Keck School Faculty

Raymond Stevens, PhD
Raymond Stevens, PhD
Provost Professor of Biological Sciences and Chemistry / Director, The Bridge@USC
Broad CIRM Center
University Park Campus, MCB 309 University Park Campus Los Angeles
My research has been focused on understanding the structure and function of biological macromolecules in the human body for over 20 years, with a particular focus on human G protein-coupled receptor (GPCR) research since the early 1990’s. After 17 years of effort, including technology developments in protein crystallography robotics for structural biology research on membrane proteins, in 2007 we solved the crystal structure of the human ß2-adrenergic receptor bound to the partial inverse agonist carazolol at 2.4 Å which was a Science Magazine “Breakthrough of the Year” candidate. Since that time, we have solved more than 20 distinct GPCR structures and more than 34 complexes including receptors from the rhodopsin (adrenergic, adenosine, dopamine, sphingolipid, opioids, purinergic, histamine, cannabinoid, chemokine, angiotensin), secretin (glucagon), glutamate (mGluR1) and frizzled (smoothened) families. Our highest resolution structures of the delta opioid and A2A adenosine receptor at 1.8 Å have shed new light into the allosteric control of GPCRs by sodium and cholesterol. Our research program is focused on understanding the structural diversity among the GPCR family, as well as technology development necessary to understand mechanisms of signal transduction and coupling of GPCRs with their partners, including G proteins, GPCR kinases, and arrestin. In combination with the crystallographic studies, we have collaborated with key leaders in the field to use NMR, HDX, and EM techniques, as well as pharmacology, biochemistry, chemistry, and biology studies to provide insight into the molecular mechanisms of this important protein family. As part of a larger collaborative program, we strive to collectively realize a dynamic, atomic-level model of the human body to accelerate the creation and implementation of novel therapies and cures for a host of heretofore intractable diseases and conditions.

Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor Nat Chem Biol. 2019 Jan; 15(1):11-17. . View in PubMed

A2A adenosine receptor functional states characterized by 19F-NMR Proc Natl Acad Sci U S A. 2018 Nov 21. . View in PubMed

Emerging Structural Biology of Lipid G-Protein Coupled Receptors Protein Sci. 2018 Sep 21. . View in PubMed

Crystal structure of the Frizzled 4 receptor in a ligand-free state Nature. 2018 Aug; 560(7720):666-670. . View in PubMed

Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors Sci Rep. 2018 Jul 24; 8(1):11380. . View in PubMed

Computational design of thermostabilizing point mutations for G protein-coupled receptors Elife. 2018 Jun 21; 7. . View in PubMed

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor J Am Chem Soc. 2018 Jun 06. . View in PubMed

Structural basis for signal recognition and transduction by platelet-activating-factor receptor Nat Struct Mol Biol. 2018 Jun; 25(6):488-495. . View in PubMed

Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors Sci Rep. 2018 May 24; 8(1):8084. . View in PubMed

Chemical Diversity in the G Protein-Coupled Receptor Superfamily Trends Pharmacol Sci. 2018 May; 39(5):494-512. . View in PubMed

Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor Nature. 2018 Apr; 556(7702):520-524. . View in PubMed

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening Chem Sci. 2018 Mar 28; 9(12):3192-3199. . View in PubMed

Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic ß Cell Cell. 2018 Mar 22; 173(1):11-19. . View in PubMed

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR PolypharmacologyCell. 2018 Feb 08; 172(4):719-730. e14. . View in PubMed

Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR SignalingStructure. 2018 Feb 06; 26(2):259-269. e5. . View in PubMed

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine ReceptorCell. 2018 Jan 11; 172(1-2):68-80. e12. . View in PubMed

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid ReceptorCell. 2018 Jan 11; 172(1-2):55-67. e15. . View in PubMed

Identification of natural products as novel ligands for the human 5-HT2C receptor Biophys Rep. 2018; 4(1):50-61. . View in PubMed

Structure of the glucagon receptor in complex with a glucagon analogue Nature. 2018 01 03; 553(7686):106-110. . View in PubMed

Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent? -OR Agonist. ACS Cent Sci. 2017 Dec 27; 3(12):1329-1336.. View in PubMed

