Keck School Faculty

Thomas H. Mc Neill, PhD
Thomas H. Mc Neill, PhD
Professor of Cell & Neurobiology
Integrative Anatomical Sciences
BMT 305D 1333 San Pablo Street Health Sciences Campus Los Angeles
Research Overview
The overall goal of Dr. McNeill's research program is to define the cellular mechanisms that regulate the ability of the brain to repair itself in response to injury (i.e. neuroplasticity) and the effect of aging on these processes. In particular, we wish to further our understanding of the cellular events underlying the synergism between neural plasticity and treatment strategies that promote the recovery of function after brain damage. Understanding the cellular mechanisms that promote neuroplasticity after brain injury is critical for determining the limits of functional recovery that can be expected in brain injured patients, and the first step in developing novel treatment strategies to facilitate the recovery of function after brain injury. Likewise, the ability to manipulate neurotrophrin and neurotransmitters pathways that are activated in response to injury offers a unique opportunity for the development of novel therapies that target a specific cellular mechanisms by translating the fundemental principles of neuroplasticty into effective clinical interventions. The knowledge gained from our studies has relevance for the treatment of neuropsychiatric disorders commonly associated with brain injury as well as in the treatment of neurological deficits associated with Parkinson's disease, Alzheimer's disease, schizophrenia and stroke

Laminin-1 induces endocytosis of 67KDa laminin receptor and protects Neuroscreen-1 cells against death induced by serum withdrawal Biochem Biophys Res Commun. 2018 01 01; 495(1):230-237. . View in PubMed

Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide J Neurochem. 2015 Jan; 132(1):70-84. . View in PubMed

Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24. . View in PubMed

Unilateral skill acquisition induces bilateral NMDA receptor subunit composition shifts in the rat sensorimotor striatum Brain Res. 2013 Jun 23; 1517:77-86. . View in PubMed

Methods for studying oxidative regulation of protein kinase C Methods Enzymol. 2013; 528:79-98. . View in PubMed

Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Ce J Biol Chem. 2012 Oct 05; 287(41):34694-708. . View in PubMed

Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species J Neurosci Res. 2010 Dec; 88(16):3644-55. . View in PubMed

Variation in Galr1 expression determines susceptibility to exocitotoxin-induced cell death in mice Genes Brain Behav. 2008 Jul; 7(5):587-98. . View in PubMed

A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells J Biol Chem. 2008 May 23; 283(21):14430-44. . View in PubMed

Intrastriatal dopamine D1 antagonism dampens neural plasticity in response to motor cortex lesion Neuroscience. 2007 May 11; 146(2):784-91. . View in PubMed

Differential regulation of the growth-associated proteins GAP-43 and superior cervical ganglion 10 in response to lesions of the cortex and substantia nigra in the adult rat Neuroscience. 2005; 135(4):1231-9. . View in PubMed

Synapse replacement in the striatum of the adult rat following unilateral cortex ablation J Comp Neurol. 2003 Dec 01; 467(1):32-43. . View in PubMed

Alterations in rat striatal glutamate synapses following a lesion of the cortico- and/or nigrostriatal pathway Exp Neurol. 2000 Sep; 165(1):191-206. . View in PubMed

Differential regulation of the growth-associated proteins, GAP-43 and SCG-10, in response to unilateral cortical ablation in adult rats Neuroscience. 1999; 90(4):1349-60. . View in PubMed

Lesion-induced axon sprouting in the deafferented striatum of adult rat Neurosci Lett. 1998 Feb 13; 242(2):69-72. . View in PubMed

The messenger RNA encoding VGF, a neuronal peptide precursor, is rapidly regulated in the rat central nervous system by neuronal activity, seizure and lesion Neuroscience. 1998 Jan; 82(1):7-19. . View in PubMed

Differential regulation of astrocytic mRNAs in the rat striatum after lesions of the cortex or substantia nigra Exp Neurol. 1998 Jan; 149(1):87-96. . View in PubMed

Upregulation of stathmin (p19) gene expression in adult rat brain during injury-induced synapse formation Neuroreport. 1997 Dec 01; 8(17):3691-5. . View in PubMed

Differential spine loss and regrowth of striatal neurons following multiple forms of deafferentation: a Golgi study Exp Neurol. 1997 Oct; 147(2):287-98. . View in PubMed

Age-related change in short-term synaptic plasticity intrinsic to excitatory striatal synapses Synapse. 1997 Sep; 27(1):57-68. . View in PubMed

Effect of buthionine sulfoximine, a synthesis inhibitor of the antioxidant glutathione, on the murine nigrostriatal neurons J Neurochem. 1996 Nov; 67(5):2164-71. . View in PubMed

