Warren Garner, MD

Professor Emeritus of Surgery

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Overview

Dr. Garner is an internationally renowned expert in the science and treatment of wounds and the scars that result from them. This is based on his clinical experience in the treatment of traumatic injuries, particularly burn injuries, and correcting the deformities that result from them. He is the Director of the LAC+USC Burn Center where he directs a multidisciplinary team which treats patients with burn and other traumatic skin injuries. With the treatment of these patients Dr Garner has developed specialized expertise and experience in the treatment of the scars and deformities that result from these injuries. He is also expert in the treatment of numerous other wound healing abnormalities of poorly healing wounds and injuries. He treats such patients in numerous health care systems within the greater Los Angeles region; Keck School of Medicine University Hospital, the LAC + USC medical center, Rancho Los Amigos Rehabilitative Center and he is the Burn and Burn Reconstructive consultant for Kaiser Permanente of Southern California. Dr. Garner and his research team investigate wound healing and scar formation in the laboratory and have received numerous federal (NIH) and industrial grants to study why wounds heal, why they do not heal and treatments for them. He has been an officer, committee chair or Board member of the Wound Healing Society, American Society of Plastic Surgeons and Plastic Surgery Research Council.

Publications

  • Hypoglycemic episodes predict length of stay in patients with acute burns J Crit Care. 2021 08; 64:68-73. . View in PubMed
  • The Impact of Peer Support Group Programs on Psychosocial Outcomes for Burn Survivors and Caregivers: A Review of the Literature J Burn Care Res. 2021 08 04; 42(4):600-609. . View in PubMed
  • Venous Thromboembolism Chemoprophylaxis in Burn Patients: A Literature Review and Single-Institution Experience J Burn Care Res. 2021 02 03; 42(1):18-22. . View in PubMed
  • The Impact of No Next of Kin Decision Makers on End-of-Life Care J Burn Care Res. 2021 02 03; 42(1):9-13. . View in PubMed
  • The State of Burn Care Training During Plastic Surgery Residency Ann Plast Surg. 2020 08; 85(2):122-126. . View in PubMed
  • Re: Combination therapy for Toxic Epidermal Necrolysis: It is time for anti-TNFa biologics comparison Burns. 2020 02; 46(1):245-246. . View in PubMed
  • Intermediate Skin Substitutes Are Unnecessary in Small (<10% TBSA) Burns J Burn Care Res. 2020 09 23; 41(5):926-928. . View in PubMed
  • The Homelessness Crisis and Burn Injuries: A Cohort Study J Burn Care Res. 2020 07 03; 41(4):820-827. . View in PubMed
  • Small Pediatric Burns Can Be Safely Managed on an Outpatient Basis J Burn Care Res. 2020 09 23; 41(5):1029-1032. . View in PubMed
  • Stimulant Abuse in Burn Patients Is Associated With an Increased Use of Hospital Resources J Burn Care Res. 2020 09 23; 41(5):921-925. . View in PubMed
  • Combination therapy: Etanercept and intravenous immunoglobulin for the acute treatment of Stevens-Johnson syndrome/toxic epidermal necrolysis Burns. 2019 11; 45(7):1634-1638. . View in PubMed
  • Measuring gastric residual volumes in critically ill burn patients – A systematic review Burns. 2019 05; 45(3):509-525. . View in PubMed
  • Plast Reconstr Surg Glob Open. 2018 Oct; 6(10):e1900. . View in PubMed
  • How long are burn patients really NPO in the perioperative period and can we effectively correct the caloric deficit using an enteral feeding “Catch-up” protocol? Burns. 2018 12; 44(8):2006-2010.. View in PubMed
