Keck School Faculty

Shuping Zhong, PhD
Shuping Zhong, PhD
Professor of Research Medicine
Medicine
HMR 604 2011 Zonal Avenue Health Sciences Campus Los Angeles
Shuping Zhong, Ph.D. received his master degree at Fudan University, Shanghai Medical College (Shanghai Medical University) and his Ph.D. at Hunan Medical University (Xiang-Ya Medical College), and finished his postdoctoral training at University of Minnesota. He joined USC in 2001 and became a faculty member in 2006 in Department of Biochemistry and Molecular Biologyof USC. His studies focus on the molecular mechanism of alcohol-associated breast cancer and hepatocellular carcinoma, which includes signal transduction, histone modifications and regulation of RNA Pol III genes on cancers. His lab discovered for the first time that alcohol-activated JNK1 upregulates Pol III gene transcription to promoted tumor formation in alcohol-fed mice. His studies were the first to demonstrate a role of histone H3 phosophorylation in deregulation of Brf1 and Pol III genes and to establish that alcohol- increased ERa activity enhanced expression of these genes, resulting in cell transformation. His lab is currently exploring the synergistic inhibitory effects of chemicals and kinase inhibitors on alcohol-associated cancers.

The significance of Brf1 overexpression in human hepatocellular carcinoma Oncotarget. 2016 Feb 02; 7(5):6243-54. . View in PubMed

Characterization and bioactivity of novel calcium antagonists - N-methoxy-benzyl haloperidol quaternary ammonium salt Oncotarget. 2015 Dec 22; 6(41):43759-69. . View in PubMed

N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy Oncotarget. 2015 Sep 22; 6(28):24709-21. . View in PubMed

Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation Sci Rep. 2015 Jul 02; 5:11809. . View in PubMed

Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes Gene. 2015 Feb 01; 556(1):74-9. . View in PubMed

Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H12. Association with Sodium-Dependent Bile Acid Transport. PLoS One. 2015; 10(5):e0125318. . View in PubMed

Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells Oncotarget. 2014 Dec 15; 5(23):12410-7. . View in PubMed

Self-assembled nanoparticles of glycyrrhetic acid-modified pullulan as a novel carrier of curcumin Molecules. 2014 Aug 28; 19(9):13305-18. . View in PubMed

Activated pregnane X receptor inhibits cervical cancer cell proliferation and tumorigenicity by inducing G2/M cell-cycle arrest Cancer Lett. 2014 May 28; 347(1):88-97. . View in PubMed

Anti-inflammatory activity of N-butanol extract from Ipomoea stolonifera in vivo and in vitro PLoS One. 2014; 9(4):e95931. . View in PubMed

N-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes Drug Des Devel Ther. 2014; 8:1257-67. . View in PubMed

Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation Carcinogenesis. 2013 Nov; 34(11):2460-9. . View in PubMed

Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4a/CAR/RXR/PSF complex Biochim Biophys Acta. 2013 Oct; 1829(10):1000-9. . View in PubMed

Elk1 and AP-1 sites in the TBP promoter mediate alcohol-induced deregulation of Pol III-dependent genes Gene. 2013 Aug 15; 526(1):54-60. . View in PubMed

Antioxidant, antibacterial and antischistosomal activities of extracts from Grateloupia livida (Harv)Yamada. PLoS One. 2013; 8(11):e80413. . View in PubMed

ERa mediates alcohol-induced deregulation of Pol III genes in breast cancer cells Carcinogenesis. 2013 Jan; 34(1):28-37. . View in PubMed

N-n-butyl haloperidol iodide ameliorates cardiomyocytes hypoxia/reoxygenation injury by extracellular calcium-dependent and -independent mechanisms Oxid Med Cell Longev. 2013; 2013:912310. . View in PubMed

Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation J Biol Chem. 2012 Sep 14; 287(38):32078-84. . View in PubMed

Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression J Biol Chem. 2011 Jan 28; 286(4):2393-401. . View in PubMed

The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12682-7. . View in PubMed

PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex Mol Cell Biol. 2008 Jun; 28(12):4204-14. . View in PubMed

PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription J Mol Signal. 2007 Jul 05; 2:5. . View in PubMed

TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation Mol Cell Biol. 2007 Jan; 27(1):54-64. . View in PubMed

Epidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity Mol Cell Biol. 2004 Jun; 24(12):5119-29. . View in PubMed

Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A Oncogene. 2003 Aug 14; 22(34):5291-7. . View in PubMed

Detection of human papillomavirus in esophageal carcinoma J Med Virol. 2002 Nov; 68(3):412-6. . View in PubMed

Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation J Biol Chem. 2002 Jul 05; 277(27):24039-48. . View in PubMed

Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1 J Biol Chem. 2001 Aug 31; 276(35):33213-9. . View in PubMed

Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation J Biol Chem. 2001 Jul 06; 276(27):25558-67. . View in PubMed

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation J Biol Chem. 2001 Jun 15; 276(24):20913-23. . View in PubMed

Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods Cancer Res. 2001 May 15; 61(10):4084-91. . View in PubMed

UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways J Biol Chem. 2001 May 04; 276(18):14572-80. . View in PubMed

MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28 J Biol Chem. 2001 Apr 20; 276(16):12932-7. . View in PubMed

Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis J Biol Chem. 2001 Apr 13; 276(15):11775-82. . View in PubMed

Organ-specific distribution of AP-1 in AP-1 luciferase transgenic mice during the maturation process Am J Physiol Regul Integr Comp Physiol. 2001 Feb; 280(2):R376-81. . View in PubMed

ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10 J Biol Chem. 2000 Jul 14; 275(28):20980-4. . View in PubMed

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