Dr. Alex K. Wong is an Associate Professor of Surgery in the Division of Plastic and Reconstructive Surgery. He is the Director of our Microvascular Surgery Fellowship Program, Director of Basic, Translation, and Clinical Research, and Director for Medical Student Education.
Dr. Wong performs aesthetic surgery of the face, breast, and body. He has a special interest in breast augmentation with implants and autologous fat grafting. His reconstructive practice is focused on microsurgical free tissue transfer for the management of complex wounds, post-oncologic reconstruction, abdominal wall reconstruction, and lymphedema surgery. Dr. Wong has attending staff appointments at Keck University Hospital of USC, LAC+USC Medical Center, Huntington Memorial Hospital, Los Robles Hospital, and Garfield Medical Center.
Some of Dr. Wong's many qualifications include: Member of the American Society of Plastic Surgeons, American Society for Reconstructive Microsurgery, World Society for Reconstructive Microsurgery, and Plastic Surgery Research Council. He is a Diplomat of the American Board of Plastic Surgery and Fellow of the American College of Surgeons. Dr. Wong has been named one of Pasadena Magazine's Top Doctors for every year since 2010, and a Rising Star for 2013, 2014, and 2015 by SuperDoctors/Los Angeles Magazine.
As a member of the full time Keck School of Medicine USC faculty, Dr. Wong teaches and mentors the next generation of doctors and plastic surgeons. He serves as the Director of Plastic Surgery Visiting Clerkship at the Keck School of Medicine.
In addition to his clinical practice, Dr. Wong directs a research laboratory at the USC Institute of Genetic Medicine with focus areas in lymphedema, adult-derived stem cells and novel biologics for wound healing, molecular pathogenesis of silicone breast implant capsular contracture, and microvascular flap physiology. Dr. Wong has received multiple grants and awards from organizations such as the National Institutes of Health, Howard Hughes Medical Institute, Plastic Surgery Educational Foundation, American Society for Maxillofacial Surgery, Wright Foundation, Whittier Foundation, American Cancer Society, and Southern California-Clinical Translational Science Institute (SC-CTSI). His work has been published in a variety of high impact peer reviewed journals.
Prior to joining the faculty at USC, Dr. Wong completed his Fellowship training at the NYU Institute of Reconstructive Plastic Surgery and completed his formal Plastic Surgery residency at the University of Pittsburgh. Dr. Wong received his medical degree from Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology and is an honors graduate of the College of Arts and Sciences of Cornell University.
USC: SC-CTSI KL2 Mentored Research Award, 2013-2016
USC: SuperDoctors Rising Star , 2013-2016
USC: Pasadena Magazine Top Doctor, 2010-2016
USC: Robert E. and May R. Wright Foundation Award , 2010-2012
Harvard Medical School: Howard Hughes Medical Institute Fellowship, 1999-2000
Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat. Sci Rep. 2017 Jul 17; 7(1):5577. View in: PubMed
Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017 Jun 20; 7(1):3876. View in: PubMed
ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439. View in: PubMed
Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. View in: PubMed
Spinning Out of Control: A 19-Year-Old Female with Spinning-Related Exertional Thigh Compartment Syndrome. Cureus. 2016 Dec 24; 8(12):e939. View in: PubMed
An update and review of cell-based wound dressings and their integration into clinical practice. Ann Transl Med. 2016 Dec; 4(23):457. View in: PubMed
Integra-based Reconstruction of Large Scalp Wounds: A Case Report and Systematic Review of the Literature. Plast Reconstr Surg Glob Open. 2016 Oct; 4(10):e1074. View in: PubMed
Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid. Ann Surg. 2016 Aug; 264(2):353-61. View in: PubMed
Efficient Assessment of Developmental, Surgical and Pathological Lymphangiogenesis Using a Lymphatic Reporter Mouse and Its Embryonic Stem Cells. PLoS One. 2016; 11(6):e0157126. View in: PubMed
Analysis of risk factors associated with microvascular free flap failure using a multi-institutional database. Microsurgery. 2015 Jan; 35(1):6-12. View in: PubMed