Structure and Function of Peptide-Binding G Protein-Coupled Receptors J Mol Biol. 2017 Aug 18; 429(17):2726-2745. . View in PubMed

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody Proc Natl Acad Sci U S A. 2017 Aug 01; 114(31):8223-8228. . View in PubMed

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled ReceptorsCell. 2017 Jul 27; 170(3):457-469. e13. . View in PubMed

How Ligands Illuminate GPCR Molecular Pharmacology Cell. 2017 Jul 27; 170(3):414-427. . View in PubMed

A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor Medchemcomm. 2017 Jun 01; 8(6):1332-1336. . View in PubMed

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand Nat Commun. 2017 May 17; 8:15383. . View in PubMed

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor J Med Chem. 2017 Apr 13; 60(7):3070-3081. . View in PubMed

Extending the Structural View of Class B GPCRs Trends Biochem Sci. 2017 12; 42(12):946-960. . View in PubMed

Structure of the full-length glucagon class B G-protein-coupled receptor Nature. 2017 06 08; 546(7657):259-264. . View in PubMed

Structural basis for selectivity and diversity in angiotensin II receptors Nature. 2017 04 20; 544(7650):327-332. . View in PubMed

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIVImmunity. 2017 06 20; 46(6):1005-1017. e5. . View in PubMed

Crystal structures of agonist-bound human cannabinoid receptor CB1 Nature. 2017 07 27; 547(7664):468-471. . View in PubMed

Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid J Am Chem Soc. 2017 04 26; 139(16):5728-5731. . View in PubMed

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators Nature. 2017 06 08; 546(7657):312-315. . View in PubMed

Structural Basis for Apelin Control of the Human Apelin ReceptorStructure. 2017 06 06; 25(6):858-866. e4. . View in PubMed

Crystal Structure of the Human Cannabinoid Receptor CB1Cell. 2016 Oct 20; 167(3):750-762. e14. . View in PubMed

Native phasing of x-ray free-electron laser data for a G protein-coupled receptor Sci Adv. 2016 Sep; 2(9):e1600292. . View in PubMed

The Molecular Mechanism of P2Y1 Receptor Activation Angew Chem Int Ed Engl. 2016 Aug 22; 55(35):10331-5. . View in PubMed

Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R) J Biol Chem. 2016 Jun 17; 291(25):12991-3004. . View in PubMed

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex Sci Data. 2016 Apr 12; 3:160021. . View in PubMed

An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels Nat Commun. 2016 Jan 12; 7:8770. . View in PubMed

In vitro expression and analysis of the 826 human G protein-coupled receptors Protein Cell. 2016 05; 7(5):325-37. . View in PubMed

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists Nature. 2016 12 15; 540(7633):458-461. . View in PubMed

ß2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop Structure. 2016 12 06; 24(12):2190-2197. . View in PubMed

In-Membrane Chemical Modification (IMCM) for Site-Specific Chromophore Labeling of GPCRs Angew Chem Int Ed Engl. 2015 Dec 07; 54(50):15246-9. . View in PubMed

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor J Biol Chem. 2015 Dec 04; 290(49):29127-39. . View in PubMed

The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor Structure. 2015 Dec 01; 23(12):2291-2299. . View in PubMed

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor ß2AR Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14254-9. . View in PubMed

Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y14 receptor Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4733-9. . View in PubMed

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):11852-7. . View in PubMed

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information J Comput Aided Mol Des. 2015 Aug; 29(8):737-56. . View in PubMed

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function Mol Pharmacol. 2015 Aug; 88(2):220-30. . View in PubMed

Conformational states of the full-length glucagon receptor Nat Commun. 2015 Jul 31; 6:7859. . View in PubMed

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser Nature. 2015 Jul 30; 523(7562):561-7. . View in PubMed

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides Chem Biol. 2015 Jun 18; 22(6):764-75. . View in PubMed

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 Cell. 2015 Jun 18; 161(7):1633-43. . View in PubMed

Exploring the potential impact of an expanded genetic code on protein function Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):6961-6. . View in PubMed

Structure of the Angiotensin receptor revealed by serial femtosecond crystallography Cell. 2015 May 07; 161(4):833-44. . View in PubMed

