Keck School Faculty

Saverio Bellusci, PhD
Saverio Bellusci, PhD
Research Associate Professor of Surgery (Part-Time)
CHL Mail Stop 35 Off Campus Los Angeles
In 2010, Dr. Bellusci moved to the Justus Liebig University in Giessen, Germany as a full Professor. He holds currently the chair of lung extracellular matrix in the Excellent Cluster Cardio Pulmonary System. Prof. Bellusci’s research is mostly focusing on the role of FGF in lung development and disease. He will serve as the chair of the next Gordon Conference on FGF in 2014, which will take place in Ventura, California.

Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE2 and the associated epithelial barrier protein Filaggrin in the bronchial epithelium Cell Biol Toxicol. 2019 Dec 28. . View in PubMed

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes Nat Commun. 2019 Dec 13; 10(1):5697. . View in PubMed

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast growth factors Front Med. 2019 Nov 18. . View in PubMed

Characterisation of endogenous players in fibroblast growth factor-regulated functions of hypothalamic tanycytes and energy-balance nuclei J Neuroendocrinol. 2019 Aug; 31(8):e12750. . View in PubMed

A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development Cell Mol Life Sci. 2019 Jul; 76(14):2817-2832. . View in PubMed

A functional variant in the miR-142 promoter modulating its expression and conferring risk of Alzheimer disease Hum Mutat. 2019 11; 40(11):2131-2145. . View in PubMed

Discordant roles for FGF ligands in lung branching morphogenesis between human and mouse J Pathol. 2019 02; 247(2):254-265. . View in PubMed

Characterization of Tg(Etv4-GFP) and Etv5RFP Reporter Lines in the Context of Fibroblast Growth Factor 10 Signaling During Mouse Embryonic Lung Development Front Genet. 2019; 10:178. . View in PubMed

Normal lung development needs self-eating J Clin Invest. 2019 06 04; 129(7):2658-2659. . View in PubMed

Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis Nat Commun. 2019 05 20; 10(1):2229. . View in PubMed

Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia Hum Mol Genet. 2019 05 01; 28(9):1429-1444. . View in PubMed

Imaging and Analysis of Mouse Embryonic Whole Lung, Isolated Tissue, and Lineage-Labelled Cell Culture Methods Mol Biol. 2019; 1940:109-127. . View in PubMed

FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury Stem Cell Reports. 2019 05 14; 12(5):1041-1055. . View in PubMed

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis Nat Commun. 2019 07 05; 10(1):2987. . View in PubMed

Low density lipoprotein receptor-related protein 1 couples ß1 integrin activation to degradation Cell Mol Life Sci. 2018 05; 75(9):1671-1685. . View in PubMed

Human lung branching morphogenesis is orchestrated by the spatiotemporal distribution of ACTA2, SOX2, and SOX9 Am J Physiol Lung Cell Mol Physiol. 2018 01 01; 314(1):L144-L149. . View in PubMed

Fibroblast Growth Factor 10 and Vertebrate Limb Development Front Genet. 2018; 9:705. . View in PubMed

miR-142-3p is associated with aberrant WNT signaling during airway remodeling in asthma Am J Physiol Lung Cell Mol Physiol. 2018 08 01; 315(2):L328-L333. . View in PubMed

2018 08 01; 315(2):L248-L252. . View in PubMed

Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L87-L101. . View in PubMed

Neonatal exposure to hyperoxia leads to persistent disturbances in pulmonary histone signatures associated with NOS3 and STAT3 in a mouse model Clin Epigenetics. 2018; 10:37. . View in PubMed

A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis Front Genet. 2018; 9:746. . View in PubMed

Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling J Cell Mol Med. 2017 Nov; 21(11):2909-2925. . View in PubMed

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany27-28 October 2016. Mol Cell Pediatr. 2017 May; 4(Suppl 1):5. . View in PubMed

A novel mouse Cre-driver line targeting Perilipin 2-expressing cells in the neonatal lung Genesis. 2017 12; 55(12). . View in PubMed

