Keck School Faculty

Sebastien G. Bouret, PhD
Sebastien G. Bouret, PhD
Associate Professor of Pediatrics
CHL Mail Stop 135 Off Campus Los Angeles
The long-range goal of the Bouret's lab is to study the hormonal and molecular signals that direct development of brain feeding circuits. Research in the Bouret’s lab has directly led to several breakthroughs in the understanding of the complex hormonal signals and neurodevelopmental substrates responsible for appetite regulation. Most notably, we found that metabolic hormones (such as leptin and ghrelin) influence the development and architecture of hypothalamic circuits involved in energy balance regulation. More recently, our lab has discovered a role for autophagy (a cellular process that degrades cytoplasmic materials, including organelles and misfolded proteins) in hypothalamic development and metabolic regulation.

Our current research projects aim at examining the cellular (e.g., ER stress and autophagy) and molecular (e.g., miRNAs, axon guidance cues) events involved in hypothalamic development and lifelong metabolic regulation. Our current research goal is also to study the molecular signals that link nmaternal obesity and the abnormal development of hypothalamic feeding circuits.

Dual contributions of noradrenaline to behavioural flexibility and motivation Psychopharmacology (Berl). 2018 Jul 11. . View in PubMed

Sex and gender differences in developmental programming of metabolism Mol Metab. 2018 Apr 30. . View in PubMed

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome Cell Rep. 2018 Mar 27; 22(13):3401-3408. . View in PubMed

Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic Toxicol Sci. 2018 Mar 01; 162(1):36-42. . View in PubMed

Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus Diabetes. 2018 05; 67(5):805-817. . View in PubMed

Contributions of Lateral and Orbital Frontal Regions to Abstract Rule Acquisition and Reversal in Monkeys Front Neurosci. 2018; 12:165. . View in PubMed

Primate Ventromedial Prefrontal Cortex Neurons Continuously Encode the Willingness to Engage in Reward-Directed Behavior Cereb Cortex. 2018 Jan 01; 28(1):73-89. . View in PubMed

Reading wild minds: A computational assay of Theory of Mind sophistication across seven primate species PLoS Comput Biol. 2017 Nov; 13(11):e1005833. . View in PubMed

Involvement of Amylin and Leptin in the Development of Projections from the Area Postrema to the Nucleus of the Solitary Tract Front Endocrinol (Lausanne). 2017; 8:324. . View in PubMed

Correction to 'Obesity Impairs the Action of the Neuroendocrine Ghrelin System': [Trends in Endocrinology and Metabolism, 27 (2016) 54-63] Trends Endocrinol Metab. 2016 May; 27(5):348. . View in PubMed

Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life Cell Rep. 2016 Apr 05; 15(1):36-44. . View in PubMed

Obesity Impairs the Action of the Neuroendocrine Ghrelin System Trends Endocrinol Metab. 2016 Jan; 27(1):54-63. . View in PubMed

Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits Hum Mol Genet. 2016 08 01; 25(15):3208-3215. . View in PubMed

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy. 2016; 12(1):1-222. . View in PubMed

Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat Am J Physiol Regul Integr Comp Physiol. 2016 12 01; 311(6):R1032-R1044. . View in PubMed

For better or worse, or for a change? Behav Brain Sci. 2016 Jan; 39:e203.. View in PubMed

Neonatal ghrelin programs development of hypothalamic feeding circuits J Clin Invest. 2015 Feb; 125(2):846-58. . View in PubMed

Perinatal overnutrition exacerbates adipose tissue inflammation caused by high-fat feeding in C57BL/6J mice PLoS One. 2015; 10(3):e0121954. . View in PubMed

Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin Mol Metab. 2015 Jan; 4(1):15-24. . View in PubMed

Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity Physiol Rev. 2015 Jan; 95(1):47-82. . View in PubMed

Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction J Clin Invest. 2014 Jun; 124(6):2550-9. . View in PubMed

Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain Cell Metab. 2014 Feb 04; 19(2):293-301. . View in PubMed

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain J Comp Neurol. 2013 Oct 15; 521(15):3389-405. . View in PubMed