Two disparate ligand-binding sites in the human P2Y1 receptor Nature. 2015 Apr 16; 520(7547):317-21. . View in PubMed

Structural biologyCrystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science. 2015 Mar 06; 347(6226):1117-22. . View in PubMed

Structural basis for bifunctional peptide recognition at human d-opioid receptor Nat Struct Mol Biol. 2015 Mar; 22(3):265-8. . View in PubMed

Transition statesTrapping a transition state in a computationally designed protein bottle. Science. 2015 Feb 20; 347(6224):863-867. . View in PubMed

Sodium ion binding pocket mutations and adenosine A2A receptor function Mol Pharmacol. 2015 Feb; 87(2):305-13. . View in PubMed

The importance of ligands for G protein-coupled receptor stability Trends Biochem Sci. 2015 Feb; 40(2):79-87. . View in PubMed

Generic GPCR residue numbers - aligning topology maps while minding the gaps Trends Pharmacol Sci. 2015 Jan; 36(1):22-31. . View in PubMed

Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes ACS Chem Biol. 2014 Dec 19; 9(12):2833-42. . View in PubMed

Constitutive phospholipid scramblase activity of a G protein-coupled receptor Nat Commun. 2014 Oct 08; 5:5115. . View in PubMed

Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges Structure. 2014 Aug 05; 22(8):1120-1139. . View in PubMed

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Nat Commun. 2014 Jul 10; 5:4355. . View in PubMed

Agonist-bound structure of the human P2Y12 receptor Nature. 2014 May 01; 509(7498):119-22. . View in PubMed

Structure of the human P2Y12 receptor in complex with an antithrombotic drug Nature. 2014 May 01; 509(7498):115-8. . View in PubMed

Allosteric sodium in class A GPCR signaling Trends Biochem Sci. 2014 May; 39(5):233-44. . View in PubMed

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Science. 2014 Apr 04; 344(6179):58-64. . View in PubMed

Molecular control of d-opioid receptor signalling Nature. 2014 Feb 13; 506(7487):191-6. . View in PubMed

The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes J Mol Biol. 2014 Jan 09; 426(1):150-68. . View in PubMed

Insights into the structure of class B GPCRs Trends Pharmacol Sci. 2014 Jan; 35(1):12-22. . View in PubMed

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography Nat Commun. 2014; 5:3309. . View in PubMed

Serial femtosecond crystallography of G protein-coupled receptors Science. 2013 Dec 20; 342(6165):1521-4. . View in PubMed

Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR Cell. 2013 Dec 05; 155(6):1258-69. . View in PubMed

The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor Structure. 2013 Dec 03; 21(12):2175-85. . View in PubMed

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors Mol Pharmacol. 2013 Dec; 84(6):794-807. . View in PubMed

J Biol Chem. 2013 Nov 29; 288(48):34470-83. . View in PubMed

Angew Chem Int Ed Engl. 2013 Oct 04; 52(41):10762-5. . View in PubMed

Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs Curr Opin Struct Biol. 2013 Oct; 23(5):740-747. . View in PubMed

Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex Science. 2013 Sep 20; 341(6152):1387-90. . View in PubMed

Asia growth in membrane protein structure Curr Opin Struct Biol. 2013 Aug; 23(4):481-2. . View in PubMed

Engineered nanostructured ß-sheet peptides protect membrane proteins Nat Methods. 2013 Aug; 10(8):759-61. . View in PubMed

Structure of the human glucagon class B G-protein-coupled receptor Nature. 2013 Jul 25; 499(7459):444-9. . View in PubMed

Structure of the human smoothened receptor bound to an antitumour agent Nature. 2013 May 16; 497(7449):338-43. . View in PubMed

Structural features for functional selectivity at serotonin receptors Science. 2013 May 03; 340(6132):615-9. . View in PubMed

Structural basis for molecular recognition at serotonin receptors Science. 2013 May 03; 340(6132):610-4. . View in PubMed

Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues J Am Chem Soc. 2013 Apr 24; 135(16):6289-99. . View in PubMed

Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13):E1203-11. . View in PubMed