Decreased duration of Ca(2+)-mediated plateau potentials in striatal neurons from aged rats J Neurophysiol. 1996 Oct; 76(4):2353-63. . View in PubMed

Dendritic remodeling of dentate granule cells following a combined entorhinal cortex/fimbria fornix lesion Exp Neurol. 1996 Sep; 141(1):145-53. . View in PubMed

Lesion-induced sprouting of commissural/associational axons and induction of GAP-43 mRNA in hilar and CA3 pyramidal neurons in the hippocampus are diminished in aged rats J Neurosci. 1995 Mar; 15(3 Pt 2):2462-70. . View in PubMed

Enhanced but delayed axonal sprouting of the commissural/associational pathway following a combined entorhinal cortex/fimbria fornix lesion J Comp Neurol. 1995 Jan 16; 351(3):453-64. . View in PubMed

Increases of glial fibrillary acidic protein in the aging female mouse brain Neurobiol Aging. 1995 Jan-Feb; 16(1):59-67. . View in PubMed

Response of striatal astrocytes to neuronal deafferentation: an immunocytochemical and ultrastructural study Neuroscience. 1994 Sep; 62(2):425-39. . View in PubMed

Differential localization of SCG10 and p19/stathmin messenger RNAs in adult rat brain indicates distinct roles for these growth-associated proteins Neuroscience. 1994 Jun; 60(4):907-26. . View in PubMed

Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus J Neurosci. 1993 Sep; 13(9):4001-14. . View in PubMed

Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus Neuroscience. 1993 Jul; 55(2):435-43. . View in PubMed

Astrocytic messenger RNA responses to striatal deafferentation in male rat Neuroscience. 1993 Mar; 53(1):199-211. . View in PubMed

Chronic estradiol administration did not cause loss of hypothalamic LHRH or TIDA neurons in young or middle-aged C57BL/6J mice Brain Res. 1992 Mar 06; 574(1-2):341-4. . View in PubMed

Striatal responses to decorticationI. Dopaminergic and astrocytic activities. Brain Res. 1991 Dec 20; 567(2):253-9. . View in PubMed

Sulfated glycoprotein-2 is increased in rat hippocampus following entorhinal cortex lesioning Brain Res. 1991 Nov 01; 563(1-2):101-6. . View in PubMed

Molecular and morphological correlates following neuronal deafferentation: a cortico-striatal model Adv Exp Med Biol. 1991; 296:249-55. . View in PubMed

Effect of chronic adrenalectomy on neuron loss and distribution of sulfated glycoprotein-2 in the dentate gyrus of prepubertal rats Exp Neurol. 1991 Jan; 111(1):140-4. . View in PubMed

Castration enhances expression of glial fibrillary acidic protein and sulfated glycoprotein-2 in the intact and lesion-altered hippocampus of the adult male rat Mol Endocrinol. 1990 Dec; 4(12):1995-2002. . View in PubMed

Quantitative analysis of age-related dendritic changes in medium spiny I (MSI) striatal neurons of C57BL/6N mice Neurobiol Aging. 1990 Sep-Oct; 11(5):537-50. . View in PubMed

Differential effects of advancing age on neurotransmitter cell loss in the substantia nigra and striatum of C57BL/6N mice Brain Res. 1990 Jun 25; 521(1-2):107-17. . View in PubMed

Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease Science. 1990 May 18; 248(4957):854-7. . View in PubMed

Golgi study of the mouse striatum: age-related dendritic changes in different neuronal populations J Comp Neurol. 1989 Jan 08; 279(2):212-27. . View in PubMed

Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease Brain Res. 1988 Jul 05; 455(1):148-52. . View in PubMed

Age-related changes in the nigrostriatal system Ann N Y Acad Sci. 1988; 515:239-48. . View in PubMed

Effect of misonidazole on neurotransmitter systems Int J Radiat Oncol Biol Phys. 1986 Jul; 12(7):1067-70. . View in PubMed

Immunocytochemical, Golgi and electron microscopic characterization of putative dendrites in the ventral glial lamina of the rat supraoptic nucleus Neuroscience. 1982 Mar; 7(3):679-94. . View in PubMed

Simultaneous monoamine histofluorescence and neuropeptide immunocytochemistry: IICorrelative distribution of catecholamine varicosities and magnocellular neurosecretory neurons in the rat supraoptic and paraventricular nuclei. J Comp Neurol. 1980 Oct 15; 193(4):1023-33. . View in PubMed

Subnuclei in the rat hypothalamic paraventricular nucleus: a cytoarchitectural, horseradish peroxidase and immunocytochemical analysis Neuroscience. 1980; 5(11):1931-58. . View in PubMed

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