Faculty

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Clive Roy Taylor, MD, PhD
Professor of Pathology
Pathology
HMR 2011 Zonal Ave Health Sciences Campus Los Angeles
+1 323 442 1215

Overview

Before joining the USC faculty, Dr. Taylor was a lecturer in pathology at the University of Oxford for five years. After 30 years as a USC professor, Dr. Taylor was named chair of Pathology and Laboratory Medicine at the University of Southern California. He has also served three years as president of the Association of Pathology Chairs, three years as president of the Biological Stain Commission and chair of the FDA Panel for Diagnostic Devices.

Publications

Whole Slide Imaging Versus Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter Blinded Randomized Noninferiority Study of 1992 Cases (Pivotal Study). Am J Surg Pathol. 2017 Sep 28. View in: PubMed

Improved and Standardized Approaches to Selection of Control Materials From ISIMM: Announcing a Workshop at the Annual ASCP Meeting, September 6-7, 2017, Sponsored by the International Society for Immunohistochemistry and Molecular Morphology. Appl Immunohistochem Mol Morphol. 2017 Aug; 25(7):451-452. View in: PubMed

Quality Control in Modern Immunohistochemistry: Real-time Performance Characteristics and Quality Control of Important Widely Used Antibodies. Appl Immunohistochem Mol Morphol. 2017 Jul; 25(6):375-376. View in: PubMed

An Audit of Failed Immunohistochemical Slides in a Clinical Laboratory: The Role of On-Slide Controls. Appl Immunohistochem Mol Morphol. 2017 May/Jun; 25(5):308-312. View in: PubMed

Distribution of RANK and RANK Ligand in Normal Human Tissues as Determined by an Optimized Immunohistochemical Method. Appl Immunohistochem Mol Morphol. 2017 May/Jun; 25(5):299-307. View in: PubMed

Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine - Part 2: Immunohistochemistry Test Performance Characteristics. Appl Immunohistochem Mol Morphol. 2017 Feb; 25(2):79-85. View in: PubMed

PD-L1 Assessment for Targeted Therapy Testing in Cancer: Urgent Need For Realistic Economic and Practice Expectations. Appl Immunohistochem Mol Morphol. 2017 Jan; 25(1):1-3. View in: PubMed

Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine: Part 4: Tissue Tools for Quality Assurance in Immunohistochemistry. Appl Immunohistochem Mol Morphol. 2016 Dec 09. View in: PubMed

FOXC1 identifies basal-like breast cancer in a hereditary breast cancer cohort. Oncotarget. 2016 Nov 15; 7(46):75729-75738. View in: PubMed

The International Society for Immunohistochemistry and Molecular Morphology (ISIMM). Appl Immunohistochem Mol Morphol. 2016 May-Jun; 24(5):307-8. View in: PubMed

HistoMosaic Detecting KRAS G12V Mutation Across Colorectal Cancer Tissue Slices through in Situ PCR. Anal Chem. 2016 Mar 01; 88(5):2792-8. View in: PubMed

Getting controls under control: the time is now for immunohistochemistry. J Clin Pathol. 2015 Nov; 68(11):879-82. View in: PubMed

Development of an automated PD-L1 immunohistochemistry (IHC) assay for non-small cell lung cancer. Appl Immunohistochem Mol Morphol. 2015 Sep; 23(8):541-9. View in: PubMed

Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay. J Natl Cancer Inst. 2015 Aug; 107(8). View in: PubMed

Quantitative in situ proteomics; a proposed pathway for quantification of immunohistochemistry at the light-microscopic level. Cell Tissue Res. 2015 Apr; 360(1):109-20. View in: PubMed

Anaplastic large cell lymphoma occurring in women with breast implants: analysis of 173 cases. Plast Reconstr Surg. 2015 Mar; 135(3):695-705. View in: PubMed

Standardization of positive controls in diagnostic immunohistochemistry: recommendations from the International Ad Hoc Expert Committee. Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):1-18. View in: PubMed

Predictive biomarkers and companion diagnostics. The future of immunohistochemistry: "in situ proteomics," or just a "stain"? Appl Immunohistochem Mol Morphol. 2014 Sep; 22(8):555-61. View in: PubMed