Coordinating the impact of structural genomics on the human a-helical transmembrane proteome Nat Struct Mol Biol. 2013 Feb; 20(2):135-8. . View in PubMed

Opportunities for functional selectivity in GPCR antibodies Biochem Pharmacol. 2013 Jan 15; 85(2):147-52. . View in PubMed

ß2-Adrenergic receptor solutions for structural biology analyzed with microscale NMR diffusion measurements Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):331-5. . View in PubMed

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function Nat Rev Drug Discov. 2013 01; 12(1):25-34. . View in PubMed

Structure-function of the G protein-coupled receptor superfamily Annu Rev Pharmacol Toxicol. 2013; 53:531-56. . View in PubMed

Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A) PLoS Pathog. 2013; 9(5):e1003369. . View in PubMed

Sphingosine-1-phosphate and its receptors: structure, signaling, and influence Annu Rev Biochem. 2013; 82:637-62. . View in PubMed

A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer Methods Mol Biol. 2013; 1013:93-127. . View in PubMed

Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes J Biol Chem. 2012 Dec 14; 287(51):43063-70. . View in PubMed

Synthesis and properties of dodecyl trehaloside detergents for membrane protein studies Langmuir. 2012 Jul 31; 28(30):11173-81. . View in PubMed

Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity ACS Chem Biol. 2012 Jul 20; 7(7):1184-9. . View in PubMed

Structural basis for allosteric regulation of GPCRs by sodium ions Science. 2012 Jul 13; 337(6091):232-6. . View in PubMed

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors Structure. 2012 Jun 06; 20(6):967-76. . View in PubMed

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Nature. 2012 May 16; 485(7398):395-9. . View in PubMed

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening J Med Chem. 2012 May 10; 55(9):4297-308. . View in PubMed

Nature. 2012 Mar 21; 485(7398):327-32. . View in PubMed

Biased signaling pathways in ß2-adrenergic receptor characterized by 19F-NMR Science. 2012 Mar 02; 335(6072):1106-10. . View in PubMed

Crystal structure of a lipid G protein-coupled receptor Science. 2012 Feb 17; 335(6070):851-5. . View in PubMed

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A2A adenosine receptor J Med Chem. 2012 Jan 12; 55(1):538-52. . View in PubMed

Chaperone-like therapy with tetrahydrobiopterin in clinical trials for phenylketonuria: is genotype a predictor of response? JIMD Rep. 2012; 5:59-70.. View in PubMed

Diversity and modularity of G protein-coupled receptor structures Trends Pharmacol Sci. 2012 Jan; 33(1):17-27. . View in PubMed

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor J Med Chem. 2011 Dec 08; 54(23):8195-206. . View in PubMed

GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles Methods. 2011 Dec; 55(4):310-7. . View in PubMed

A roadmap to membrane protein structures Methods. 2011 Dec; 55(4):271-2. . View in PubMed

Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of Phenylketonuria Mol Genet Metab. 2011 Nov; 104(3):249-54. . View in PubMed

Ligand-dependent perturbation of the conformational ensemble for the GPCR ß2 adrenergic receptor revealed by HDX Structure. 2011 Oct 12; 19(10):1424-32. . View in PubMed

Trapping small caffeine in a large GPCR pocket Structure. 2011 Sep 07; 19(9):1204-7. . View in PubMed

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment Structure. 2011 Aug 10; 19(8):1108-26. . View in PubMed

Structure of the human histamine H1 receptor complex with doxepin Nature. 2011 Jun 22; 475(7354):65-70. . View in PubMed

The crystal structure of the a-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function Structure. 2011 Jun 08; 19(6):767-78. . View in PubMed

Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222 Appl Environ Microbiol. 2011 Jun; 77(12):4217-22. . View in PubMed

Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility Biochemistry. 2011 May 17; 50(19):4019-28. . View in PubMed

Reversible competitive a-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics J Med Chem. 2011 Apr 28; 54(8):2805-22. . View in PubMed

Structure of an agonist-bound human A2A adenosine receptor Science. 2011 Apr 15; 332(6027):322-7. . View in PubMed

Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases Cryst Growth Des. 2011 Apr 06; 11(4):1193-1201. . View in PubMed

Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent a-ketoheterocycle inhibitor of fatty acid amide hydrolase J Am Chem Soc. 2011 Mar 23; 133(11):4092-100. . View in PubMed

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists Science. 2010 Nov 19; 330(6007):1066-71. . View in PubMed

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist Science. 2010 Nov 19; 330(6007):1091-5. . View in PubMed

RAMP-ing up class-B GPCR ECD structural coverage Structure. 2010 Sep 08; 18(9):1067-8. . View in PubMed

Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography J Am Chem Soc. 2010 Aug 25; 132(33):11443-5. . View in PubMed

Growth and excitement in membrane protein structural biology Curr Opin Struct Biol. 2010 Aug; 20(4):399-400. . View in PubMed

FoldGPCR: structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A Proteins. 2010 Aug 01; 78(10):2189-201. . View in PubMed

Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation J Mol Biol. 2010 Jul 23; 400(4):743-54. . View in PubMed

Design, synthesis, and properties of branch-chained maltoside detergents for stabilization and crystallization of integral membrane proteins: human connexin 26 Langmuir. 2010 Jun 01; 26(11):8690-6. . View in PubMed

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues J Biol Chem. 2010 Apr 23; 285(17):13032-44. . View in PubMed

LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment Biophys J. 2010 Apr 21; 98(8):1539-48. . View in PubMed

Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding J Mol Biol. 2010 Apr 16; 397(5):1287-97. . View in PubMed

A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region J Mol Biol. 2010 Apr 09; 397(4):1106-18. . View in PubMed

Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists J Med Chem. 2010 Feb 25; 53(4):1799-809. . View in PubMed

Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange Anal Chem. 2010 Feb 01; 82(3):1100-8. . View in PubMed

X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase J Med Chem. 2010 Jan 14; 53(1):230-40. . View in PubMed

Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets Methods Mol Biol. 2010; 654:141-68. . View in PubMed

Converting an injectable protein therapeutic into an oral form: phenylalanine ammonia lyase for phenylketonuria Mol Genet Metab. 2010 Jan; 99(1):4-9. . View in PubMed

Rescue of misfolded proteins and stabilization by small molecules Methods Mol Biol. 2010; 648:313-24. . View in PubMed

Structural aspects of therapeutic enzymes to treat metabolic disorders Hum Mutat. 2009 Dec; 30(12):1591-610. . View in PubMed

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam J R Soc Interface. 2009 Oct 06; 6 Suppl 5:S587-97. . View in PubMed

Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures J Am Chem Soc. 2009 Aug 05; 131(30):10497-506. . View in PubMed

Retraction: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 20 A resolution. Nat Struct Mol Biol. 2009 Jul; 16(7):795. . View in PubMed

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain Chem Biol. 2009 Apr 24; 16(4):411-20. . View in PubMed

Discovery of new GPCR biology: one receptor structure at a time Structure. 2009 Jan 14; 17(1):8-14. . View in PubMed

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008 Nat Rev Drug Discov. 2009 06; 8(6):455-63. . View in PubMed

Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20894-9. . View in PubMed

Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes Biochemistry. 2008 Dec 23; 47(51):13514-23. . View in PubMed

The 26 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science. 2008 Nov 21; 322(5905):1211-7. . View in PubMed

Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5847-50. . View in PubMed

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications Nature. 2008 Nov 06; 456(7218):121-4. . View in PubMed

Structure-guided inhibitor design for human FAAH by interspecies active site conversion Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12820-4. . View in PubMed

Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction PLoS Pathog. 2008 Aug 15; 4(8):e1000129. . View in PubMed

Structural and biochemical characterization of the therapeutic Anabaena variabilis phenylalanine ammonia lyase J Mol Biol. 2008 Jul 18; 380(4):623-35. . View in PubMed

Microscale NMR screening of new detergents for membrane protein structural biology J Am Chem Soc. 2008 Jun 11; 130(23):7357-63. . View in PubMed

A specific cholesterol binding site is established by the 28 A structure of the human beta2-adrenergic receptor. Structure. 2008 Jun; 16(6):897-905. . View in PubMed

Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3 J Virol. 2008 Jun; 82(11):5279-94. . View in PubMed

Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments J Membr Biol. 2008 May; 223(1):13-26. . View in PubMed

Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(341), a critical residue in GPCR structure. J Mol Biol. 2008 Mar 07; 376(5):1305-19. . View in PubMed

Microscale fluorescent thermal stability assay for membrane proteins Structure. 2008 Mar; 16(3):351-9. . View in PubMed

Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog J Mol Biol. 2008 Feb 22; 376(3):758-70. . View in PubMed

Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 205 A resolution. Proteins. 2008 Feb 01; 70(2):603-8. . View in PubMed

In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels Acta Crystallogr D Biol Crystallogr. 2008 Feb; 64(Pt 2):189-97. . View in PubMed

Protein production and purification Nat Methods. 2008 Feb; 5(2):135-46. . View in PubMed

Protein crystallization in restricted geometry: advancing old ideas for modern times in structural proteomics Methods Mol Biol. 2008; 426:363-76. . View in PubMed

Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency Hum Mutat. 2008 Jan; 29(1):167-75. . View in PubMed

LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization Cryst Growth Des. 2008; 8(12):4307-4315. . View in PubMed

Generation of protein structures for the 21(st) century Structure. 2007 Dec; 15(12):1517-9. . View in PubMed

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function Science. 2007 Nov 23; 318(5854):1266-73. . View in PubMed

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Science. 2007 Nov 23; 318(5854):1258-65. . View in PubMed

Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus J Virol. 2007 Nov; 81(21):12049-60. . View in PubMed

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression Protein Expr Purif. 2007 Nov; 56(1):85-92. . View in PubMed

Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria Mol Genet Metab. 2007 Aug; 91(4):325-34. . View in PubMed

Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch J Virol. 2007 Jun; 81(12):6700-8. . View in PubMed

Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein J Virol. 2007 Apr; 81(8):3913-21. . View in PubMed

Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin Genet Test. 2007; 11(2):174-8. . View in PubMed

Designing facial amphiphiles for the stabilization of integral membrane proteins Angew Chem Int Ed Engl. 2007; 46(37):7023-5. . View in PubMed

Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin Nat Biotechnol. 2007 Jan; 25(1):107-16. . View in PubMed

Structural basis of cell surface receptor recognition by botulinum neurotoxin B Nature. 2006 Dec 21; 444(7122):1096-100. . View in PubMed

Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization Angew Chem Int Ed Engl. 2006 Dec 11; 45(48):8156-60. . View in PubMed

Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 175 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Proteins. 2006 Nov 15; 65(3):777-82. . View in PubMed

Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 26 A resolution reveals a new fold with a novel active site. Proteins. 2006 Nov 15; 65(3):771-6. . View in PubMed

Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 20 A resolution. Proteins. 2006 Nov 15; 65(3):527-37. . View in PubMed

Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 270 A resolution reveals a new fold. Proteins. 2006 Oct 01; 65(1):243-8. . View in PubMed

Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 190 A resolution. Proteins. 2006 Oct 01; 65(1):249-54. . View in PubMed

A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4 J Mol Biol. 2006 Sep 29; 362(4):733-42. . View in PubMed

Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 158 A resolution. Proteins. 2006 Sep 01; 64(4):1083-90. . View in PubMed

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 206 angstrom resolution. Proteins. 2006 Aug 15; 64(3):808-13. . View in PubMed

Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs J Virol. 2006 Aug; 80(16):7894-901. . View in PubMed

Crystal structure of TM1367 from Thermotoga maritima at 190 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins. 2006 Jun 01; 63(4):1112-8. . View in PubMed

Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 215 A resolution. Proteins. 2006 Jun 01; 63(4):1106-11. . View in PubMed

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5717-22. . View in PubMed

Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 260 A resolution. Proteins. 2006 Apr 01; 63(1):256-60. . View in PubMed

Structure of botulinum neurotoxin type D light chain at 165 A resolution: repercussions for VAMP-2 substrate specificity. Biochemistry. 2006 Mar 14; 45(10):3255-62. . View in PubMed

Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 225 A resolution reveals a new fold. Proteins. 2006 Jan 01; 62(1):292-6. . View in PubMed

Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR J Struct Funct Genomics. 2005 Dec; 6(4):259-67. . View in PubMed

Response of patients with phenylketonuria in the US to tetrahydrobiopterin Mol Genet Metab. 2005 Dec; 86 Suppl 1:S17-21. . View in PubMed

In situ data collection and structure refinement from microcapillary protein crystallization J Appl Crystallogr. 2005 Dec; 38(6):900-905. . View in PubMed

Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 190 A resolution reveals a new fold. Proteins. 2005 Dec 01; 61(4):1132-6. . View in PubMed

Crystallization Optimum Solubility Screening: using crystallization results to identify the optimal buffer for protein crystal formation Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 01; 61(Pt 12):1035-8. . View in PubMed

Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 220 A resolution. Proteins. 2005 Nov 15; 61(3):669-73. . View in PubMed

Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 205 A resolution reveals a new fold. Proteins. 2005 Nov 01; 61(2):449-53. . View in PubMed

Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 195 A resolution reveals a new fold. Proteins. 2005 Nov 01; 61(2):444-8. . View in PubMed

Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3 Structure. 2005 Nov; 13(11):1665-75. . View in PubMed

Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7 J Virol. 2005 Oct; 79(20):12905-13. . View in PubMed

Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 183 A resolution. Proteins. 2005 Sep 01; 60(4):797-802. . View in PubMed

Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria Mol Genet Metab. 2005 Sep-Oct; 86(1-2):134-40. . View in PubMed

The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases Structure. 2005 Sep; 13(9):1385-96. . View in PubMed

Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition Biochemistry. 2005 Jul 19; 44(28):9574-80. . View in PubMed

Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 20 A resolution reveals a new fold. Proteins. 2005 Jun 01; 59(4):869-74. . View in PubMed

Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 190 A resolution reveals a new fold. Proteins. 2005 Jun 01; 59(4):864-8. . View in PubMed

Development of pegylated forms of recombinant Rhodosporidium toruloides phenylalanine ammonia-lyase for the treatment of classical phenylketonuria Mol Ther. 2005 Jun; 11(6):986-9. . View in PubMed

The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex J Mol Biol. 2005 Mar 04; 346(4):1083-93. . View in PubMed

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 280 A resolution reveals a new fold. Proteins. 2005 Mar 01; 58(4):976-81. . View in PubMed

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena spat 1. 70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 2005 Mar 01; 58(4):971-5. . View in PubMed

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 185 A resolution. Proteins. 2005 Feb 15; 58(3):755-8. . View in PubMed

NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):1901-5. . View in PubMed

Shotgun crystallization strategy for structural genomics II: crystallization conditions that produce high resolution structures for Tmaritima proteins. J Struct Funct Genomics. 2005; 6(2-3):209-17. . View in PubMed

Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics J Mol Biol. 2004 Dec 03; 344(4):977-91. . View in PubMed

Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16903-8. . View in PubMed

Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screens Methods. 2004 Nov; 34(3):373-89. . View in PubMed

Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations Hum Mutat. 2004 Nov; 24(5):388-99. . View in PubMed

Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 187 A resolution. Proteins. 2004 Oct 01; 57(1):213-7. . View in PubMed

Scalable high-throughput micro-expression device for recombinant proteins Biotechniques. 2004 Sep; 37(3):364, 366, 368 passim. . View in PubMed

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 24 A resolution. Proteins. 2004 Aug 15; 56(3):619-24. . View in PubMed

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 200-A resolution reveals a new fold. Proteins. 2004 Aug 15; 56(3):607-10. . View in PubMed

Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 165 A resolution. Proteins. 2004 Aug 15; 56(3):611-4. . View in PubMed

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 210 A resolution. Proteins. 2004 Aug 15; 56(3):629-33. . View in PubMed

Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 183 A resolution. Proteins. 2004 Aug 15; 56(3):615-8. . View in PubMed

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 190 A resolution. Proteins. 2004 Aug 01; 56(2):404-8. . View in PubMed

Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 195 A resolution. Proteins. 2004 Aug 01; 56(2):392-5. . View in PubMed

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 18 A resolution. Proteins. 2004 Aug 01; 56(2):387-91. . View in PubMed

