Keck School Faculty

 
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Shuping Zhong

Shuping Zhong

Professor of Research Medicine
Medicine
HMR 604 2011 Zonal Avenue Health Sciences Campus Los Angeles

Contact

+1 323 442 1141
szhong@usc.edu

Role of betaine in inhibiting the induction of RNA Pol III gene transcription and cell growth caused by alcohol Chem Biol Interact. 2020 Jul 01; 325:109129. . View in PubMed

The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription Chem Biol Interact. 2020 May 25; 323:109057. . View in PubMed

Mitogen- and Stress-Activated Protein Kinase 1 Mediates Alcohol-Upregulated Transcription of Brf1 and tRNA Genes to Cause Phenotypic Alteration Oxid Med Cell Longev. 2020; 2020:2067959. . View in PubMed

The significance of Brf1 overexpression in human hepatocellular carcinoma Oncotarget. 2016 Feb 02; 7(5):6243-54. . View in PubMed

Characterization and bioactivity of novel calcium antagonists - N-methoxy-benzyl haloperidol quaternary ammonium salt Oncotarget. 2015 Dec 22; 6(41):43759-69. . View in PubMed

N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy Oncotarget. 2015 Sep 22; 6(28):24709-21. . View in PubMed

Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation Sci Rep. 2015 Jul 02; 5:11809. . View in PubMed

Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes Gene. 2015 Feb 01; 556(1):74-9. . View in PubMed

Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H12. Association with Sodium-Dependent Bile Acid Transport. PLoS One. 2015; 10(5):e0125318. . View in PubMed

Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells Oncotarget. 2014 Dec 15; 5(23):12410-7. . View in PubMed

Self-assembled nanoparticles of glycyrrhetic acid-modified pullulan as a novel carrier of curcumin Molecules. 2014 Aug 28; 19(9):13305-18. . View in PubMed

Activated pregnane X receptor inhibits cervical cancer cell proliferation and tumorigenicity by inducing G2/M cell-cycle arrest Cancer Lett. 2014 May 28; 347(1):88-97. . View in PubMed

N-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes Drug Des Devel Ther. 2014; 8:1257-67. . View in PubMed

Anti-inflammatory activity of N-butanol extract from Ipomoea stolonifera in vivo and in vitro PLoS One. 2014; 9(4):e95931. . View in PubMed

Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation Carcinogenesis. 2013 Nov; 34(11):2460-9. . View in PubMed

Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4a/CAR/RXR/PSF complex Biochim Biophys Acta. 2013 Oct; 1829(10):1000-9. . View in PubMed

Elk1 and AP-1 sites in the TBP promoter mediate alcohol-induced deregulation of Pol III-dependent genes Gene. 2013 Aug 15; 526(1):54-60. . View in PubMed

ERa mediates alcohol-induced deregulation of Pol III genes in breast cancer cells Carcinogenesis. 2013 Jan; 34(1):28-37. . View in PubMed

Antioxidant, antibacterial and antischistosomal activities of extracts from Grateloupia livida (Harv)Yamada. PLoS One. 2013; 8(11):e80413. . View in PubMed

N-n-butyl haloperidol iodide ameliorates cardiomyocytes hypoxia/reoxygenation injury by extracellular calcium-dependent and -independent mechanisms Oxid Med Cell Longev. 2013; 2013:912310. . View in PubMed

Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation J Biol Chem. 2012 Sep 14; 287(38):32078-84. . View in PubMed

Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression J Biol Chem. 2011 Jan 28; 286(4):2393-401. . View in PubMed

The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12682-7. . View in PubMed

[Diagnostic values of the clinical characteristics of chronic cough] Zhonghua Jie He He Hu Xi Za Zhi. 2009 Jun; 32(6):418-21. . View in PubMed

PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex Mol Cell Biol. 2008 Jun; 28(12):4204-14. . View in PubMed

PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription J Mol Signal. 2007 Jul 05; 2:5. . View in PubMed

TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation Mol Cell Biol. 2007 Jan; 27(1):54-64. . View in PubMed

Epidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity Mol Cell Biol. 2004 Jun; 24(12):5119-29. . View in PubMed

Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A Oncogene. 2003 Aug 14; 22(34):5291-7. . View in PubMed

Detection of human papillomavirus in esophageal carcinoma J Med Virol. 2002 Nov; 68(3):412-6. . View in PubMed

Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation J Biol Chem. 2002 Jul 05; 277(27):24039-48. . View in PubMed

Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1 J Biol Chem. 2001 Aug 31; 276(35):33213-9. . View in PubMed

Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation J Biol Chem. 2001 Jul 06; 276(27):25558-67. . View in PubMed

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation J Biol Chem. 2001 Jun 15; 276(24):20913-23. . View in PubMed

Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods Cancer Res. 2001 May 15; 61(10):4084-91. . View in PubMed

UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways J Biol Chem. 2001 May 04; 276(18):14572-80. . View in PubMed

MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28 J Biol Chem. 2001 Apr 20; 276(16):12932-7. . View in PubMed

Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis J Biol Chem. 2001 Apr 13; 276(15):11775-82. . View in PubMed

Organ-specific distribution of AP-1 in AP-1 luciferase transgenic mice during the maturation process Am J Physiol Regul Integr Comp Physiol. 2001 Feb; 280(2):R376-81. . View in PubMed

ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10 J Biol Chem. 2000 Jul 14; 275(28):20980-4. . View in PubMed

Shuping Zhong, Ph.D. received his master degree at Fudan University, Shanghai Medical College (Shanghai Medical University) and his Ph.D. at Hunan Medical University (Xiang-Ya Medical College), and finished his postdoctoral training at University of Minnesota. He joined USC in 2001 and became a faculty member in 2006 in Department of Biochemistry and Molecular Biologyof USC. His studies focus on the molecular mechanism of alcohol-associated breast cancer and hepatocellular carcinoma, which includes signal transduction, histone modifications and regulation of RNA Pol III genes on cancers. His lab discovered for the first time that alcohol-activated JNK1 upregulates Pol III gene transcription to promoted tumor formation in alcohol-fed mice. His studies were the first to demonstrate a role of histone H3 phosophorylation in deregulation of Brf1 and Pol III genes and to establish that alcohol- increased ER? activity enhanced expression of these genes, resulting in cell transformation. His lab is currently exploring the synergistic inhibitory effects of chemicals and kinase inhibitors on alcohol-associated cancers.
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