  • Acute Fluid Management of Large Burns: Pathophysiology, Monitoring, and Resuscitation Clin Plast Surg. 2017 Jul; 44(3):495-503. . View in PubMed
  • Steven Johnson Syndrome and Toxic Epidermal Necrolysis in a burn unit: A 15-year experience Burns. 2017 Feb; 43(1):200-205. . View in PubMed
  • Delayed-onset thrombocytopenia in a pediatric burn patient Am J Hematol. 2016 Sep; 91(9):958-60. . View in PubMed
  • Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs Mol Ther Methods Clin Dev. 2016; 3:16041. . View in PubMed
  • Cost-effectiveness comparison between topical silver sulfadiazine and enclosed silver dressing for partial-thickness burn treatment J Burn Care Res. 2014 Jul-Aug; 35(4):284-90. . View in PubMed
  • Donor-site preferences in women during autologous skin grafting Plast Reconstr Surg. 2014 Mar; 133(3):378e-382e. . View in PubMed
  • Simulation of plastic surgery and microvascular procedures using perfused fresh human cadavers J Plast Reconstr Aesthet Surg. 2014 Feb; 67(2):e42-8. . View in PubMed
  • Summary of the 2012 ABA Burn Quality Consensus conference J Burn Care Res. 2013 Jul-Aug; 34(4):361-85. . View in PubMed
  • Incorporation of fresh tissue surgical simulation into plastic surgery education: maximizing extraclinical surgical experience J Surg Educ. 2013 Jul-Aug; 70(4):466-74. . View in PubMed
  • High frequency percussive ventilation and low FiO(2) Burns. 2012 Nov; 38(7):984-91. . View in PubMed
  • Discussion: mast cells are required in the proliferation and remodeling phases of microdeformational wound therapy Plast Reconstr Surg. 2011 Dec; 128(6):659e-660e. . View in PubMed
  • An open, parallel, randomized, comparative, multicenter study to evaluate the cost-effectiveness, performance, tolerance, and safety of a silver-containing soft silicone foam dressing (intervention) vs silver sulfadiazine cream J Burn Care Res. 2011 Nov-Dec; 32(6):617-26. . View in PubMed
  • A simplified procedure to reconstitute hair-producing skin Tissue Eng Part C Methods. 2011 Apr; 17(4):391-400. . View in PubMed
  • Gastric feedings effectively prophylax against upper gastrointestinal hemorrhage in burn patients J Burn Care Res. 2011 Mar-Apr; 32(2):263-8. . View in PubMed
  • Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein-2 Am J Pathol. 2010 May; 176(5):2247-58. . View in PubMed
  • Matrix metalloproteinase-9 delays wound healing in a murine wound model Surgery. 2010 Feb; 147(2):295-302. . View in PubMed
  • A ten-year experience with hemodialysis in burn patients at Los Angeles County + USC Medical Center J Burn Care Res. 2009 Sep-Oct; 30(5):832-5. . View in PubMed
  • Burn surge for Los Angeles County, California J Trauma. 2009 Aug; 67(2 Suppl):S143-6. . View in PubMed
  • Alpha1-antichymotrypsin activity correlates with and may modulate matrix metalloproteinase-9 in human acute wounds Wound Repair Regen. 2009 May-Jun; 17(3):418-26. . View in PubMed
  • Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1 BMC Immunol. 2009 Mar 19; 10:15. . View in PubMed
  • Proteolytic activation of matrix metalloproteinase-9 in skin wound healing is inhibited by alpha-1-antichymotrypsin J Invest Dermatol. 2008 Sep; 128(9):2334-42. . View in PubMed
  • Acute burns Plast Reconstr Surg. 2008 May; 121(5):311e-319e. . View in PubMed
  • Integra in lower extremity reconstruction after burn injury Plast Reconstr Surg. 2008 Apr; 121(4):1256-1262. . View in PubMed
  • TNF-alpha suppresses alpha-smooth muscle actin expression in human dermal fibroblasts: an implication for abnormal wound healing J Invest Dermatol. 2007 Nov; 127(11):2645-55. . View in PubMed
  • American Burn Association consensus conference to define sepsis and infection in burns J Burn Care Res. 2007 Nov-Dec; 28(6):776-90. . View in PubMed
