatient and field settings J Investig Med. 2019 Feb 28. . View in PubMed

A comparison of metabolic outcomes between obese HIV-exposed uninfected youth from the PHACS SMARTT Study and HIV-unexposed youth from the NHANES Study in the US. J Acquir Immune Defic Syndr. 2019 Feb 27. . View in PubMed

Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents AIDS. 2018 Mar 13; 32(5):613-622. . View in PubMed

For Debate: Combination Growth Hormone and Insulin-Like Growth Factor-I Therapy for Childhood Growth Disorders: Prime Time or Too Much Dime? Pediatr Endocrinol Rev. 2018 Mar; 15(3):196-199.. View in PubMed

Improvement in lipids after switch to boosted atazanavir or darunavir in children/adolescents with perinatally acquired HIV on older protease inhibitors: results from the Pediatric HIV/AIDS Cohort Study HIV Med. 2018 03; 19(3):175-183. . View in PubMed

Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents AIDS. 2018 03 13; 32(5):613-622. . View in PubMed

Birth Weight and Preterm Delivery Outcomes of Perinatally vs Nonperinatally Human Immunodeficiency Virus-Infected Pregnant Women in the United States: Results From the PHACS SMARTT Study and IMPAACT P1025 Protocol Clin Infect Dis. 2017 Sep 15; 65(6):982-989. . View in PubMed

Delay in sexual maturation in perinatally HIV-infected youths is mediated by poor growth AIDS. 2017 Jun 01; 31(9):1333-1341. . View in PubMed

Are aromatase inhibitors in boys with predicted short stature and/or rapidly advancing bone age effective and safe? J Pediatr Endocrinol Metab. 2017 Mar 01; 30(3):311-317.. View in PubMed

Growth at 2 Years of Age in HIV-exposed Uninfected Children in the United States by Trimester of Maternal Antiretroviral Initiation Pediatr Infect Dis J. 2017 Feb; 36(2):189-197. . View in PubMed

Insulin resistance in HIV-infected youth is associated with decreased mitochondrial respiration AIDS. 2017 Jan 02; 31(1):15-23. . View in PubMed

Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting Eur J Endocrinol. 2017 09; 177(3):G1-G70. . View in PubMed

Effects of exenatide on weight and appetite in overweight adolescents and young adults with Prader-Willi syndrome Pediatr Obes. 2017 06; 12(3):221-228. . View in PubMed

Growth at 2 Years of Age in HIV-exposed Uninfected Children in the United States by Trimester of Maternal Antiretroviral Initiation Pediatr Infect Dis J. 2017 02; 36(2):189-197. . View in PubMed

Associations of Low Vitamin D and Elevated Parathyroid Hormone Concentrations With Bone Mineral Density in Perinatally HIV-Infected Children J Acquir Immune Defic Syndr. 2017 09 01; 76(1):33-42. . View in PubMed

Insulin resistance in HIV-infected youth is associated with decreased mitochondrial respiration AIDS. 2017 01 02; 31(1):15-23. . View in PubMed

Brain Malformations Do Not Predict Hypopituitarism in Young Children with Optic Nerve Hypoplasia Horm Res Paediatr. 2017; 88(3-4):251-257. . View in PubMed

Baseline Characteristics and Gender Differences in Prepubertal Children Treated with Growth Hormone in Europe, USA, and Japan: 25 Years' KIGS® Experience (1987-2012) and Review Horm Res Paediatr. 2017; 87(1):30-41. . View in PubMed

Delay in sexual maturation in perinatally HIV-infected youths is mediated by poor growth AIDS. 2017 06 01; 31(9):1333-1341. . View in PubMed

Dynamic response of C-type natriuretic peptide and its aminoterminal propeptide (NTproCNP) to growth hormone treatment in children with short stature Clin Endocrinol (Oxf). 2016 Oct; 85(4):561-8. . View in PubMed

Benefits and barriers to participating in longitudinal research of youth-onset type 2 diabetes: Results from the TODAY retention survey Clin Trials. 2016 Apr; 13(2):240-3. . View in PubMed

Carotid Intima-Media Thickness Is Associated with Increased Androgens in Adolescents and Young Adults with Classical Congenital Adrenal Hyperplasia Horm Res Paediatr. 2016; 85(4):242-9. . View in PubMed

Efficacy of growth hormone replacement on anthropometric outcomes, obesity, and lipids in children with optic nerve hypoplasia and growth hormone deficiency Int J Pediatr Endocrinol. 2016; 2016:5. . View in PubMed

Increased Abdominal Adiposity in Adolescents and Young Adults With Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency J Clin Endocrinol Metab. 2015 Aug; 100(8):E1153-9. . View in PubMed

Clinical trials in youth-onset type 2 diabetes: needs, barriers, and options Curr Diab Rep. 2015 May; 15(5):28. . View in PubMed