Trends in enzyme therapy for phenylketonuria Mol Ther. 2004 Aug; 10(2):220-4. . View in PubMed

Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 19 A resolution. Proteins. 2004 Aug 01; 56(2):396-400. . View in PubMed

A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform Chembiochem. 2004 Jul 05; 5(7):921-7. . View in PubMed

Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 190 A resolution. Proteins. 2004 Jul 01; 56(1):171-5. . View in PubMed

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 160 A resolution. Proteins. 2004 Jul 01; 56(1):167-70. . View in PubMed

Structural commonalities among integral membrane enzymes FEBS Lett. 2004 Jun 04; 567(2-3):159-65. . View in PubMed

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 23 A resolution. Proteins. 2004 Jun 01; 55(4):1078-81. . View in PubMed

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 250 A resolution. Proteins. 2004 May 15; 55(3):768-71. . View in PubMed

Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 190 A resolution. Proteins. 2004 May 15; 55(3):759-63. . View in PubMed

Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 177-A resolution. Proteins. 2004 May 01; 55(2):474-8. . View in PubMed

Automated sample mounting and alignment system for biological crystallography at a synchrotron source Structure. 2004 Apr; 12(4):537-45. . View in PubMed

Long live structural biology Nat Struct Mol Biol. 2004 Apr; 11(4):293-5. . View in PubMed

Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 17 A resolution. Proteins. 2004 Mar 01; 54(4):801-5. . View in PubMed

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 175 A resolution. Proteins. 2004 Mar 01; 54(4):806-9. . View in PubMed

Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 25 A resolution. Proteins. 2004 Mar 01; 54(4):810-3. . View in PubMed

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):751-6. . View in PubMed

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 20 A resolution. Proteins. 2004 Jan 01; 54(1):157-61. . View in PubMed

Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase Mol Ther. 2004 Jan; 9(1):124-9. . View in PubMed

Biopterin responsive phenylalanine hydroxylase deficiency Genet Med. 2004 Jan-Feb; 6(1):27-32. . View in PubMed

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 13 A resolution. Proteins. 2004 Jan 01; 54(1):174-7. . View in PubMed

Structural studies on phenylalanine hydroxylase and implications toward understanding and treating phenylketonuria Pediatrics. 2003 Dec; 112(6 Pt 2):1557-65. . View in PubMed

Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 285 A resolution. Proteins. 2003 Oct 01; 53(1):142-5. . View in PubMed

Structural plasticity and the evolution of antibody affinity and specificity J Mol Biol. 2003 Jul 18; 330(4):651-6. . View in PubMed

Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome Acta Crystallogr D Biol Crystallogr. 2003 Jun; 59(Pt 6):1028-37. . View in PubMed

A fully integrated protein crystallization platform for small-molecule drug discovery J Struct Biol. 2003 Apr; 142(1):207-17. . View in PubMed

PAHdb 2003: what a locus-specific knowledgebase can do Hum Mutat. 2003 Apr; 21(4):333-44. . View in PubMed

Structural evidence for substrate strain in antibody catalysis Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):856-61. . View in PubMed

Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 15 A resolution. Proteins. 2003 Feb 01; 50(2):371-4. . View in PubMed

Robotics for automated crystal formation and analysis Methods Enzymol. 2003; 368:45-76. . View in PubMed

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling Science. 2002 Nov 29; 298(5599):1793-6. . View in PubMed

Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Biochemistry. 2002 Oct 22; 41(42):12569-74. . View in PubMed

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 225 A resolution. Proteins. 2002 Oct 01; 49(1):142-5. . View in PubMed

The genesis of high-throughput structure-based drug discovery using protein crystallography Curr Opin Chem Biol. 2002 Oct; 6(5):704-10. . View in PubMed

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11664-9. . View in PubMed

Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates J Mol Biol. 2002 Jul 12; 320(3):645-61. . View in PubMed

Morphological manipulation of bolaamphiphilic polydiacetylene assemblies by controlled lipid doping Chem Phys Lipids. 2002 Feb; 114(2):203-14. . View in PubMed

Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant Forms Chem Rev. 1999 Aug 11; 99(8):2137-2160. . View in PubMed

Powered by SC CTSI
Go to Top