Faculty

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Carol Ann Miller, MD
Professor of Pathology
Pathology
MCA 1333 San Pablo Street Off Campus Los Angeles
+1 323 442 1602

Publications

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 Sep; 49(9):1373-1384. View in: PubMed

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Synaptic Amyloid-ß Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol. 2016 Jan; 186(1):185-98. View in: PubMed

Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):216-27. View in: PubMed

Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul; 18(7):978-87. View in: PubMed

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. J Neurochem. 2015 May; 133(3):368-79. View in: PubMed

Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States. JAMA Neurol. 2015 Feb 1; 72(2):209-16. View in: PubMed

Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. View in: PubMed

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. View in: PubMed

Effects of multiple genetic Loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov 1; 71(11):1394-404. View in: PubMed

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathol. 2014 Mar; 127(3):407-18. View in: PubMed

Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways. Am J Physiol Lung Cell Mol Physiol. 2014 Jan; 306(2):L162-9. View in: PubMed

Levels of soluble apolipoprotein E/amyloid-ß (Aß) complex are reduced and oligomeric Aß increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J Biol Chem. 2013 Feb 22; 288(8):5914-26. View in: PubMed

Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses. Brain Pathol. 2012 Nov; 22(6):826-33. View in: PubMed

DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease. J Mol Neurosci. 2012 Sep; 48(1):97-110. View in: PubMed

AD synapses contain abundant Aß monomer and multiple soluble oligomers, including a 56-kDa assembly. Neurobiol Aging. 2012 Aug; 33(8):1545-55. View in: PubMed

Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. View in: PubMed

Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex. Neurobiol Dis. 2012 Jan; 45(1):381-7. View in: PubMed

Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. Acta Neuropathol. 2012 Jan; 123(1):39-52. View in: PubMed

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. View in: PubMed

High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease. Cell Calcium. 2011 Apr; 49(4):208-16. View in: PubMed

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage. 2011 Jan; 54 Suppl 1:S204-17. View in: PubMed

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. View in: PubMed

Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease. PLoS One. 2009; 4(3):e4936. View in: PubMed

Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Am J Pathol. 2008 Jun; 172(6):1683-92. View in: PubMed

Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex. Neurobiol Aging. 2007 Jan; 28(1):8-17. View in: PubMed

Mitogen-activated protein kinase signaling, oxygen sensors and hypoxic induction of neurogenesis. Neurodegener Dis. 2006; 3(1-2):50-5. View in: PubMed

JIP1 regulates neuronal apoptosis in response to stress. Brain Res Mol Brain Res. 2005 Apr 04; 134(2):282-93. View in: PubMed

JIP1 regulates neuronal apoptosis in response to stress. Brain Res Mol Brain Res. 2005 Apr 4; 134(2):282-93. View in: PubMed

Phospho-beta-catenin accumulation in Alzheimer's disease and in aggresomes attributable to proteasome dysfunction. J Mol Neurosci. 2005; 25(1):79-94. View in: PubMed

Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol. 2004 Nov; 165(5):1809-17. View in: PubMed

Detecting bioactive amyloid beta peptide species in Alzheimer's disease. J Neurochem. 2004 Nov; 91(3):648-56. View in: PubMed

Neurogenesis response to hypoxia-induced cell death: map kinase signal transduction mechanisms. Brain Res. 2004 Sep 17; 1021(1):8-19. View in: PubMed

Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4210-5. View in: PubMed

Beta-amyloid racemized at the Ser26 residue in the brains of patients with Alzheimer disease: implications in the pathogenesis of Alzheimer disease. J Neuropathol Exp Neurol. 2003 Mar; 62(3):248-59. View in: PubMed

Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. View in: PubMed

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