Keck School Faculty

Tiffany Chow, MD
Tiffany Chow, MD
Professor of Clinical Neurology
ATR 9860 Mesa Rim Road Health Sciences Campus San Diego
Dr. Tiffany Chow serves the USC Alzheimer’s Therapeutic Research Institute as the Director of Clinical Monitoring and Diversity Strategist. Clinical monitors assure that clinical trial sites are documenting their procedures and collecting data in ways that maximize participant safety and safeguard the integrity of the dataset.

Building on her work with the Asian and Pacific Islander community in Los Angeles that began during her Fellowship training, she now finally has a mandate to operate nationally through the Alzheimer's Clinical Trials Consortium.

Prior to her current work for ATRI, Dr. Chow cared for patients with early-onset dementias and their families. Her research has spanned observational studies of behavioral disturbance in dementia, structural and functional neuroimaging, clinical trials, and knowledge translation. Her publications include reporting from both quantitative and qualitative approaches to the field.

Dr. Chow’s commitment to caregiver issues in dementia has motivated her active participation on the Boards of Directors for the Alzheimer’s Association and the Alzheimer’s Society, as well as her position as a charter Medical Advisory Council member of the international Association for Frontotemporal Degeneration. She has brought an intergenerational approach to her outreach to caregivers: there is a website for children who are caregivers to middle-aged parents with dementia, and an educational activity book for children too young to access the internet, Frank and Tess, Detectives! which was translated into Welsh (download at

In the past, she has served as a Councilor and Education Chair for the AAN’s Geriatric Neurology section; she has also been a member of the Behavioral Neurology section and earned UCNS certification for Behavioral Neurology in 2013.

Fun Facts:
USC Legacy: Dr. Chow’s dad graduated from the dental school in 1964.
Dr. Chow’s first job at USC was as an executive assistant in the Purchasing Department.

BrainWorks: A Comparative Effectiveness Trial to Examine Alzheimer's Disease Education for Community-Dwelling African Americans Am J Geriatr Psychiatry. 2019 Jan; 27(1):53-61. . View in PubMed

Fundamental causes of barriers to participation in Alzheimer's clinical research among African Americans Ethn Health. 2018 Oct 30; 1-15. . View in PubMed

BrainWorks: A Comparative Effectiveness Trial to Examine Alzheimer's Disease Education for Community-Dwelling African Americans Am J Geriatr Psychiatry. 2018 Sep 21. . View in PubMed

Characterizing familial corticobasal syndrome due to Alzheimer's disease pathology and PSEN1 mutations Alzheimers Dement. 2017 May; 13(5):520-530. . View in PubMed

Cognitive and psychosocial function in retired professional hockey players J Neurol Neurosurg Psychiatry. 2017 06; 88(6):512-519. . View in PubMed

White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia Dement Geriatr Cogn Dis Extra. 2017 Jan-Apr; 7(1):52-73. . View in PubMed

Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia Dement Geriatr Cogn Dis Extra. 2016 Sep-Dec; 6(3):407-423. . View in PubMed

Amyloid deposition in semantic dementia: a positron emission tomography study Int J Geriatr Psychiatry. 2016 09; 31(9):1064-74. . View in PubMed

Lifetime History of Depression Predicts Increased Amyloid-ß Accumulation in Patients with Mild Cognitive Impairment J Alzheimers Dis. 2016; 49(4):1189-90. . View in PubMed

Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) PLoS One. 2016; 11(1):e0147573. . View in PubMed

Trajectories of Behavioural Disturbances Across Dementia Types Can J Neurol Sci. 2015 Nov; 42(6):389-94. . View in PubMed

Emotional evaluation and memory in behavioral variant frontotemporal dementia Neurocase. 2015; 21(4):429-37. . View in PubMed

Lifetime History of Depression Predicts Increased Amyloid-ß Accumulation in Patients with Mild Cognitive Impairment J Alzheimers Dis. 2015; 45(3):907-19. . View in PubMed

Grey matter atrophy in mild cognitive impairment / early Alzheimer disease associated with delusions: a voxel-based morphometry study Curr Alzheimer Res. 2015; 12(2):165-72. . View in PubMed

Early neuropsychological characteristics of progranulin mutation carriers J Int Neuropsychol Soc. 2014 Aug; 20(7):694-703. . View in PubMed

Verb production in the nonfluent and semantic variants of primary progressive aphasia: the influence of lexical and semantic factors Cogn Neuropsychol. 2014; 31(7-8):565-83. . View in PubMed

Salience network resting-state activity: prediction of frontotemporal dementia progression JAMA Neurol. 2013 Oct; 70(10):1249-53. . View in PubMed

