Keck School Faculty

Susan Groshen, PhD
Susan Groshen, PhD
Retired Faculty
Emeriti Center
Dr. Groshen is involved in the evaluation of new drugs and therapeutic strategies for treating cancer. As the statistician overseeing the clinical trials program at the USC/Norris Comprehensive Cancer Center, Dr. Groshen is responsible for statistical and design issues and is involved in the planning of data management. As studies are completed, she is responsible for statistical analysis of the results.

A Phase I Study of the Combination of Rituximab and Ipilimumab in Patients with Relapsed/Refractory B-Cell Lymphoma Clin Cancer Res. 2019 Dec 01; 25(23):7004-7013. . View in PubMed

Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method Pharm Stat. 2019 Nov; 18(6):659-670. . View in PubMed

Contrast-Enhanced Ultrasound Imaging of Breast Masses: Adjunct Tool to Decrease the Number of False-Positive Biopsy Results J Ultrasound Med. 2019 Sep; 38(9):2259-2273. . View in PubMed

Phase 1 Trial of SBRT to the Prostate Fossa After Prostatectomy Int J Radiat Oncol Biol Phys. 2019 05 01; 104(1):50-60. . View in PubMed

Biliary-Enteric Drainage vs Primary Liver Transplant as Initial Treatment for Children With Biliary Atresia JAMA Surg. 2019 01 01; 154(1):26-32. . View in PubMed

Active Surveillance for Prostate Cancer: Are We Failing Latino Patients at a Large Safety Net Hospital? Clin Genitourin Cancer. 2018 08; 16(4):e719-e727.. View in PubMed

Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis Clin Cancer Res. 2017 Sep 15; 23(18):5374-5383. . View in PubMed

Baseline Glomerular Filtration Rate and Cisplatin- Induced Renal Toxicity in Urothelial Cancer Patients Clin Genitourin Cancer. 2017 Sep 06. . View in PubMed

Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126 Oncotarget. 2017 Aug 08; 8(32):52193-52210. . View in PubMed

Accuracy of Contrast-Enhanced Ultrasound Compared With Magnetic Resonance Imaging in Assessing the Tumor Response After Neoadjuvant Chemotherapy for Breast Cancer J Ultrasound Med. 2017 May; 36(5):901-911. . View in PubMed

A Phase II Trial of AEZS-108 in Castration- and Taxane-Resistant Prostate Cancer Clin Genitourin Cancer. 2017 12; 15(6):742-749. . View in PubMed

No Acute Changes in LVEF Observed With Concurrent Trastuzumab and Breast Radiation With Low Heart Doses Clin Breast Cancer. 2017 11; 17(7):510-515. . View in PubMed

Improvement in the Outcomes of MELD = 40 Liver Transplantation: An Analysis of 207 Consecutive Transplants in a Highly Competitive DSA Transplantation. 2017 10; 101(10):2360-2367. . View in PubMed

Inequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease J Hepatol. 2017 09; 67(3):517-525. . View in PubMed

Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials Eur J Cancer. 2017 05; 77:13-20. . View in PubMed

Effects of recipient size and allograft type on pediatric liver transplantation for biliary atresia Liver Transpl. 2017 02; 23(2):221-233. . View in PubMed

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice Sci Rep. 2017 02 01; 7:40919. . View in PubMed

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease Sci Transl Med. 2017 02 15; 9(377). . View in PubMed

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4020-E4029. . View in PubMed

AXIN2 expression predicts prostate cancer recurrence and regulates invasion and tumor growth Prostate. 2016 May; 76(6):597-608. . View in PubMed

Monoamine oxidase A (MAO A) inhibitors decrease glioma progression Oncotarget. 2016 Mar 22; 7(12):13842-53. . View in PubMed

Kidney transplantation in the Hispanic population Clin Transplant. 2016 Feb; 30(2):118-23. . View in PubMed

Assessing the New American Society of Clinical Oncology/College of American Pathologists Guidelines for HER2 Testing by Fluorescence In Situ Hybridization: Experience of an Academic Consultation Practice Arch Pathol Lab Med. 2016 11; 140(11):1250-1258. . View in PubMed

