Keck School Faculty

Richard Sposto, PhD
Richard Sposto, PhD
Professor of Research Preventive Medicine
Preventive Medicine
CHL 4650 Sunset Blvd Health Sciences Campus Los Angeles
Dr. Richard Sposto holds a joint appointment as Professor of Research in the Department of Preventive Medicine and the Department of Pediatrics of the Keck School of Medicine, USC. He is also currently Director of Biostatistics/Bioinformatics for the Children's Center for Cancer and Blood Diseases, Division of Hematology-Oncology, Childrens Hospital Los Angeles (CHLA). For most of his career Dr. Sposto's primary research focus has been in pediatric cancer research as a senior statistician with the Children's Cancer Group and its successor organization, the Children's Oncology Group (COG). During these times Dr. Sposto was the principal statistician in CCG's research efforts in CNS tumors and lymphomas. He served as COG Associate Group Statistician and COG Group Statistician, and also as principal statistician and coordinator of the Statistics and Data Center in the formation of COG Phase I and Pilot Consortium. In the Fall of 2004 he assumed his current position at CHLA.

Between 1988 and 1992, Dr. Sposto was a Research Scientist in the Department of Statistics at the Radiation Effects Research Foundation, in Hiroshima, Japan, and between 1992 and 1994, he was Co-Principal Investigator for the Data Coordinating and Analysis Center of the Aids Vaccine Evaluation Group, a Phase I clinical trials consortium sponsored by the National Institution of Allergy and Infectious Diseases to investigate experimental vaccines for the prevention of HIV infection.

Besides his collaborative work, Dr. Sposto's primary statistical research interests have been in the areas of clinical trials design, especially as related to developmental therapeutics trials in pediatric cancer and strategies for clinical trials research in low incidence cancer; modeling cure as an outcome of cancer treatment, and developing a statistical modeling framework to optimize risk stratification in pediatric cancer.

Correction: Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia Leukemia. 2019 Mar 07. . View in PubMed

Factors Leading to Decreased Rates of Immediate Postmastectomy Reconstruction J Surg Res. 2019 Feb 14; 238:207-217. . View in PubMed

Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia Leukemia. 2018 Sep 28. . View in PubMed

Dose Sculpting Intensity Modulated Radiation Therapy for Vertebral Body Sparing in Children With Neuroblastoma Int J Radiat Oncol Biol Phys. 2018 Jul 01; 101(3):550-557. . View in PubMed

Colony stimulating factor 1 receptor blockade improves the efficacy of chemotherapy against human neuroblastoma in the absence of T lymphocytes Int J Cancer. 2018 Apr 17. . View in PubMed

Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study Leukemia. 2018 Mar 15. . View in PubMed

A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium Blood. 2018 Mar 08; 131(10):1145-1148. . View in PubMed

Dose Sculpting Intensity Modulated Radiation Therapy for Vertebral Body Sparing in Children With Neuroblastoma Int J Radiat Oncol Biol Phys. 2018 Feb 15. . View in PubMed

A multi-institutional registry of pediatric hospital-acquired thrombosis cases: The Children's Hospital-Acquired Thrombosis (CHAT) project Thromb Res. 2018 01; 161:67-72. . View in PubMed

Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy Leuk Lymphoma. 2018 01; 59(1):138-145. . View in PubMed

Colony stimulating factor 1 receptor blockade improves the efficacy of chemotherapy against human neuroblastoma in the absence of T lymphocytes Int J Cancer. 2018 09 15; 143(6):1483-1493. . View in PubMed

Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy Leuk Lymphoma. 2018 Jan; 59(1):138-145. . View in PubMed

A novel cross-correlation methodology for assessing biophysical responses associated with pain J Pain Res. 2018; 11:2207-2219. . View in PubMed

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain Am J Hematol. 2017 Nov; 92(11):1137-1145. . View in PubMed

A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia Leuk Lymphoma. 2017 Oct; 58(10):2370-2378. . View in PubMed

Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis Clin Cancer Res. 2017 Sep 15; 23(18):5374-5383. . View in PubMed

Inflammatory Breast Cancer Outcomes in a Contemporary Series Anticancer Res. 2017 09; 37(9):5057-5063. . View in PubMed

Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease PLoS One. 2017; 12(5):e0178353. . View in PubMed

Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells Cancer Res. 2017 09 15; 77(18):5142-5157. . View in PubMed

Endoplasmic reticulum stress in complex atypical hyperplasia as a possible predictor of occult carcinoma and progestin response Gynecol Oncol. 2016 Dec; 143(3):650-654. . View in PubMed