The potential role of dopamine D3 receptor neurotransmission in cognition Eur Neuropsychopharmacol. 2013 Aug; 23(8):799-813. . View in PubMed

Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation Cortex. 2013 Jul-Aug; 49(7):1856-73. . View in PubMed

Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasia Hum Brain Mapp. 2013 Apr; 34(4):973-84. . View in PubMed

Incorporating new diagnostic schemas, genetics, and proteinopathy into the evaluation of frontotemporal degeneration Continuum (Minneap Minn). 2013 Apr; 19(2 Dementia):438-56. . View in PubMed

Development of supportive services for frontotemporal dementias through community engagement Int Rev Psychiatry. 2013 Apr; 25(2):246-52. . View in PubMed

Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development Alzheimers Dement. 2013 Mar; 9(2):176-88. . View in PubMed

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier) Alzheimers Dement. 2013 Mar; 9(2):189-98. . View in PubMed

Int J Geriatr Psychiatry. 2013 Mar; 28(3):319-25. . View in PubMed

Changes to saccade behaviors in Parkinson's disease following dancing and observation of dancing Front Neurol. 2013; 4:22. . View in PubMed

A case of apathy due to frontotemporal dementia responsive to memantine Neurocase. 2013; 19(3):256-61. . View in PubMed

When dementia is in the house: needs assessment survey for young caregivers Can J Neurol Sci. 2013 Jan; 40(1):21-8. . View in PubMed

Serotonergic function and treatment of behavioral and psychological symptoms of frontotemporal dementia Am J Geriatr Psychiatry. 2012 Sep; 20(9):789-97. . View in PubMed

Cholinergic pathways and cognition in patients with schizophrenia: a pilot study Schizophr Res. 2012 Aug; 139(1-3):46-52. . View in PubMed

A case of semantic variant primary progressive aphasia with severe insular atrophy Neurocase. 2012; 18(6):450-6. . View in PubMed

Trajectories of behavioral disturbance in dementia J Alzheimers Dis. 2012; 31(1):143-9. . View in PubMed

Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections Int J Geriatr Psychiatry. 2011 Dec; 26(12):1300-8. . View in PubMed

What are the different initial presentations of frontotemporal dementia? J Mol Neurosci. 2011 Nov; 45(3):710-2.. View in PubMed

An international needs assessment of caregivers for frontotemporal dementia Can J Neurol Sci. 2011 Sep; 38(5):753-7. . View in PubMed

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia Brain. 2011 Sep; 134(Pt 9):2456-77. . View in PubMed

Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia Neuropsychiatr Dis Treat. 2011; 7:415-24. . View in PubMed

Visual rating versus volumetry to detect frontotemporal dementia Dement Geriatr Cogn Disord. 2011; 31(5):371-8. . View in PubMed

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia can present as frontotemporal dementia syndrome Dement Geriatr Cogn Disord. 2011; 32(2):150-8. . View in PubMed

Occupation attributes relate to location of atrophy in frontotemporal lobar degeneration Neuropsychologia. 2010 Oct; 48(12):3634-41. . View in PubMed

Prevalence of primitive reflexes and Parkinsonian signs in dementia Can J Neurol Sci. 2010 Sep; 37(5):601-7. . View in PubMed

Recollection and familiarity for public events in neurologically intact older adults and two brain-damaged patients Neuropsychologia. 2010 Mar; 48(4):945-60. . View in PubMed

Alzheimer's disease neuropathologic changes in semantic dementia Neurocase. 2010 Feb; 16(1):15-22. . View in PubMed

Apathy is not associated with basal ganglia atrophy in frontotemporal dementia Am J Geriatr Psychiatry. 2009 Sep; 17(9):819-21. . View in PubMed

Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults BMC Med Imaging. 2009 Jul 06; 9:12. . View in PubMed

Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type Arch Neurol. 2009 Jul; 66(7):888-93. . View in PubMed

100 years after Alzheimer: contemporary neurology practice assessment of referrals for dementia Am J Alzheimers Dis Other Demen. 2008 Dec-2009 Jan; 23(6):516-27. . View in PubMed

Review: insufficient evidence on Huperzine A for Alzheimer's Evid Based Ment Health. 2008 Nov; 11(4):112. . View in PubMed

Overlap in frontotemporal atrophy between normal aging and patients with frontotemporal dementias Alzheimer Dis Assoc Disord. 2008 Oct-Dec; 22(4):327-35. . View in PubMed

Diagnosis and treatment of dementia: 2Diagnosis. CMAJ. 2008 Mar 25; 178(7):825-36. . View in PubMed

Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophy Dement Geriatr Cogn Disord. 2008; 26(1):79-88. . View in PubMed

Distraction during relational reasoning: the role of prefrontal cortex in interference control Neuropsychologia. 2008; 46(7):2020-32. . View in PubMed

Multidisciplinary design and implementation of a day program specialized for the frontotemporal dementias Am J Alzheimers Dis Other Demen. 2007 Dec-2008 Jan; 22(6):499-506. . View in PubMed

Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions Alzheimer Dis Assoc Disord. 2007 Oct-Dec; 21(4):S14-8. . View in PubMed

Structural neuroimaging in the diagnosis of dementia Alzheimers Dement. 2007 Oct; 3(4):333-5. . View in PubMed

Comparison of manual and semi-automated delineation of regions of interest for radioligand PET imaging analysis BMC Nucl Med. 2007 Jan 29; 7:2. . View in PubMed

Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease Neuropsychiatr Dis Treat. 2007; 3(5):627-36. . View in PubMed

Exploring the recognition memory deficit in Parkinson's disease: estimates of recollection versus familiarity Brain. 2006 Jul; 129(Pt 7):1768-79. . View in PubMed

Variations in regional SPECT hypoperfusion and clinical features in frontotemporal dementia Neurology. 2006 Feb 28; 66(4):517-22. . View in PubMed

MMSE scores decline at a greater rate in frontotemporal degeneration than in AD Dement Geriatr Cogn Disord. 2006; 22(3):194-9. . View in PubMed

Treatment approaches to symptoms associated with frontotemporal degeneration Curr Psychiatry Rep. 2005 Oct; 7(5):376-80. . View in PubMed

Frontotemporal lobar degeneration: demographic characteristics of 353 patients Arch Neurol. 2005 Jun; 62(6):925-30. . View in PubMed

Rivastigmine modestly improves dementia associated with Parkinson's disease, but has important adverse effects Evid Based Ment Health. 2005 May; 8(2):41. . View in PubMed

The differential diagnosis of pseudobulbar affect (PBA)Distinguishing PBA among disorders of mood and affect. Proceedings of a roundtable meeting. CNS Spectr. 2005 May; 10(5):1-14; quiz 15-6. . View in PubMed

Referral patterns for syndromes associated with frontotemporal lobar degeneration Alzheimer Dis Assoc Disord. 2005 Jan-Mar; 19(1):17-9. . View in PubMed

Clinicopathological concordance of dementia diagnoses by community versus tertiary care clinicians Am J Alzheimers Dis Other Demen. 2004 May-Jun; 19(3):161-5. . View in PubMed

Relational integration and executive function in Alzheimer's disease Neuropsychology. 2004 Apr; 18(2):296-305. . View in PubMed

A neurocomputational model of analogical reasoning and its breakdown in frontotemporal lobar degeneration J Cogn Neurosci. 2004 Mar; 16(2):260-71. . View in PubMed

Randomized controlled trials in long-term care residents with dementia: a systematic review J Am Med Dir Assoc. 2003 Nov-Dec; 4(6):302-7. . View in PubMed

Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia Arch Neurol. 2003 May; 60(5):698-702. . View in PubMed

Frontotemporal dementias: clinical features and management Semin Clin Neuropsychiatry. 2003 Jan; 8(1):58-70. . View in PubMed

Goals in symptomatic pharmacologic management of frontotemporal lobar degeneration Am J Alzheimers Dis Other Demen. 2002 Sep-Oct; 17(5):267-72. . View in PubMed

Frontotemporal dementia classification and neuropsychiatry Neurologist. 2002 Jul; 8(4):263-9. . View in PubMed

Effect of neuropsychiatric symptoms of Alzheimer's disease on Chinese and American caregivers Int J Geriatr Psychiatry. 2002 Jan; 17(1):29-34. . View in PubMed

Neuropsychiatric symptoms of Alzheimer's disease differ in Chinese and American patients Int J Geriatr Psychiatry. 2002 Jan; 17(1):22-8. . View in PubMed

Quality indicators for dementia in vulnerable community-dwelling and hospitalized elders Ann Intern Med. 2001 Oct 16; 135(8 Pt 2):668-76. . View in PubMed

Utilization of Alzheimer's disease community resources by Asian-Americans in California Int J Geriatr Psychiatry. 2000 Sep; 15(9):838-47. . View in PubMed

Inheritance of frontotemporal dementia Arch Neurol. 1999 Jul; 56(7):817-22. . View in PubMed

Treatment of Depression in the Patient with Parkinson's Disease Clin Geriatr. 1998 Oct; 6(11):34-46. . View in PubMed

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