Standardization of negative controls in diagnostic immunohistochemistry: recommendations from the international ad hoc expert panel. Appl Immunohistochem Mol Morphol. 2014 Apr; 22(4):241-52. View in: PubMed

Immunohistochemistry in surgical pathology: principles and practice. Methods Mol Biol. 2014; 1180:81-109. View in: PubMed

Practicing pathology in the era of big data and personalized medicine. Appl Immunohistochem Mol Morphol. 2014 Jan; 22(1):1-9. View in: PubMed

Immunohistochemistry. Curr Protoc Immunol. 2013 Nov 18; 103:Unit 21. 4. View in: PubMed

Thomas Hodgkin: the "man" and "his disease": humani nihil a se alienum putabit (nothing human was foreign to him). Virchows Arch. 2013 Sep; 463(3):353-65. View in: PubMed

The rise and fall of the autopsy. Virchows Arch. 2013 Apr; 462(4):371-80. View in: PubMed

Complete solubilization of formalin-fixed, paraffin-embedded tissue may improve proteomic studies. Proteomics Clin Appl. 2013 Apr; 7(3-4):264-72. View in: PubMed

Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1. Urology. 2013 Feb; 81(2):464. e1-9. View in: PubMed

Anaplastic large cell lymphoma occurring in association with breast implants: review of pathologic and immunohistochemical features in 103 cases. Appl Immunohistochem Mol Morphol. 2013 Jan; 21(1):13-20. View in: PubMed

Immunohistochemistry cocktails are here to stay: Center of Medicare and Medicaid Services should revise its new reimbursement policy. Appl Immunohistochem Mol Morphol. 2012 Jul; 20(4):331-3. View in: PubMed

From microscopy to whole slide digital images: a century and a half of image analysis. Appl Immunohistochem Mol Morphol. 2011 Dec; 19(6):491-3. View in: PubMed

Human breast cancer histoid: an in vitro 3-dimensional co-culture model that mimics breast cancer tissue. J Histochem Cytochem. 2011 Dec; 59(12):1087-100. View in: PubMed

New revised Clinical and Laboratory Standards Institute Guidelines for Immunohistochemistry and Immunocytochemistry. Appl Immunohistochem Mol Morphol. 2011 Jul; 19(4):289-90. View in: PubMed

Classifications of lymphoma; reflections of time and technology. Virchows Arch. 2011 Jun; 458(6):637-48. View in: PubMed

Focus on biospecimens: the issue is the tissue. observations on the "NCI-NIST fitness-for-purpose quality assessment and standards development workshop," October 2010. Appl Immunohistochem Mol Morphol. 2011 Mar; 19(2):95-8. View in: PubMed

Antigen retrieval immunohistochemistry: review and future prospects in research and diagnosis over two decades. J Histochem Cytochem. 2011 Jan; 59(1):13-32. View in: PubMed

"Liquid morphology": Immunochemical analysis of proteins extracted from formalin-fixed paraffin-embedded tissues: Combining proteomics with immunohistochemistry. Appl Immunohistochem Mol Morphol. 2011 Jan; 19(1):1-9. View in: PubMed

A "medical student practice profile" as the foundation for a case-based curriculum revision. Teach Learn Med. 2010 Oct; 22(4):307-11. View in: PubMed

From anatomy to surgery to pathology: eighteenth century London and the Hunterian schools. Virchows Arch. 2010 Oct; 457(4):405-14. View in: PubMed

The development of a comprehensive school-wide simulation-based procedural skills curriculum for medical students. J Surg Educ. 2010 Sep-Oct; 67(5):309-15. View in: PubMed

Introduction to the History of Pathology series. Virchows Arch. 2010 Jul; 457(1):1-2. View in: PubMed

A brief history of pathology: Preface to a forthcoming series that highlights milestones in the evolution of pathology as a discipline. Virchows Arch. 2010 Jul; 457(1):3-10. View in: PubMed

Perspective: a tale of two curricula: a case for evidence-based education? Acad Med. Perspective: a tale of two curricula: a case for evidence-based education? Acad Med. 2010 Mar; 85(3):507-11. View in: PubMed

Internally calibrated quantification of VEGF in human plasma by fluorescence immunoassays in disposable elastomeric microfluidic devices. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jan 15; 878(2):258-63. View in: PubMed