Ex vivo analysis of the contribution of FGF10+ cells to airway smooth muscle cell formation during early lung development Dev Dyn. 2017 07; 246(7):531-538. . View in PubMed

Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development Stem Cells. 2017 06; 35(6):1566-1578. . View in PubMed

MicroRNA-142 is a multifaceted regulator in organogenesis, homeostasis, and disease Dev Dyn. 2017 04; 246(4):285-290. . View in PubMed

Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem CellsDev Cell. 2017 10 09; 43(1):48-59. e5. . View in PubMed

Mesenchymal Stem Cells in Fibrotic Disease Cell Stem Cell. 2017 08 03; 21(2):166-177. . View in PubMed

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia J Pathol. 2017 Jan; 241(1):91-103. . View in PubMed

Alveologenesis: key cellular players and fibroblast growth factor 10 signaling Mol Cell Pediatr. 2016 Dec; 3(1):17. . View in PubMed

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate BMC Biol. 2016 Mar 16; 14:19. . View in PubMed

MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15; 310(6):L519-31. . View in PubMed

Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate EMBO Mol Med. 2016 12; 8(12):1380-1389. . View in PubMed

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair PLoS Pathog. 2016 06; 12(6):e1005544. . View in PubMed

Hematopoietic and Mesenchymal Stem Cells in Biomedical and Clinical Applications Stem Cells Int. 2016; 2016:3157365. . View in PubMed

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development Development. 2015 Dec 01; 142(23):4139-50. . View in PubMed

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis Thorax. 2015 Nov; 70(11):1022-32. . View in PubMed

Characterization of the platelet-derived growth factor receptor-a-positive cell lineage during murine late lung development Am J Physiol Lung Cell Mol Physiol. 2015 Nov 01; 309(9):L942-58. . View in PubMed

Non-canonical WNT signalling in the lung J Biochem. 2015 Nov; 158(5):355-65. . View in PubMed

Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis Respir Res. 2015 Jul 03; 16:83. . View in PubMed

High mobility group protein-mediated transcription requires DNA damage marker? -H2AX. Cell Res. 2015 Jul; 25(7):837-50.. View in PubMed

Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development BMC Biol. 2015 Jun 20; 13:42. . View in PubMed

Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair Am J Physiol Lung Cell Mol Physiol. 2015 May 15; 308(10):L1014-24. . View in PubMed

Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 308(8):G678-90. . View in PubMed

CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis Biomed Res Int. 2015; 2015:189638. . View in PubMed

A breath of fresh air on the mesenchyme: impact of impaired mesenchymal development on the pathogenesis of bronchopulmonary dysplasia Front Med (Lausanne). 2015; 2:27. . View in PubMed

Generation and Validation of miR-142 Knock Out Mice PLoS One. 2015; 10(9):e0136913. . View in PubMed

FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry Cardiovasc Res. 2014 Dec 01; 104(3):432-42. . View in PubMed

Hmga2 is required for canonical WNT signaling during lung development BMC Biol. 2014 Mar 24; 12:21. . View in PubMed

miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development Development. 2014 Mar; 141(6):1272-81. . View in PubMed

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally Development. 2014 Jan; 141(2):296-306. . View in PubMed

Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs Mol Cell. 2013 Sep 26; 51(6):707-22. . View in PubMed

Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centers of the postnatal and adult hypothalamus J Neurosci. 2013 Apr 03; 33(14):6170-80. . View in PubMed

Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease Thorax. 2013 Apr; 68(4):380-4. . View in PubMed

FGF10 Signaling Enhances Epicardial Cell Expansion during Neonatal Mouse Heart Repair J Cardiovasc Dis Diagn. 2013 Mar; 1(1). . View in PubMed

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype J Clin Invest. 2012 Nov; 122(11):3862-72. . View in PubMed

FGF9-Pitx2-FGF10 signaling controls cecal formation in mice Dev Biol. 2012 Sep 15; 369(2):340-8. . View in PubMed

Embryonic epithelial Pten deletion through Nkx21-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-122. . View in PubMed

Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model Pediatr Pulmonol. 2012 Feb; 47(2):162-71. . View in PubMed

Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis PLoS One. 2012; 7(11):e49127. . View in PubMed

Characterization of a novel fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development PLoS One. 2012; 7(6):e38452. . View in PubMed

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium Development. 2011 Apr; 138(7):1395-407. . View in PubMed

Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung Dev Biol. 2011 Feb 01; 350(1):112-26. . View in PubMed

Ectodermal influx and cell hypertrophy provide early growth for all murine mammary rudiments, and are differentially regulated among them by Gli3 PLoS One. 2011; 6(10):e26242. . View in PubMed

FGF10 controls the patterning of the tracheal cartilage rings via Shh Development. 2011 Jan; 138(2):273-82. . View in PubMed

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair PLoS One. 2011; 6(8):e23139. . View in PubMed

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation Hum Mol Genet. 2010 Sep 01; 19(17):3457-67. . View in PubMed

Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia Am J Respir Crit Care Med. 2010 Jul 15; 182(2):207-19. . View in PubMed

Lung organogenesis Curr Top Dev Biol. 2010; 90:73-158. . View in PubMed

Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury Am J Respir Crit Care Med. 2009 Oct 15; 180(8):701-12. . View in PubMed

Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome Pediatr Res. 2009 Oct; 66(4):386-90. . View in PubMed

miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution Dev Biol. 2009 Sep 15; 333(2):238-50. . View in PubMed

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice Am J Respir Crit Care Med. 2009 Sep 01; 180(5):424-36. . View in PubMed

Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation Dev Dyn. 2009 Feb; 238(2):294-301. . View in PubMed

Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages Stem Cells. 2008 Nov; 26(11):2902-11. . View in PubMed

Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx21 and Pten. Dev Biol. 2008 Aug 15; 320(2):340-50. . View in PubMed

Lung stem cells in the balance Nat Genet. 2008 Jul; 40(7):822-4. . View in PubMed

Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis Mol Cell Neurosci. 2008 Apr; 37(4):857-68. . View in PubMed

Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation Hepatology. 2007 Oct; 46(4):1187-97. . View in PubMed

Lung development and adult lung diseases Chest. 2007 Aug; 132(2):651-6. . View in PubMed

Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development Dev Biol. 2006 Nov 15; 299(2):373-85. . View in PubMed

Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung Dev Biol. 2006 Nov 01; 299(1):52-62. . View in PubMed

Lung development and susceptibility to chronic obstructive pulmonary disease Proc Am Thorac Soc. 2006 Nov; 3(8):668-72. . View in PubMed

Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes Development. 2006 Jun; 133(12):2325-35. . View in PubMed

FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis BMC Dev Biol. 2005 Jun 22; 5:11. . View in PubMed

A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis Dev Biol. 2005 Jun 15; 282(2):422-31. . View in PubMed

Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage Development. 2005 May; 132(9):2157-66. . View in PubMed

Molecular mechanisms of early lung specification and branching morphogenesis Pediatr Res. 2005 May; 57(5 Pt 2):26R-37R. . View in PubMed

Fibroblast growth factor-10 serves a regulatory role in duodenal development J Pediatr Surg. 2005 Feb; 40(2):313-6. . View in PubMed

Colonic atresia without mesenteric vascular occlusionThe role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg. 2005 Feb; 40(2):390-6. . View in PubMed

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung Dev Biol. 2005 Jan 15; 277(2):316-31. . View in PubMed

Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L52-9. . View in PubMed

Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia J Pediatr Surg. 2004 Jun; 39(6):872-4. . View in PubMed

Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice J Pediatr Surg. 2004 Mar; 39(3):360-5; discussion 360-5. . View in PubMed

Identification of the mammary line in mouse by Wnt10b expression Dev Dyn. 2004 Feb; 229(2):349-56. . View in PubMed

Functional analysis of the human Sprouty2 gene promoter Gene. 2003 Dec 11; 322:175-85. . View in PubMed

Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry Respir Res. 2003; 4:5. . View in PubMed

Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation Differentiation. 2003 Jan; 71(1):1-17. . View in PubMed

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