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Axel Montagne, PhD
Assistant Professor of Research Physiology & Neuroscience
Assistant Director, Functional Biological Imaging Core
Zilkha Neurogenetic Institute
ZNI 301, 1501 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 2565


Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 Feb 05. View in: PubMed

Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169. View in: PubMed

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci. 2017 Jul; 18(7):419-434. View in: PubMed

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling. PLoS One. 2017; 12(4):e0176225. View in: PubMed

Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons. Mol Neurobiol. 2016 Sep; 53(7):5000-12. View in: PubMed

Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med. 2016 May; 75(5):1967-77. View in: PubMed

Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathol. 2016 May; 131(5):687-707. View in: PubMed

Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research. JAMA Neurol. 2016 Jan; 73(1):13-4. View in: PubMed

ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. BMC Med Imaging. 2015 Jun 16; 15:19. View in: PubMed

Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activator. Stroke. 2015 Jun; 46(6):1641-50. View in: PubMed

Vascular plasticity and cognition during normal aging and dementia. JAMA Neurol. 2015 May; 72(5):495-6. View in: PubMed

7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice. Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. View in: PubMed

Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. View in: PubMed

Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis. Neuropharmacology. 2014 Oct; 85:158-65. View in: PubMed

GpIba-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice. Blood. 2014 May 22; 123(21):3354-63. View in: PubMed

Molecular magnetic resonance imaging of brain-immune interactions. Front Cell Neurosci. 2014; 8:389. View in: PubMed

Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy. Stroke. 2013 Dec; 44(12):3482-9. View in: PubMed

Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes. Stroke. 2013 Jul; 44(7):1988-96. View in: PubMed

Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-D-aspartate glutamate receptors improves hemorrhagic stroke outcome. Neuropharmacology. 2013 Apr; 67:267-71. View in: PubMed

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity. Cell Death Differ. 2012 Dec; 19(12):1983-91. View in: PubMed

Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders. Neuroimage. 2012 Nov 01; 63(2):760-70. View in: PubMed

Memantine improves safety of thrombolysis for stroke. Stroke. 2012 Oct; 43(10):2774-81. View in: PubMed

Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci. 2012 Apr 11; 32(15):5186-99. View in: PubMed

Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence. J Cereb Blood Flow Metab. 2011 Nov; 31(11):2119-34. View in: PubMed

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo. Mol Neurodegener. 2011 Oct 05; 6:68. View in: PubMed

Tissue plasminogen activator prevents white matter damage following stroke. J Exp Med. 2011 Jun 06; 208(6):1229-42. View in: PubMed

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity. Cell Death Differ. 2010 May; 17(5):860-71. View in: PubMed

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