Tumors of uncertain origin and their ilk. Appl Immunohistochem Mol Morphol. 2010 Jan; 18(1):1-2. View in: PubMed

Immunohistochemical detection of hepatitis C virus (genotype 4) in B-cell NHL in an Egyptian population: correlation with serum HCV-RNA. Appl Immunohistochem Mol Morphol. 2010 Jan; 18(1):29-34. View in: PubMed

A real-time pluripotency reporter for human stem cells. Stem Cells Dev. 2010 Jan; 19(1):47-52. View in: PubMed

Elastomeric microfluidic diode and rectifier work with Newtonian fluids. J Appl Phys. 2009 Dec 01; 106(11):114311. View in: PubMed

The WHO classification of lymphomas: cost-effective immunohistochemistry using a deductive reasoning "decision tree" approach: part II: the decision tree approach: diffuse patterns of proliferation in lymph nodes. Appl Immunohistochem Mol Morphol. 2009 Dec; 17(6):470-82. View in: PubMed

IHC and the WHO classification of lymphomas: cost effective immunohistochemistry using a deductive reasoning "decision tree" approach. Appl Immunohistochem Mol Morphol. 2009 Oct; 17(5):366-74. View in: PubMed

J1-31 protein expression in astrocytes and astrocytomas. Neuropathology. 2009 Oct; 29(5):521-7. View in: PubMed

Development of a career pathways program to help students with specialty choices. Med Teach. 2009 Sep; 31(9):871. View in: PubMed

Internally calibrated quantification of protein analytes in human serum by fluorescence immunoassays in disposable elastomeric microfluidic devices. Electrophoresis. 2008 Dec; 29(24):5010-6. View in: PubMed

Consensus recommendations on estrogen receptor testing in breast cancer by immunohistochemistry. Appl Immunohistochem Mol Morphol. 2008 Dec; 16(6):513-20. View in: PubMed

Pathology education: quo vadis? Hum Pathol. Pathology education: quo vadis? Hum Pathol. 2008 Nov; 39(11):1555-61. View in: PubMed

Re: High concordance between immunohistochemistry and fluorescence in situ hybridization testing for HER2 status in breast cancer requires a normalized IHC scoring system. Mod Pathol. 2008 Oct; 21(10):1278-80; author reply 1280-1. View in: PubMed

Evaluation of the value of frozen tissue section used as "gold standard" for immunohistochemistry. Am J Clin Pathol. 2008 Mar; 129(3):358-66. View in: PubMed

Antigen retrieval for proteomic characterization of formalin-fixed and paraffin-embedded tissues. J Proteome Res. 2008 Mar; 7(3):1098-108. View in: PubMed

A microfluidic processor for gene expression profiling of single human embryonic stem cells. Lab Chip. 2008 Jan; 8(1):68-74. View in: PubMed

Microfluidic devices for investigating stem cell gene regulation via single-cell analysis. Curr Med Chem. 2008; 15(28):2897-900. View in: PubMed

Begin at the beginning, with the tissue! The key message underlying the ASCO/CAP Task-force Guideline Recommendations for HER2 testing. Appl Immunohistochem Mol Morphol. 2007 Sep; 15(3):239-41. View in: PubMed

Viral RNA extraction for in-the-field analysis. J Virol Methods. 2007 Sep; 144(1-2):98-102. View in: PubMed

Telomerase and markers of cellular proliferation are associated with the progression of cervical intraepithelial neoplasia lesions. Int J Gynecol Pathol. 2007 Jul; 26(3):214-22. View in: PubMed

Recommendations for improved standardization of immunohistochemistry. Appl Immunohistochem Mol Morphol. 2007 Jun; 15(2):124-33. View in: PubMed

Editorial--a personal perspective. Appl Immunohistochem Mol Morphol. 2007 Jun; 15(2):121-3. View in: PubMed

Standardization of immunohistochemistry for formalin-fixed, paraffin-embedded tissue sections based on the antigen-retrieval technique: from experiments to hypothesis. J Histochem Cytochem. 2007 Feb; 55(2):105-9. View in: PubMed

Experimentally validated quantitative linear model for the device physics of elastomeric microfluidic valves. J Appl Phys. 2007; 101(6):64505. View in: PubMed

