Faculty

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Austin K Mircheff, PhD
Professor of Physiology & Biophysics
Physiology and Biophysics
BMT 11-A, 1333 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 1242

Publications

. View in: PubMed

Multiple Natural and Experimental Inflammatory Rabbit Lacrimal Gland Phenotypes. Ocul Surf. 2016 Oct; 14(4):460-483. e3. View in: PubMed

Dry eye in postmenopausal women: a hormonal disorder. Menopause. 2016 Mar; 23(3):343-51. View in: PubMed

Potentially pathogenic immune cells and networks in apparently healthy lacrimal glands. Ocul Surf. 2015 Jan; 13(1):47-81. View in: PubMed

Diverse mediators modulate the chloride ion fluxes that drive lacrimal fluid production. Invest Ophthalmol Vis Sci. 2013 Apr 26; 54(4):2927-33. View in: PubMed

Autoimmune dacryoadenitis and sialadenitis induced in rabbits by intravenous injection of autologous lymphocytes activated ex vivo against lacrimal antigens. Cornea. 2012 Jun; 31(6):693-701. View in: PubMed

A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. View in: PubMed

Systematic variations in immune response-related gene transcript abundance suggest new questions about environmental influences on lacrimal gland immunoregulation. Curr Eye Res. 2011 Apr; 36(4):285-94. View in: PubMed

Adeno-associated virus-mediated IL-10 gene transfer suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5137-44. View in: PubMed

Distinct dacryoadenitides autoadoptively transferred to rabbits by different subpopulations of lymphocytes activated ex vivo. Cornea. 2010 Oct; 29(10):1153-62. View in: PubMed

A lacrimal gland is a lacrimal gland, but rodent's and rabbit's are not human. Ocul Surf. 2010 Jul; 8(3):111-34. View in: PubMed

Microporous poly(L-lactic acid) membranes fabricated by polyethylene glycol solvent-cast/particulate leaching technique. Tissue Eng Part C Methods. 2009 Sep; 15(3):463-74. View in: PubMed

Cytopathology and exocrine dysfunction induced in ex vivo rabbit lacrimal gland acinar cell models by chronic exposure to histamine or serotonin. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3164-75. View in: PubMed

Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis. J Ocul Pharmacol Ther. 2009 Jun; 25(3):285-92. View in: PubMed

Animal models of dry eye. Dev Ophthalmol. 2008; 41:298-312. View in: PubMed

Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells. Exp Eye Res. 2007 Dec; 85(6):749-61. View in: PubMed

Transepithelial bioelectrical properties of rabbit acinar cell monolayers on polyester membrane scaffolds. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1412-9. View in: PubMed

Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34. View in: PubMed

Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Mol Cancer Ther. 2007 Apr; 6(4):1262-75. View in: PubMed

Tissue-engineered tear secretory system: functional lacrimal gland acinar cells cultured on matrix protein-coated substrata. J Biomed Mater Res B Appl Biomater. 2007 Jan; 80(1):192-200. View in: PubMed

Current status of gene delivery and gene therapy in lacrimal gland using viral vectors. Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57. View in: PubMed

Characterization of beta-hexosaminidase secretion in rabbit lacrimal gland. Exp Eye Res. 2006 Nov; 83(5):1081-8. View in: PubMed

Interacting influences of pregnancy and corneal injury on rabbit lacrimal gland immunoarchitecture and function. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1368-75. View in: PubMed

Mucosal immunity and self-tolerance in the ocular surface system. Ocul Surf. 2005 Oct; 3(4):182-92. View in: PubMed

Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis. J Autoimmune Dis. 2005 Jun 28; 2:6. View in: PubMed

Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation. Exp Eye Res. 2004 Nov; 79(5):665-75. View in: PubMed

Role of the microtubule cytoskeleton in traffic of EGF through the lacrimal acinar cell endomembrane network. Exp Eye Res. 2004 Jun; 78(6):1093-106. View in: PubMed

Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis. Invest Ophthalmol Vis Sci. 2004 May; 45(5):1375-81. View in: PubMed

Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells. J Cell Physiol. 2004 Apr; 199(1):108-25. View in: PubMed

Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413. View in: PubMed

Sjogrens syndrome as failed local immunohomeostasis: prospects for cell-based therapy. Ocul Surf. 2003 Oct; 1(4):160-79. View in: PubMed

Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells. J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. View in: PubMed

Tumor necrosis factor inhibitor gene expression suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. Cornea. 2003 May; 22(4):343-51. View in: PubMed

Lacrimal histopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis. Cornea. 2003 Jan; 22(1):25-32. View in: PubMed

The Ocular Surface Center at the University of Southern California. Ocul Surf. 2003 Jan; 1(1):41-5. View in: PubMed

Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra. DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42. View in: PubMed

Growth of purified lacrimal acinar cells in Matrigel raft cultures. Exp Eye Res. 2002 Mar; 74(3):349-60. View in: PubMed

Expression of IL-10 and TNF-inhibitor genes in lacrimal gland epithelial cells suppresses their ability to activate lymphocytes. Cornea. 2002 Mar; 21(2):210-4. View in: PubMed

Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system. Exp Eye Res. 2002 Jan; 74(1):7-22. View in: PubMed

Effect of anti-inflammatory cytokines on the activation of lymphocytes by lacrimal gland acinar cells in an autologous mixed cell reaction. Adv Exp Med Biol. 2002; 506(Pt B):789-94. View in: PubMed

Glycolipid-rich membrane microdomains in lacrimal acinar cell endomembrane compartments. Adv Exp Med Biol. 2002; 506(Pt A):207-11. View in: PubMed

M3 receptor autoimmunity: losing tolerance to a familiar protein. Adv Exp Med Biol. 2002; 506(Pt A):51-8. View in: PubMed

Prolactin inhibits carbachol-dependent secretion by lacrimal acinar cells in vitro. Adv Exp Med Biol. 2002; 506(Pt A):231-5. View in: PubMed

Epidermal growth factor traffic in lacrimal acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):213-7. View in: PubMed

A new model system for studying lacrimal physiology using cultured lacrimal gland acinar cells on Matrigel rafts. Adv Exp Med Biol. 2002; 506(Pt A):159-63. View in: PubMed

IL-2 immunoreactive proteins in lacrimal acinar cells. Adv Exp Med Biol. 2002; 506(Pt B):795-9. View in: PubMed

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