  • Rate of healing in skin-grafted burn wounds Plast Reconstr Surg. 2007 Aug; 120(2):451-456. . View in PubMed
  • Hypertrophic scar, wound contraction and hyper-hypopigmentation J Burn Care Res. 2007 Jul-Aug; 28(4):593-7. . View in PubMed
  • Interleukin-1alpha-induced proteolytic activation of metalloproteinase-9 by human skin Surgery. 2005 Nov; 138(5):932-9. . View in PubMed
  • Wound-healing perspectives Dermatol Clin. 2005 Apr; 23(2):181-92. . View in PubMed
  • Acute burn injury Clin Plast Surg. 2005 Apr; 32(2):187-93. . View in PubMed
  • Burn care in Los Angeles, California: LAC+USC experience 1994-2004 Burns. 2005 Jan; 31 Suppl 1:S32-5. . View in PubMed
  • Signals that initiate, augment, and provide directionality for human keratinocyte motility J Invest Dermatol. 2004 Oct; 123(4):622-33. . View in PubMed
  • Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen J Biol Chem. 2004 Feb 06; 279(6):4820-8. . View in PubMed
  • Polytetrafluoroethylene facial implants: 15 years later Plast Reconstr Surg. 2004 Jan; 113(1):347-9. . View in PubMed
  • Fibrinogen inhibits fibroblast-mediated contraction of collagen Wound Repair Regen. 2003 Sep-Oct; 11(5):380-5. . View in PubMed
  • Inflammatory mediators in wound healing Surg Clin North Am. 2003 Jun; 83(3):483-507. . View in PubMed
  • Migration of human keratinocytes in plasma and serum and wound re-epithelialisation Lancet. 2003 Feb 15; 361(9357):574-6. . View in PubMed
  • Fibroproliferative scars Clin Plast Surg. 2003 Jan; 30(1):77-89. . View in PubMed
  • IL-8-stimulated expression of urokinase-type plasminogen activator in human skin and human epidermal cells J Surg Res. 2002 Aug; 106(2):328-34. . View in PubMed
  • Tumor necrosis factor-alpha-induced proteolytic activation of pro-matrix metalloproteinase-9 by human skin is controlled by down-regulating tissue inhibitor of metalloproteinase-1 and mediated by tissue-associated chymotrypsin-like proteinase J Biol Chem. 2002 Jul 26; 277(30):27319-27. . View in PubMed
  • Recombinant human platelet-derived growth factor and transforming growth factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but does not require phosphatidylinositol-3′ kinase Wound Repair Regen. 2002 May-Jun; 10(3):169-76. . View in PubMed
  • Transforming growth factor-beta – and tumor necrosis factor-alpha -mediated induction and proteolytic activation of MMP-9 in human skin J Biol Chem. 2001 Jun 22; 276(25):22341-50. . View in PubMed
  • The use of 5% mafenide acetate solution in the postgraft treatment of necrotizing fasciitis J Burn Care Rehabil. 2001 Jan-Feb; 22(1):35-40. . View in PubMed
  • TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP J Cell Sci. 2001 Jan; 114(Pt 1):131-139. . View in PubMed
  • Memory of past exposure to the chemokine IL-8 inhibits the contraction of fibroblast-populated collagen lattices Exp Mol Pathol. 2000 Dec; 69(3):242-7. . View in PubMed
  • Acute burns Plast Reconstr Surg. 2000 Jun; 105(7):2482-92; quiz 2493; discussion 2494. . View in PubMed
  • Acute Burns Plast Reconstr Surg. 2000 Jun; 101(7):2482-2493. . View in PubMed
  • Interleukin-8 levels and activity in delayed-healing human thermal wounds Wound Repair Regen. 2000 May-Jun; 8(3):216-25. . View in PubMed
  • Management of chemical injuries to the upper extremity Hand Clin. 2000 May; 16(2):215-24. . View in PubMed
  • Epidermal regulation of dermal fibroblast activity Plast Reconstr Surg. 1998 Jul; 102(1):135-9. . View in PubMed
  • If we are not plastic surgeons, who are we? Plast Reconstr Surg. 1998 Apr; 101(4):1123-4.. View in PubMed
  • Gore-Tex facial implantsPlastic Surgery Educational Foundation DATA Committee. Plast Reconstr Surg. 1997 Dec; 100(7):1899-900. . View in PubMed
  • Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture J Clin Invest. 1997 Sep 01; 100(5):1271-81. . View in PubMed
  • Biomechanical alterations in normal skin and hypertrophic scar after thermal injury J Burn Care Rehabil. 1997 Mar-Apr; 18(2):104-8. . View in PubMed
  • Review of the use of botulinum toxin for aesthetic improvement Ann Plast Surg. 1996 Feb; 36(2):192. . View in PubMed
  • Fibroblast responses to cytokines are maintained during aging Ann Plast Surg. 1995 Sep; 35(3):290-6. . View in PubMed
  • The effect of essential fatty acid supplementation on keratinocyte replication Prostaglandins Leukot Essent Fatty Acids. 1995 May; 52(5):349-55. . View in PubMed
  • Increased types I and III collagen and transforming growth factor-beta 1 mRNA and protein in hypertrophic burn scar J Invest Dermatol. 1995 May; 104(5):750-4. . View in PubMed
  • Hypertrophic scar fibroblasts accelerate collagen gel contraction Wound Repair Regen. 1995 Apr-Jun; 3(2):185-91. . View in PubMed
  • Excessive scarring as a consequence of healing Wound Repair Regen. 1995 Jan-Mar; 3(1):6-14. . View in PubMed
  • Morphological and immunochemical differences between keloid and hypertrophic scar Am J Pathol. 1994 Jul; 145(1):105-13. . View in PubMed
  • Acute skin injury releases neutrophil chemoattractants Surgery. 1994 Jul; 116(1):42-8. . View in PubMed
  • The role of xanthine oxidase and xanthine dehydrogenase in skin ischemia J Surg Res. 1994 Feb; 56(2):162-7. . View in PubMed
  • Donor site repair Am J Surg. 1994 Jan; 167(1A):49S-51S. . View in PubMed
  • Burn wounds: infection and healing Am J Surg. 1994 Jan; 167(1A):46S-48S. . View in PubMed
  • Phenotypic differences in cytokine responsiveness of hypertrophic scar versus normal dermal fibroblasts J Invest Dermatol. 1993 Dec; 101(6):875-9. . View in PubMed
  • Control of hemorrhage during renal failure with triglycyl-lysine-vasopressin Ann Plast Surg. 1993 Jul; 31(1):78-81. . View in PubMed
  • Effect of triglycyl-lysine-vasopressin on skin blood flow and blood loss during wound excision in patients with burns J Burn Care Rehabil. 1993 Jul-Aug; 14(4):458-60. . View in PubMed
  • Correlation of the local and systemic cytokine response with clinical outcome following thermal injury J Trauma. 1993 May; 34(5):684-94; discussion 694-5. . View in PubMed
  • The effects of burn blister fluid on keratinocyte replication and differentiation J Burn Care Rehabil. 1993 Mar-Apr; 14(2 Pt 1):127-31. . View in PubMed
  • Reconstruction of burns of the trunk and breast Clin Plast Surg. 1992 Jul; 19(3):683-91. . View in PubMed
  • Skin grafting: dermal components in inhibition of wound contraction South Med J. 1990 Jul; 83(7):789-95. . View in PubMed
  • The effects of hyperoxia during fulminant sepsis Surgery. 1989 Jun; 105(6):747-51. . View in PubMed
  • Identification of the collagen-producing cells in healing flexor tendons Plast Reconstr Surg. 1989 May; 83(5):875-9. . View in PubMed
  • Physical, biomechanical, histologic, and biochemical effects of rapid versus conventional tissue expansion Plast Reconstr Surg. 1989 Apr; 83(4):687-91. . View in PubMed
  • Hemodialysis of amikacin in critically ill patients Crit Care Med. 1988 May; 16(5):517-20. . View in PubMed
  • Real-time continuous estimation of gas exchange by dual oximetry Intensive Care Med. 1988; 14(2):118-22. . View in PubMed
  • Recurrent hypersplenism caused by alcoholic cardiomyopathy after distal splenorenal shunt Surgery. 1986 Apr; 99(4):514-6. . View in PubMed
  • Reye’s syndrome associated with adenovirus infections in infants Am J Dis Child. 1985 Apr; 139(4):343-6. . View in PubMed