A Phase I Study of Quizartinib Combined with Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study Clin Cancer Res. 2016 Aug 15; 22(16):4014-22. . View in PubMed

Impact of a Rapid Blood Culture Assay for Gram-Positive Identification and Detection of Resistance Markers in a Pediatric Hospital Arch Pathol Lab Med. 2016 Mar; 140(3):267-75. . View in PubMed

A parent-directed intervention for addressing academic risk in Latino survivors of childhood leukemia: results of a pilot study Psychooncology. 2016 10; 25(10):1246-1249. . View in PubMed

Nonrandomized comparison of neurofibromatosis type 1 and non-neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low-grade glioma: A report from the Children's Oncology Group Cancer. 2016 06 15; 122(12):1928-36. . View in PubMed

Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy Neuro Oncol. 2016 Jan; 18(1):126-31. . View in PubMed

Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Pediatr Blood Cancer. 2015 Dec; 62(12):2140-9. . View in PubMed

Intersection of Race/Ethnicity and Socioeconomic Status in Mortality After Breast Cancer J Community Health. 2015 Dec; 40(6):1287-99. . View in PubMed

Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis Int J Cancer. 2015 Aug 15; 137(4):797-809. . View in PubMed

Contribution of the neighborhood environment and obesity to breast cancer survival: the California Breast Cancer Survivorship Consortium Cancer Epidemiol Biomarkers Prev. 2015 Aug; 24(8):1282-90. . View in PubMed

History of Recreational Physical Activity and Survival After Breast Cancer: The California Breast Cancer Survivorship Consortium Am J Epidemiol. 2015 Jun 15; 181(12):944-55. . View in PubMed

Improving access to novel agents for childhood leukemia Cancer. 2015 Jun 15; 121(12):1927-36. . View in PubMed

Correlation of pulmonary function abnormalities with dose volume histograms in children treated with lung irradiation Pediatr Pulmonol. 2015 Jun; 50(6):596-603. . View in PubMed

Escalation of oncologic services at the end of life among patients with gynecologic cancer at an urban, public hospital J Oncol Pract. 2015 Mar; 11(2):e163-9. . View in PubMed

Diabetes and other comorbidities in breast cancer survival by race/ethnicity: the California Breast Cancer Survivorship Consortium (CBCSC) Cancer Epidemiol Biomarkers Prev. 2015 Feb; 24(2):361-8. . View in PubMed

Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia Blood. 2014 Dec 18; 124(26):3932-8. . View in PubMed

Molecular and clinical diagnosis of group A streptococcal pharyngitis in children J Clin Microbiol. 2014 Nov; 52(11):3884-9. . View in PubMed

MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival Cancer Res. 2014 Nov 01; 74(21):5999-6009. . View in PubMed

Characterization of transfusion-derived iron deposition in childhood cancer survivors Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1913-9. . View in PubMed

A phase I study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium J Pediatr Hematol Oncol. 2014 Aug; 36(6):458-63. . View in PubMed

A retrospective analysis of recurrent intracranial ependymoma Pediatr Blood Cancer. 2014 Jul; 61(7):1195-201. . View in PubMed

Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group J Clin Oncol. 2014 May 01; 32(13):1331-7. . View in PubMed

Ferritin trends do not predict changes in total body iron in patients with transfusional iron overload Am J Hematol. 2014 Apr; 89(4):391-4. . View in PubMed

Intensive induction chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic progenitor cell rescue for young children newly-diagnosed with central nervous system atypical teratoid/rhabdoid tumors: the Head Start III experience Pediatr Blood Cancer. 2014 Jan; 61(1):95-101. . View in PubMed

Obesity and mortality after breast cancer by race/ethnicity: The California Breast Cancer Survivorship Consortium Am J Epidemiol. 2014 Jan 01; 179(1):95-111. . View in PubMed

Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFß1 Cancer Immunol Immunother. 2013 Oct; 62(10):1637-48. . View in PubMed

Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation Int J Radiat Oncol Biol Phys. 2013 Aug 01; 86(5):942-8. . View in PubMed

A phase I study of oxaliplatin and doxorubicin in pediatric patients with relapsed or refractory extracranial non-hematopoietic solid tumors Pediatr Blood Cancer. 2013 Jul; 60(7):1103-7. . View in PubMed

Cure trends in acute lymphoblastic leukemia: is it time for a revised concept of cure? Haematologica. 2013 May; 98(5):655-6.. View in PubMed

Growth and activation of natural killer cells ex vivo from children with neuroblastoma for adoptive cell therapy Clin Cancer Res. 2013 Apr 15; 19(8):2132-43. . View in PubMed

