Keck School Faculty

Takahiro Ohyama, PhD
Takahiro Ohyama, PhD
Assistant Professor of Research Otolaryngology-Head and Neck Surgery
CHP 204M 1540 Alcazar Street Health Sciences Campus Los Angeles
Hearing loss is one of the most common birth defects. Approximately one in five hundred newborns suffer from significant hearing impairment. In addition, once mechanosensory hair cells in the inner ear are damaged and lost by any of a variety of reasons such as aging and loud noises, they never regenerate. Thus, majority of sensorineural hearing loss, such as age-related hearing loss and noise-induced hearing loss is permanent and significantly affect the quality of one?s life. Recently, stem cell research has shed light on the possibility of regeneration of hair cells in humans. Our research goal is to understand the molecular mechanisms of inner ear development and to explore the possibility of regenerating sensory cells to treat hearing and balance disorders.

Role of Dach1 revealed using a novel inner ear-specific Dach1-knockdown mouse model Biol Open. 2019 Aug 20; 8(8). . View in PubMed

Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea PLoS Genet. 2017 Oct; 13(10):e1007048. . View in PubMed

Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. . View in PubMed

Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice Hear Res. 2016 Feb; 332:113-120. . View in PubMed

Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation Stem Cells. 2016 07; 34(7):1896-908. . View in PubMed

The mouse Foxi3 transcription factor is necessary for the development of posterior placodes Dev Biol. 2016 Jan 01; 409(1):139-151. . View in PubMed

Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing J Neurosci. 2016 08 03; 36(31):8200-9. . View in PubMed

Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning Development. 2015 Nov 15; 142(22):3954-63. . View in PubMed

Fgf10 is required for specification of non-sensory regions of the cochlear epithelium Dev Biol. 2015 Apr 01; 400(1):59-71. . View in PubMed

Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers Dev Biol. 2014 Jun 01; 390(1):1-13. . View in PubMed

Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa J Neurosci. 2011 Jun 01; 31(22):8046-58. . View in PubMed

SOX9 controls epithelial branching by activating RET effector genes during kidney development Hum Mol Genet. 2011 Mar 15; 20(6):1143-53. . View in PubMed

BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea J Neurosci. 2010 Nov 10; 30(45):15044-51. . View in PubMed

Unraveling inner ear induction by gene manipulation using Pax2-Cre BAC transgenic mice Brain Res. 2009 Jun 24; 1277:84-9. . View in PubMed

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti Dev Cell. 2009 Jan; 16(1):58-69. . View in PubMed

Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode Development. 2008 Jul; 135(13):2251-61. . View in PubMed

The first steps towards hearing: mechanisms of otic placode induction Int J Dev Biol. 2007; 51(6-7):463-72. . View in PubMed

Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients Hum Mol Genet. 2006 May 15; 15(10):1629-39. . View in PubMed

Wnt signals mediate a fate decision between otic placode and epidermis Development. 2006 Mar; 133(5):865-75. . View in PubMed

Wnt10a is involved in AER formation during chick limb development Dev Dyn. 2005 Jun; 233(2):282-7. . View in PubMed

Expression of mouse Foxi class genes in early craniofacial development Dev Dyn. 2004 Nov; 231(3):640-6. . View in PubMed

Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome Genesis. 2004 Apr; 38(4):195-9. . View in PubMed

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