A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma Pediatr Blood Cancer. 2016 08; 63(8):1349-56. . View in PubMed

Impact of the 2010 Consensus Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee Clin Cancer Res. 2015 Nov 15; 21(22):5057-63. . View in PubMed

Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables J Surg Oncol. 2015 Aug; 112(2):125-32. . View in PubMed

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan Cell Metab. 2015 Jul 07; 22(1):86-99. . View in PubMed

Lymph Node Micrometastases in Early-Stage Cervical Cancer are Not Predictive of Survival Int J Gynecol Pathol. 2015 Jul; 34(4):379-84. . View in PubMed

131I-metaiodobenzylguanidine with intensive chemotherapy and autologous stem cell transplantation for high-risk neuroblastomaA new approaches to neuroblastoma therapy (NANT) phase II study. Biol Blood Marrow Transplant. 2015 Apr; 21(4):673-81. . View in PubMed

Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression PLoS One. 2015; 10(2):e0117758. . View in PubMed

Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee Clin Cancer Res. 2014 Aug 15; 20(16):4210-7. . View in PubMed

Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness Cancer Res. 2014 May 15; 74(10):2857-68. . View in PubMed

Comparative performance of PET tracers in biochemical recurrence of prostate cancer: a critical analysis of literature Am J Nucl Med Mol Imaging. 2014; 4(6):580-601. . View in PubMed

Efficacy of oxaliplatin plus pemetrexed in chemotherapy pretreated metastatic castration-resistant prostate cancer Clin Genitourin Cancer. 2013 Dec; 11(4):416-22. . View in PubMed

Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells J Immunother. 2013 Jun; 36(5):319-29. . View in PubMed

Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program Cancer. 2013 Feb 15; 119(4):756-65. . View in PubMed

Dose escalation study of no-carrier-added 131I-metaiodobenzylguanidine for relapsed or refractory neuroblastoma: new approaches to neuroblastoma therapy consortium trial J Nucl Med. 2012 Jul; 53(7):1155-63. . View in PubMed

A phase II study of halichondrin B analog eribulin mesylate (E7389) in patients with advanced non-small cell lung cancer previously treated with a taxane: a California cancer consortium trial J Thorac Oncol. 2012 Mar; 7(3):574-8. . View in PubMed

Human breast cancer histoid: an in vitro 3-dimensional co-culture model that mimics breast cancer tissue J Histochem Cytochem. 2011 Dec; 59(12):1087-100. . View in PubMed

A wide-spectrum paired comparison of the properties of the Rolling 6 and 3+3 Phase I study designs Contemp Clin Trials. 2011 Sep; 32(5):694-703. . View in PubMed

Long-term outcome in patients with a Gleason score = 6 prostate cancer treated by radical prostatectomy BJU Int. 2011 Sep; 108(5):660-4. . View in PubMed

A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis Cancer Res. 2011 Apr 15; 71(8):2848-57. . View in PubMed

GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy Int J Cancer. 2011 Feb 01; 128(3):726-31. . View in PubMed

Genome-scale screen for DNA methylation-based detection markers for ovarian cancer PLoS One. 2011; 6(12):e28141. . View in PubMed

Hypertension, diuretics and antihypertensives in relation to bladder cancer Carcinogenesis. 2010 Nov; 31(11):1964-71. . View in PubMed

A phase I biological study of azacitidine (Vidaza™) to determine the optimal dose to inhibit DNA methylation Epigenetics. 2010 Nov-Dec; 5(8):750-7. . View in PubMed

Expression of receptors for luteinizing hormone-releasing hormone (LH-RH) in prostate cancers following therapy with LH-RH agonists Clin Cancer Res. 2010 Sep 15; 16(18):4675-80. . View in PubMed

A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy Cancer Chemother Pharmacol. 2010 Apr; 65(5):979-88. . View in PubMed

Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents Clin Cancer Res. 2010 Mar 15; 16(6):1745-55. . View in PubMed

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines BMC Med Genomics. 2009 Nov 30; 2:67. . View in PubMed