The obesogenic effect of high fructose exposure during early development Nat Rev Endocrinol. 2013 Aug; 9(8):494-500. . View in PubMed

Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting Cell Metab. 2013 Apr 02; 17(4):607-17. . View in PubMed

Development of the hypothalamic melanocortin system Front Endocrinol (Lausanne). 2013; 4:38. . View in PubMed

Organizational actions of metabolic hormones Front Neuroendocrinol. 2013 Jan; 34(1):18-26. . View in PubMed

RIPping off GABA release in hypothalamic circuits causes obesity Cell Metab. 2012 Nov 07; 16(5):557-8. . View in PubMed

Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress Psychoneuroendocrinology. 2012 Oct; 37(10):1646-58. . View in PubMed

Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function J Neurosci. 2012 Aug 15; 32(33):11486-94. . View in PubMed

Embryonic birthdate of hypothalamic leptin-activated neurons in mice Endocrinology. 2012 Aug; 153(8):3657-67. . View in PubMed

Weighing on autophagy: a novel mechanism for the CNS regulation of energy balance Cell Cycle. 2012 Apr 15; 11(8):1477-8. . View in PubMed

Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation Cell Metab. 2012 Feb 08; 15(2):247-55. . View in PubMed

Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits J Neurosci. 2012 Jan 25; 32(4):1244-52. . View in PubMed

Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring Endocrinology. 2011 Nov; 152(11):4171-9. . View in PubMed

Developmental effects of ghrelin Peptides. 2011 Nov; 32(11):2362-6. . View in PubMed

Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice J Mol Neurosci. 2011 Mar; 43(3):478-84. . View in PubMed

Neurodevelopmental actions of leptin Brain Res. 2010 Sep 02; 1350:2-9. . View in PubMed

Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese Endocrinology. 2010 Sep; 151(9):4270-9. . View in PubMed

Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain J Comp Neurol. 2010 Apr 01; 518(7):943-62. . View in PubMed

Role of early hormonal and nutritional experiences in shaping feeding behavior and hypothalamic development J Nutr. 2010 Mar; 140(3):653-7. . View in PubMed

Distribution of leptin-sensitive cells in the postnatal and adult mouse brain J Comp Neurol. 2010 Feb 15; 518(4):459-76. . View in PubMed

Development of hypothalamic neural networks controlling appetite Forum Nutr. 2010; 63:84-93. . View in PubMed

Leptin, nutrition, and the programming of hypothalamic feeding circuits Nestle Nutr Workshop Ser Pediatr Program. 2010; 65:25-35; discussion 35-9. . View in PubMed

Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R537-48. . View in PubMed

Early life origins of obesity: role of hypothalamic programming J Pediatr Gastroenterol Nutr. 2009 Mar; 48 Suppl 1:S31-8. . View in PubMed

Crossing the border: developmental regulation of leptin transport to the brain Endocrinology. 2008 Mar; 149(3):875-6. . View in PubMed

Hypothalamic neural projections are permanently disrupted in diet-induced obese rats Cell Metab. 2008 Feb; 7(2):179-85. . View in PubMed

Neuronal-glial-endothelial interactions and cell plasticity in the postnatal hypothalamus: implications for the neuroendocrine control of reproduction Psychoneuroendocrinology. 2007 Aug; 32 Suppl 1:S46-51. . View in PubMed

Development of leptin-sensitive circuits J Neuroendocrinol. 2007 Aug; 19(8):575-82. . View in PubMed

Developmental programming of hypothalamic feeding circuits Clin Genet. 2006 Oct; 70(4):295-301. . View in PubMed

Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins J Pediatr Endocrinol Metab. 2006 Jan; 19(1):3-9. . View in PubMed

Minireview: Leptin and development of hypothalamic feeding circuits Endocrinology. 2004 Jun; 145(6):2621-6. . View in PubMed

Trophic action of leptin on hypothalamic neurons that regulate feeding Science. 2004 Apr 02; 304(5667):108-10. . View in PubMed

Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus Endocrinology. 2004 Apr; 145(4):1794-801. . View in PubMed

Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice J Neurosci. 2004 Mar 17; 24(11):2797-805. . View in PubMed

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