Outcome and pathologic classification of children and adolescents with mediastinal large B-cell lymphoma treated with FAB/LMB96 mature B-NHL therapy Blood. 2013 Jan 10; 121(2):278-85. . View in PubMed

A phase I study of vincristine, irinotecan, temozolomide and bevacizumab (vitb) in pediatric patients with relapsed solid tumors PLoS One. 2013; 8(7):e68416. . View in PubMed

A crossover randomized prospective pilot study evaluating a central venous catheter team in reducing catheter-related bloodstream infections in pediatric oncology patients J Pediatr Oncol Nurs. 2012 Nov-Dec; 29(6):307-15. . View in PubMed

Association of projected transfusional iron burden with treatment intensity in childhood cancer survivors Pediatr Blood Cancer. 2012 Oct; 59(4):697-702. . View in PubMed

Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma J Clin Oncol. 2012 Oct 01; 30(28):3525-32. . View in PubMed

Long-term results of CCG 5942: a randomized comparison of chemotherapy with and without radiotherapy for children with Hodgkin's lymphoma--a report from the Children's Oncology Group J Clin Oncol. 2012 Sep 10; 30(26):3174-80. . View in PubMed

Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study Blood. 2012 Jul 12; 120(2):285-90. . View in PubMed

Accuracy of predicting axillary lymph node positivity by physical examination, mammography, ultrasonography, and magnetic resonance imaging Ann Surg Oncol. 2012 Jun; 19(6):1825-30. . View in PubMed

A galectin-3-dependent pathway upregulates interleukin-6 in the microenvironment of human neuroblastoma Cancer Res. 2012 May 01; 72(9):2228-38. . View in PubMed

Advanced stage, increased lactate dehydrogenase, and primary site, but not adolescent age (= 15 years), are associated with an increased risk of treatment failure in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB LMB 96 study J Clin Oncol. 2012 Feb 01; 30(4):387-93. . View in PubMed

Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation Pediatr Blood Cancer. 2011 Oct; 57(4):669-73. . View in PubMed

A wide-spectrum paired comparison of the properties of the Rolling 6 and 3+3 Phase I study designs Contemp Clin Trials. 2011 Sep; 32(5):694-703. . View in PubMed

BEACOPP chemotherapy is a highly effective regimen in children and adolescents with high-risk Hodgkin lymphoma: a report from the Children's Oncology Group Blood. 2011 Mar 03; 117(9):2596-603. . View in PubMed

Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group Clin Cancer Res. 2011 Jan 01; 17(1):56-66. . View in PubMed

Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53 Mol Cancer Ther. 2010 Dec; 9(12):3289-301. . View in PubMed

Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia Cancer Res. 2010 Oct 01; 70(19):7411-20. . View in PubMed

Outcome for children treated for relapsed or refractory acute myelogenous leukemia (rAML): a Therapeutic Advances in Childhood Leukemia (TACL) Consortium study Pediatr Blood Cancer. 2010 Sep; 55(3):421-9. . View in PubMed

Commentary on paper, 'cancer survival analysis' Surg Oncol. 2010 Jun; 19(2):59-60; discussion 61. . View in PubMed

Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group J Clin Oncol. 2010 Apr 20; 28(12):1989-94. . View in PubMed

Nuclear factor IA is expressed in astrocytomas and is associated with improved survival Neuro Oncol. 2010 Feb; 12(2):122-32. . View in PubMed

An adjustment for patient heterogeneity in the design of two-stage phase II trials Stat Med. 2009 Sep 10; 28(20):2566-79. . View in PubMed

A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate- and high-risk Hodgkin lymphoma: the results of P9425 Blood. 2009 Sep 03; 114(10):2051-9. . View in PubMed

A phase II study of preradiotherapy chemotherapy followed by hyperfractionated radiotherapy for newly diagnosed high-risk medulloblastoma/primitive neuroectodermal tumor: a report from the Children's Oncology Group (CCG 9931) Int J Radiat Oncol Biol Phys. 2009 Jul 15; 74(4):1006-11. . View in PubMed

Intensive chemotherapy for systemic anaplastic large cell lymphoma in children and adolescents: final results of Children's Cancer Group Study 5941 Pediatr Blood Cancer. 2009 Mar; 52(3):335-9. . View in PubMed

Late congestive heart failure after hematopoietic cell transplantation J Clin Oncol. 2008 Dec 01; 26(34):5537-43. . View in PubMed

Excellent survival following two courses of COPAD chemotherapy in children and adolescents with resected localized B-cell non-Hodgkin's lymphoma: results of the FAB/LMB 96 international study Br J Haematol. 2008 Jun; 141(6):840-7. . View in PubMed