Growth hormone treatment for childhood short stature and risk of stroke in early adulthood Neurology. 2015 Mar 10; 84(10):1062-3. . View in PubMed

A 4-Year, Open-Label, Multicenter, Randomized Trial of Genotropin® Growth Hormone in Patients with Idiopathic Short Stature: Analysis of 4-Year Data Comparing Efficacy, Efficiency, and Safety between an Individualized, Target-Driven Regimen and Standard Dosing Horm Res Paediatr. 2015; 84(2):79-87. . View in PubMed

A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing J Pediatr Hematol Oncol. 2015 Jan; 37(1):54-9. . View in PubMed

Decreased adrenomedullary function in infants with classical congenital adrenal hyperplasia J Clin Endocrinol Metab. 2014 Aug; 99(8):E1597-601. . View in PubMed

Aggregate risk of cardiovascular disease among adolescents perinatally infected with the human immunodeficiency virus Circulation. 2014 Mar 18; 129(11):1204-12. . View in PubMed

Clinical characteristics and effects of GH replacement therapy in adults with childhood-onset craniopharyngioma compared with those in adults with other causes of childhood-onset hypothalamic-pituitary dysfunction Eur J Endocrinol. 2013 Oct; 169(4):511-9. . View in PubMed

Gestational diabetes mellitus in HIV-infected and -uninfected pregnant women in Cameroon Diabetes Care. 2013 Sep; 36(9):e141-2. . View in PubMed

Are there parental socialization effects on the sex-typed behavior of individuals with congenital adrenal hyperplasia? Arch Sex Behav. 2013 Apr; 42(3):381-91.. View in PubMed

Bone mineral density in children and adolescents with perinatal HIV infection AIDS. 2013 Jan 14; 27(2):211-20. . View in PubMed

A four-year, open-label, multi-center, randomized, two-arm study of Genotropin® in patients with idiopathic short stature: comparison of an individualized, target-driven treatment regimen to standard dosing of Genotropin® - analysis of two-year data Horm Res Paediatr. 2013; 80(4):242-51. . View in PubMed

C-type natriuretic peptide forms in adult hyperthyroidism: correlation with thyroid hormones and markers of bone turnover Clin Endocrinol (Oxf). 2012 Jun; 76(6):790-6. . View in PubMed

Body fat distribution in perinatally HIV-infected and HIV-exposed but uninfected children in the era of highly active antiretroviral therapy: outcomes from the Pediatric HIV/AIDS Cohort Study Am J Clin Nutr. 2011 Dec; 94(6):1485-95. . View in PubMed

Growth hormone: the expansion of available products and indications Pediatr Clin North Am. 2011 Oct; 58(5):1141-65, x. . View in PubMed

Growth hormone therapy: emerging dilemmas--a US. perspective. Pediatr Endocrinol Rev. 2011 Sep; 9(1):480. . View in PubMed

Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline J Clin Endocrinol Metab. 2011 Jan; 96(1):159-67. . View in PubMed

Factors associated with insulin resistance among children and adolescents perinatally infected with HIV-1 in the pediatric HIV/AIDS cohort study Horm Res Paediatr. 2011; 76(6):386-91. . View in PubMed

Discontinuation of growth hormone (GH) treatment during the transition phase is an important factor determining the phenotype of young adults with nonidiopathic childhood-onset GH deficiency J Clin Endocrinol Metab. 2010 Jun; 95(6):2646-54. . View in PubMed

Diagnosis and management of primary insulin-like growth factor-I deficiency: current perspectives and clinical update Pediatr Endocrinol Rev. 2010 Feb; 7 Suppl 1:154-71. . View in PubMed

Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative Int J Pediatr Endocrinol. 2010; 2010:275213. . View in PubMed

Igf-I stimulates in vivo thymopoiesis after stem cell transplantation in a child with Omenn syndrome J Clin Immunol. 2010 Jan; 30(1):114-20. . View in PubMed

Evolving central hypothyroidism in children with optic nerve hypoplasia J Pediatr Endocrinol Metab. 2010 Jan-Feb; 23(1-2):53-8. . View in PubMed

Hereditary vitamin D resistant rickets: identification of a novel splice site mutation in the vitamin D receptor gene and successful treatment with oral calcium therapy Bone. 2009 Oct; 45(4):743-6. . View in PubMed

Growth hormone: the expansion of available products and indications Endocrinol Metab Clin North Am. 2009 Sep; 38(3):587-611. . View in PubMed

Aromatase inhibitors to augment height: continued caution and study required J Clin Res Pediatr Endocrinol. 2009; 1(6):256-61. . View in PubMed

Growth hormone replacement therapy: transition from adolescence to adulthood J Clin Res Pediatr Endocrinol. 2009; 1(5):205-8. . View in PubMed