Determination of a perfusion threshold in experimental perforator flap surgery using indocyanine green angiography. Ann Plast Surg. 2014 Nov; 73(5):602-6. View in: PubMed
Assessment of three-dimensional high-definition visualization technology to perform microvascular anastomosis. J Plast Reconstr Aesthet Surg. 2014 Jul; 67(7):967-72. View in: PubMed
Update and Review on the Surgical Management of Primary Cutaneous Melanoma. Healthcare (Basel). 2014 Jun 10; 2(2):234-49. View in: PubMed
Abstract 31: DNA methylation analysis of radiated skin reveals chonic inflammation with a predominance of polymorphonuclear granulocytes. Plast Reconstr Surg. 2014 Mar; 133(3 Suppl):42. View in: PubMed
Simulation of plastic surgery and microvascular procedures using perfused fresh human cadavers. J Plast Reconstr Aesthet Surg. 2014 Feb; 67(2):e42-8. View in: PubMed
Identification of the critical therapeutic entity in secreted Hsp90a that promotes wound healing in newly re-standardized healthy and diabetic pig models. PLoS One. 2014; 9(12):e113956. View in: PubMed
Metastasis of hepatocellular and renal cell carcinoma to the hand. Plast Reconstr Surg Glob Open. 2013 Dec; 1(9):e83. View in: PubMed
Risk factors associated with venous thromboembolism in 49,028 mastectomy patients. Breast. 2013 Aug; 22(4):444-8. View in: PubMed
Incidence of surgical-site infection is not affected by method of immediate breast reconstruction. Plast Reconstr Surg. 2013 Jul; 132(1):20e-9e. View in: PubMed
Identifying risk factors for surgical site infections in mastectomy patients using the National Surgical Quality Improvement Program database. Am J Surg. 2013 Feb; 205(2):194-9. View in: PubMed
Novel biomarkers of arterial and venous ischemia in microvascular flaps. PLoS One. 2013; 8(8):e71628. View in: PubMed
Effect of immediate reconstruction on postmastectomy surgical site infection. Ann Surg. 2012 Aug; 256(2):326-33. View in: PubMed
Breast implants and minimally invasive cardiac surgery: a case series. Ann Plast Surg. 2012 Jul; 69(1):10-3. View in: PubMed
A systematic review and meta-analysis of complications associated with acellular dermal matrix-assisted breast reconstruction. Ann Plast Surg. 2012 Apr; 68(4):346-56. View in: PubMed
9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema. Circulation. 2012 Feb 21; 125(7):872-82. View in: PubMed
The variation in the absence of the palmaris longus in a multiethnic population of the United States: an epidemiological study. Plast Surg Int. 2012; 2012:282959. View in: PubMed
Use of human acellular dermal matrix in implant- based breast reconstruction: evaluating the evidence. J Plast Reconstr Aesthet Surg. 2011 Dec; 64(12):1553-61. View in: PubMed
Radioprotection of osteoblasts by a fractionated dose regimen and amifostine. Plast Reconstr Surg. 2009 Feb; 123(2 Suppl):104S-13S. View in: PubMed
Ionizing radiation of mesenchymal stem cells results in diminution of the precursor pool and limits potential for multilineage differentiation. Plast Reconstr Surg. 2008 Jul; 122(1):64-76. View in: PubMed
Hyperbaric oxygen inhibits growth but not differentiation of normal and irradiated osteoblasts. J Craniofac Surg. 2008 May; 19(3):757-65. View in: PubMed
Histologic analysis of angiogenesis and lymphangiogenesis in acellular human dermis. Plast Reconstr Surg. 2008 Apr; 121(4):1144-52. View in: PubMed
Treatment of hydroxyapatite scaffolds with fibronectin and fetal calf serum increases osteoblast adhesion and proliferation in vitro. Plast Reconstr Surg. 2008 Mar; 121(3):751-62. View in: PubMed
Soft-tissue coverage of the hand following sarcoma resection. Plast Reconstr Surg. 2008 Feb; 121(2):534-43. View in: PubMed
The effect of hyperbaric oxygen treatment on squamous cell cancer growth and tumor hypoxia. Ann Plast Surg. 2008 Jan; 60(1):81-8. View in: PubMed
Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene. 2006 Apr 13; 25(16):2304-17. View in: PubMed
Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7481-6. View in: PubMed
An inducible melanoma model implicates a role for RAS in tumor maintenance and angiogenesis. Cancer Metastasis Rev. 2000; 19(1-2):121-9. View in: PubMed