Outcome of children less than three years old at diagnosis with non-metastatic medulloblastoma treated with chemotherapy on the "Head Start" I and II protocols Pediatr Blood Cancer. 2008 Jun; 50(6):1169-75. . View in PubMed

Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation J Natl Cancer Inst. 2008 Apr 16; 100(8):580-95. . View in PubMed

Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and II experience Pediatr Blood Cancer. 2008 Feb; 50(2):312-8. . View in PubMed

Metastatic ependymoma: a multi-institutional retrospective analysis of prognostic factors Pediatr Blood Cancer. 2008 Feb; 50(2):231-5. . View in PubMed

Metabolism of diffuse intrinsic brainstem gliomas in children Neuro Oncol. 2008 Feb; 10(1):32-44. . View in PubMed

Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma J Clin Invest. 2007 Sep; 117(9):2702-12. . View in PubMed

Immunophenotypic identification of possible therapeutic targets in paediatric non-Hodgkin lymphomas: a children's oncology group report Br J Haematol. 2007 Aug; 138(4):506-12. . View in PubMed

Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide J Natl Cancer Inst. 2007 Jul 18; 99(14):1107-19. . View in PubMed

Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue Pediatr Blood Cancer. 2007 Jul; 49(1):34-40. . View in PubMed

Criteria for optimizing prognostic risk groups in pediatric cancer: analysis of data from the Children's Oncology Group J Clin Oncol. 2007 May 20; 25(15):2070-7. . View in PubMed

A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis J Proteome Res. 2007 Mar; 6(3):1165-75. . View in PubMed

Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin's disease J Clin Oncol. 2007 Feb 10; 25(5):493-500. . View in PubMed

Chromosome abnormalities in advanced stage lymphoblastic lymphoma of children and adolescents: a report from CCG-E08 Cancer Genet Cytogenet. 2007 Jan 01; 172(1):1-11. . View in PubMed

Complex secondary chromosome abnormalities in advanced stage anaplastic large cell lymphoma of children and adolescents: a report from CCG-E08 Cancer Genet Cytogenet. 2006 Dec; 171(2):89-96. . View in PubMed

Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children's Oncology Group J Neurosurg. 2006 Dec; 105(6 Suppl):444-51. . View in PubMed

Mature B-cell lymphoma in children and adolescents: International group pathologist consensus correlates with histology technical quality J Pediatr Hematol Oncol. 2006 Sep; 28(9):568-74. . View in PubMed

Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children's Cancer Group J Clin Oncol. 2005 Oct 20; 23(30):7621-31. . View in PubMed

High-dose chemotherapy with autologous stem-cell rescue in the treatment of patients with recurrent non-cerebellar primitive neuroectodermal tumors Pediatr Blood Cancer. 2004 Mar; 42(3):261-7. . View in PubMed

Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas of children and adolescents: a report from Children's Cancer Group Study CCG-E08 J Pediatr Hematol Oncol. 2004 Mar; 26(3):169-78. . View in PubMed

Breast cancer: do specialists make a difference? Ann Surg Oncol. 2003 Jul; 10(6):606-15.. View in PubMed

Assessment of minimal residual disease in childhood non-hodgkin lymphoma by polymerase chain reaction using patient-specific primers J Pediatr Hematol Oncol. 2003 Feb; 25(2):109-13. . View in PubMed

Burkitt's and Burkitt-like lymphoma in children and adolescents: a review of the Children's Cancer Group experience Br J Haematol. 2003 Feb; 120(4):660-70. . View in PubMed

Childhood and adolescent large-cell lymphoma (LCL): a review of the Children's Cancer Group experience Am J Hematol. 2003 Jan; 72(1):53-63. . View in PubMed

Lymph node status combined with lymphovascular invasion creates a more powerful tool for predicting outcome in patients with invasive breast cancer Am J Surg. 2002 Oct; 184(4):337-40. . View in PubMed

Impact of proliferation index on outcome in childhood malignant gliomas: results in a multi-institutional cohort Neurosurgery. 2002 Jun; 50(6):1238-44; discussion 1244-5. . View in PubMed

Non-Hodgkin's lymphoma arising in bone in children and adolescents is associated with an excellent outcome: a Children's Cancer Group report J Clin Oncol. 2002 May 01; 20(9):2293-301. . View in PubMed

Expression of p53 and prognosis in children with malignant gliomas N Engl J Med. 2002 Feb 07; 346(6):420-7. . View in PubMed

Cure model analysis in cancer: an application to data from the Children's Cancer Group Stat Med. 2002 Jan 30; 21(2):293-312. . View in PubMed

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