Gynecomastia in prepubertal and pubertal men Curr Opin Pediatr. 2008 Aug; 20(4):465-70. . View in PubMed

For debate: Aromatase inhibitors to augment height: have we lost our inhibitions? Pediatr Endocrinol Rev. 2008 Mar; 5(3):756-9.. View in PubMed

Impact of the primary aetiology upon the clinical outcome of adults with childhood-onset GH deficiency Eur J Endocrinol. 2007 Nov; 157(5):589-96. . View in PubMed

Increased aggression and activity level in 3- to 11-year-old girls with congenital adrenal hyperplasia (CAH) Horm Behav. 2007 Sep; 52(3):368-74. . View in PubMed

Growth hormone treatment of early growth failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial J Clin Endocrinol Metab. 2007 Sep; 92(9):3406-16. . View in PubMed

Future directions: growth prediction models Horm Res. 2007; 68 Suppl 5:51-6. . View in PubMed

Compound heterozygosity of a frameshift mutation in the coding region and a single base substitution in the promoter of the ACTH receptor gene in a family with isolated glucocorticoid deficiency J Pediatr Endocrinol Metab. 2006 Sep; 19(9):1157-66. . View in PubMed

A hypocalcemic child with a novel activating mutation of the calcium-sensing receptor gene: successful treatment with recombinant human parathyroid hormone J Clin Endocrinol Metab. 2006 Jul; 91(7):2474-9. . View in PubMed

Improvement in risk factors for metabolic syndrome and insulin resistance in overweight youth who are treated with lifestyle intervention Pediatrics. 2006 Jun; 117(6):e1111-8. . View in PubMed

Endocrinological and auxological abnormalities in young children with optic nerve hypoplasia: a prospective study J Pediatr. 2006 Jan; 148(1):78-84. . View in PubMed

Craniopharyngioma in childhood Adv Pediatr. 2006; 53:183-209. . View in PubMed

Baseline characteristics and response to 2 years of growth hormone (GH) replacement of hypopituitary patients with GH deficiency due to adult-onset craniopharyngioma in comparison with patients with nonfunctioning pituitary adenoma: data from KIMS (Pfizer International Metabolic Database) J Clin Endocrinol Metab. 2005 Aug; 90(8):4636-43. . View in PubMed

Changes in height, weight, and body mass index in children with craniopharyngioma after three years of growth hormone therapy: analysis of KIGS (Pfizer International Growth Database) J Clin Endocrinol Metab. 2004 Nov; 89(11):5435-40. . View in PubMed

Growth hormone treatment in children with familial dysautonomia J Pediatr. 2004 Jan; 144(1):63-7. . View in PubMed

Hypothalamic-pituitary-adrenal activity among Armenian adolescents with PTSD symptoms J Trauma Stress. 2003 Aug; 16(4):319-23. . View in PubMed

Hypertension in hypophosphatemic rickets--role of secondary hyperparathyroidism Pediatr Nephrol. 2003 Feb; 18(2):155-8. . View in PubMed

Hypopituitarism in childhood Cancer Control. 2002 May-Jun; 9(3):212-22. . View in PubMed

Cognitive and behavioral characteristics of turner syndrome: exploring a role for ovarian hormones in female sexual differentiation Horm Behav. 2002 Mar; 41(2):139-55. . View in PubMed

From the control tower: some is better than none and a little bit goes a long way J Pediatr. 2001 Dec; 139(6):766-8. . View in PubMed

Effect of protease inhibitors combined with standard antiretroviral therapy on linear growth and weight gain in human immunodeficiency virus type 1-infected children Pediatr Infect Dis J. 2001 Mar; 20(3):315-6. . View in PubMed

[Anterior ischemic optic neuropathy in children] Rev Neurol. 1999 Aug 16-31; 29(4):366-75. . View in PubMed

Aplasia of right internal carotid artery and hypopituitarism Pediatr Radiol. 1999 Aug; 29(8):586-8; discussion 585. . View in PubMed

Growth hormone exerts potent anabolic effects in an adolescent with human immunodeficiency virus wasting Pediatr Infect Dis J. 1999 Feb; 18(2):167-9. . View in PubMed

Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor J Clin Endocrinol Metab. 1998 Dec; 83(12):4481-9. . View in PubMed

Effects of growth hormone and insulin-like growth factor I on T- and B-lymphocytes and immune function Acta Paediatr Suppl. 1997 Nov; 423:76-9. . View in PubMed

Impact of overnight dexamethasone suppression on the adrenal androgen response to an oral glucose tolerance test in women with and without polycystic ovary syndrome Hum Reprod. 1997 Jun; 12(6):1138-41. . View in PubMed