[Updates on antigen retrieval techniques for immunohistochemistry]. Zhonghua Bing Li Xue Za Zhi. 2007 Jan; 36(1):7-10. View in: PubMed

The nonphysician "medical student educator": a formal addition to the clerkships and key programs at an academic medical center. Teach Learn Med. 2007; 19(2):154-61. View in: PubMed

Electrical microfluidic pressure gauge for elastomer microelectromechanical systems. J Appl Phys. 2007; 102(8):84909-849094. View in: PubMed

Quantifiable internal reference standards for immunohistochemistry: the measurement of quantity by weight. Appl Immunohistochem Mol Morphol. 2006 Sep; 14(3):253-9. View in: PubMed

Microfluidic vias enable nested bioarrays and autoregulatory devices in Newtonian fluids. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12280-4. View in: PubMed

Protein extraction from formalin-fixed, paraffin-embedded tissue sections: quality evaluation by mass spectrometry. J Histochem Cytochem. 2006 Jun; 54(6):739-43. View in: PubMed

131I-chTNT radioimmunotherapy of 43 patients with advanced lung cancer. Cancer Biother Radiopharm. 2006 Feb; 21(1):5-14. View in: PubMed

Cell reservoirs in lymph nodes infected with HIV-1 subtype E differ from subtype B: identification by combined in situ polymerase chain reaction and immunohistochemistry. Mod Pathol. 2006 Feb; 19(2):255-63. View in: PubMed

Role of coordinated molecular alterations in the development of androgen-independent prostate cancer: an in vitro model that corroborates clinical observations. BJU Int. 2006 Jan; 97(1):170-8. View in: PubMed

High-throughput multi-antigen microfluidic fluorescence immunoassays. Biotechniques. 2006 Jan; 40(1):85-90. View in: PubMed

Distribution and ZAP-70 expression of WHO lymphoma categories in Shanxi, China: a review of 447 cases using a tissue microarray technique. Appl Immunohistochem Mol Morphol. 2005 Dec; 13(4):323-32. View in: PubMed

Protein-embedding technique: a potential approach to standardization of immunohistochemistry for formalin-fixed, paraffin-embedded tissue sections. J Histochem Cytochem. 2005 Sep; 53(9):1167-70. View in: PubMed

Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer. J Clin Oncol. 2005 Mar 01; 23(7):1538-47. View in: PubMed

Hodgkin's disease is a non-Hodgkin lymphoma. Hum Pathol. 2005 Jan; 36(1):1-4. View in: PubMed

The prognostic importance of immunohistochemically detected node metastases in resected esophageal adenocarcinoma. Ann Thorac Surg. 2004 Oct; 78(4):1161-9; discussion 1161-9. View in: PubMed

DNA extraction from archival formalin-fixed, paraffin-embedded tissues: heat-induced retrieval in alkaline solution. Histochem Cell Biol. 2004 Sep; 122(3):211-8. View in: PubMed

LEA-135 expression: its association with a lower risk of recurrence and increased overall survival of patients with lymph node-positive primary invasive breast cancer. Anticancer Res. 2004 Jul-Aug; 24(4):2391-400. View in: PubMed

Acute immunodeficiency, multiple organ injury, and the pathogenesis of SARS. Appl Immunohistochem Mol Morphol. 2003 Dec; 11(4):281-2. View in: PubMed

Apoptosis and cell cycle-related genes and proteins in classical Hodgkin lymphoma: application of tissue microarray technique. Appl Immunohistochem Mol Morphol. 2003 Sep; 11(3):206-13. View in: PubMed

A modified reduced-temperature antigen retrieval protocol effective for use with a polyclonal antibody to cyclooxygenase-2 (PG 27). Appl Immunohistochem Mol Morphol. 2002 Dec; 10(4):368-73. View in: PubMed

LEA. 135 expression: identifies low-risk patients with breast ductal carcinoma in situ. Anticancer Res. 2002 Sep-Oct; 22(5):2933-7. View in: PubMed

Globalization of pathology training and examination: The time to begin is now. Hum Pathol. 2002 Sep; 33(9):861-2. View in: PubMed

DNA extraction from archival formalin-fixed, paraffin-embedded tissue sections based on the antigen retrieval principle: heating under the influence of pH. J Histochem Cytochem. 2002 Aug; 50(8):1005-11. View in: PubMed

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