Comparison of iodine-123 metaiodobenzylguanidine (MIBG) scan and [18F]fluorodeoxyglucose positron emission tomography to evaluate response after iodine-131 MIBG therapy for relapsed neuroblastoma J Clin Oncol. 2009 Nov 10; 27(32):5343-9. . View in PubMed

J1-31 protein expression in astrocytes and astrocytomas Neuropathology. 2009 Oct; 29(5):521-7. . View in PubMed

Formamide as a denaturant for bisulfite conversion of genomic DNA: Bisulfite sequencing of the GSTPi and RARbeta2 genes of 43 formalin-fixed paraffin-embedded prostate cancer specimens Anal Biochem. 2009 Sep 15; 392(2):117-25. . View in PubMed

Generation of a concise gene panel for outcome prediction in urinary bladder cancer J Clin Oncol. 2009 Aug 20; 27(24):3929-37. . View in PubMed

Oral fenretinide in biochemically recurrent prostate cancer: a California cancer consortium phase II trial Clin Genitourin Cancer. 2009 Jan; 7(1):43-50. . View in PubMed

[F-18]-fluorodeoxyglucose PET-CT of the normal prostate gland Ann Nucl Med. 2008 Nov; 22(9):787-93. . View in PubMed

Guidelines for development of diagnostic markers in bladder cancer World J Urol. 2008 Feb; 26(1):5-11. . View in PubMed

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development Cancer Res. 2008 Jan 15; 68(2):498-505. . View in PubMed

Overexpression of E-cadherin and beta-catenin proteins in metastatic prostate cancer cells in bone Prostate. 2008 Jan 01; 68(1):78-84. . View in PubMed

p53 gene and protein status: the role of p53 alterations in predicting outcome in patients with bladder cancer J Clin Oncol. 2007 Dec 01; 25(34):5352-8. . View in PubMed

DNA methylation profile of 28 potential marker loci in malignant mesothelioma Lung Cancer. 2007 Nov; 58(2):220-30. . View in PubMed

Overexpression of E-cadherin protein in metastatic breast cancer cells in bone Anticancer Res. 2007 Nov-Dec; 27(6B):3903-8. . View in PubMed

Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival Hum Pathol. 2007 Oct; 38(10):1547-52. . View in PubMed

FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab J Clin Oncol. 2007 Aug 20; 25(24):3712-8. . View in PubMed

Alcohol consumption and risk of bladder cancer in Los Angeles County Int J Cancer. 2007 Aug 15; 121(4):839-45. . View in PubMed

Functional heterogeneity of prostatic intraepithelial neoplasia: the duration of hormonal therapy influences the response BJU Int. 2007 May; 99(5):1024-7. . View in PubMed

Alum with interleukin-12 augments immunity to a melanoma peptide vaccine: correlation with time to relapse in patients with resected high-risk disease Clin Cancer Res. 2007 Jan 01; 13(1):215-22. . View in PubMed

Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer Clin Colorectal Cancer. 2006 Nov; 6(4):305-11. . View in PubMed

GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer Cancer Res. 2006 Aug 15; 66(16):7849-53. . View in PubMed

Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab Pharmacogenet Genomics. 2006 Jul; 16(7):475-83. . View in PubMed

Detection of occult lymph node metastases in locally advanced node-negative prostate cancer J Clin Oncol. 2006 Jun 20; 24(18):2735-42. . View in PubMed

Comparisons of PCR-based genome amplification systems using CpG island microarrays Hum Mutat. 2006 Jun; 27(6):589-96. . View in PubMed

Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation Pharmacogenomics. 2006 Jan; 7(1):67-88. . View in PubMed

Gene polymorphisms of epidermal growth factor receptor and its downstream effector, interleukin-8, predict oxaliplatin efficacy in patients with advanced colorectal cancer Clin Colorectal Cancer. 2005 Jul; 5(2):124-31. . View in PubMed

Molecular determinants of cetuximab efficacy J Clin Oncol. 2005 May 20; 23(15):3536-44. . View in PubMed