IGF-I does not mediate T-lymphoblast colony formation in response to estradiol, testosterone, 1,25(OH)2 vitamin D3, and triiodothyronine: studies in control and pygmy T-cell lines Biochem Mol Med. 1996 Oct; 59(1):72-9. . View in PubMed

Decreased insulin-like growth factor I receptor expression and function in immortalized African Pygmy T cells J Clin Endocrinol Metab. 1996 Jun; 81(6):2257-63. . View in PubMed

IGF-I resistance in virus-transformed B-lymphocytes from African Efe Pygmies Biochem Mol Med. 1996 Jun; 58(1):31-6. . View in PubMed

Insulin-like growth factor I resistance in immortalized T cell lines from African Efe Pygmies J Clin Endocrinol Metab. 1995 Dec; 80(12):3732-8. . View in PubMed

Growth-promoting actions of parathyroid hormone, adrenocorticotrophic hormone, and thyroid-stimulating hormone: in vitro studies in normal and pygmy T-lymphoblast cell lines Pediatr Res. 1995 Apr; 37(4 Pt 1):507-11. . View in PubMed

Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty Hum Mol Genet. 1995 Feb; 4(2):183-8. . View in PubMed

Continuous insulin infusions in neonates: pharmacologic availability of insulin in intravenous solutions J Pediatr. 1994 May; 124(5 Pt 1):818-20. . View in PubMed

Growth hormone induces resistance to the mitogenic action of insulin through local IGF-IStudies in normal and Pygmy T-cell lines. Diabetes. 1994 Jan; 43(1):68-72. . View in PubMed

Dominant and nondominant negative C-erbA beta 1 receptors associated with thyroid hormone resistance syndromes augment 12-O-tetradecanoyl-phorbol-13-acetate induction of the collagenase promoter and exhibit defective 3,5,3'-triiodothyronine-mediated repression Mol Endocrinol. 1993 Sep; 7(9):1112-20. . View in PubMed

In vitro insulin-like growth factor-I, growth hormone, and insulin resistance occurs in symptomatic human immunodeficiency virus-1-infected children Pediatr Res. 1993 Jul; 34(1):66-72. . View in PubMed

Growth hormone induces insulin resistance in Laron dwarf cells via lactogenic receptors J Clin Endocrinol Metab. 1993 Apr; 76(4):1039-47. . View in PubMed

An arginine to histidine mutation in codon 311 of the C-erbA beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype J Clin Invest. 1993 Feb; 91(2):538-46. . View in PubMed

Bromocriptine and Triac therapy for hyperthyroidism due to pituitary resistance to thyroid hormone J Clin Endocrinol Metab. 1992 Oct; 75(4):1071-5. . View in PubMed

Insulin and insulin-like growth factor-I responsiveness in polycystic ovarian syndrome Fertil Steril. 1992 Apr; 57(4):796-803. . View in PubMed

Growth hormone mediates the growth of T-lymphoblast cell lines via locally generated insulin-like growth factor-I J Clin Endocrinol Metab. 1990 Aug; 71(2):464-9. . View in PubMed

Childhood hypoglycemia: differentiating hyperinsulinemic from nonhyperinsulinemic causes J Pediatr. 1990 Jan; 116(1):105-8. . View in PubMed

Absence of nonclassical congenital adrenal hyperplasia in patients with precocious adrenarche J Clin Endocrinol Metab. 1989 Oct; 69(4):709-15. . View in PubMed

Hypertrophic cardiomyopathy in total lipodystrophy: insulin action in the face of insulin resistance? J Pediatr. 1987 Jan; 110(1):161.. View in PubMed

Aortic dilation, dissection, and rupture in patients with Turner syndrome J Pediatr. 1986 Nov; 109(5):820-6. . View in PubMed

Growth without growth hormone: evidence for a potent circulating human growth factor Lancet. 1986 Feb 15; 1(8477):343-7. . View in PubMed

Associated non-ovarian problems of polycystic ovarian disease: insulin resistance Clin Obstet Gynaecol. 1985 Sep; 12(3):675-85. . View in PubMed

Diminished in vitro responsiveness of circulating erythroid progenitor cells to insulin as an indicator of insulin resistance J Clin Endocrinol Metab. 1985 Jan; 60(1):103-8. . View in PubMed

Insulin resistance in a young man with cystic fibrosis Am J Dis Child. 1984 Jul; 138(7):677-80. . View in PubMed

Early-morning hyperglycemia in diabetic individuals treated with continuous subcutaneous insulin infusion Diabetes Care. 1983 Mar-Apr; 6(2):135-9. . View in PubMed

Echocardiography reveals a high incidence of bicuspid aortic valve in Turner syndrome J Pediatr. 1983 Jan; 102(1):47-50. . View in PubMed

Acquired methemoglobinemia West J Med. 1981 Jan; 134(1):7-10. . View in PubMed

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