Neoplastic meningitis-related encephalopathy J Neurooncol. 2005 Apr; 72(2):185-9. . View in PubMed

Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancer J Am Coll Surg. 2005 Mar; 200(3):336-44. . View in PubMed

Comparisons of substitution, insertion and deletion probes for resequencing and mutational analysis using oligonucleotide microarrays Nucleic Acids Res. 2005 Feb 18; 33(3):e33. . View in PubMed

Impact of gene polymorphisms on clinical outcome for stage IV melanoma patients treated with biochemotherapy: an exploratory study Clin Cancer Res. 2005 Feb 01; 11(3):1237-46. . View in PubMed

Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma J Clin Oncol. 2005 Feb 01; 23(4):741-50. . View in PubMed

Epidermal growth factor receptor gene polymorphisms predict pelvic recurrence in patients with rectal cancer treated with chemoradiation Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):600-5. . View in PubMed

Concepts for banking tissue in urologic oncology--the International Bladder Cancer Bank Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):413-5. . View in PubMed

Neoplastic meningitis-related encephalopathy: prognostic significance Neurology. 2004 Dec 14; 63(11):2159-61. . View in PubMed

Association between monocyte Fcgamma subclass expression and acute coronary syndrome Immun Ageing. 2004 Nov 12; 1(1):4. . View in PubMed

Increased CXCL8 (IL-8) expression in Multiple Sclerosis J Neuroimmunol. 2004 Oct; 155(1-2):161-71. . View in PubMed

LEA-135 expression: its association with a lower risk of recurrence and increased overall survival of patients with lymph node-positive primary invasive breast cancer Anticancer Res. 2004 Jul-Aug; 24(4):2391-400. . View in PubMed

Identification of micrometastases in histologically negative lymph nodes of early-stage cervical cancer patients Obstet Gynecol. 2004 Jun; 103(6):1204-10. . View in PubMed

Combined effects of p53, p21, and pRb expression in the progression of bladder transitional cell carcinoma J Clin Oncol. 2004 Mar 15; 22(6):1007-13. . View in PubMed

Microscopic and gross extravesical extension in pathological staging of bladder cancer J Urol. 2004 Feb; 171(2 Pt 1):640-5. . View in PubMed

Natural history of surgically treated bladder carcinoma with extravesical tumor extension Cancer. 2003 Sep 01; 98(5):955-61. . View in PubMed

A phase I trial of SD-9427 (progenipoietin) with a multipeptide vaccine for resected metastatic melanoma Clin Cancer Res. 2003 Apr; 9(4):1301-12. . View in PubMed

Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus Br J Haematol. 2003 Apr; 121(1):139-42. . View in PubMed

ERCC1 gene polymorphism as a predictor for clinical outcome in advanced colorectal cancer patients treated with platinum-based chemotherapy Clin Adv Hematol Oncol. 2003 Mar; 1(3):162-6. . View in PubMed

Establishment of a nude mouse model of hepatic metastasis for evaluation of targeted retroviral gene delivery J Surg Oncol. 2003 Feb; 82(2):121-30; discussion 131. . View in PubMed

P7 antigen expression in human breast cancer Clin Cancer Res. 2003 Jan; 9(1):201-6. . View in PubMed

Ceramide signaling in fenretinide-induced endothelial cell apoptosis J Biol Chem. 2002 Dec 20; 277(51):49531-7. . View in PubMed

LEA135 expression: identifies low-risk patients with breast ductal carcinoma in situ. Anticancer Res. 2002 Sep-Oct; 22(5):2933-7. . View in PubMed

Comparison of different antibodies for detection of progesterone receptor in breast cancer Steroids. 2002 Aug; 67(9):799-813. . View in PubMed

Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer J Natl Cancer Inst. 2002 Jun 19; 94(12):936-42. . View in PubMed

Low HER2/neu gene expression is associated with pathological response to concurrent paclitaxel and radiation therapy in locally advanced breast cancer Int J Radiat Oncol Biol Phys. 2002 Feb 01; 52(2):397-405. . View in PubMed

Powered by SC CTSI
Go to Top